JP5273695B2 - ビフィズス菌を有効成分とするアレルギー予防および／または治療剤 - Google Patents
ビフィズス菌を有効成分とするアレルギー予防および／または治療剤 Download PDFInfo
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- JP5273695B2 JP5273695B2 JP2006057675A JP2006057675A JP5273695B2 JP 5273695 B2 JP5273695 B2 JP 5273695B2 JP 2006057675 A JP2006057675 A JP 2006057675A JP 2006057675 A JP2006057675 A JP 2006057675A JP 5273695 B2 JP5273695 B2 JP 5273695B2
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- bifidobacterium longum
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- bifidobacterium
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| CN109069555A (zh) * | 2016-04-13 | 2018-12-21 | 株式会社明治 | 面向新生儿的用于改善脑功能的组合物 |
| KR20190007251A (ko) * | 2017-07-12 | 2019-01-22 | 대한민국(농촌진흥청장) | 피부염 치료용 비피도박테리움 롱검 kacc 91563 및 이를 함유하는 치즈 |
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| JP2008195673A (ja) * | 2007-02-14 | 2008-08-28 | Nippon Meat Packers Inc | 延命効果物質、および感染防御効果・ワクチン効果促進物質、前記物質の検定用コンストラクト、並びにそれらの用途 |
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| BRPI0810087A2 (pt) * | 2007-03-28 | 2014-10-21 | Alimentary Health Ltd | Cepas de bifidobacterium probióticas |
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| JP2009057346A (ja) * | 2007-09-03 | 2009-03-19 | Kirin Holdings Co Ltd | 免疫バランス調節用組成物 |
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| WO2010101175A1 (ja) * | 2009-03-04 | 2010-09-10 | 明治乳業株式会社 | 凍結乾燥粉末状菌体及びその製造方法 |
| AU2010285128B2 (en) * | 2009-08-18 | 2015-05-14 | Société des Produits Nestlé S.A. | A nutritional composition comprising Bifidobacterium longum strains and reducing food allergy symtoms, especially in infants and children |
| JP5737646B2 (ja) * | 2010-03-24 | 2015-06-17 | 森下仁丹株式会社 | 抗アレルギー剤 |
| EP2449891A1 (en) * | 2010-11-05 | 2012-05-09 | Nestec S.A. | Drinking yoghurt preparations containing non-replicating probiotic micro-organisms |
| EP2449890A1 (en) * | 2010-11-05 | 2012-05-09 | Nestec S.A. | Powdered cereal compositions comprising non-replicating probiotic microorganisms |
| TW201636010A (zh) * | 2014-12-26 | 2016-10-16 | Meiji Co Ltd | 有機酸的產生促進劑、發炎性腸疾病的預防及／或改善劑 |
| JP6823302B2 (ja) * | 2015-10-19 | 2021-02-03 | 株式会社明治 | 乳児向けの抗アレルギー剤 |
| CA3052134C (en) * | 2017-01-31 | 2023-01-03 | University-Industry Cooperation Group Of Kyung Hee University | Novel lactic acid bacteria and use thereof |
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Family Cites Families (1)
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|---|---|---|---|---|
| JPH10309178A (ja) * | 1997-05-09 | 1998-11-24 | Wakamoto Pharmaceut Co Ltd | ビフィズス菌を有効成分とする抗アレルギー剤および醗酵食品 |
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| CN109069555A (zh) * | 2016-04-13 | 2018-12-21 | 株式会社明治 | 面向新生儿的用于改善脑功能的组合物 |
| EP3443969A4 (en) * | 2016-04-13 | 2019-11-20 | Meiji Co., Ltd. | COMPOSITION FOR IMPROVING BRAIN FUNCTION IN NEWBORNS |
| US10925906B2 (en) | 2016-04-13 | 2021-02-23 | Meiji Co., Ltd. | Composition for improving brain function for neonates |
| CN109069555B (zh) * | 2016-04-13 | 2022-07-26 | 株式会社明治 | 面向新生儿的用于改善脑功能的组合物 |
| KR20190007251A (ko) * | 2017-07-12 | 2019-01-22 | 대한민국(농촌진흥청장) | 피부염 치료용 비피도박테리움 롱검 kacc 91563 및 이를 함유하는 치즈 |
| KR101987678B1 (ko) * | 2017-07-12 | 2019-06-11 | 대한민국 | 피부염 치료용 비피도박테리움 롱검 kacc 91563 및 이를 함유하는 치즈 |
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