JP5269796B2 - ４種のデング血清型に対する免疫付与の方法 - Google Patents
４種のデング血清型に対する免疫付与の方法 Download PDFInfo
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- JP5269796B2 JP5269796B2 JP2009530916A JP2009530916A JP5269796B2 JP 5269796 B2 JP5269796 B2 JP 5269796B2 JP 2009530916 A JP2009530916 A JP 2009530916A JP 2009530916 A JP2009530916 A JP 2009530916A JP 5269796 B2 JP5269796 B2 JP 5269796B2
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0608660 | 2006-10-04 | ||
| FR0608660A FR2906724B1 (fr) | 2006-10-04 | 2006-10-04 | Methode d'immunisation contre les 4 serotypes de la dengue. |
| PCT/FR2007/052054 WO2008047023A2 (fr) | 2006-10-04 | 2007-10-02 | Methode d'immunisation contre les 4 serotypes de la dengue |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010505801A JP2010505801A (ja) | 2010-02-25 |
| JP2010505801A5 JP2010505801A5 (enExample) | 2010-10-28 |
| JP5269796B2 true JP5269796B2 (ja) | 2013-08-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009530916A Expired - Fee Related JP5269796B2 (ja) | 2006-10-04 | 2007-10-02 | ４種のデング血清型に対する免疫付与の方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7718358B2 (enExample) |
| EP (3) | EP2526965A1 (enExample) |
| JP (1) | JP5269796B2 (enExample) |
| KR (1) | KR20090064593A (enExample) |
| CN (2) | CN101553251B (enExample) |
| AR (1) | AR063057A1 (enExample) |
| AU (1) | AU2007311792B2 (enExample) |
| BR (1) | BRPI0719849A2 (enExample) |
| CA (1) | CA2663885A1 (enExample) |
| FR (1) | FR2906724B1 (enExample) |
| IL (2) | IL197768A0 (enExample) |
| MX (1) | MX2009003417A (enExample) |
| TW (2) | TWI406673B (enExample) |
| WO (1) | WO2008047023A2 (enExample) |
| ZA (1) | ZA200901816B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1924280A4 (en) * | 2005-08-10 | 2008-12-10 | Acambis Inc | VACCINATION AGAINST DENGUE VIRUS INFECTION |
| FR2903605A1 (fr) * | 2006-07-12 | 2008-01-18 | Sanofi Pasteur Sa | Methode d'immunisation contre les quatres serotypes de la dengue |
| FR2909286B1 (fr) * | 2006-12-01 | 2012-06-08 | Sanofi Pasteur | Methode d'immunisation contre les 4 serotypes de la dengue |
| AU2009221180B2 (en) | 2008-03-05 | 2014-02-13 | Sanofi Pasteur | Process for stabilizing an adjuvant containing vaccine composition |
| EP2143440A1 (fr) * | 2008-07-09 | 2010-01-13 | Sanofi Pasteur | Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués |
| WO2010141386A1 (en) * | 2009-06-01 | 2010-12-09 | Inviragen, Inc. | Compositions and methods for administration of vaccines against dengue virus |
| US8968996B2 (en) | 2009-06-01 | 2015-03-03 | Takeda Vaccines, Inc. | Compositions and methods for rapid immunization against dengue virus |
| EP2473624B1 (en) | 2009-08-31 | 2019-05-01 | Gen-Probe Incorporated | Dengue virus assay |
| EP2353609A1 (en) * | 2010-02-04 | 2011-08-10 | Sanofi Pasteur | Immunization compositions and methods |
| US10238734B2 (en) * | 2010-03-23 | 2019-03-26 | The Regents Of The University Of California | Compositions and methods for self-adjuvanting vaccines against microbes and tumors |
| SG195115A1 (en) * | 2011-06-29 | 2013-12-30 | Immunotope Inc | Cytotoxic t-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of dengue virus infection |
| EP2858668A1 (en) * | 2012-06-10 | 2015-04-15 | Takeda Vaccines, Inc. | Compositions and methods for administration of vaccines against dengue virus |
| US8895028B2 (en) * | 2012-07-20 | 2014-11-25 | Arbovax, Inc. | Methods and compositions for dengue virus 3 (DV3) infectious clone |
| JP2015524421A (ja) * | 2012-07-24 | 2015-08-24 | サノフィ・パスツールＳａｎｏｆｉｐａｓｔｅｕｒ | ワクチン組成物 |
| US20150265695A1 (en) | 2012-07-24 | 2015-09-24 | Sanofi Pasteur | Vaccine compositions for prevention against dengue virus infection |
| BR112015012515B1 (pt) | 2012-11-30 | 2023-04-11 | Sanofi Pasteur | Uso de antígenos, construções de ácido nucleico ou vetores virais capazes de expressar uma partícula do tipo vírus (vlp) da dengue e de uma vacina contra sarampo, uma vacina contra caxumba e uma vacina contra rubéola |
| CA2933472A1 (en) * | 2012-12-14 | 2014-06-19 | Takeda Vaccines, Inc. | Compositions, methods of administration and uses for trivalent dengue virus formulations |
| WO2014204892A1 (en) | 2013-06-21 | 2014-12-24 | Merck Sharp & Dohme Corp. | Dengue virus vaccine compositions and methods of use thereof |
| TWI852899B (zh) | 2014-09-02 | 2024-08-21 | 法商賽諾菲巴斯德公司 | 疫苗組合物 |
| MY192543A (en) | 2014-12-22 | 2022-08-26 | Merck Sharp & Dohme | Dengue virus vaccine compositions and methods of use thereof |
| EP3316905A1 (en) | 2015-07-03 | 2018-05-09 | Sanofi Pasteur | Concomitant dengue and yellow fever vaccination |
| TWI736563B (zh) * | 2015-11-27 | 2021-08-21 | 日商Ｋｍ生物醫藥股份有限公司 | 庫存之登革熱病毒減毒株的活病毒及以此等做為抗原之登革熱疫苗 |
| US11690903B2 (en) | 2017-10-05 | 2023-07-04 | Sanofi Pasteur | Compositions for booster vaccination against dengue |
| KR20210071979A (ko) | 2018-09-05 | 2021-06-16 | 다케다 백신즈 인코포레이티드 | 뎅기열 백신 단위 용량 및 이의 투여 |
| KR20220049023A (ko) | 2019-08-16 | 2022-04-20 | 다케다 백신즈 인코포레이티드 | 뎅기열 및 a형 간염을 예방하기 위한 방법 |
| WO2021174059A1 (en) | 2020-02-27 | 2021-09-02 | Takeda Vaccines, Inc. | Method for removing host cell dna from virus preparation |
| WO2023147337A2 (en) | 2022-01-25 | 2023-08-03 | Takeda Vaccines, Inc. | Large-scale flaviviral vaccine production and manufacture |
| WO2023158989A1 (en) | 2022-02-15 | 2023-08-24 | Takeda Vaccines, Inc. | Dengue vaccine batch mixing process |
| EP4519847A1 (en) | 2022-05-04 | 2025-03-12 | Takeda Vaccines, Inc. | Computer-based determination of flavivirus infectivity |
| WO2024108087A1 (en) | 2022-11-18 | 2024-05-23 | Takeda Vaccines, Inc. | A method for determining the proportion of a live, attenuated flavivirus having a nucleotide sequence comprising at least one attenuation locus in a formulation |
| WO2024118740A1 (en) | 2022-11-29 | 2024-06-06 | Takeda Vaccines, Inc. | Large-scale flaviviral vaccine production and manufacture |
| WO2025072259A1 (en) | 2023-09-25 | 2025-04-03 | Takeda Vaccines, Inc. | Coadministration of tetravalent dengue vaccine with hpv vaccine |
| WO2025122855A1 (en) | 2023-12-08 | 2025-06-12 | Takeda Vaccines, Inc. | A method for determining the concentration of residual vero cell genomic dna in a sample containing virus obtained from production in vero cells |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6093296A (en) | 1995-06-07 | 1996-12-30 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Infectious dengue 2 virus pdk-53 as quadravalent vaccine |
| DE69830579T2 (de) | 1997-02-28 | 2006-05-04 | Acambis, Inc., Cambridge | Chimäre impfstoffe gegen flaviviren |
| EP1080370A4 (en) | 1998-05-29 | 2003-07-30 | Epimmune Inc | IDENTIFICATION OF RESILIENT DR EPITOPES LARGELY REACTIVE |
| CA2365728A1 (en) | 1999-03-26 | 2000-10-05 | Walter Reed Army Institute Of Research | Attenuated dengue-1 virus vaccine |
| AU4040400A (en) * | 1999-03-26 | 2000-10-16 | Walter Reed Army Institute Of Research | Attenuated dengue-4 virus vaccine |
| EP1165127B1 (en) * | 1999-03-26 | 2008-12-31 | Walter Reed Army Institute of Research | Multivalent dengue virus vaccine |
| US6511667B1 (en) | 1999-03-26 | 2003-01-28 | The United States Of America As Represented By The Secretary Of The Army | Attenuated dengue-2 virus vaccine |
| US6528065B1 (en) | 1999-03-26 | 2003-03-04 | The United States Of America As Represented By The Secretary Of The Army | Attenuated dengue-3 virus vaccine |
| US6632663B1 (en) | 1999-09-22 | 2003-10-14 | Aventis Pasteur Limited | DNA immunization against chlamydia infection |
| ATE526411T1 (de) | 2000-02-16 | 2011-10-15 | Us Gov Health & Human Serv | Avirulente, immunogene flavivirus-chimäre |
| ES2315221T3 (es) * | 2000-05-30 | 2009-04-01 | Mahidol University | Cepas atenuadas del virus del dengue y su utilizacion en una composicion vaccinea. |
| EP1159969A1 (fr) | 2000-05-30 | 2001-12-05 | Aventis Pasteur | Vaccine composition |
| AT410634B (de) | 2001-02-21 | 2003-06-25 | Franz X Dr Heinz | Attenuierte lebendimpfstoffe |
| ES2533085T3 (es) | 2001-05-22 | 2015-04-07 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Desarrollo de mutaciones útiles para atenuar virus del dengue y virus del dengue quiméricos |
| JP2005518332A (ja) | 2001-05-23 | 2005-06-23 | デンドレオン コーポレイション | 細胞表面のプロテアーゼにより活性化される結合体およびその治療的使用 |
| AU2002322026B2 (en) | 2001-06-01 | 2008-03-13 | Acambis Inc. | Chimeric flavivirus vectors |
| US20040120964A1 (en) * | 2001-10-29 | 2004-06-24 | Mikszta John A. | Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses |
| US7459160B2 (en) * | 2002-01-15 | 2008-12-02 | Acambis Inc. | Chimeric flaviviruses |
| AU2003239932A1 (en) * | 2002-05-31 | 2003-12-19 | Acambis, Inc. | Tetravalent dengue vaccines |
| CN1791433B (zh) * | 2003-03-24 | 2010-05-26 | 斯克里普斯研究学院 | 抗肿瘤生长的dna疫苗及其使用方法 |
| JP5197362B2 (ja) * | 2005-06-17 | 2013-05-15 | サノフィ・パスツール | デング熱セロタイプ１弱毒株 |
| EP1924280A4 (en) * | 2005-08-10 | 2008-12-10 | Acambis Inc | VACCINATION AGAINST DENGUE VIRUS INFECTION |
| FR2903605A1 (fr) * | 2006-07-12 | 2008-01-18 | Sanofi Pasteur Sa | Methode d'immunisation contre les quatres serotypes de la dengue |
| FR2909286B1 (fr) * | 2006-12-01 | 2012-06-08 | Sanofi Pasteur | Methode d'immunisation contre les 4 serotypes de la dengue |
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| US20100270202A1 (en) | 2010-10-28 |
| AU2007311792B2 (en) | 2013-05-02 |
| AU2007311792A1 (en) | 2008-04-24 |
| ZA200901816B (en) | 2010-06-30 |
| US7718358B2 (en) | 2010-05-18 |
| EP2526964A1 (fr) | 2012-11-28 |
| EP2077857B1 (fr) | 2013-11-20 |
| FR2906724B1 (fr) | 2009-03-20 |
| CN103285386A (zh) | 2013-09-11 |
| CA2663885A1 (en) | 2008-04-24 |
| WO2008047023A2 (fr) | 2008-04-24 |
| JP2010505801A (ja) | 2010-02-25 |
| US20080085288A1 (en) | 2008-04-10 |
| TW201336508A (zh) | 2013-09-16 |
| AR063057A1 (es) | 2008-12-23 |
| TWI406673B (zh) | 2013-09-01 |
| EP2077857A2 (fr) | 2009-07-15 |
| MX2009003417A (es) | 2009-04-09 |
| FR2906724A1 (fr) | 2008-04-11 |
| IL197768A0 (en) | 2011-08-01 |
| KR20090064593A (ko) | 2009-06-19 |
| WO2008047023A3 (fr) | 2008-10-23 |
| CN101553251A (zh) | 2009-10-07 |
| EP2526965A1 (fr) | 2012-11-28 |
| CN101553251B (zh) | 2013-05-22 |
| BRPI0719849A2 (pt) | 2014-04-29 |
| TW200826959A (en) | 2008-07-01 |
| IL224572A (en) | 2014-06-30 |
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