JP5256049B2 - 抗癌剤 - Google Patents

抗癌剤 Download PDF

Info

Publication number
JP5256049B2
JP5256049B2 JP2008556382A JP2008556382A JP5256049B2 JP 5256049 B2 JP5256049 B2 JP 5256049B2 JP 2008556382 A JP2008556382 A JP 2008556382A JP 2008556382 A JP2008556382 A JP 2008556382A JP 5256049 B2 JP5256049 B2 JP 5256049B2
Authority
JP
Japan
Prior art keywords
chroman
tetramethyl
acid
dimethylnonanyl
succinate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008556382A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009538823A (ja
JP2009538823A5 (enExample
Inventor
チン−シー チェン，
ダシェン ワン，
Original Assignee
ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション filed Critical ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション
Publication of JP2009538823A publication Critical patent/JP2009538823A/ja
Publication of JP2009538823A5 publication Critical patent/JP2009538823A5/ja
Application granted granted Critical
Publication of JP5256049B2 publication Critical patent/JP5256049B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
JP2008556382A 2006-02-21 2007-02-21 抗癌剤 Expired - Fee Related JP5256049B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77510706P 2006-02-21 2006-02-21
US60/775,107 2006-02-21
PCT/US2007/004337 WO2007098139A2 (en) 2006-02-21 2007-02-21 Anticancer agents

Publications (3)

Publication Number Publication Date
JP2009538823A JP2009538823A (ja) 2009-11-12
JP2009538823A5 JP2009538823A5 (enExample) 2011-03-03
JP5256049B2 true JP5256049B2 (ja) 2013-08-07

Family

ID=38437941

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008556382A Expired - Fee Related JP5256049B2 (ja) 2006-02-21 2007-02-21 抗癌剤

Country Status (6)

Country Link
US (2) US20080009545A1 (enExample)
EP (1) EP1986635A4 (enExample)
JP (1) JP5256049B2 (enExample)
AU (1) AU2007217810B2 (enExample)
CA (1) CA2643546A1 (enExample)
WO (1) WO2007098139A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2414205T3 (es) 2006-06-02 2013-07-18 The Ohio State University Research Foundation Agentes terapéuticos para el tratamiento de linfoma de células del manto
WO2009155009A1 (en) * 2008-05-27 2009-12-23 Memorial Sloan Kettering Cancer Center Models for combinatorial perturbations of living biological systems
US8461362B2 (en) 2009-04-13 2013-06-11 The Ohio State University Research Foundation Protein phosphatase 2A-activating agents
AU2010236323A1 (en) * 2009-04-17 2011-11-24 The Ohio State University Research Foundation Antiadhesion agents
WO2012074960A2 (en) 2010-11-29 2012-06-07 The Ohio State University Research Foundation Fty720-derived anticancer agents
US20140197449A1 (en) * 2013-01-14 2014-07-17 Electronics And Telecommunications Research Institute Semiconductor rectifier device

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2680749A (en) * 1951-12-01 1954-06-08 Eastman Kodak Co Water-soluble tocopherol derivatives
US3459774A (en) * 1967-02-06 1969-08-05 Eisai Co Ltd Method of producing alpha-tocopheryl acid succinate
DE2822324C3 (de) * 1978-05-22 1981-02-26 Basf Ag, 6700 Ludwigshafen Herstellung von Vitamin-E-Trockenpulver
JPS59222415A (ja) * 1983-05-31 1984-12-14 Kuraray Co Ltd 免疫調節剤
US4751224A (en) * 1983-07-21 1988-06-14 Brown University Research Foundation Treatment of metastasis
US4938949A (en) * 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US6335358B1 (en) * 1995-04-12 2002-01-01 President And Fellows Of Harvard College Lactacystin analogs
RU2156127C2 (ru) * 1995-12-28 2000-09-20 Еситоми Фармасьютикал Индустриз, Лтд. Препарат местного применения для иммуносупрессии и лечения аутоиммунных или аллергических заболеваний
US6476004B1 (en) * 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
US6004656A (en) * 1997-11-14 1999-12-21 3M Innovative Properties Company Color changeable device
US6703384B2 (en) * 1998-09-23 2004-03-09 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
KR100712383B1 (ko) * 1998-09-23 2007-05-02 리서치 디벨럽먼트 파운데이션 토코페롤, 토코트리엔올, 기타 크로만 및 측쇄 유도체, 및 이를 포함하는 약제학적 조성물
US6770672B1 (en) * 1998-09-23 2004-08-03 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
JP2004504268A (ja) * 2000-02-11 2004-02-12 リサーチ　ディベロップメント　ファンデーション トコフェロール、トコトリエノール、その他のクロマン、及びそれらの側鎖誘導体とその利用法
JP2004538304A (ja) * 2001-07-27 2004-12-24 ユニバーシティー オブ ロチェスター アンドロゲンレセプターのビタミンｅ阻害および前立腺癌細胞中の前立腺特異的抗原の発現
US6858227B1 (en) * 2001-11-21 2005-02-22 Sonus Pharmaceuticals, Inc. Vitamin E conjugates
US20050215531A1 (en) * 2002-05-16 2005-09-29 Thomas Baumruker Use of edg receptor binding agents in cancer
US20050090520A1 (en) * 2003-09-12 2005-04-28 Per Lindquist Treatment of disease or injury of the nervous system with FTY720
CA2583087C (en) * 2003-09-19 2012-07-10 Galileo Pharmaceuticals, Inc. Chroman derivatives
ES2369520T3 (es) * 2005-12-15 2011-12-01 Mitsubishi Tanabe Pharma Corporation Compuesto amínico y su uso para propósitos médicos.
WO2008153159A1 (ja) * 2007-06-14 2008-12-18 Mitsubishi Tanabe Pharma Corporation アミン化合物及びその医薬用途

Also Published As

Publication number Publication date
EP1986635A2 (en) 2008-11-05
JP2009538823A (ja) 2009-11-12
EP1986635A4 (en) 2009-04-22
CA2643546A1 (en) 2007-08-30
AU2007217810B2 (en) 2012-10-11
US20080009545A1 (en) 2008-01-10
WO2007098139A3 (en) 2008-11-20
WO2007098139A2 (en) 2007-08-30
AU2007217810A1 (en) 2007-08-30
US20100273871A1 (en) 2010-10-28

Similar Documents

Publication Publication Date Title
US11161831B2 (en) Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia
US8309582B2 (en) Small molecule Bcl-Xl/Bcl-2 binding inhibitors
JP5256049B2 (ja) 抗癌剤
US7960435B2 (en) Anti-cancer agents and androgen inhibition activity compound
AU2015314772B2 (en) Compositions and methods for treatment of prostate carcinoma
PT1663194E (pt) Utilizaã†o de saha para o tratamento de mesotelioma
US7807705B2 (en) Potent indole-3-carbinol-derived antitumor agents
US7026346B2 (en) Compounds and methods for inducing apoptosis in proliferating cells
US12428405B2 (en) Chalcone-based chemotherapeutic compound for triple negative breast cancer
JP6863742B2 (ja) 新規アントラニルアミドとその使用
CA2338122A1 (en) Macrophage scavenger receptor antagonists
WO2006050451A2 (en) Methods and compositions to treat motor neuron disease
WO2004039797A1 (en) A special kind of indole compounds, their preparation, and their use in treatment and prevention of those disease such as cancer
Liu et al. Novel agents derived from natural product β-elemene: A second round of design and synthesis to enhance antitumor properties
US20060142368A1 (en) Compounds and methods for inducing apoptosis in proliferating cells
EP2642856B1 (en) Integrin-linked kinase inhibitors
WO2025117337A1 (en) Genistein phosphate derivatives
Avci et al. Synthesis and Biological Evaluation of Novel Naproxen–Paracetamol Triazole Hybrides as Promising Anti-Inflammatory Agents with Enhanced Gastrointestinal Tolerability
Chamcheu et al. Identification of Potential Inhibitors of Cutaneous Melanoma and Non-Melanoma Skin Cancer Cells Through In-Vitro and In-Silico Screening of a Small Library of Phenolic Compounds

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100113

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100113

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110107

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120809

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121029

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20121109

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130222

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20130306

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130325

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130422

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20160426

Year of fee payment: 3

LAPS Cancellation because of no payment of annual fees