JP5242855B2 - 免疫アジュバント - Google Patents

免疫アジュバント Download PDF

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Publication number
JP5242855B2
JP5242855B2 JP2012526548A JP2012526548A JP5242855B2 JP 5242855 B2 JP5242855 B2 JP 5242855B2 JP 2012526548 A JP2012526548 A JP 2012526548A JP 2012526548 A JP2012526548 A JP 2012526548A JP 5242855 B2 JP5242855 B2 JP 5242855B2
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JP
Japan
Prior art keywords
test group
vaccine
antibody titer
nasal
culture
Prior art date
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Active
Application number
JP2012526548A
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English (en)
Japanese (ja)
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JPWO2012014978A1 (ja
Inventor
直幸 守屋
▲祐▼生子 守屋
忠昭 宮崎
安弘 二川
志保 青木
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AUREO SCIENCE CO., LTD.
Hokkaido University NUC
Aureo Co Ltd
Original Assignee
AUREO SCIENCE CO., LTD.
Hokkaido University NUC
Aureo Co Ltd
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Publication date
Application filed by AUREO SCIENCE CO., LTD., Hokkaido University NUC, Aureo Co Ltd filed Critical AUREO SCIENCE CO., LTD.
Priority to JP2012526548A priority Critical patent/JP5242855B2/ja
Application granted granted Critical
Publication of JP5242855B2 publication Critical patent/JP5242855B2/ja
Publication of JPWO2012014978A1 publication Critical patent/JPWO2012014978A1/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2012526548A 2010-07-29 2011-07-28 免疫アジュバント Active JP5242855B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2012526548A JP5242855B2 (ja) 2010-07-29 2011-07-28 免疫アジュバント

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2010171060 2010-07-29
JP2010171060 2010-07-29
PCT/JP2011/067262 WO2012014978A1 (fr) 2010-07-29 2011-07-28 Adjuvant immunitaire
JP2012526548A JP5242855B2 (ja) 2010-07-29 2011-07-28 免疫アジュバント

Publications (2)

Publication Number Publication Date
JP5242855B2 true JP5242855B2 (ja) 2013-07-24
JPWO2012014978A1 JPWO2012014978A1 (ja) 2013-09-12

Family

ID=45530178

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012526548A Active JP5242855B2 (ja) 2010-07-29 2011-07-28 免疫アジュバント

Country Status (2)

Country Link
JP (1) JP5242855B2 (fr)
WO (1) WO2012014978A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10857228B2 (en) 2015-06-10 2020-12-08 The University Of Tokyo Adjuvant for vaccines, vaccine, and immunity induction method

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015029967A1 (fr) 2013-08-26 2015-03-05 株式会社明治 Agent d'augmentation du titre d'anticorps au moyen de bactéries lactiques

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002204687A (ja) * 2000-11-09 2002-07-23 Onaka Yasushi β−１．３−１．６グルカン（アウレオバシジウム培養液）の医療、保健、福祉、食品および各種産業分野での応用
JP2003523401A (ja) * 2000-02-23 2003-08-05 バイオテク ファーマコン エイエスエイ 粘膜体表面に接触させてワクチン抗原を包含する物質の効果を調節する新規非抗原性粘膜アジュバント処方
JP2009051863A (ja) * 1994-04-29 2009-03-12 Biotec Pharmacon Asa 免疫刺激組成物を製造するためのグルカンの使用及び薬剤としてのグルカンの使用
JP2009528267A (ja) * 2006-01-17 2009-08-06 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ 治療を増強するグルカン
JP2009242367A (ja) * 2008-03-31 2009-10-22 Research Foundation For Microbial Diseases Of Osaka Univ 混合免疫賦活剤を含む新規ワクチン

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009051863A (ja) * 1994-04-29 2009-03-12 Biotec Pharmacon Asa 免疫刺激組成物を製造するためのグルカンの使用及び薬剤としてのグルカンの使用
JP2003523401A (ja) * 2000-02-23 2003-08-05 バイオテク ファーマコン エイエスエイ 粘膜体表面に接触させてワクチン抗原を包含する物質の効果を調節する新規非抗原性粘膜アジュバント処方
JP2002204687A (ja) * 2000-11-09 2002-07-23 Onaka Yasushi β−１．３−１．６グルカン（アウレオバシジウム培養液）の医療、保健、福祉、食品および各種産業分野での応用
JP2009528267A (ja) * 2006-01-17 2009-08-06 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ 治療を増強するグルカン
JP2009242367A (ja) * 2008-03-31 2009-10-22 Research Foundation For Microbial Diseases Of Osaka Univ 混合免疫賦活剤を含む新規ワクチン

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6011044603; Ｔｈａｎｈ　Ｈｏａ　Ｌｅ．　ｅｔ　ａｌ: 'Ａｄｊｕｖａｎｔ　ｅｆｆｅｃｔｓ　ｏｆ　ｓｏｐｈｙ　beta-ｇｌｕｃａｎ　ｏｎ　Ｈ５Ｎ１　ａｎｄ　Ｈ５Ｎ２　ｖａｃｃｉｎａｔｉｏｎ　ｕｓｉｎｇ　ａ　ｍｏｕｓｅ　ｍｏｄｅｌ' Ｔｒｏｐｉｃａｌ　Ｍｅｄｉｃｉｎｅ　ａｎｄ　Ｈｅａｌｔｈ Ｖｏｌ．３８，　Ｎｏ．１, 2010, ｐ．２３-２７ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10857228B2 (en) 2015-06-10 2020-12-08 The University Of Tokyo Adjuvant for vaccines, vaccine, and immunity induction method

Also Published As

Publication number Publication date
JPWO2012014978A1 (ja) 2013-09-12
WO2012014978A1 (fr) 2012-02-02

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