JP5232138B2 - ｔＲＮＡ遺伝子をしようする、組み換えタンパク質産生のための方法および組成物 - Google Patents

ｔＲＮＡ遺伝子をしようする、組み換えタンパク質産生のための方法および組成物 Download PDF

Info

Publication number
JP5232138B2
JP5232138B2 JP2009506813A JP2009506813A JP5232138B2 JP 5232138 B2 JP5232138 B2 JP 5232138B2 JP 2009506813 A JP2009506813 A JP 2009506813A JP 2009506813 A JP2009506813 A JP 2009506813A JP 5232138 B2 JP5232138 B2 JP 5232138B2
Authority
JP
Japan
Prior art keywords
host cell
trna
rrna
rare
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2009506813A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009534043A5 (enExample
JP2009534043A (ja
Inventor
フレデリック アール． ブラットナー，
ジョン ウォルター キャンベル，
ガイ プランケット，
Original Assignee
スカラブ ゲノミクス， エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by スカラブ ゲノミクス， エルエルシー filed Critical スカラブ ゲノミクス， エルエルシー
Publication of JP2009534043A publication Critical patent/JP2009534043A/ja
Publication of JP2009534043A5 publication Critical patent/JP2009534043A5/ja
Application granted granted Critical
Publication of JP5232138B2 publication Critical patent/JP5232138B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2009506813A 2006-04-22 2007-04-23 ｔＲＮＡ遺伝子をしようする、組み換えタンパク質産生のための方法および組成物 Active JP5232138B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79375506P 2006-04-22 2006-04-22
US60/793,755 2006-04-22
PCT/US2007/067232 WO2007124493A2 (en) 2006-04-22 2007-04-23 Methods and compositions for producing recombinant proteins using a gene for trna

Publications (3)

Publication Number Publication Date
JP2009534043A JP2009534043A (ja) 2009-09-24
JP2009534043A5 JP2009534043A5 (enExample) 2010-05-13
JP5232138B2 true JP5232138B2 (ja) 2013-07-10

Family

ID=38625811

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009506813A Active JP5232138B2 (ja) 2006-04-22 2007-04-23 ｔＲＮＡ遺伝子をしようする、組み換えタンパク質産生のための方法および組成物

Country Status (6)

Country Link
US (1) US7989181B2 (enExample)
EP (1) EP2027268B1 (enExample)
JP (1) JP5232138B2 (enExample)
AT (1) ATE473278T1 (enExample)
DE (1) DE602007007612D1 (enExample)
WO (1) WO2007124493A2 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9052790B2 (en) 2008-01-04 2015-06-09 Tactus Technology, Inc. User interface and methods
US9423875B2 (en) 2008-01-04 2016-08-23 Tactus Technology, Inc. Dynamic tactile interface with exhibiting optical dispersion characteristics
US8570295B2 (en) 2008-01-04 2013-10-29 Tactus Technology, Inc. User interface system
US9280224B2 (en) 2012-09-24 2016-03-08 Tactus Technology, Inc. Dynamic tactile interface and methods
US8456438B2 (en) 2008-01-04 2013-06-04 Tactus Technology, Inc. User interface system
US9612659B2 (en) 2008-01-04 2017-04-04 Tactus Technology, Inc. User interface system
US9274612B2 (en) 2008-01-04 2016-03-01 Tactus Technology, Inc. User interface system
US8199124B2 (en) * 2009-01-05 2012-06-12 Tactus Technology User interface system
US8970403B2 (en) 2008-01-04 2015-03-03 Tactus Technology, Inc. Method for actuating a tactile interface layer
US8928621B2 (en) 2008-01-04 2015-01-06 Tactus Technology, Inc. User interface system and method
US20160187981A1 (en) 2008-01-04 2016-06-30 Tactus Technology, Inc. Manual fluid actuator
US9430074B2 (en) 2008-01-04 2016-08-30 Tactus Technology, Inc. Dynamic tactile interface
US8547339B2 (en) 2008-01-04 2013-10-01 Tactus Technology, Inc. System and methods for raised touch screens
US8553005B2 (en) 2008-01-04 2013-10-08 Tactus Technology, Inc. User interface system
US9063627B2 (en) 2008-01-04 2015-06-23 Tactus Technology, Inc. User interface and methods
US9557915B2 (en) 2008-01-04 2017-01-31 Tactus Technology, Inc. Dynamic tactile interface
US9298261B2 (en) 2008-01-04 2016-03-29 Tactus Technology, Inc. Method for actuating a tactile interface layer
US9552065B2 (en) 2008-01-04 2017-01-24 Tactus Technology, Inc. Dynamic tactile interface
US8243038B2 (en) 2009-07-03 2012-08-14 Tactus Technologies Method for adjusting the user interface of a device
US9720501B2 (en) 2008-01-04 2017-08-01 Tactus Technology, Inc. Dynamic tactile interface
US9588683B2 (en) 2008-01-04 2017-03-07 Tactus Technology, Inc. Dynamic tactile interface
US8154527B2 (en) * 2008-01-04 2012-04-10 Tactus Technology User interface system
US8179375B2 (en) * 2008-01-04 2012-05-15 Tactus Technology User interface system and method
US8947383B2 (en) 2008-01-04 2015-02-03 Tactus Technology, Inc. User interface system and method
KR101147860B1 (ko) * 2008-09-22 2012-05-25 한국과학기술원 특정 아미노산의 ｔＲＮＡ와의 동시 발현을 통한 특정 아미노산 함량이 높은 단백질의 제조방법
US9588684B2 (en) 2009-01-05 2017-03-07 Tactus Technology, Inc. Tactile interface for a computing device
WO2010078597A1 (en) * 2009-01-05 2010-07-08 Tactus Technology, Inc. User interface system
JP2012532384A (ja) 2009-07-03 2012-12-13 タクタス テクノロジー ユーザインターフェイス拡張システム
EP2517089A4 (en) 2009-12-21 2016-03-09 Tactus Technology USER INTERFACE SYSTEM
CN102725716B (zh) 2009-12-21 2016-04-13 泰克图斯科技公司 用户界面系统
US9239623B2 (en) 2010-01-05 2016-01-19 Tactus Technology, Inc. Dynamic tactile interface
US8619035B2 (en) 2010-02-10 2013-12-31 Tactus Technology, Inc. Method for assisting user input to a device
WO2011112984A1 (en) 2010-03-11 2011-09-15 Tactus Technology User interface system
WO2011133604A1 (en) 2010-04-19 2011-10-27 Tactus Technology User interface system
CN103109255A (zh) 2010-10-20 2013-05-15 泰克图斯科技公司 用户接口系统
US9405417B2 (en) 2012-09-24 2016-08-02 Tactus Technology, Inc. Dynamic tactile interface and methods
US9557813B2 (en) 2013-06-28 2017-01-31 Tactus Technology, Inc. Method for reducing perceived optical distortion
WO2019175316A1 (en) * 2018-03-15 2019-09-19 Universität Hamburg Synthetic transfer rna with extended anticodon loop
CN117264859B (zh) * 2023-09-18 2025-02-28 广东丸美生物技术股份有限公司 一种原核表达系统及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU618640B2 (en) * 1988-11-11 1992-01-02 Boehringer Mannheim Gmbh Process for the expression of a recombinant gene
EP1147211B1 (en) * 1999-01-27 2009-06-17 Stratagene California High level expression of a heterologous protein having rare codons
US6989265B2 (en) * 2002-01-23 2006-01-24 Wisconsin Alumni Research Foundation Bacteria with reduced genome

Also Published As

Publication number Publication date
US7989181B2 (en) 2011-08-02
DE602007007612D1 (de) 2010-08-19
WO2007124493A3 (en) 2008-12-18
ATE473278T1 (de) 2010-07-15
WO2007124493A2 (en) 2007-11-01
US20090053766A1 (en) 2009-02-26
EP2027268A2 (en) 2009-02-25
JP2009534043A (ja) 2009-09-24
EP2027268B1 (en) 2010-07-07

Similar Documents

Publication Publication Date Title
JP5232138B2 (ja) ｔＲＮＡ遺伝子をしようする、組み換えタンパク質産生のための方法および組成物
Sletta et al. The presence of N-terminal secretion signal sequences leads to strong stimulation of the total expression levels of three tested medically important proteins during high-cell-density cultivations of Escherichia coli
Peubez et al. Antibiotic-free selection in E. coli: new considerations for optimal design and improved production
DK2386642T3 (en) Expression system
KR20080067614A (ko) 환원형의 게놈 대장균
WO2018083116A1 (en) Temperature based plasmid regulation system
WO1999016858A1 (en) Expression control sequences
JP7084388B2 (ja) 温度に基づくプラスミド調節系
CN109988802B (zh) 一种高效分泌表达人源fgf21蛋白的表达盒及其应用
US12325860B2 (en) Bacterial expression vector for enhanced protein secretion
TWI751154B (zh) 一種重組人粒細胞集落刺激因子的製備方法
JP4927103B2 (ja) ヒトｇ−ｃｓｆの調整方法
JP2003520598A (ja) フラボバクテリウム・ヘパリナム発現系
JP6027019B2 (ja) 発現プロセス
US7405059B2 (en) Modified Shine-Dalgarno sequences and methods of uses thereof
JP4531570B2 (ja) 封入体結合タンパク質をコードする遺伝子（ｉｂｐＡおよび／またはｉｂｐＢ）を欠失あるいは増幅させて目的タンパク質を製造する方法
WO2010008764A1 (en) Pseudomonas fluorescens strains for production of extracellular recombinant protein
CN117264859B (zh) 一种原核表达系统及其制备方法和应用
US20080268503A1 (en) Method for Achieving High-Level Expression of Recombinant Human Interleukin-2 Upon Destabilization of the Rna Secondary Structure
CN116064357B (zh) 一株有效提高Fcl29产量的改良菌株及改良方法
EP3601577B1 (en) Expression system
CN121022707A (zh) 用于提升燕窝酸产量的微生物及其应用
Wang et al. Construction of probiotic Escherichia coli Nissle 1917 as a next-generation expression platform and its application in therapeutic protein production
WO2025252176A1 (zh) 表达载体及其用途
AU653362B2 (en) Insertion of DNA by modified transposons

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100323

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100323

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120521

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130228

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130322

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20160329

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 5232138

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250