JP5229221B2 - チェックポイント・キナーゼのインヒビターとしてのトリアゾロキナゾリノン誘導体 - Google Patents

チェックポイント・キナーゼのインヒビターとしてのトリアゾロキナゾリノン誘導体 Download PDF

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Publication number
JP5229221B2
JP5229221B2 JP2009507739A JP2009507739A JP5229221B2 JP 5229221 B2 JP5229221 B2 JP 5229221B2 JP 2009507739 A JP2009507739 A JP 2009507739A JP 2009507739 A JP2009507739 A JP 2009507739A JP 5229221 B2 JP5229221 B2 JP 5229221B2
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JP
Japan
Prior art keywords
triazolo
isoquinolin
alkyl
heterocyclyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2009507739A
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English (en)
Japanese (ja)
Other versions
JP2009535334A (ja
JP2009535334A5 (cg-RX-API-DMAC7.html
Inventor
アリントン，ケネス，エル
バーナディック，エドワード，ジェイ
ダドキン，バディム，ワイ
フラリー，マーク，イー
ヒャング，シャエイ，ワイ
ワン，チェン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of JP2009535334A publication Critical patent/JP2009535334A/ja
Publication of JP2009535334A5 publication Critical patent/JP2009535334A5/ja
Application granted granted Critical
Publication of JP5229221B2 publication Critical patent/JP5229221B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009507739A 2006-04-25 2007-04-20 チェックポイント・キナーゼのインヒビターとしてのトリアゾロキナゾリノン誘導体 Expired - Fee Related JP5229221B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79469406P 2006-04-25 2006-04-25
US60/794,694 2006-04-25
PCT/US2007/009643 WO2007127138A1 (en) 2006-04-25 2007-04-20 Triazoloquinazolinone derivatives as inhibitors of checkpoint kinases

Publications (3)

Publication Number Publication Date
JP2009535334A JP2009535334A (ja) 2009-10-01
JP2009535334A5 JP2009535334A5 (cg-RX-API-DMAC7.html) 2010-10-14
JP5229221B2 true JP5229221B2 (ja) 2013-07-03

Family

ID=38441857

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009507739A Expired - Fee Related JP5229221B2 (ja) 2006-04-25 2007-04-20 チェックポイント・キナーゼのインヒビターとしてのトリアゾロキナゾリノン誘導体

Country Status (9)

Country Link
US (1) US7501435B2 (cg-RX-API-DMAC7.html)
EP (1) EP2013212A1 (cg-RX-API-DMAC7.html)
JP (1) JP5229221B2 (cg-RX-API-DMAC7.html)
AR (1) AR060619A1 (cg-RX-API-DMAC7.html)
AU (1) AU2007243520B2 (cg-RX-API-DMAC7.html)
CA (1) CA2649811A1 (cg-RX-API-DMAC7.html)
DO (1) DOP2007000082A (cg-RX-API-DMAC7.html)
TW (1) TW200806670A (cg-RX-API-DMAC7.html)
WO (1) WO2007127138A1 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102017525A (zh) * 2005-01-06 2011-04-13 默克公司 关卡激酶抑制剂
CN102014902A (zh) * 2005-01-06 2011-04-13 默克公司 检查点激酶抑制剂
WO2007081572A2 (en) 2006-01-04 2007-07-19 Merck & Co., Inc. Inhibitors of checkpoint kinases
US9000027B2 (en) * 2008-02-04 2015-04-07 Dana-Farber Cancer Institute, Inc. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, bcl-2 and caspase-3
AU2009215073A1 (en) * 2008-02-14 2009-08-20 Merck Sharp & Dohme Corp. Inhibitors of checkpoint kinases
US8614221B2 (en) 2009-03-11 2013-12-24 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
WO2013103899A2 (en) * 2012-01-06 2013-07-11 H. Lee Moffitt Cancer Center And Research Institute Phosphorylation of histones and uses thereof
CA2938626A1 (en) 2013-07-26 2015-01-29 John Rothman Compositions to improve the therapeutic benefit of bisantrene
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
EP3950064A4 (en) * 2019-04-03 2023-01-04 Tera Stone Co., Ltd THYMINE NUCLEOBASE BASED TRIAZOLOPYRIMIDINES AND PROCESS FOR THEIR PRODUCTION
CN117486890A (zh) 2019-06-06 2024-02-02 和记黄埔医药（上海）有限公司 三环类化合物及其用途
CN115197225B (zh) * 2021-09-03 2023-04-11 贵州大学 一种五元杂环并喹唑啉酮类化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1244501A (en) * 1968-03-09 1971-09-02 Aspro Nicholas Ltd Heterocyclic amines
RU2145606C1 (ru) * 1994-05-24 2000-02-20 Ф.Хоффманн-Ля Рош Аг Трициклические дикарбонильные производные и лекарственный препарат на их основе
US5677309A (en) * 1996-03-22 1997-10-14 Neurogen Corporation 1,2,4-triazolo 4,3-c! quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones; a new class of GABA brain receptor ligands
US20070149560A1 (en) * 2003-03-14 2007-06-28 Astrazeneca Ab Novel fused triazolones and the uses thereof
JP5055494B2 (ja) * 2005-06-10 2012-10-24 メルク・シャープ・エンド・ドーム・コーポレイション Ａｋｔ活性阻害剤
WO2007081572A2 (en) 2006-01-04 2007-07-19 Merck & Co., Inc. Inhibitors of checkpoint kinases

Also Published As

Publication number Publication date
AU2007243520B2 (en) 2012-07-19
WO2007127138A1 (en) 2007-11-08
AU2007243520A1 (en) 2007-11-08
US20070254879A1 (en) 2007-11-01
TW200806670A (en) 2008-02-01
CA2649811A1 (en) 2007-11-08
JP2009535334A (ja) 2009-10-01
AR060619A1 (es) 2008-07-02
EP2013212A1 (en) 2009-01-14
DOP2007000082A (es) 2007-12-31
US7501435B2 (en) 2009-03-10

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