DOP2007000082A - Inhibidores de quinasas de puntos de control - Google Patents

Inhibidores de quinasas de puntos de control

Info

Publication number
DOP2007000082A
DOP2007000082A DO2007000082A DO2007000082A DOP2007000082A DO P2007000082 A DOP2007000082 A DO P2007000082A DO 2007000082 A DO2007000082 A DO 2007000082A DO 2007000082 A DO2007000082 A DO 2007000082A DO P2007000082 A DOP2007000082 A DO P2007000082A
Authority
DO
Dominican Republic
Prior art keywords
kinase inhibitors
control points
points
kinase
inhibitors
Prior art date
Application number
DO2007000082A
Other languages
English (en)
Inventor
Kenneth L Arrington
Edward J Brnardic
Vadim Dudkin
Mark E Fraley
Shaei Y Huang
Cheng Wang
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DOP2007000082A publication Critical patent/DOP2007000082A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
DO2007000082A 2006-04-25 2007-04-25 Inhibidores de quinasas de puntos de control DOP2007000082A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79469406P 2006-04-25 2006-04-25

Publications (1)

Publication Number Publication Date
DOP2007000082A true DOP2007000082A (es) 2007-12-31

Family

ID=38441857

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2007000082A DOP2007000082A (es) 2006-04-25 2007-04-25 Inhibidores de quinasas de puntos de control

Country Status (9)

Country Link
US (1) US7501435B2 (es)
EP (1) EP2013212A1 (es)
JP (1) JP5229221B2 (es)
AR (1) AR060619A1 (es)
AU (1) AU2007243520B2 (es)
CA (1) CA2649811A1 (es)
DO (1) DOP2007000082A (es)
TW (1) TW200806670A (es)
WO (1) WO2007127138A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008526865A (ja) * 2005-01-06 2008-07-24 メルク エンド カムパニー インコーポレーテッド チェックポイントキナーゼの阻害剤
AU2006204072C1 (en) * 2005-01-06 2010-07-29 Merck Sharp & Dohme Corp. Inhibitors of checkpoint kinases
JP2009522359A (ja) 2006-01-04 2009-06-11 メルク エンド カムパニー インコーポレーテッド チェックポイントキナーゼの阻害剤
EP2247953A2 (en) * 2008-02-04 2010-11-10 Dana-farber Cancer Institute, Inc. Chk1 suppresses a caspase-2 apoptotic response to dna damage that bypasses p53, bcl-2 and caspase-3
WO2009102537A1 (en) * 2008-02-14 2009-08-20 Merck & Co., Inc. Inhibitors of checkpoint kinases
EP2406250B1 (en) * 2009-03-11 2015-08-12 Merck Sharp & Dohme Corp. Inhibitors of akt activity
US20140134178A1 (en) * 2012-01-06 2014-05-15 H. Lee Moffit Cancer Center And Research Institute Phosphorylation of histones and uses thereof
WO2015013579A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
TW201702218A (zh) 2014-12-12 2017-01-16 美國杰克森實驗室 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
CA3135449A1 (en) * 2019-04-03 2020-10-08 Tera Stone Co., Ltd Triazolopyrimidines based on thymine nucleobase and methods for producing them
CN115197225B (zh) * 2021-09-03 2023-04-11 贵州大学 一种五元杂环并喹唑啉酮类化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1244501A (en) * 1968-03-09 1971-09-02 Aspro Nicholas Ltd Heterocyclic amines
RU2145606C1 (ru) * 1994-05-24 2000-02-20 Ф.Хоффманн-Ля Рош Аг Трициклические дикарбонильные производные и лекарственный препарат на их основе
US5677309A (en) * 1996-03-22 1997-10-14 Neurogen Corporation 1,2,4-triazolo 4,3-c! quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones; a new class of GABA brain receptor ligands
CA2519107A1 (en) * 2003-03-14 2004-09-23 Astrazeneca Ab Novel fused triazolones and the uses thereof
RU2421454C2 (ru) * 2005-06-10 2011-06-20 Мерк Шарп Энд Домэ Корп. Ингибиторы активности акт
JP2009522359A (ja) 2006-01-04 2009-06-11 メルク エンド カムパニー インコーポレーテッド チェックポイントキナーゼの阻害剤

Also Published As

Publication number Publication date
US20070254879A1 (en) 2007-11-01
TW200806670A (en) 2008-02-01
JP5229221B2 (ja) 2013-07-03
CA2649811A1 (en) 2007-11-08
AU2007243520B2 (en) 2012-07-19
AU2007243520A1 (en) 2007-11-08
WO2007127138A1 (en) 2007-11-08
US7501435B2 (en) 2009-03-10
AR060619A1 (es) 2008-07-02
EP2013212A1 (en) 2009-01-14
JP2009535334A (ja) 2009-10-01

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