JP5210733B2 - Biological light measuring device having stimulation presentation function and stimulation task presentation method - Google Patents

Description

  The present invention relates to a living body light measurement device and a stimulation task presentation method, and in particular, irradiates a living body with near-infrared light and measures light passing through or reflecting inside the living body to measure blood circulation and hemodynamics inside the living body. In addition, the present invention relates to a biological light measurement device that measures a change in the amount of hemoglobin and a stimulation task presentation method.

  A biological light measurement device is a device that can easily measure blood circulation, hemodynamics, and hemoglobin changes in a living body with low restraint and no harm to a subject. Imaging has been realized and clinical application is expected.

  An apparatus for measuring a biological function using visible to near-infrared light is described in Patent Document 1 or Patent Document 2, for example. The brain function is mainly measured using this device. The subject is stimulated, and the brain activity is evaluated by comparing the measurement data at that time with the data in a resting state. In general, stimulation and rest are repeated several times, and after the measurement is completed, analysis such as addition averaging is performed. Depending on the case, there are multiple types of stimuli (such as left and right finger tapping experiments), and the difference in brain activity between the stimuli is also measured.

  Therefore, when obtaining measurement data using this type of apparatus, it is important to set parameters such as the presentation stimulus type, the stimulus time, the rest time, the stimulus presentation order, and the number of repetitions. For example, Patent Document 3 or Patent Document 4 describes an apparatus that realizes these parameter settings by an easy-to-understand operation without requiring specialized knowledge of a computer using the principle of the apparatus described above.

  One of the important factors when presenting a stimulus is the prediction of the subject. While the stimulus-rest is repeated several times, the subject predicts the next stimulus at the time of several rests, and unconsciously prepares, and the effect appears in the measurement. As an effective stimulus presentation method for such a problem, a device having a function of randomizing the type and timing of the next stimulus is described in Patent Document 5, for example. That is, in Patent Document 5, when creating a stimulus presentation pattern, it is possible to set so that one stimulus is presented randomly by selecting “random stimulus”.

JP-A-57-115232 JP-A 63-275323 JP 2000-237194 A Japanese Patent Laying-Open No. 2005-095465 JP 2007-54138 A

  However, the devices described in each of the above patent documents are not yet sufficient as an apparatus that is easy to use by a measurer and that effectively measures brain activity.

  That is, an apparatus that can perform random measurement and also considers the operability of the measurer is necessary. However, the apparatuses described in Patent Documents 1 to 4 are automatically and as stimulus presentation means to be given to the subject. No one uses a random technique. Therefore, there is a possibility that problems related to the prediction of the subject cannot be avoided.

  On the other hand, as described above, as an effective method for solving the problem that the preparation posture based on the prediction of the subject may affect the measurement, as described above, randomization of stimulus presentation described in Patent Document 5 There is. However, in this random presentation control unit, the most important random feeling is still insufficient. That is, the method described in Patent Document 5 is set in the range of stimulation or rest time, that is, the upper and lower limits of the presentation time set at random, for example, in the range of 10 to 20 seconds. In this method, for example, when the presentation time is set to 10 [s] to 20 [s], the subject is actually given a random feeling such as 10 [s], 12 [s], 11 [s]. It is possible that no value will occur continuously. Furthermore, the frequency of appearance is not sufficient. Therefore, there is a possibility that the occurrence frequency of a specific stimulus type among a plurality of random stimulus type candidates may be prominently increased. Such bias in the appearance frequency of stimulating species is inconvenient in analyzing the measurement results. As described above, regarding the randomized stimulus presentation pattern, there is a possibility that the generation form of individual stimuli and rest times may not be appropriately controlled. Therefore, there is a possibility that data that is not very effective from the viewpoint of acquiring data suitable for analyzing the measurement result.

  As another example, a stimulus presentation method is also known in which a measurer can arbitrarily give a stimulus-rest timing by manual operation. This makes it possible to present artificially random stimuli to some extent. However, it will be completely manual operation by the measurer, and the operation of the measurer's personal computer will increase, and it will be difficult to make the time exactly the same in multiple measurements, and it will not be possible to change the order of the stimulus types. For reasons such as difficulty, it is not very effective from the viewpoint of obtaining data suitable for analyzing the measurement result. In other words, although the parameter to be set when performing the averaging process depends on the resting time, the current device has no restriction on the timing of stimulation-resting at the time of setting, and parameters that cannot be analyzed are set. However, it will not be noticed until the calculation process is executed. If the resting time becomes variable by manual operation, this setting error is expected to increase.

  Therefore, the object of the present invention is to improve the operability of the measurer, and regarding the stimulus presentation pattern, there is no bias in the appearance frequency of each stimulus and rest time, and data suitable for analyzing the measurement result is obtained. An object of the present invention is to provide a biological function measuring device and a stimulation task presentation method that can be obtained.

An example of a representative one of the present invention is as follows. That is, the biological light measurement device of the present invention provides a stimulus presentation unit that repeatedly presents a stimulus to the subject, a stimulus presentation control unit that controls the stimulus presentation unit, and the subject in parallel with the presentation of the stimulus. A light measuring unit that measures the passing light intensity of the irradiated light at a plurality of measurement points and outputs a signal corresponding to the passing light intensity at each measurement point as measurement data, and measurement data from the light measuring unit. a signal processing unit for processing and outputting, a table radical 113, the stimulus presentation control unit, as a parameter of the stimulus presentation, the stimulus presentation pattern composed of a plurality of stimulation species presenting the individual stimuli species A parameter setting unit that randomly sets an order or stimulation time and a resting time, and a repetition period of the stimulation presentation pattern; and an analysis unit that performs an analysis process, the parameter setting unit including the stimulus type to be presented Setting A stimulation time setting unit that sets the stimulation time, and a resting time setting unit that sets the resting time that is limited in advance based on the time required for the analysis process. Based on the parameters set by the parameter setting unit, the stimulus presentation unit randomly presents the plurality of stimulus types constituting the stimulus presentation pattern to the subject, and the subject is presented in parallel with the presentation of the stimulus. The signal processing unit processes measurement data of the intensity of light passing through the light irradiated on the specimen, performs analysis processing by addition averaging on the analysis unit based on the processed data, and displays the result of the analysis processing on the display unit It is characterized by displaying .

  According to the present invention, it is possible to acquire data suitable for analyzing measurement results without increasing the frequency of appearance of individual stimuli and rest times constituting the stimulus presentation pattern without increasing the burden on the measurer. Therefore, the brain activity can be measured with higher accuracy.

  According to a typical embodiment of the present invention, two kinds of random functions are realized when setting measurement parameters, and the problem of subject prediction is solved. That is, first, regarding the stimulus presentation pattern, the rest time of each of the plurality of stimulus types constituting the stimulus presentation pattern is made variable so that the subject cannot predict the next stimulus start timing. Secondly, the next action to be performed cannot be predicted by making it possible to variably set the stimulus type to be presented next.

  According to the biological function measuring device of the present invention, after considering the improvement of the operability of the measurer, such as clearly indicating the next stimulus type to the measurer, or setting a limit on the setting parameter at the time of condition input or analysis It is possible to set the resting time at random in the stimulus presentation, and in that case, in order to emphasize the randomness, a method of setting the Step width together with the time width, and in the plural kinds of stimuli constituting the stimulus presentation pattern It is possible to realize an apparatus capable of performing biological function measurement with higher accuracy by providing a method of randomizing the order without occurrence frequency bias.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.
The biological light measurement apparatus according to the first embodiment of the present invention irradiates a living body with near-infrared light and detects light reflected from the vicinity of the surface of the living body or passed through the living body (hereinafter simply referred to as passing light). The device generates an electrical signal corresponding to the intensity of light. As shown in FIG. 1, this biological light measurement device includes, as an optical topography device 1, a light source unit 10 that irradiates near infrared light, a light measurement unit 12 that measures passing light and converts it into an electrical signal, and a light source. The control part 14 which controls the drive of the part 10 and the optical measurement part 12 is provided. The control unit 14 includes a stimulus presentation control unit 100 for randomly setting the type and time of the stimulus task presentation constituting the stimulus presentation pattern to be given to the subject via the stimulus presentation unit 110.

  The light source unit 10 includes a semiconductor laser 16 that emits light of a predetermined wavelength, and a plurality of optical modules 18 that include modulators for modulating light generated by the semiconductor laser 16 at a plurality of different frequencies. The output light of the optical module 18 is irradiated from a predetermined measurement region of the subject 22, for example, a plurality of locations on the head, via the optical fiber 20. The probe holder 23 is attached to the subject 22, and the optical fiber 20 is fixed to the probe holder 23.

  The light source unit 18 includes n (n is a natural number) optical modules. The wavelength of light depends on the spectral characteristics of the substance of interest in the living body, but when measuring oxygen saturation and blood volume from the concentrations of Hb and HbO2, select one or more wavelengths from light in the wavelength range of 600 nm to 1400 nm. Use.

  The optical measurement unit 12 includes a photoelectric conversion element 28 such as a photodiode that converts passing light guided from a plurality of measurement locations in the measurement region via the detection optical fiber 26 into an electric quantity corresponding to the amount of light, and photoelectric conversion. A lock-in amplifier 30 that receives an electrical signal from the element 28 and selectively detects a modulation signal corresponding to the light irradiation position; and an A / D converter 32 that converts an output signal of the lock-in amplifier 30 into a digital signal; Consists of.

  The light source unit 10 is configured to generate light of two wavelengths, for example, 695 nm and 830 nm, corresponding to two types of measurement objects, oxygenated hemoglobin and deoxygenated hemoglobin, and these two wavelengths of light are synthesized. Irradiation from one irradiation position. The lock-in amplifier 30 selectively detects a light irradiation position and a modulation signal corresponding to these two wavelengths. A hemoglobin amount change signal having the number of channels twice the number of points (measurement points) between the light irradiation position and the detection position is obtained. These signals are converted into digital signals by the control unit 14 and sent to the signal processing unit 34.

  The signal processing unit 34 processes the hemoglobin amount change signal converted into the digital signal, and displays a graph showing the oxygenated hemoglobin concentration change, deoxygenated hemoglobin concentration change, total hemoglobin concentration change, etc. Create an image plotted on a two-dimensional image. The biological light measurement apparatus further includes a display unit 36 for displaying the processing result of the signal processing unit 34, a storage unit 38 for storing data and processing results necessary for the processing of the signal processing unit 34, and operation of the device. An input / output unit 40 for inputting various necessary commands is provided.

  A specific configuration example of the stimulus presentation control unit 100 included in the control unit 14 is shown as a functional block diagram in FIG. The living body light measurement apparatus according to the present embodiment includes a stimulus presentation unit 110 that presents a stimulus to a subject using a monitor screen in addition to the stimulus presentation control unit 100 that performs processing such as hand generation, presentation, and analysis of a stimulus task. The microphone 112, which is a response means from the subject, the button 114, the processing result of the stimulus presentation control unit 100, and the like are configured by the display unit 36 that displays for the measurer. The display unit 36 also displays the output of the optical topography device 1 that performs brain function measurement.

  The stimulus presentation control unit 100 includes a rest parameter setting unit 101 that performs settings related to a rest parameter such as a rest time, a rest database 102 that stores data of set rest parameters, and a stimulus parameter setting unit that performs settings related to a stimulus parameter such as a stimulus task. 103, a stimulus database 104 that holds data of the set stimulation parameters, and presents a resting task and a stimulation task based on the set parameters to the stimulation presenting unit 110, and a response from the subject to the presented stimulation A task presentation control unit 105 that measures and analyzes the reaction is provided. The task presentation control unit 105 analyzes the response from the subject obtained from the microphone 112 and the button 114 as response means, and analyzes the response / reaction result, and outputs the result to the display unit 36. An analysis unit 107 is provided. In addition, when the measurer performs a random setting of the presentation stimulus, the task presentation control unit 105 displays the next presentation stimulus type and presentation timing that have become variable during the measurement on the display unit 36 to the measurer. It has a function to inform. The optical topography device 1 has a function of irradiating a subject (subject's head) with light having a wavelength in the visible to infrared region, and detecting light of a plurality of signals that have passed through the subject with the same photodetector. ing. Note that the processing functions of the stimulus presentation control unit 100 and the optical topography apparatus 1 in the control unit 14 are realized by the CPU executing various programs loaded in the memory in the host computer or a personal computer connected to the network. Is done.

  The input / output of data including various parameter settings in the rest parameter setting unit 101, the stimulation parameter setting unit 103, etc. may be performed by the input / output unit 40, or the input / output function of the display unit 36, for example, a personal computer The user interface function on the display screen may be used.

  FIG. 3 is a functional block diagram illustrating a detailed configuration example of the parameter setting units 101 and 103 in FIG. The parameter setting unit includes a “feedback generation unit” 120, a “random generation unit” 130, and a “manual generation unit” 140 as functions realized using a computer program, and selects one of the stimulation parameter generation modes. Can be set. In the “feedback generation unit” 120, the task presentation is automatically set using the correct answer rate and the reaction time in the stimulus task in real time. In the “random generator” 130, the type and time of the stimulation task are set at random. The “manual generation unit” 140 applies the task type and time arbitrarily set by the operator.

  The “random generation unit” 130 includes a function “Relax Random” 131 that randomizes the stimulus presentation timing and a function “Mark Random” 132 that randomizes the stimulus presentation order. As a result, regarding a stimulus presentation pattern composed of a plurality of stimuli and rest periods, appropriate settings can be made not only for the entire pattern but also for individual stimuli and rest times that constitute the stimulus presentation pattern. . That is, the function 131 for randomizing the stimulus presentation timing is to set the stimulus to the stimulus setting unit (Sequence) 133 for setting the stimulus to be presented and the stimulus setting unit (Sequence) 133 by assigning an identification symbol to the stimulus type. A stimulation class setting unit (Mark Class) 134, a name input unit (Name) 135 for inputting an arbitrary name to each stimulation type, a stimulation time setting unit (Stimulation) 136 for setting a stimulation time, and a resting time. A rest time setting unit (Relax) and (Relax End) 137 for inputting and setting, a part (Step) 138 for setting the Step width of the rest time, and a repeat count setting unit (Repeat Count) 139 for setting the repeat count Composed. Predetermined items are set for the number of stimulus types to be given to the subject, and when the stimulus type setting unit is pressed, the identification symbol is input and set as a presentation stimulus constituting the stimulus presentation pattern.

  The function 132 for randomizing the stimulus presentation order includes the stimulus setting unit 133, the stimulus type setting unit 134, the name input unit 135, the stimulus time setting unit 136, the rest time setting unit 137, and 139. The Stimulus presentation is performed by a method in which the presentation order of stimulation presentation patterns composed of a plurality of stimulation types set by the stimulation setting unit 133 is random.

  FIG. 4 is a schematic diagram of a measurement scene by the biological light measurement device of the present embodiment. As shown in FIG. 4, the subject 22 receives a stimulus from the stimulus presentation control unit 100 in parallel with the brain function measurement by the optical topography device 1, and the response is a response processing device such as a microphone 112 or a button 114. To the stimulus presentation control unit 100. The stimulus presentation control unit 100 records the response result in the rest database 102 and the stimulus database 104 (hereinafter, when there is no need for distinction, simply the database of the stimulus presentation control unit 100).

  When the task is “button determination”, for example, the subject 22 is repeatedly pressed by pressing the controller button 114 when “◯” is displayed on the screen 110 and not pressing the button when “X” is displayed. give. As a stimulus task presented after the resting time, both ○ and × are displayed. Or the subject of pressing the same predetermined button at the time of rest and pressing a different button as a stimulus task is given. The timing at which the subject 22 presses the button 114 of the controller is recorded in the database of the stimulus presentation control unit 100 as the reaction time and the number of reactions, and the match between the XX display displayed on the monitor screen 110 and the presence or absence of the button press is a correct answer. Recorded as a rate.

  In addition, when the task is “microphone determination”, a predetermined rest time is given to the subject, or a task of repeated utterances such as “A, I, U, E, O” is given as a rest task, and then a stimulus is given. You may make it give the subject of the presentation initials and the number of word recall as a subject. The uttered voice is recorded in the database of the stimulus presentation control unit 100 by the microphone 112, and the utterance reaction time and the number of utterances are measured with the syllable between words as a break. The recorded reaction time, number of reactions, correct answer rate, and the like are displayed on the display unit 36 of the stimulus presentation control unit 100 in real time.

  FIG. 5 is a table showing an example of a determination criterion for a task based on “button determination” and “microphone determination”. When the task is “button determination”, the subject is given a task requiring a predetermined button operation, for example, and the threshold value is set based on the criteria shown in the table for the correct answer rate, response time, and number of reactions at that time. Set and use as criteria for judgment. Furthermore, when the task is “Mic”, the subject is given a task to repeat a predetermined utterance, and the threshold is set based on the criteria shown in the table for the utterance speed and utterance size of the subject at that time. This is a criterion for judgment.

  FIG. 6 is a diagram illustrating a configuration example of a user interface unit displayed on the display unit 36 and designed to be operated by a measurer. Transition is based on the main screen 200 for setting the stimulus presentation pattern, the input / output setting screen 204 for setting the rest parameter and the parameter of the stimulus presentation pattern, and the type of stimulus generation selected on the input / output setting screen 204. In addition, there are input / output setting screens 206, 208, 210, and the like for setting the stimulus generation more specifically.

  First, the measurer operates the main screen 200 to input and set various parameters of the stimulus presentation control unit 100. FIG. 7 shows an example of information recorded in the databases 102 and 104 of the stimulus presentation control unit 100. In the stimulation parameter setting unit 204 displayed on the main screen 200, initial settings such as various parameters are performed, and the results are recorded in the databases 102 and 104 of the stimulation presentation control unit 100. When “random generation” of the stimulation task generation parameter is selected on the input / output setting screen 204, the screen transits to the random stimulation setting screen 210.

  In the stimulus task generation parameter input / setting screen 204 of FIG. 6, the method for presenting the stimulus task and the number of times are set. In this example, it is possible to select any one of “feedback generation”, “random generation”, and “manual generation”. In “feedback generation”, the task presentation is automatically set using the correct answer rate and the reaction time in the stimulus task in real time. For example, when the button press correct answer rate and the reaction time during the stimulation task are good and the subject is an easy task, it is possible to increase the difficulty by shortening the presentation time. In addition, when the number of word recalls in the stimulation task is small, it is possible to automatically present an acronym with a large number of words and concentrate the subject on the task. In “random generation”, the type and time of the stimulation task are set randomly. In “manual generation”, the task type and time arbitrarily set by the operator are applied.

  In “feedback generation” and “random generation”, the task presentation time is adjusted in real time. As the adjustment time width, the value input in the “stimulation task presentation time width” is used.

  In the case of “button determination”, the number of reactions is detected when the button is pressed. As an example of the correct answer rate, the reaction time (average value, standard deviation value), and the number of reactions at the time of the task, the correct answer rate with respect to the number of reactions is obtained as 6 to 12 times / 10 to 20 times (60%). Further, assuming that the reaction time (average value) until the button is pressed is (200 to 300 ms) / number of times = A, the standard deviation value (variation) is obtained by the following equation.

((A ₁ −A) ² + (A ₂ −A) ² ... + (A _n −A) ² ) / N = 100 to 150 ms
Further, when the task is “microphone determination”, the speech rate of the subject is set to 1000 ms ± 100 ms as a threshold value from the peak value of the speech waveform to the next peak value. This waveform value is measured by an accelerometer, for example. The size of the utterance is 20 dB to 30 dB. For example, the waveform is visually observed.

  FIG. 8 is a flowchart showing the overall processing flow of measurement and analysis by the living body light measurement apparatus according to the present embodiment. The measurer first attaches the probe holder 23 to the subject 22 (S801), and then sets measurement parameters at the input / output unit 40 (S802). That is, the stimulus type, the stimulus time, the rest time, the number of repetitions, and the like constituting the stimulus presentation pattern are set. These data are held in a database.

  Here, setting of measurement parameters will be described with reference to FIGS.

  FIG. 9 is a diagram schematically showing the main screen of the input / output unit 40. This main screen 210 is displayed when “random generation” is selected in the item of stimulation task generation parameter on the input / setting screen 204 for various parameters shown in FIG.

  The main screen 210 includes a measurement data display unit 211, an information display unit 212 for displaying information such as subject information, measurement date and time, and measurement conditions, and an operation unit 213 operated when performing measurement such as measurement start and end. ing. Measurement data is displayed in real time as a waveform or topography image, and analysis result data is also displayed on this screen. The measurer advances the measurement while looking at the main screen 210. The information display unit 212 is provided with a next stimulus display unit 214. As a result, when "random generation" is selected and multiple stimuli (Stim) are set to be presented randomly, the next variable stimulus type and presentation timing that have become variable are displayed for the measurer. To do. The display example of the next stimulus display unit 214 in FIG. 9 indicates that “Stim A” is presented after 24.9 seconds as the next stimulus. This enables the measurer to give an accurate stimulus to the subject without increasing the burden on the measurer. That is, in the setting of the stimulus presentation pattern, it is possible to eliminate the bias in the appearance frequency of the stimulus species.

  When the measurement parameter setting (S802) is completed and then stimulus measurement is started (S803), the signal processing unit 34 sequentially processes the hemoglobin signals obtained during the measurement, and the display unit 36 converts the signal into the main signal. Display on the screen 210 in real time. That is, measurement data such as a hemoglobin change signal is displayed on the main screen 210 in real time as a waveform or a topographic image. Also, parameter information input by the measurer is always displayed on the main screen. The measurer advances the measurement by operating a button on the operation unit 213 on the main screen 210. In the measurement parameter setting, when the stimulus presentation order is random, the stimulus type in the stimulus measurement is random (Mark Random).

  Subsequently, measurement at rest is started (S804), measurement data such as a hemoglobin change signal is displayed on the main screen 210 in real time as a waveform or a topographic image, and the measurer uses the operation unit 213 on the main screen 210. Advance measurement with button operation. In the measurement parameter setting, when the stimulus presentation order is random, the rest time is random (Relax Random). The measurement is repeated a predetermined number of times with one set of stimulus measurement and rest time as a stimulus set.

  After the measurement is completed, the measurer sets analysis parameters for performing analysis such as addition averaging processing in the input / output unit 40 (S805), and based on this, analysis processing is performed in the control unit 14 (S806). . The result is held in the database and displayed on the main screen of the display unit 36 via the signal processing unit 34 (S807).

  FIG. 10 is a display before input displayed on the monitor screen of the presented stimulus setting unit 110 when “random generation” is selected as the stimulus task generation parameter in the measurement parameter setting (S802) of the flowchart of FIG. 3 is an example of a screen 300. The display screen 300 is a combo box 301 for selecting a stimulus presentation method. When measuring by a method of randomizing the stimulus presentation timing, “Relax Random” (see FIG. 11) is measured by a method of randomizing the order. Select “Mark Random” (see FIG. 13). Then, the item to be set can be edited.

  In the display screen 300 when “Relax Random” that selects the stimulus presentation timing at random is selected, the stimulus setting unit (Sequence) 308 for setting the stimulus to be presented, and the stimulus setting unit (Sequence) by assigning an identification symbol to the stimulus type A stimulus type setting unit (Mark Class) 302 for setting the stimulus to 308, a name input unit (Name) 303 for inputting an arbitrary name to each stimulus type, and a stimulus time setting unit (for setting the stimulus time) (Stimulation) 304, rest time setting unit (Relax) 305 and (Relax End) 306 for inputting and setting the rest time, a step (Step) 307 for setting the Step width (duration) of the rest time, and the number of repetitions Repeat count setting section to be set (Repeat Count) 309 is displayed and input becomes possible (valid). Therefore, when the above-described items 303 to 307 are set for the number of types of stimulation given to the subject and the button 302 is pressed (Sequence), the identification symbols are input in order from the left of 308 and set as a stimulation presentation pattern. The random width of the resting time is (Relax) 305 or more and (Relax End) 306 or less, and within the range, a number for each Step width of (Step) 307 of the resting time is randomly generated. The order of stimulus presentation is the order set by the stimulus setting unit (Sequence) 308.

  On the other hand, on the display screen 300 when “Mark Random” that selects the stimulus presentation order at random is selected, the stimulus setting unit 308, the stimulus type setting unit 302, the name input unit 303, the stimulus time setting unit 304, and the rest The time setting unit 305 and the repetition number setting unit 309 can be input (valid). The rest time is constant. The stimulus presentation is performed by a method in which the order of presenting the stimulus types set by the stimulus setting unit 308 is random. Therefore, in the stimulus presentation pattern in this case, all of the stimulus species set in 1 Repeat Count appear, and the appearance frequencies between the stimulus species match.

  That is, when the stimulus presentation timing is set at random, it is set via the “Relax Random” setting screen of FIG. The “Relax Random” setting screen includes a stimulation setting unit (Sequence) 308, a stimulation type setting unit (Mark Class) 302, a name input unit (Name) 303, a stimulation time setting unit (Stimulation) 304, and a resting time setting unit ( The Relax 305 and (Relax End) 306, the step width of the rest time (Step) 307, and the repeat count setting unit (Repeat Count) 309 are valid. When the above-mentioned items 303 to 307 are set for the number of types of stimulation given to the subject and the button 302, for example, A, B is pressed (Sequence), the identification symbols, for example, A, B are input in order from the left of the 308, and presented. Set as a stimulus. By pressing the (Sequence) 308 button, the stimulus type is canceled, and the identification symbols of the remaining stimulus types are displayed in advance. The random width of the rest time is (Relax) 305 or more and (Relax End) 306 or less, and a number for each Step width of the rest time is randomly generated within the range. The order of stimulus presentation is the order set by the stimulus setting unit (Sequence) 308. That is, the random width of the resting time that constitutes the stimulus presentation pattern can be obtained with data suitable for analyzing the measurement results and eliminates the prediction of the subject in advance from the upper limit and the lower limit. The upper and lower limits of the difference between the value and the length are set, and the total measurement time is controlled.

  Specific numerical values in FIG. 11 are setting examples in “Relax Random”. As shown in FIG. 11, when the rest time setting unit (Relax) 305, (Relax End) 306, and (Step) 307 are set, the rest time is 10 [s], 20 [s], 30 [s], 40 [s. ], 50 [s], and 60 [s]. In addition, Stim (stimulus) A and Stim (stimulus) B input in the name input unit (Name) 303 are based on the order set in the stimulus setting unit (Sequence) 308 in the order of stimulus A and stimulus B, respectively. In addition, the stimulation time 15 [s] set in the stimulation time setting unit (Stimulation) 304 and the rest time (random time) are generated 5 times based on the setting of the repeat count setting unit (Repeat Count) 309. . According to the present embodiment, the upper limit of the length of the rest time in the stimulus presentation pattern is 60 seconds, and the difference in the length of the rest time is at least 10 seconds. In other words, in the present invention, as the stimulus presentation pattern, rest times that are substantially unchanged in length, for example, continuous rest times such as 31 [s], 32 [s], and 33 [s] are set. It is configured not to be able to.

  Further, in the case of measuring by a method of randomizing the order, the setting is made via the “Mark Random” setting screen of FIG. In the setting screen of “Mark Random”, the stimulation setting unit 308, the setting unit 302, the name input unit 303, the stimulation time setting unit 304, the rest time setting unit 305, and the repetition number setting unit 309 are enabled. The rest time is constant. The stimulus presentation is performed by a method in which the order of presenting the stimulus types set by the stimulus setting unit 308 is random. Therefore, all the stimulus species set in 1 Repeat Count appear, and the appearance frequencies between the stimulus species are the same. In other words, in order to enable acquisition of data suitable for analyzing the measurement results and to eliminate the subject's prediction, the presentation order of the stimulation tasks of the stimulation presentation pattern is randomly set within a preset range. It is changed and the total measurement time is controlled.

  The specific numerical values in FIG. 12 are setting examples in “Mark Random”. When the rest time setting unit (Relax) 305 is set as shown in FIG. 12, Stim A, Stim B, and Stim C are changed in order, for example, “Stimulus C, Stimulus A, Stimulus B”, “Stimulus B, Stimulus C, Stimulus A ”,“ Stimulus A, Stimulus C, Stimulus B ”, etc., occur 5 times in total with a stimulation time of 15 [s] and a rest time of 30 [s], respectively.

  In the present embodiment, a parameter portion that is set when performing the averaging process is represented, and parameter input restrictions are provided. First, FIG. 13 is a parameter setting screen of the main screen 210 when performing analysis processing (S805, S806) by addition averaging of the flowchart of FIG. The items of “Pre Time”, “Recovery Time”, and “Post Time” are set and the averaging process analysis is performed by pressing the OK button. The details of the process of the addition average process analysis will be described in detail with reference to Patent Document 3. The range of parameters that can be analyzed is divided into three time units, “Pre Time”, “Recovery Time”, and “Post Time”, which are shown in the figure. It depends on the minimum rest time set by the time setting unit (Relax) 305 and (Relax End) 306. In the present invention, there is a limit to this minimum rest time in the stimulus presentation pattern.

  Next, FIG. 14 is a diagram illustrating the cutout of the averaging process. The resting time of the stimulus presentation pattern is variable because it can be set for each identification symbol set in the set unit (Mark Class) 302. It also became variable due to randomization of rest time. On the other hand, the three parameters (Pre Time in FIG. 13, “Recovery Time” and “Post Time”) set when data is cut out by addition analysis are unique. The extraction condition is that “Recovery Time” + “Post Time” or “Recovery Time” + “Pre Time” does not exceed the rest time. Therefore, the three parameters, “Pre Time”, “Recovery Time”, and “Post Time” must be set based on the minimum rest time.

  For example, when the rest time is set as shown in FIGS. 11 and 12 and “Recovery Time” is set to 20 [s], the upper limit values of “Pre Time” and “Post Time” are each within 10 [s]. is there. The rest time setting unit is limited in the range of input time values so that input settings outside the range cannot be made. That is, in the present invention, the minimum rest time in the stimulus presentation pattern, in other words, the minimum time (lower limit) acquired for the addition averaging process analysis is set in advance. In other words, there is a restriction on the randomization of the rest time so that data suitable for analyzing the measurement result can be acquired.

  As described above, according to the present invention, two types of random functions are realized when setting measurement parameters. First, by making the rest time of the stimulus presentation pattern variable, the subject cannot predict the next stimulus start timing. Second, the stimulus type to be presented next in the stimulus presentation pattern is variable. By doing so, it is impossible to predict the next action. Thus, by adding two types of random functions to the setting of measurement parameters, it is possible to reliably give a random repeated stimulus to the subject. Therefore, it is possible to prevent the occurrence of a situation in which the subject predicts the next stimulus while resting and unconsciously stands, and the influence appears in the result. In addition, the upper and lower limits of the difference between the upper and lower limits and the length difference are set in advance in the random width of the rest period in the stimulus presentation pattern so that data suitable for analyzing the measurement results can be acquired. Yes. Therefore, accurate measurement and analysis are always possible.

It is a figure for demonstrating the whole structure of the biological optical measuring device which has a stimulus presentation function which becomes an Example of this invention. It is a functional block diagram which shows the specific structural example of the control part stimulus presentation control part of FIG. It is a functional block diagram which shows the detailed structural example of the parameter setting part of FIG. It is a schematic diagram of the measurement scenery by the biological light measuring device of a present Example. It is a table | surface which shows an example of the determination criteria of the resting state by "button determination" and "microphone determination". It is a schematic diagram which shows an example of the input / setting screen of various parameters of the stimulus presentation control part of a present Example. The example of the information recorded on the database of the stimulus presentation control part of a present Example is shown. It is a flowchart showing the flow of the whole process of the measurement and analysis by the biological light measuring device of a present Example. It is a figure which shows the main screen displayed to a measurer during a measurement in a present Example. It is a figure for demonstrating the presentation stimulus setting part (before input) of a present Example. It is a figure for demonstrating the setting screen of the presentation stimulus "Relax Random" by a present Example. It is a figure for demonstrating the setting screen of the presentation stimulus "Mark Random" by a present Example. It is a figure explaining the parameter part set when performing an addition average process by a present Example, and having provided the input restriction of the parameter. It is a figure explaining the data cut-out in an addition average process by a present Example.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1 ... Optical topography apparatus, 10 ... Light source part, 12 ... Optical measurement part, 14 ... Control part, 16 ... Semiconductor laser, 18 ... Optical module, 20 ... Optical fiber, 22 ... Test object, 26 ... Optical fiber for detection, 28 DESCRIPTION OF SYMBOLS ... Photoelectric conversion element, 30 ... Lock-in amplifier, 32 ... A / D converter, 34 ... Signal processing part, 36 ... Display part, 38 ... Memory | storage part, 40 ... Input / output part, 100 ... Stimulus presentation control part, 101 ... Rest parameter setting unit, 102 ... Rest database, 103 ... Stimulus parameter setting unit, 104 ... Stimulus database, 105 ... Task presentation control unit, 110 ... Stimulus presentation unit, 210 ... Main screen, 211 ... Measurement data display unit, 212 ... Information Display unit, 213 ... operation unit, 214 ... next stimulus display unit, 301 ... stimulus presentation method selection unit, 302 ... stimulus set unit, 303 ... stimulus name input unit, 304 ... stimulus time setting unit , 305 ... Rest time setting section 1, 306 ... Rest time setting section 2, 307 ... Rest time step width setting section, 308 ... Stimulus type setting section, 309 ... Repeat count setting section.

Claims (7)

A stimulus presentation unit that repeatedly presents a stimulus to a subject;
A stimulus presentation control unit for controlling the stimulus presentation unit;
In parallel with the presentation of the stimulus, light that measures the passing light intensity of the light irradiated on the subject at a plurality of measurement points and outputs a signal corresponding to the passing light intensity at each measurement point as measurement data A measurement unit;
A signal processing unit that processes and outputs measurement data from the optical measurement unit;
And a table radical 113,
The stimulus presentation control unit
Parameters for randomly setting the presentation order or stimulation time and rest time of individual stimulation types, and the repetition cycle of the stimulation presentation pattern in the stimulation presentation pattern composed of a plurality of stimulation types, as the stimulation presentation parameters A setting section ;
Including an analysis unit that performs analysis processing,
The parameter setting unit
A stimulus type setting unit for setting the stimulus type to be presented;
A stimulation time setting unit for setting the stimulation time;
A resting time setting unit that sets the resting time in which a minimum time is limited in advance based on the time required for the analysis process,
Based on the parameters set by the parameter setting unit, the stimulus presentation unit randomly presents the plurality of stimulus types constituting the stimulus presentation pattern to the subject,
In parallel with the presentation of the stimulus, the measurement data of the intensity of the light passing through the subject is processed by the signal processing unit, and the analysis unit performs an analysis process by addition averaging based on the processed data. The biological light measurement device characterized in that the result of the analysis process is displayed on the display unit. Te claim 1 smell,
The parameter setting unit, the stimulus the stimulus time width presenting individual stimuli species patterns constituting are presented, and the biological light measuring device, characterized in that it has a function of setting the Step width of the resting time. In claim 1,
The parameter setting unit may have a function of said preselected plurality of stimulus types to be given to the subject, randomly setting a plurality of stimulation kinds of individual presentation timing and the rest time for forming the stimulus presentation pattern An optical measuring device characterized by. In claim 1,
The parameter setting unit has a function of said preselected plurality of stimulus types to be given to the subject, the individual presentation order of the plurality of stimulation species constituting the stimulus presentation pattern as a random, setting the rest time constant A living body light measuring device comprising:   The biological light measurement device according to claim 1, wherein the parameter setting unit includes a display unit that informs the measurer of a next stimulus presentation type. In claim 5 ,
The living body light measuring device characterized by setting the upper limit of the rest time based on the time required for the analysis processing . A stimulation task presentation control method in a biological light measurement device,
  The biological light measuring device is
  A stimulus presenting unit that repeatedly presents a stimulus to the subject, a stimulus presentation control unit that controls the stimulus presenting unit, and a passing light intensity of the light irradiated to the subject are measured at a plurality of measurement points. An optical measurement unit that outputs a signal corresponding to the transmitted light intensity as measurement data, a signal processing unit that processes and outputs measurement data from the optical measurement unit, and a display unit,
  The stimulus presentation control unit
  Parameters for randomly setting the presentation order or stimulation time and rest time of individual stimulation types, and the repetition cycle of the stimulation presentation pattern in the stimulation presentation pattern composed of a plurality of stimulation types, as the stimulation presentation parameters A setting section;
  Including an analysis unit that performs analysis processing,
  In the stimulus presentation control unit, as the stimulus presentation parameter, a minimum time is previously limited based on the order of presentation or stimulus time of the plurality of stimulus types constituting the stimulus presentation pattern, and the time required for the analysis processing. The rest time and the stimulus presentation pattern repetition period are set randomly,
  Based on the set parameters, the stimulus presentation unit randomly presents the plurality of stimulus types constituting the stimulus presentation pattern to the subject,
  Based on the parameters set by the parameter setting unit, the stimulus presentation unit randomly presents the plurality of stimulus types constituting the stimulus presentation pattern to the subject,
  In parallel with the presentation of the stimulus, the measurement data of the passing light intensity of the light irradiated on the subject is processed, the analysis processing is performed by the addition average based on the processed data, and the result of the analysis processing is displayed on the display Display in the department
A method for presenting a stimulus task in living body light measurement.

Images