JP5208730B2 - Ｃｄ４０シグナル伝達によって媒介される増殖性障害の診断および治療のための方法 - Google Patents

Ｃｄ４０シグナル伝達によって媒介される増殖性障害の診断および治療のための方法 Download PDF

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JP5208730B2
JP5208730B2 JP2008512536A JP2008512536A JP5208730B2 JP 5208730 B2 JP5208730 B2 JP 5208730B2 JP 2008512536 A JP2008512536 A JP 2008512536A JP 2008512536 A JP2008512536 A JP 2008512536A JP 5208730 B2 JP5208730 B2 JP 5208730B2
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cd40l
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cells
seq
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シャロン リー オーカーマン，
バヒジャ ジャラル，
モハマド ルクマン，
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ノバルティス アーゲー
ゾーマ テクノロジー リミテッド
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154

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JP2008512536A 2005-05-18 2006-05-18 Ｃｄ４０シグナル伝達によって媒介される増殖性障害の診断および治療のための方法 Expired - Fee Related JP5208730B2 (ja)

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US68258205P 2005-05-18 2005-05-18
US60/682,582 2005-05-18
US74928505P 2005-12-09 2005-12-09
US60/749,285 2005-12-09
PCT/US2006/019414 WO2006125143A2 (en) 2005-05-18 2006-05-18 Methods for diagnosis and treatment of proliferative disorders mediated by cd40 signaling

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JP2012272271A Division JP2013057686A (ja) 2005-05-18 2012-12-13 Ｃｄ４０シグナル伝達によって媒介される増殖性障害の診断および治療のための方法

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JP2008539794A JP2008539794A (ja) 2008-11-20
JP2008539794A5 JP2008539794A5 (cg-RX-API-DMAC7.html) 2009-09-24
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JP2012272271A Pending JP2013057686A (ja) 2005-05-18 2012-12-13 Ｃｄ４０シグナル伝達によって媒介される増殖性障害の診断および治療のための方法

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AU (1) AU2006247067B2 (cg-RX-API-DMAC7.html)
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WO2006125143A3 (en) 2007-03-22
JP2008539794A (ja) 2008-11-20
US8337851B2 (en) 2012-12-25
WO2006125143A2 (en) 2006-11-23
JP2013057686A (ja) 2013-03-28
EP1894012A2 (en) 2008-03-05
CA2608751A1 (en) 2006-11-23
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