JP5201510B2 - 骨誘導性リン酸カルシウム - Google Patents
骨誘導性リン酸カルシウム Download PDFInfo
- Publication number
- JP5201510B2 JP5201510B2 JP2008555181A JP2008555181A JP5201510B2 JP 5201510 B2 JP5201510 B2 JP 5201510B2 JP 2008555181 A JP2008555181 A JP 2008555181A JP 2008555181 A JP2008555181 A JP 2008555181A JP 5201510 B2 JP5201510 B2 JP 5201510B2
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- JP
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- Prior art keywords
- tricalcium phosphate
- porous
- tcp
- osteoinductive
- ceramic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims description 233
- 239000001506 calcium phosphate Substances 0.000 title claims description 121
- 235000011010 calcium phosphates Nutrition 0.000 title claims description 87
- 229910000389 calcium phosphate Inorganic materials 0.000 title claims description 84
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 134
- 239000002245 particle Substances 0.000 claims description 98
- 239000000463 material Substances 0.000 claims description 97
- 239000000843 powder Substances 0.000 claims description 80
- 230000002138 osteoinductive effect Effects 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 48
- 108090000623 proteins and genes Proteins 0.000 claims description 47
- 102000004169 proteins and genes Human genes 0.000 claims description 47
- 210000000988 bone and bone Anatomy 0.000 claims description 40
- 239000007943 implant Substances 0.000 claims description 40
- 239000002002 slurry Substances 0.000 claims description 39
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 36
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 33
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 31
- 239000012091 fetal bovine serum Substances 0.000 claims description 28
- 238000001179 sorption measurement Methods 0.000 claims description 28
- 239000011575 calcium Substances 0.000 claims description 27
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims description 26
- 239000011859 microparticle Substances 0.000 claims description 24
- 239000011148 porous material Substances 0.000 claims description 24
- 239000000126 substance Substances 0.000 claims description 21
- 239000000758 substrate Substances 0.000 claims description 20
- 238000005245 sintering Methods 0.000 claims description 19
- 239000004604 Blowing Agent Substances 0.000 claims description 12
- 239000013078 crystal Substances 0.000 claims description 12
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 12
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 230000015572 biosynthetic process Effects 0.000 claims description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical group OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 8
- 229910052586 apatite Inorganic materials 0.000 claims description 8
- 230000001788 irregular Effects 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 238000000227 grinding Methods 0.000 claims description 6
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 238000005187 foaming Methods 0.000 claims description 5
- 239000004088 foaming agent Substances 0.000 claims description 5
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 4
- 229910000392 octacalcium phosphate Inorganic materials 0.000 claims description 4
- 238000001356 surgical procedure Methods 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 claims description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- 230000008020 evaporation Effects 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims description 2
- 239000010419 fine particle Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000002407 tissue scaffold Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000000919 ceramic Substances 0.000 description 106
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- 241000282472 Canis lupus familiaris Species 0.000 description 8
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
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- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 4
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 4
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- 239000007858 starting material Substances 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 210000002449 bone cell Anatomy 0.000 description 3
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- 229940043256 calcium pyrophosphate Drugs 0.000 description 3
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- 239000012894 fetal calf serum Substances 0.000 description 3
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- 235000019691 monocalcium phosphate Nutrition 0.000 description 3
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- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 2
- JUQPZRLQQYSMEQ-UHFFFAOYSA-N CI Basic red 9 Chemical compound [Cl-].C1=CC(N)=CC=C1C(C=1C=CC(N)=CC=1)=C1C=CC(=[NH2+])C=C1 JUQPZRLQQYSMEQ-UHFFFAOYSA-N 0.000 description 2
- 239000005574 MCPA Substances 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- WHKUVVPPKQRRBV-UHFFFAOYSA-N Trasan Chemical compound CC1=CC(Cl)=CC=C1OCC(O)=O WHKUVVPPKQRRBV-UHFFFAOYSA-N 0.000 description 2
- 238000002441 X-ray diffraction Methods 0.000 description 2
- 229940052223 basic fuchsin Drugs 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 229960005069 calcium Drugs 0.000 description 2
- VEJCUEBBRSCJRP-UHFFFAOYSA-L calcium;hydron;phosphonato phosphate Chemical compound [Ca+2].OP(O)(=O)OP([O-])([O-])=O VEJCUEBBRSCJRP-UHFFFAOYSA-L 0.000 description 2
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- 230000000877 morphologic effect Effects 0.000 description 2
- RFWLACFDYFIVMC-UHFFFAOYSA-D pentacalcium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O RFWLACFDYFIVMC-UHFFFAOYSA-D 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 230000008569 process Effects 0.000 description 2
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- ZRMMVODKVLXCBB-UHFFFAOYSA-N 1-n-cyclohexyl-4-n-phenylbenzene-1,4-diamine Chemical compound C1CCCCC1NC(C=C1)=CC=C1NC1=CC=CC=C1 ZRMMVODKVLXCBB-UHFFFAOYSA-N 0.000 description 1
- 239000004135 Bone phosphate Substances 0.000 description 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 239000004134 Dicalcium diphosphate Substances 0.000 description 1
- HECLRDQVFMWTQS-UHFFFAOYSA-N Dicyclopentadiene Chemical compound C1C2C3CC=CC3C1C=C2 HECLRDQVFMWTQS-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 206010049811 Extraskeletal ossification Diseases 0.000 description 1
- 208000034970 Heterotopic Ossification Diseases 0.000 description 1
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- 230000002378 acidificating effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
- 235000019815 calcium dihydrogen diphosphate Nutrition 0.000 description 1
- 229940062672 calcium dihydrogen phosphate Drugs 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- ROPDWRCJTIRLTR-UHFFFAOYSA-L calcium metaphosphate Chemical compound [Ca+2].[O-]P(=O)=O.[O-]P(=O)=O ROPDWRCJTIRLTR-UHFFFAOYSA-L 0.000 description 1
- 229910000394 calcium triphosphate Inorganic materials 0.000 description 1
- GFIKIVSYJDVOOZ-UHFFFAOYSA-L calcium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Ca+2].[O-]P([O-])(F)=O GFIKIVSYJDVOOZ-UHFFFAOYSA-L 0.000 description 1
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- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium phosphate dihydrate Substances O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 1
- OLSDWRNWUGHKSY-UHFFFAOYSA-J dicalcium;phosphonato phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O OLSDWRNWUGHKSY-UHFFFAOYSA-J 0.000 description 1
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Porous Artificial Stone Or Porous Ceramic Products (AREA)
- Compositions Of Oxide Ceramics (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77484006P | 2006-02-17 | 2006-02-17 | |
| EP06075368A EP1829564A1 (en) | 2006-02-17 | 2006-02-17 | Osteoinductive calcium phosphate |
| US60/774,840 | 2006-02-17 | ||
| EP06075368.8 | 2006-02-17 | ||
| PCT/NL2007/050069 WO2007094672A1 (en) | 2006-02-17 | 2007-02-19 | Osteoinductive calcium phosphates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009526600A JP2009526600A (ja) | 2009-07-23 |
| JP2009526600A5 JP2009526600A5 (enExample) | 2010-01-21 |
| JP5201510B2 true JP5201510B2 (ja) | 2013-06-05 |
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| JP2008555181A Active JP5201510B2 (ja) | 2006-02-17 | 2007-02-19 | 骨誘導性リン酸カルシウム |
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| EP (1) | EP1993624B1 (enExample) |
| JP (1) | JP5201510B2 (enExample) |
| KR (1) | KR101391846B1 (enExample) |
| AU (1) | AU2007215625B2 (enExample) |
| CA (1) | CA2642830A1 (enExample) |
| WO (1) | WO2007094672A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110020419A1 (en) * | 2006-02-17 | 2011-01-27 | Huipin Yuan | Osteoinductive calcium phosphates |
| AU2007215625B2 (en) * | 2006-02-17 | 2012-06-28 | Progentix Orthobiology B.V. | Osteoinductive calcium phosphates |
| GB0801935D0 (en) | 2008-02-01 | 2008-03-12 | Apatech Ltd | Porous biomaterial |
| RU2392007C2 (ru) * | 2008-04-11 | 2010-06-20 | Государственное Учебно-Научное Учреждение Химический Факультет Московского Государственного Университета Имени М.В. Ломоносова | Способ получения пористого материала на основе фосфата кальция |
| JP2012533373A (ja) * | 2009-07-23 | 2012-12-27 | プロゲンティックス・オーソバイオロジー・ベー・フェー | 注入及び成形可能な骨誘導性セラミック材料 |
| US20110307074A1 (en) * | 2010-05-24 | 2011-12-15 | University Of The Witwatersrand, Johannesburg | Biomaterials for use in methods of bone replacement therapy |
| US20120021008A1 (en) * | 2010-07-23 | 2012-01-26 | Joost Dick De Bruijn | Injectable and moldable ceramic materials |
| US9272072B1 (en) | 2012-10-19 | 2016-03-01 | Nuvasive, Inc. | Osteoinductive bone graft substitute |
| NL2011195C2 (en) | 2013-07-18 | 2015-01-21 | Xpand Biotechnology B V | Method for producing an osteoinductive calcium phosphate and products thus obtained. |
| AU2018399962B2 (en) | 2018-01-02 | 2024-11-14 | Cartiheal (2009) Ltd. | Implantation tool and protocol for optimized solid substrates promoting cell and tissue growth |
| WO2021194477A1 (en) * | 2020-03-24 | 2021-09-30 | Secada Medical, Llc Dba Ventris Medical, Llc | Methods of producing an osteoinductive calcium phosphate material for bone grafting |
| US10786597B1 (en) | 2020-03-24 | 2020-09-29 | Secada Medical Llc | Methods of producing an osteoinductive calcium phosphate material for bone grafting |
| US11083557B1 (en) | 2020-05-01 | 2021-08-10 | Secada Medical Llc | Bone graft containment system |
| NL2027599B1 (en) * | 2021-02-19 | 2022-09-19 | Instructure Labs B V | Biocompatible polymeric implant material having a textured surface |
| GB202306382D0 (en) | 2023-04-28 | 2023-06-14 | Locate Bio Ltd | Osteoinstructive calcium phosphate ceramic material |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5654841A (en) * | 1979-10-08 | 1981-05-15 | Mitsubishi Mining & Cement Co | Bone broken portion and filler for void portion and method of treating bone of animal using said filler |
| US4294753A (en) * | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
| US4693986A (en) * | 1985-06-25 | 1987-09-15 | Orthomatrix, Inc. | Ceramic process and products |
| JPS62281953A (ja) * | 1986-05-28 | 1987-12-07 | 旭光学工業株式会社 | 骨補填材 |
| JPS63125259A (ja) * | 1986-11-14 | 1988-05-28 | 旭光学工業株式会社 | リン酸カルシウム系多孔質骨補填材 |
| JP2572606B2 (ja) * | 1987-09-14 | 1997-01-16 | 旭光学工業株式会社 | 表面多孔質なリン酸カルシウム系セラミックスの製造法 |
| JPH04212369A (ja) | 1991-01-04 | 1992-08-03 | Asahi Optical Co Ltd | 骨補填材の製造方法 |
| US5783217A (en) * | 1995-11-07 | 1998-07-21 | Etex Corporation | Low temperature calcium phosphate apatite and a method of its manufacture |
| US20020098222A1 (en) * | 1997-03-13 | 2002-07-25 | John F. Wironen | Bone paste |
| CA2285430C (en) * | 1997-04-01 | 2008-11-18 | Cap Biotechnology, Inc. | Calcium phosphate microcarriers and microspheres |
| NL1008582C2 (nl) | 1998-01-05 | 1999-07-06 | Vrije Universiteit | Botmateriaal. |
| AU766735B2 (en) * | 1998-09-15 | 2003-10-23 | Isotis N.V. | Osteoinduction |
| ATE268309T1 (de) * | 2000-04-26 | 2004-06-15 | Ecole Polytech | Kalziumphosphatmikrogranulate |
| JP4212369B2 (ja) | 2003-01-22 | 2009-01-21 | 中国電力株式会社 | 電力供給サービス方法およびシステム |
| EP3254710B1 (en) * | 2003-04-11 | 2019-05-22 | Etex Corporation | Osteoinductive bone material |
| TWI230058B (en) * | 2003-08-05 | 2005-04-01 | Univ Nat Taiwan | Hydroxylapatite powder, porous body and method for preparing thereof |
| US8029755B2 (en) * | 2003-08-06 | 2011-10-04 | Angstrom Medica | Tricalcium phosphates, their composites, implants incorporating them, and method for their production |
| EP1716873A1 (en) * | 2005-04-25 | 2006-11-02 | Progentix B.V. i.o. | Method of improving the osteoinductivity of bioactive materials |
| US20060257492A1 (en) * | 2005-05-13 | 2006-11-16 | Depuy Products, Inc. | Suspension of calcium phosphate particulates for local delivery of therapeutic agents |
| US7901650B2 (en) * | 2005-06-22 | 2011-03-08 | Skeletal Kinectics, LLC | Porous beta-tricalcium phosphate and methods for producing the same |
| EP1829564A1 (en) * | 2006-02-17 | 2007-09-05 | Progentix B.V. i.o. | Osteoinductive calcium phosphate |
| AU2007215625B2 (en) * | 2006-02-17 | 2012-06-28 | Progentix Orthobiology B.V. | Osteoinductive calcium phosphates |
| US20110020419A1 (en) | 2006-02-17 | 2011-01-27 | Huipin Yuan | Osteoinductive calcium phosphates |
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2007
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- 2007-02-19 KR KR1020087022635A patent/KR101391846B1/ko not_active Expired - Fee Related
- 2007-02-19 WO PCT/NL2007/050069 patent/WO2007094672A1/en not_active Ceased
- 2007-02-19 EP EP07715889A patent/EP1993624B1/en active Active
- 2007-02-19 JP JP2008555181A patent/JP5201510B2/ja active Active
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2009
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2015
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2019
- 2019-12-05 US US16/704,580 patent/US11590263B2/en active Active
Also Published As
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|---|---|
| US20200108180A1 (en) | 2020-04-09 |
| AU2007215625A1 (en) | 2007-08-23 |
| US20160067382A1 (en) | 2016-03-10 |
| EP1993624B1 (en) | 2011-05-04 |
| WO2007094672A1 (en) | 2007-08-23 |
| EP1993624A1 (en) | 2008-11-26 |
| KR101391846B1 (ko) | 2014-05-19 |
| US20100034865A1 (en) | 2010-02-11 |
| US11590263B2 (en) | 2023-02-28 |
| US7942934B2 (en) | 2011-05-17 |
| JP2009526600A (ja) | 2009-07-23 |
| US10532131B2 (en) | 2020-01-14 |
| CA2642830A1 (en) | 2007-08-23 |
| AU2007215625B2 (en) | 2012-06-28 |
| KR20090017470A (ko) | 2009-02-18 |
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