JP5180967B2 - ピロロトリアジンキナーゼ阻害剤 - Google Patents

ピロロトリアジンキナーゼ阻害剤 Download PDF

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Publication number
JP5180967B2
JP5180967B2 JP2009536401A JP2009536401A JP5180967B2 JP 5180967 B2 JP5180967 B2 JP 5180967B2 JP 2009536401 A JP2009536401 A JP 2009536401A JP 2009536401 A JP2009536401 A JP 2009536401A JP 5180967 B2 JP5180967 B2 JP 5180967B2
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JP
Japan
Prior art keywords
substituted
alkyl
aryl
cancer
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2009536401A
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English (en)
Japanese (ja)
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JP2010509348A5 (https=
JP2010509348A (ja
Inventor
ブライアン・イー・フィンク
ピン・チェン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication date
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Publication of JP2010509348A publication Critical patent/JP2010509348A/ja
Publication of JP2010509348A5 publication Critical patent/JP2010509348A5/ja
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Publication of JP5180967B2 publication Critical patent/JP5180967B2/ja
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2009536401A 2006-11-03 2007-11-02 ピロロトリアジンキナーゼ阻害剤 Expired - Fee Related JP5180967B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86417506P 2006-11-03 2006-11-03
US60/864,175 2006-11-03
PCT/US2007/083436 WO2008057994A2 (en) 2006-11-03 2007-11-02 Pyrrolotriazine kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2010509348A JP2010509348A (ja) 2010-03-25
JP2010509348A5 JP2010509348A5 (https=) 2011-07-14
JP5180967B2 true JP5180967B2 (ja) 2013-04-10

Family

ID=39365255

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009536401A Expired - Fee Related JP5180967B2 (ja) 2006-11-03 2007-11-02 ピロロトリアジンキナーゼ阻害剤

Country Status (6)

Country Link
US (1) US7982033B2 (https=)
EP (1) EP2081936B1 (https=)
JP (1) JP5180967B2 (https=)
CN (1) CN101535312B (https=)
NO (1) NO20091374L (https=)
WO (1) WO2008057994A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20140688T1 (hr) 2006-07-07 2014-10-24 Bristol-Myers Squibb Company Inhibitori piroltriazin kinaze
US8268998B2 (en) * 2006-11-03 2012-09-18 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
PT2300013T (pt) 2008-05-21 2017-10-31 Ariad Pharma Inc Derivados de fósforo como inibidores de cinases
US8445676B2 (en) * 2008-10-08 2013-05-21 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
ES2539620T3 (es) 2008-12-19 2015-07-02 Cephalon, Inc. Pirrolotriazina como inhibidor de ALK y de JAK2
JP5093527B2 (ja) * 2010-02-10 2012-12-12 日本電気株式会社 複合光導波路、波長可変フィルタ、波長可変レーザ、および光集積回路
WO2012025186A1 (en) * 2010-08-27 2012-03-01 Merck Patent Gmbh Triazolopyrazine derivatives
CN103848833B (zh) * 2012-11-28 2016-08-31 上海希迈医药科技有限公司 吡咯并三嗪类衍生物、其制备方法及其在医药上的应用
KR101879422B1 (ko) * 2013-09-18 2018-07-17 베이징 한미 파마슈티컬 컴퍼니 리미티드 Btk 및/또는 jak3 키나제의 활성을 억제하는 화합물
CN104974163B (zh) * 2014-04-14 2017-11-07 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
FR3025717A1 (fr) * 2014-09-16 2016-03-18 Univ Lille Sciences Tech Utilisation conjointe d'un inhibiteur de trka et d'un inhibiteur de epha2 pour une utilisation dans le traitement de cancers
WO2016190847A1 (en) * 2015-05-26 2016-12-01 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
WO2017004134A1 (en) * 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60026297T2 (de) * 1999-05-21 2006-11-02 Bristol-Myers Squibb Co. Pyrrolotriazin kinasehemmer
US6982265B1 (en) * 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
US6670357B2 (en) 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
YU37903A (sh) * 2000-11-17 2006-05-25 Bristol-Myers Squibb Company POSTUPCI LEČENJA STANJA POVEZANIH SA p38 KINAZOM I JEDINJENJA PIROLOTRIAZINA KOJA SE KORISTE KAO INHIBITORI KINAZE
KR101025675B1 (ko) * 2002-04-23 2011-03-30 브리스톨-마이어스 스큅 컴퍼니 키나제 억제제로서 유용한 피롤로-트리아진 아닐린 화합물
WO2004013145A1 (en) * 2002-08-02 2004-02-12 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
CA2425123C (en) * 2003-01-16 2010-09-21 Decoma International Inc. Lightweight composite tailgate
US7605160B2 (en) 2006-08-09 2009-10-20 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7531539B2 (en) 2006-08-09 2009-05-12 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
CN101687874B (zh) 2007-04-18 2013-01-30 百时美施贵宝公司 吡咯并三嗪激酶抑制剂

Also Published As

Publication number Publication date
US7982033B2 (en) 2011-07-19
EP2081936A2 (en) 2009-07-29
JP2010509348A (ja) 2010-03-25
NO20091374L (no) 2009-07-21
US20100081662A1 (en) 2010-04-01
CN101535312A (zh) 2009-09-16
EP2081936B1 (en) 2014-04-02
WO2008057994A3 (en) 2008-09-12
WO2008057994A2 (en) 2008-05-15
CN101535312B (zh) 2013-04-24

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