JP5134362B2 - 修飾アネキシンタンパク質および血栓症を防止するための方法 - Google Patents

修飾アネキシンタンパク質および血栓症を防止するための方法 Download PDF

Info

Publication number
JP5134362B2
JP5134362B2 JP2007503052A JP2007503052A JP5134362B2 JP 5134362 B2 JP5134362 B2 JP 5134362B2 JP 2007503052 A JP2007503052 A JP 2007503052A JP 2007503052 A JP2007503052 A JP 2007503052A JP 5134362 B2 JP5134362 B2 JP 5134362B2
Authority
JP
Japan
Prior art keywords
annexin
protein
nucleic acid
modified
thrombosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2007503052A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008502592A (ja
JP2008502592A5 (fr
Inventor
アリソン，アンソニー
Original Assignee
アラビタ・ファーマシューティカルズ・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アラビタ・ファーマシューティカルズ・インコーポレーテッド filed Critical アラビタ・ファーマシューティカルズ・インコーポレーテッド
Publication of JP2008502592A publication Critical patent/JP2008502592A/ja
Publication of JP2008502592A5 publication Critical patent/JP2008502592A5/ja
Application granted granted Critical
Publication of JP5134362B2 publication Critical patent/JP5134362B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2007503052A 2004-03-11 2005-03-10 修飾アネキシンタンパク質および血栓症を防止するための方法 Expired - Fee Related JP5134362B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US55242804P 2004-03-11 2004-03-11
US60/552,428 2004-03-11
US57958904P 2004-06-14 2004-06-14
US60/579,589 2004-06-14
PCT/US2005/008193 WO2005086955A2 (fr) 2004-03-11 2005-03-10 Proteines d'annexine modifiees et procedes destines a prevenir la thrombose

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012161761A Division JP2012254992A (ja) 2004-03-11 2012-07-20 修飾アネキシンタンパク質および血栓症を防止するための方法

Publications (3)

Publication Number Publication Date
JP2008502592A JP2008502592A (ja) 2008-01-31
JP2008502592A5 JP2008502592A5 (fr) 2008-03-21
JP5134362B2 true JP5134362B2 (ja) 2013-01-30

Family

ID=34976262

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007503052A Expired - Fee Related JP5134362B2 (ja) 2004-03-11 2005-03-10 修飾アネキシンタンパク質および血栓症を防止するための方法
JP2012161761A Withdrawn JP2012254992A (ja) 2004-03-11 2012-07-20 修飾アネキシンタンパク質および血栓症を防止するための方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012161761A Withdrawn JP2012254992A (ja) 2004-03-11 2012-07-20 修飾アネキシンタンパク質および血栓症を防止するための方法

Country Status (5)

Country Link
EP (1) EP1734983A4 (fr)
JP (2) JP5134362B2 (fr)
AU (1) AU2005221195B2 (fr)
CA (1) CA2559167A1 (fr)
WO (1) WO2005086955A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7635676B2 (en) * 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
US7645739B2 (en) * 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
DK2328622T3 (en) 2008-08-26 2015-02-02 Mosamedix Bv Radiolabelled annexins
EP2742064B1 (fr) * 2011-08-09 2016-07-27 UAB Profarma Dérivés de protéines recombinantes, homomultimères du facteur de stimulation de colonie de granulocytes et leur procédé de préparation
GB2542391A (en) 2015-09-17 2017-03-22 Annexin Pharmaceuticals Ab Process of manufacture
US11357823B2 (en) * 2019-08-30 2022-06-14 Suzhou Yabao Pharmaceutical R&D Co., Ltd Method for treating cerebral stroke
EP4355765A2 (fr) * 2021-06-14 2024-04-24 Institut National de la Santé et de la Recherche Médicale (INSERM) Polypeptides d'annexine a5 mutants et leurs utilisations à des fins thérapeutiques

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968477A (en) * 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
JP3742675B2 (ja) * 1995-06-28 2006-02-08 東菱薬品工業株式会社 虚血−再灌流障害の予防および治療薬
ATE230614T1 (de) * 1998-07-13 2003-01-15 Univ Texas Krebsbehandlung mit aminophospholipide bindenden, therapeutischen konjugaten
CN1125084C (zh) * 1999-03-12 2003-10-22 中国科学院上海生物化学研究所 一种血栓靶向性溶栓融合蛋白
EP1839670A3 (fr) * 2001-02-21 2009-11-11 Alavita Pharmaceuticals, Inc. Protéines d'annexine modifiées et leur utilisation contre la thrombose
US20030152513A1 (en) * 2001-09-06 2003-08-14 Imetrix, Inc. Intravascular delivery of therapeutic and imaging agents to stressed and apoptotic cells using annexin V as a targeting vector
JP4444821B2 (ja) * 2002-06-06 2010-03-31 ツェ・チェイン・ウン 遺伝子組み換えによる新しい抗凝血性蛋白質
WO2004013303A2 (fr) * 2002-08-02 2004-02-12 Surromed, Inc. Proteines d'annexine modifiees, et procedes de traitement de la drepanocytose a crise vaso-occlusive

Also Published As

Publication number Publication date
WO2005086955A3 (fr) 2006-03-09
JP2008502592A (ja) 2008-01-31
CA2559167A1 (fr) 2005-09-22
EP1734983A4 (fr) 2009-11-18
WO2005086955A2 (fr) 2005-09-22
AU2005221195B2 (en) 2011-05-19
EP1734983A2 (fr) 2006-12-27
JP2012254992A (ja) 2012-12-27
AU2005221195A1 (en) 2005-09-22

Similar Documents

Publication Publication Date Title
US20050222030A1 (en) Modified annexin proteins and methods for preventing thrombosis
US7407475B2 (en) Modified annexin proteins, and methods and compositions for using them
JP2009514553A (ja) 修飾アネキシンタンパク質および臓器移植における該タンパク質の使用法
US7645739B2 (en) Modified annexin compositions and methods of using same
US7635680B2 (en) Attenuation of reperfusion injury
JP2012254992A (ja) 修飾アネキシンタンパク質および血栓症を防止するための方法
US20090291086A1 (en) Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia
US11897924B2 (en) Anticoagulant fusion proteins and uses thereof
WO2004013303A2 (fr) Proteines d'annexine modifiees, et procedes de traitement de la drepanocytose a crise vaso-occlusive
JP4873784B2 (ja) 膜結合能を有する可溶性ペプチド化合物の複合体を含有する器官移植用溶液
US6982154B2 (en) Modified annexin proteins and methods for treating vaso-occlusive sickle-cell disease

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080130

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080130

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101126

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110222

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110301

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110525

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110804

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110826

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111125

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120321

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120720

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20120903

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120919

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120920

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20121011

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20121109

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20151116

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees