JP5133373B2 - ベータグルコシダーゼ活性増強剤及び生理活性配糖体の吸収促進剤 - Google Patents
ベータグルコシダーゼ活性増強剤及び生理活性配糖体の吸収促進剤 Download PDFInfo
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- JP5133373B2 JP5133373B2 JP2010152690A JP2010152690A JP5133373B2 JP 5133373 B2 JP5133373 B2 JP 5133373B2 JP 2010152690 A JP2010152690 A JP 2010152690A JP 2010152690 A JP2010152690 A JP 2010152690A JP 5133373 B2 JP5133373 B2 JP 5133373B2
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- glycoside
- beta
- glucosidase activity
- glycosides
- bioactive
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Description
また、フラボノイド類、イソフラボノイド類、サポニン類、アントシアニン類、ピリドキシン等生体に有用な食品成分には配糖体として経口摂取されるものが多く知られている。特に、フラボノイド配糖体やイソフラボノイド配糖体に関しては、小腸の糖水解酵素による水解後に糖とアグリコンが遊離した後吸収されるとされている。しかしながら、その水解、吸収は完全ではなく、これらの配糖体の一部は大腸に到達し、腸内細菌由来の酵素による水解後に吸収されるが、これによる水解の能力も完全ではなく、摂取したこれらの配糖体の一部は、体内に吸収され機能を発揮することなく、そのまま体外に排出されている。
大腸でフラボノイド配糖体やイソフラボノイド配糖体を水解する腸内細菌由来の酵素としては、ベータグルコシダーゼの寄与が大きいことが知られている。(非特許文献1:Rowland Iら British Journal of Nutrition 89巻 別冊1 S45−S58頁 2003年)
(2)ダイフラクトース アンハイドライドを有効成分とする生理活性を持つ配糖体の吸収促進剤
(3)生理活性を持つ配糖体がポリフェノール配糖体である(2)の剤
(4)生理活性を持つ配糖体がフラボノイド配糖体、又はイソフラボノイド配糖体である(2)の剤
ベータグルコシダーゼ活性を増強することにより、生理活性を持つ配糖体の吸収を促進することができる。
ダイフラクトース アンハイドライドと生理活性を持つ配糖体を配合した経口剤を提供することにより、効果よく生理活性を持つ配糖体を体内に吸収することができる。
ポリフェノールとはベンゼン環に複数の水酸基を持つ化合物を指し、タンニン(加水分解タンニンとしてガロタンニン、エラジタンニン、縮合型タンニンとしてカテキンやエピカテキンの縮合体)、カテキン(カテキン、エピカテキン)、フラボノイド(フラボン、フラボノール、フラバノン、フラバノノール、イソフラボン、カルコン、オーロン、ロイコアントシアニン、カテキン)、リグナン(セサミノール、ピノレジノール)、リグニン、クマリン、シンプルフェノール(プロトカテチュ酸、没食子酸、シリンガ酸)などが上げられ、抗酸化作用を有することが知られている。本発明のダイフラクトース アンハイドライドを摂取することにより、これらポリフェノールの消化吸収を促進することができる。
以下の実施例をもって本発明をより詳細に説明するが、これらは単に例示するのみであり、本発明はこれらによって何ら限定されるものではない。
Wistar系雄ラット(3週齢)24匹を3日間固形飼料で予備飼育した後、基本食7gを3日間与え、4群に分けた。それぞれに基本食7gにDFAIII0.5gまたは ショ糖 0.5gずつ足した飼料を与えた。3週間の本飼育の後、屠殺し、盲腸内容物を採取し、以下の方法により、ベータグルコシダーゼの測定を行った。
盲腸内容物を採取した後、その場で内容物を均一になるように攪拌した。内容物の全重量を測定し、分析まで−20℃で保管した。約0.5gのサンプルを採取し、0.1Mリン酸バッファー(pH6.4)を1:20(w/w)となるように添加し、氷冷下でホモジナイズを行った後、超音波(20s)破砕を行い、遠心分離(500G×15min)した上清を測定に供した。p−nitrophenol glucoside(1.5mg/mL)100μLに測定サンプルを200μL添加し、37℃で30分間インキュベートを行った。その後、0.25mol/L炭酸ナトリウム溶液を1.6mL添加し400nmの吸光度を測定した。測定された吸光度より、サンプルブランクの吸光度を差し引きp−nitrophenol溶液の検量線を用いて30分間当たりの生成物量を算出した。
図1のSはショ糖、DはDFAIIIの略である。また、0.5は7gの基本食にそれぞれ0.5g足した飼料を与えたことを示す。
この結果から明らかなように、DFAの摂取により、腸管内容物のベータグルコシダーゼ活性の増強が認められた。
処方例1 錠剤 (配合量:質量%)
DFAII 77
ケルセチン4グルコシド ※ 2
コーンスターチ 20
グアーガム 1
※ ケルセチン4グルコシドはフラボノイドの一種であるケルセチンのグルコース配糖体である。
処方例2 ジュース (配合量:質量%)
DFAIII 10
ダイジン※ 2
冷凍濃縮温州ミカン果汁 5
クエン酸 0.2
L−アスコルビン酸 0.02
香料 0.2
色素 0.1
水 82.48
※ ダイジンはフラボノイドの一種であるダイゼインのグルコース配糖体である。
Claims (4)
- ダイフラクトース アンハイドライドを有効成分とする腸管内容物中のベータグルコシダーゼ活性増強剤。
- ダイフラクトース アンハイドライドを有効成分とする生理活性を持つ配糖体の吸収促進剤。
- 生理活性を持つ配糖体がポリフェノール配糖体である請求項2の剤。
- 生理活性を持つ配糖体がフラボノイド配糖体、又はイソフラボノイド配糖体である請求項2の剤。
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