JP5113958B2 - 薬剤多量体微粒子及びその製造方法 - Google Patents

薬剤多量体微粒子及びその製造方法 Download PDF

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JP5113958B2
JP5113958B2 JP2012519401A JP2012519401A JP5113958B2 JP 5113958 B2 JP5113958 B2 JP 5113958B2 JP 2012519401 A JP2012519401 A JP 2012519401A JP 2012519401 A JP2012519401 A JP 2012519401A JP 5113958 B2 JP5113958 B2 JP 5113958B2
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drug
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fine particles
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JPWO2011155501A1 (ja
Inventor
均 笠井
八郎 中西
耕一 馬場
英俊 及川
達也 村上
博 今堀
充 橋田
勇 王
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Japan Science and Technology Agency
National Institute of Japan Science and Technology Agency
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2012519401A 2010-06-11 2011-06-07 薬剤多量体微粒子及びその製造方法 Active JP5113958B2 (ja)

Priority Applications (1)

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JP2012519401A JP5113958B2 (ja) 2010-06-11 2011-06-07 薬剤多量体微粒子及びその製造方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2010133486 2010-06-11
JP2010133486 2010-06-11
JP2012519401A JP5113958B2 (ja) 2010-06-11 2011-06-07 薬剤多量体微粒子及びその製造方法
PCT/JP2011/063084 WO2011155501A1 (ja) 2010-06-11 2011-06-07 薬剤多量体微粒子及びその製造方法

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JP2012225014A Division JP2013040189A (ja) 2010-06-11 2012-10-10 薬剤多量体微粒子及びその製造方法

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JP5113958B2 true JP5113958B2 (ja) 2013-01-09
JPWO2011155501A1 JPWO2011155501A1 (ja) 2013-08-01

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JP2012519401A Active JP5113958B2 (ja) 2010-06-11 2011-06-07 薬剤多量体微粒子及びその製造方法
JP2012225014A Pending JP2013040189A (ja) 2010-06-11 2012-10-10 薬剤多量体微粒子及びその製造方法

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US (1) US20130096097A1 (enExample)
EP (1) EP2586463B1 (enExample)
JP (2) JP5113958B2 (enExample)
CN (1) CN103068404B (enExample)
WO (1) WO2011155501A1 (enExample)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
WO2013188727A2 (en) * 2012-06-15 2013-12-19 The Children's Hospital Of Philadelphia Novel pro- and codrug derivatives for nanoparticle delivery of select anticancer agents formed using rapidly cleavable phenolic ester bridges
WO2020154815A1 (en) 2019-02-01 2020-08-06 Ripple Therapeutics Corporation Crystalline forms of dexamethasone dimers and uses thereof
US12509469B2 (en) 2019-08-07 2025-12-30 Ripple Therapeutics Corporation Compositions and methods for the treatment of pain and dependence disorders
AU2022234045B2 (en) * 2021-03-12 2025-05-29 Japan Science And Technology Agency Sn-38 derivative, nano-particles containing said derivative, medicine, and method for producing said nano-particles
AU2023390747A1 (en) * 2022-12-09 2025-06-26 Japan Science And Technology Agency Compound, nanoparticles, medicine and method for producing nanoparticles

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0679168A (ja) * 1992-09-07 1994-03-22 Hitoshi Kasai 有機超微粒子の製法
WO2007075825A2 (en) * 2005-12-20 2007-07-05 Sonus Pharmaceuticals, Inc. Lipophilic anticancer drug compounds
WO2009013466A1 (en) * 2007-07-20 2009-01-29 Fujifilm Manufacturing Europe B.V. Preparation of fine particles
WO2009075391A1 (en) * 2007-12-13 2009-06-18 Kyushu University, National University Corporation Drug-containing nanoparticles
CN101628919A (zh) * 2009-08-20 2010-01-20 浙江大学 喜树碱及其衍生物的自乳化药物前体及其应用
WO2010053101A1 (ja) * 2008-11-06 2010-05-14 国立大学法人東北大学 眼内移行性の高い点眼剤および蛍光イメージング剤ならびにそれらの製造方法

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
ES2262223T3 (es) 1997-02-14 2006-11-16 Bionumerik Pharmaceuticals, Inc. Derivados de camptotecina altamente lipofilos.
US6011042A (en) 1997-10-10 2000-01-04 Enzon, Inc. Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
JP2005537266A (ja) * 2002-07-12 2005-12-08 バイオマリン ファーマシューティカル インコーポレイテッド 加水分解性活性物質であるバイオポリマーコンジュゲートを作製するためのイソシアネートリンカーの使用
US20070041093A1 (en) 2005-08-22 2007-02-22 Stuart Bard Projector screen for use in a lighted room
JP2010503708A (ja) 2006-09-15 2010-02-04 エンゾン ファーマスーティカルズ インコーポレイテッド 多官能性リンカーを含む標的化ポリマープロドラッグ
US8367065B2 (en) 2006-09-15 2013-02-05 Enzon Pharmaceuticals, Inc. Targeted polymeric prodrugs containing multifunctional linkers

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0679168A (ja) * 1992-09-07 1994-03-22 Hitoshi Kasai 有機超微粒子の製法
WO2007075825A2 (en) * 2005-12-20 2007-07-05 Sonus Pharmaceuticals, Inc. Lipophilic anticancer drug compounds
WO2009013466A1 (en) * 2007-07-20 2009-01-29 Fujifilm Manufacturing Europe B.V. Preparation of fine particles
WO2009075391A1 (en) * 2007-12-13 2009-06-18 Kyushu University, National University Corporation Drug-containing nanoparticles
WO2010053101A1 (ja) * 2008-11-06 2010-05-14 国立大学法人東北大学 眼内移行性の高い点眼剤および蛍光イメージング剤ならびにそれらの製造方法
CN101628919A (zh) * 2009-08-20 2010-01-20 浙江大学 喜树碱及其衍生物的自乳化药物前体及其应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6012030505; Ｊｏｕｒｎａｌ　ｏｆ　Ａｍｅｒｉｃａｎ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ Ｖｏｌ．１３２，　Ｎｏ．１２，ｐｐ．４２５９-４２６５，Ｓ１-１２, 20100310 *
JPN6012030509; Ａｎｇｅｗａｎｄｔｅ　Ｃｈｅｍｉｅ Ｖｏｌ．４４, 2005, ｐｐ．７１６-７２０，Ｓｕｐｐｏｒｔｉｎｇ　Ｉｎｆｏｒｍａｔｉｏｎｐｐ．１-２２ *
JPN7012002242; 高分子論文集 Ｖｏｌ．５９　，　Ｎｏ．１０，　ｐｐ．６３７-６４１, 2002 *

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Publication number Publication date
JP2013040189A (ja) 2013-02-28
CN103068404A (zh) 2013-04-24
CN103068404B (zh) 2015-11-25
US20130096097A1 (en) 2013-04-18
EP2586463A1 (en) 2013-05-01
EP2586463A4 (en) 2014-03-19
WO2011155501A1 (ja) 2011-12-15
EP2586463B1 (en) 2016-08-17
JPWO2011155501A1 (ja) 2013-08-01

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