JP5112587B2 - 改変された免疫原性応答を生み出す蛋白質およびその作製および使用法 - Google Patents

改変された免疫原性応答を生み出す蛋白質およびその作製および使用法 Download PDF

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JP5112587B2
JP5112587B2 JP2001558466A JP2001558466A JP5112587B2 JP 5112587 B2 JP5112587 B2 JP 5112587B2 JP 2001558466 A JP2001558466 A JP 2001558466A JP 2001558466 A JP2001558466 A JP 2001558466A JP 5112587 B2 JP5112587 B2 JP 5112587B2
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エステル，デービット・エイ
ハーディング，フィオーナ・エイ
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ダニスコ・ユーエス・インコーポレーテッド
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    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
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    • C12Y302/01004—Cellulase (3.2.1.4), i.e. endo-1,4-beta-glucanase
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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JP2001558466A 2000-02-08 2001-01-22 改変された免疫原性応答を生み出す蛋白質およびその作製および使用法 Expired - Fee Related JP5112587B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/500,135 2000-02-08
US09/500,135 US6838269B1 (en) 1998-04-15 2000-02-08 Proteins producing an altered immunogenic response and methods of making and using the same
PCT/US2001/002204 WO2001059130A2 (en) 2000-02-08 2001-01-22 Proteins producing an altered immunogenic response and methods of making and using the same

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JP2004500088A JP2004500088A (ja) 2004-01-08
JP2004500088A5 JP2004500088A5 (enExample) 2007-11-08
JP5112587B2 true JP5112587B2 (ja) 2013-01-09

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JP2001558466A Expired - Fee Related JP5112587B2 (ja) 2000-02-08 2001-01-22 改変された免疫原性応答を生み出す蛋白質およびその作製および使用法

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US (1) US6838269B1 (enExample)
EP (1) EP1254240B1 (enExample)
JP (1) JP5112587B2 (enExample)
KR (1) KR20020073582A (enExample)
CN (3) CN1721442A (enExample)
AR (1) AR027358A1 (enExample)
AT (1) ATE355377T1 (enExample)
AU (1) AU3651201A (enExample)
CA (1) CA2399019A1 (enExample)
DE (1) DE60126915T2 (enExample)
DK (1) DK1254240T3 (enExample)
WO (1) WO2001059130A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
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US6967080B1 (en) * 1990-12-05 2005-11-22 Novozymes A/S Proteins with changed epitopes and methods for the production thereof
US6936249B1 (en) * 1998-04-15 2005-08-30 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
CA2249648A1 (en) * 1998-11-04 2000-05-04 Nabil G. Seidah Mammalian subtilisin/kexin isozyme ski-1: a proprotein convertase with a unique cleavage specificity
JP2004532618A (ja) * 2001-02-06 2004-10-28 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 低減された免疫原性を有する修飾されたレプチン
WO2003057246A1 (en) * 2001-12-31 2003-07-17 Genencor International, Inc. Proteases producing an altered immunological response and methods of making and using the same
EP2287321B1 (en) * 2002-01-16 2014-08-13 Danisco US Inc. Multiply-substituted protease variants
AU2003213580A1 (en) * 2002-02-26 2003-09-09 Genencor International, Inc. Subtilisin carlsberg proteins with reduced immunogenicity
CN101597601B (zh) * 2002-06-26 2013-06-05 诺维信公司 具有改变的免疫原性的枯草杆菌酶和枯草杆菌酶变体
WO2004078960A1 (en) * 2003-02-26 2004-09-16 Genencor International, Inc. Amylases producing an altered immunogenic response and methods of making and using the same
EP2500423B1 (en) * 2003-02-26 2015-06-17 Danisco US Inc. Amylases producing an altered immunogenic response and methods of making and using the same
KR20160064249A (ko) 2005-03-23 2016-06-07 글락소스미스클라인 바이오로지칼즈 에스.에이. Ｃｄ4 ｔ－세포 및/또는 개선된 ｂ－메모리 세포 반응을 유도하는 인플루엔자 바이러스 및 수중유 에멀젼 애주번트의 용도
WO2006113209A1 (en) * 2005-04-15 2006-10-26 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen
PL2043682T3 (pl) 2006-07-17 2014-09-30 Glaxosmithkline Biologicals Sa Szczepionka przeciw grypie
JP5230397B2 (ja) * 2008-12-18 2013-07-10 独立行政法人科学技術振興機構 抗膜貫通型タンパク質抗体の抗原結合部位を決定する方法
US8937159B2 (en) 2009-12-16 2015-01-20 Abbvie Biotherapeutics Inc. Anti-HER2 antibodies and their uses
EP3164486B1 (en) 2014-07-04 2020-05-13 Novozymes A/S Subtilase variants and polynucleotides encoding same
CN106661566A (zh) 2014-07-04 2017-05-10 诺维信公司 枯草杆菌酶变体以及编码它们的多核苷酸
EP3464582A1 (en) * 2016-06-03 2019-04-10 Novozymes A/S Subtilase variants and polynucleotides encoding same

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BR7904209A (pt) 1978-07-04 1980-06-17 Novo Industri As Preparacao de protease adequada para mistura a composicoes de lavagem processo para preparatease cepa de b licheniformis e composicao de lavagem
US5700676A (en) * 1984-05-29 1997-12-23 Genencor International Inc. Modified subtilisins having amino acid alterations
WO1992010755A1 (en) 1990-12-05 1992-06-25 Novo Nordisk A/S Proteins with changed epitopes and methods for the production thereof
US5593877A (en) * 1993-03-11 1997-01-14 The Rockefeller University Nucleic acid and recombinant production of vespid venom hyaluronidase
DK96493D0 (da) 1993-08-26 1993-08-26 Mouritsen Og Elsner Aps Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden
CU22615A1 (es) * 1994-06-30 2000-02-10 Centro Inmunologia Molecular Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
JPH10509324A (ja) 1994-11-24 1998-09-14 ノボ ノルディスク アクティーゼルスカブ 抑制されたアレルゲン性を有するポリペプチドの製造のための方法
US5951980A (en) * 1995-01-06 1999-09-14 Leuven Research & Development Vzw Identification, production and use of new staphylokinase derivatives with reduced immunogenicity
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WO1999006061A1 (en) 1997-07-29 1999-02-11 The Administrators Of The Tulane Educational Fund Prediction, detection, and design of t cell epitopes
US6495136B1 (en) * 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
US6835550B1 (en) 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6642011B2 (en) * 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
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Publication number Publication date
CN101906464B (zh) 2013-03-27
EP1254240B1 (en) 2007-02-28
WO2001059130A2 (en) 2001-08-16
CN101906464A (zh) 2010-12-08
KR20020073582A (ko) 2002-09-27
CA2399019A1 (en) 2001-08-16
DK1254240T3 (da) 2007-07-02
JP2004500088A (ja) 2004-01-08
AR027358A1 (es) 2003-03-26
DE60126915T2 (de) 2007-11-15
CN1721442A (zh) 2006-01-18
CN1418253A (zh) 2003-05-14
AU3651201A (en) 2001-08-20
US6838269B1 (en) 2005-01-04
ATE355377T1 (de) 2006-03-15
DE60126915D1 (de) 2007-04-12
WO2001059130A3 (en) 2002-03-07
EP1254240A2 (en) 2002-11-06

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