JP2004500088A5 - - Google Patents

Download PDF

Info

Publication number
JP2004500088A5
JP2004500088A5 JP2001558466A JP2001558466A JP2004500088A5 JP 2004500088 A5 JP2004500088 A5 JP 2004500088A5 JP 2001558466 A JP2001558466 A JP 2001558466A JP 2001558466 A JP2001558466 A JP 2001558466A JP 2004500088 A5 JP2004500088 A5 JP 2004500088A5
Authority
JP
Japan
Prior art keywords
polypeptide
variant
cell epitope
interest
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2001558466A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004500088A (ja
JP5112587B2 (ja
Filing date
Publication date
Priority claimed from US09/500,135 external-priority patent/US6838269B1/en
Application filed filed Critical
Publication of JP2004500088A publication Critical patent/JP2004500088A/ja
Publication of JP2004500088A5 publication Critical patent/JP2004500088A5/ja
Application granted granted Critical
Publication of JP5112587B2 publication Critical patent/JP5112587B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

JP2001558466A 2000-02-08 2001-01-22 改変された免疫原性応答を生み出す蛋白質およびその作製および使用法 Expired - Fee Related JP5112587B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/500,135 2000-02-08
US09/500,135 US6838269B1 (en) 1998-04-15 2000-02-08 Proteins producing an altered immunogenic response and methods of making and using the same
PCT/US2001/002204 WO2001059130A2 (en) 2000-02-08 2001-01-22 Proteins producing an altered immunogenic response and methods of making and using the same

Publications (3)

Publication Number Publication Date
JP2004500088A JP2004500088A (ja) 2004-01-08
JP2004500088A5 true JP2004500088A5 (enExample) 2007-11-08
JP5112587B2 JP5112587B2 (ja) 2013-01-09

Family

ID=23988185

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001558466A Expired - Fee Related JP5112587B2 (ja) 2000-02-08 2001-01-22 改変された免疫原性応答を生み出す蛋白質およびその作製および使用法

Country Status (12)

Country Link
US (1) US6838269B1 (enExample)
EP (1) EP1254240B1 (enExample)
JP (1) JP5112587B2 (enExample)
KR (1) KR20020073582A (enExample)
CN (3) CN1721442A (enExample)
AR (1) AR027358A1 (enExample)
AT (1) ATE355377T1 (enExample)
AU (1) AU3651201A (enExample)
CA (1) CA2399019A1 (enExample)
DE (1) DE60126915T2 (enExample)
DK (1) DK1254240T3 (enExample)
WO (1) WO2001059130A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6967080B1 (en) * 1990-12-05 2005-11-22 Novozymes A/S Proteins with changed epitopes and methods for the production thereof
US6936249B1 (en) * 1998-04-15 2005-08-30 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
CA2249648A1 (en) * 1998-11-04 2000-05-04 Nabil G. Seidah Mammalian subtilisin/kexin isozyme ski-1: a proprotein convertase with a unique cleavage specificity
CN1491232A (zh) * 2001-02-06 2004-04-21 Ĭ��ר�����޹�˾ 免疫原性减弱的经修饰肥胖蛋白
CA2471972A1 (en) * 2001-12-31 2003-07-17 Genencor International, Inc. Proteases producing an altered immunological response and methods of making and using the same
BR0306956A (pt) * 2002-01-16 2006-04-11 Genencor Int variantes de protease multiplamente substituìdas
WO2003072746A2 (en) * 2002-02-26 2003-09-04 Genencor International, Inc. Subtilisin carlsberg proteins with reduced immunogenicity
CN101597601B (zh) * 2002-06-26 2013-06-05 诺维信公司 具有改变的免疫原性的枯草杆菌酶和枯草杆菌酶变体
CN1745169A (zh) * 2003-02-26 2006-03-08 金克克国际有限公司 产生改变的免疫原应答的淀粉酶及其制备和使用方法
EP2500423B1 (en) * 2003-02-26 2015-06-17 Danisco US Inc. Amylases producing an altered immunogenic response and methods of making and using the same
DK1861120T3 (en) * 2005-03-23 2016-07-25 Glaxosmithkline Biologicals Sa Use of an influenza virus and an oil-in-water emulsion adjuvant to induce CD 4 T cell and / or enhanced B memory cell response
CA2604909A1 (en) * 2005-04-15 2006-10-26 The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen
PL2043682T3 (pl) 2006-07-17 2014-09-30 Glaxosmithkline Biologicals Sa Szczepionka przeciw grypie
JP5230397B2 (ja) * 2008-12-18 2013-07-10 独立行政法人科学技術振興機構 抗膜貫通型タンパク質抗体の抗原結合部位を決定する方法
WO2011084496A1 (en) 2009-12-16 2011-07-14 Abbott Biotherapeutics Corp. Anti-her2 antibodies and their uses
EP3164486B1 (en) 2014-07-04 2020-05-13 Novozymes A/S Subtilase variants and polynucleotides encoding same
EP3327122B1 (en) 2014-07-04 2021-02-17 Novozymes A/S Subtilase variants and polynucleotides encoding same
EP3464582A1 (en) * 2016-06-03 2019-04-10 Novozymes A/S Subtilase variants and polynucleotides encoding same

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU161379A (en) 1978-07-04 1984-04-30 Novo Industri As Process for obtaining protease products of reduced allergic action
US5801038A (en) * 1984-05-29 1998-09-01 Genencor International Inc. Modified subtilisins having amino acid alterations
WO1992010755A1 (en) 1990-12-05 1992-06-25 Novo Nordisk A/S Proteins with changed epitopes and methods for the production thereof
US5593877A (en) * 1993-03-11 1997-01-14 The Rockefeller University Nucleic acid and recombinant production of vespid venom hyaluronidase
DK96493D0 (da) 1993-08-26 1993-08-26 Mouritsen Og Elsner Aps Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden
CU22615A1 (es) * 1994-06-30 2000-02-10 Centro Inmunologia Molecular Procedimiento de obtención de anticuerpos monoclonales murinos menos inmunogénicos. anticuerpos monoclonales obtenidos
AU3924095A (en) 1994-11-24 1996-06-17 Novo Nordisk A/S A process for producing polypeptides with reduced allergenicity
US5951980A (en) * 1995-01-06 1999-09-14 Leuven Research & Development Vzw Identification, production and use of new staphylokinase derivatives with reduced immunogenicity
US5837517A (en) * 1995-05-05 1998-11-17 Novo Nordisk A/S Protease variants and compositions
DE69637907D1 (de) 1995-05-05 2009-06-04 Novozymes As Protease-varianten und verbindungen
WO1997030148A1 (en) 1996-02-15 1997-08-21 Novo Nordisk A/S Conjugation of polypeptides
ATE409743T1 (de) 1996-11-04 2008-10-15 Novozymes As Subtilase varianten und verbindungen
GB2339430A (en) 1997-05-21 2000-01-26 Biovation Ltd Method for the production of non-immunogenic proteins
AU8595298A (en) 1997-07-29 1999-02-22 The Administrators Of The Tulane Eductional Fund Prediction, detection, and design of t cell epitopes
US6495136B1 (en) * 1998-03-26 2002-12-17 The Procter & Gamble Company Proteases having modified amino acid sequences conjugated to addition moieties
US6835550B1 (en) 1998-04-15 2004-12-28 Genencor International, Inc. Mutant proteins having lower allergenic response in humans and methods for constructing, identifying and producing such proteins
US6642011B2 (en) * 1998-04-15 2003-11-04 Genencor International, Inc. Human protease and use of such protease for pharmaceutical applications and for reducing the allergenicity of non-human proteins
CA2238660A1 (en) 1998-05-22 1999-11-22 Janet Chantler Gene sequences of rubella virus associated with attenuation
DE69934967T2 (de) 1998-12-08 2007-12-06 Biovation Ltd. Verfahren zur verminderung der immunogenität von proteinen

Similar Documents

Publication Publication Date Title
JP2004500088A5 (enExample)
Loo et al. Using secretion to solve a solubility problem: high-yield expression in Escherichia coli and purification of the bacterial glycoamidase PNGase F
WO1995016048A3 (en) Recombinant protein production in bovine adenovirus expression vector system
AU7599500A (en) Novel gl50 molecules and uses therefor
WO2001025793A3 (en) Diagnosis of coeliac disease using a gliadin epitope
NZ331829A (en) Clostridium perfringens vaccines
BR0015137A (pt) Peptìdeos antigênicos de neisseria
JP2002510494A5 (enExample)
WO2001072976A3 (en) 32142, 21481, 25964, 21686, novel human dehydrogenase molecules and uses therefor
Lingnau et al. Identification and purification of novel internalin-related proteins in Listeria monocytogenes and Listeria ivanovii
EP0528686B8 (en) Process for producing peptides
WO2022168927A1 (ja) タンパク質脱アミド酵素
AU2002211446A1 (en) 32144, a human fatty acid amide hydrolase and uses thereof
TW218882B (enExample)
DE69021886D1 (de) Äusseres membranprotein p1 und peptide von haemophilus influenzae typ b.
KR100369839B1 (ko) 바실러스리케니포미스균주에서유래한아미노펩티다제,그의제조방법및이를이용한천연형단백질의제조방법
AU2001280639A1 (en) 13237,18480,2245 or 16228 human protein kinase molecules and uses therefor
WO2003012121A3 (en) Collagen xxii, a novel human collagen and uses thereof
WO2001079489A3 (en) 39228, a human alcohol dehydrogenase and uses therefor
AU2001249649A1 (en) 16836, a novel human phospholipase c family member and uses thereof
WO2001075076A3 (en) 33167, a novel human hydrolase and uses therefor
WO2002029042A3 (en) 48120, 23479, and 46689, novel human hydrolases and uses thereof
WO2001066764A3 (en) 16835, a human phospholipase c and uses thereof
AU2001251410A1 (en) 12303, a novel human twik molecule and uses thereof
AU2002234132A1 (en) 13245, a novel human myotonic dystrophy type protein kinase and uses therefor