JP5080440B2 - 抗菌活性を有するポリペプチド及びそれをコードするポリヌクレオチド - Google Patents
抗菌活性を有するポリペプチド及びそれをコードするポリヌクレオチド Download PDFInfo
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- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 102000003601 transglutaminase Human genes 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- FTKYRNHHOBRIOY-HQUBJAAMSA-N tritrptcin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)C(C)C)C1=CC=CC=C1 FTKYRNHHOBRIOY-HQUBJAAMSA-N 0.000 description 1
- 101150016309 trpC gene Proteins 0.000 description 1
- 239000001974 tryptic soy broth Substances 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000003253 viricidal effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 235000012711 vitamin K3 Nutrition 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 241000228158 x Triticosecale Species 0.000 description 1
- 101150110790 xylB gene Proteins 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- ZKIAWZPHVZQYMG-QYJCGYSGSA-N θ-defensin Chemical class O=C([C@@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(=O)N1)=O)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)[C@@H](C)CC)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CSSC1 ZKIAWZPHVZQYMG-QYJCGYSGSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Fodder In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200500392 | 2005-03-18 | ||
| DKPA200500392 | 2005-03-18 | ||
| DKPA200501033 | 2005-07-14 | ||
| DKPA200501032 | 2005-07-14 | ||
| DKPA200501034 | 2005-07-14 | ||
| DKPA200501034 | 2005-07-14 | ||
| DKPA200501038 | 2005-07-14 | ||
| DKPA200501038 | 2005-07-14 | ||
| DKPA200501037 | 2005-07-14 | ||
| DKPA200501036 | 2005-07-14 | ||
| DKPA200501037 | 2005-07-14 | ||
| DKPA200501035 | 2005-07-14 | ||
| DKPA200501033 | 2005-07-14 | ||
| DKPA200501032 | 2005-07-14 | ||
| DKPA200501036 | 2005-07-14 | ||
| DKPA200501035 | 2005-07-14 | ||
| DKPA200501367 | 2005-09-30 | ||
| DKPA200501367 | 2005-09-30 | ||
| DKPA200501365 | 2005-09-30 | ||
| DKPA200501365 | 2005-09-30 | ||
| PCT/DK2006/000155 WO2006097110A2 (en) | 2005-03-18 | 2006-03-20 | Polypeptides having antimicrobial activity and polynucleotides encoding same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012151360A Division JP2012191951A (ja) | 2005-03-18 | 2012-07-05 | 抗菌活性を有するポリペプチド及びそれをコードするポリヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008537675A JP2008537675A (ja) | 2008-09-25 |
| JP2008537675A5 JP2008537675A5 (enExample) | 2009-05-21 |
| JP5080440B2 true JP5080440B2 (ja) | 2012-11-21 |
Family
ID=36235484
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008501161A Expired - Fee Related JP5080440B2 (ja) | 2005-03-18 | 2006-03-20 | 抗菌活性を有するポリペプチド及びそれをコードするポリヌクレオチド |
| JP2012151360A Pending JP2012191951A (ja) | 2005-03-18 | 2012-07-05 | 抗菌活性を有するポリペプチド及びそれをコードするポリヌクレオチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012151360A Pending JP2012191951A (ja) | 2005-03-18 | 2012-07-05 | 抗菌活性を有するポリペプチド及びそれをコードするポリヌクレオチド |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1863836B1 (enExample) |
| JP (2) | JP5080440B2 (enExample) |
| AR (1) | AR052947A1 (enExample) |
| AU (1) | AU2006224944B2 (enExample) |
| CA (1) | CA2601525A1 (enExample) |
| TW (1) | TW200700076A (enExample) |
| WO (1) | WO2006097110A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1922333T1 (sl) * | 2005-08-26 | 2010-06-30 | Novozymes Adenium Biotech As | Polipeptidi z antimikrobno aktivnostjo in polinukleotidi ki kodirajo le te |
| CN101704886B (zh) * | 2009-11-17 | 2012-03-21 | 中国人民解放军第三军医大学 | 人α-防御素5抗病毒活性突变体多肽及制备方法和应用 |
| WO2011104284A1 (en) * | 2010-02-25 | 2011-09-01 | Novozymes A/S | Polypeptides having antimicrobial activity |
| US8835604B2 (en) | 2010-06-12 | 2014-09-16 | Adenium Biotech Aos | Antimicrobial peptide variants and polynucleotides encoding same |
| US10568930B2 (en) | 2014-04-24 | 2020-02-25 | Hexima Limited | Agents and methods of treatment |
| RU2597789C2 (ru) * | 2014-11-10 | 2016-09-20 | Илья Владимирович Духовлинов | Анальгетическое средство на основе плазмидной днк, кодирующей hnp-1, либо hnp-2, либо hnp-3 (варианты) |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| US6592876B1 (en) * | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| IL114697A0 (en) * | 1994-07-22 | 1995-11-27 | Demeter Biotech Ltd | Polypeptides comprising ubiquitin-lytic peptide fusion protein products deriving therefrom their preparation and use |
| GB9526238D0 (en) * | 1995-12-21 | 1996-02-21 | Sandoz Ltd | Improvements in or relating to organic compounds |
| WO1998058061A1 (en) * | 1997-06-19 | 1998-12-23 | Schering Corporation | Mammalian genes; related reagents |
| US7338937B2 (en) * | 1997-11-17 | 2008-03-04 | Cornell Research Foundation, Inc. | Calcium-activated chloride channel proteins and their use in anti-metastatic therapy |
| FR2777568B1 (fr) | 1998-04-15 | 2002-10-31 | Rhone Poulenc Agrochimie | Gene codant pour l'heliomicine, proteine obtenue, vecteur le contenant, organismes transformes obtenus et procede de preparation |
| US6335318B1 (en) * | 1999-05-10 | 2002-01-01 | The Regents Of The University Of California | Antimicrobial theta defensins and methods of using same |
| JP4972264B2 (ja) * | 1999-12-06 | 2012-07-11 | ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 高親和性ｔｃｒタンパク質および方法 |
| GB0026002D0 (en) * | 2000-10-24 | 2000-12-13 | Smithkline Beecham Biolog | Novel compounds |
| FR2823754B1 (fr) | 2001-04-19 | 2004-02-13 | Entomed | Peptides antibacteriens, les compositions les contenant et leurs utilisations |
| NZ532962A (en) | 2001-11-20 | 2006-11-30 | Novozymes As | Antimicrobial polypeptides from pseudoplectania nigrella |
| JP2004329215A (ja) * | 2004-06-07 | 2004-11-25 | National Agriculture & Bio-Oriented Research Organization | 複合病害抵抗性を有する植物 |
-
2006
- 2006-03-20 WO PCT/DK2006/000155 patent/WO2006097110A2/en not_active Ceased
- 2006-03-20 JP JP2008501161A patent/JP5080440B2/ja not_active Expired - Fee Related
- 2006-03-20 EP EP06706125A patent/EP1863836B1/en active Active
- 2006-03-20 AR ARP060101082A patent/AR052947A1/es not_active Application Discontinuation
- 2006-03-20 AU AU2006224944A patent/AU2006224944B2/en not_active Ceased
- 2006-03-20 CA CA002601525A patent/CA2601525A1/en not_active Abandoned
- 2006-03-20 TW TW095109518A patent/TW200700076A/zh unknown
-
2012
- 2012-07-05 JP JP2012151360A patent/JP2012191951A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AR052947A1 (es) | 2007-04-11 |
| JP2012191951A (ja) | 2012-10-11 |
| CA2601525A1 (en) | 2006-09-21 |
| EP1863836B1 (en) | 2012-07-11 |
| WO2006097110A2 (en) | 2006-09-21 |
| AU2006224944B2 (en) | 2012-01-12 |
| EP1863836A2 (en) | 2007-12-12 |
| TW200700076A (en) | 2007-01-01 |
| WO2006097110A3 (en) | 2007-04-12 |
| JP2008537675A (ja) | 2008-09-25 |
| AU2006224944A1 (en) | 2006-09-21 |
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