JP5053080B2 - 痙攣療法を行うためのシステム - Google Patents
痙攣療法を行うためのシステム Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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Description
この出願の発明に関連する先行技術文献情報としては、以下のものがある(国際出願日以降国際段階で引用された文献及び他国に国内移行した際に引用された文献を含む)。
痙攣は、重度のうつ病性障害、妄想性うつ病、重度の内因性うつ病、急性躁病エピソード、および短期的急性発症の情動症状を有する統合失調症の治療に有効であることが知られている。さらに、当業者であれば、ECTまたは薬物療法と比べるとMSTは副作用が少ないことは周知である。
図1で図示するように、モニターシステム3は患者をモニターするよう提供されている。モニター工程では従来の脳波(「EEG」)法または当該脳波法のサブセットを使用する場合もある。痙攣の開始時および停止時を決定するためにEEGを使用することが可能である。通常、MSTによって誘発された痙攣は約20秒間継続する。これと比較すると、ECTによって誘発された痙攣は約120秒間継続する可能性がある。前記EEGモニターでは3〜6のリード線のみを必要とする。また、バースト間の皮質興奮性(即ち、α(アルファ)波活動)をモニターするためにEEGを使用することが可能である。
前記システム1はさらにコンピュータ4を具備する。前記コンピュータはディスプレイなどのユーザーインターフェースと中央処理装置などのシステムインテリジェンスとを有する。
一般的に磁場の強度および切替速度は、運動閾値の2倍を超える程度である必要がある。この運動閾値は、患者の短母指外転筋(abductor pollicis brevis:APB)(即ち、患者の親指の運動)に対応する運動皮質の領域がパルス磁場によって刺激されたときに、当該短母指外転筋に誘発電位を発生させるのに必要な磁場の最低強度および切替速度を表す。本発明によると、右側の運動野の位置および弛緩時の運動閾値は、左半球よりも先に特定化された(Epstein CM,Lah JK,Meador K,Weissman JD,Gaitan LE, Dihenia B,Optimized stimulus parameters for lateralized suppression of speech with magnetic brain stimulation,Neurology,1996;47:1590−1593を参照。この参照により、この内容の全体の開示は本明細書に組み込まれる。)1ヘルツの速度で刺激中、刺激コイルを中央左の領域全体で移動させ、前記装置の出力を徐々に調節して活性化の最低強度の点を位置決定し、当該位置における磁気閾値を決定する。次に前記位置を記録する。運動閾値を決定するために第1の治療セッションでは約5〜10分必要であるが、前記活性化の最低強度の位置が既に記録されているため、後続のセッションではより短時間で済む。
MST療法で刺激を行うために、前記コイルは通常頭頂上に再配置される。1実施形態において、患者に痙攣を誘発する方法は、当該患者に痙攣を起させるのに十分な磁場強度および切替速度を利用して磁場を当該患者に印加する工程を有する。この実施形態においては、周波数約40〜60ヘルツの少なくとも1つのバーストを約2〜8秒間印加する。あるいは、前記バースト強度は患者の運動閾値の2倍を超える程度である必要がある。
1実施形態において、前記制御システム5は、(ECGの測定値によって決定される)心不整脈または臨床介入必要とする他の異常などが起こった場合アラームを提供し、またこのような状態下では刺激をロックアウトする。
1実施形態において、前記制御システム5は、さらに、痙攣を誘発する設定、痙攣持続時間、心拍数、前記コイルの位置、皮質興奮性レベル、事前痙攣閾値情報、血圧、またはEEG(あるいはECG)データなどのセッションにおける記録パラメータを含む。
1実施形態において、電源スイッチ6は前記制御システム5によってトリガーされ、電源7から電圧を印加する。1実施形態において、前記電源スイッチは、シリコン制御整流器(silicon controlled rectifier:SCR)、絶縁ゲート双極トランジスタ(insulated gate bi−polar transistor:IGBT)、絶縁ゲート整流サイリスタ(insulated gate commutated thyristor:IGCT)などの固体切替装置である。本実施形態において、前記電源7は、1〜2kVに充電した大型のコンデンサ(例えば50〜100マイクロファラッド)を具備する。これによりインダクタンスおよび抵抗を基にして正弦波の電流パルスがコイル8を貫流し患者に印加される比例磁場が発生する。
1実施形態において、前記磁場は、(1秒につき20〜100パルス)のパルス繰り返し数およびMSTに必要とされる出力レベル(患者の運動閾値レベルの1.5〜3.0倍)で効率的に動作するよう設計されたコイル8によって提供される。前記電源で説明したように、IGBTおよびIGCT電源切替回路は、当該パラメータでの最適な動作に特に適している。最も簡略的なコイルは、当該コイルの平面に対して垂直に向う磁場を伴う円形ループ状のものである。強磁性コアコイルおよび空芯コイル設計を使用する場合もある。
1実施形態において、前記コイルは、神経学研究に通常使用されているような(例えばMagstim、Medtronic)8の字空芯コイルである。頭部形状に容易に適合する類似形状(例えば「Magstim1対円錐形コイル」)が使用される場合もある。当業者であれば周知のように、空芯コイルは形状制限および熱制限の範囲内で使用される。
強磁性コアにおいては前記巻線をコアの周囲に分布させることが可能なため、巻線が頭蓋骨近接部に密集することがなく、電極をより最適な位置に配置する空間が生まれる。また、強磁性コアにおいては効率性が向上するため、同様の空芯コイルによって発生する磁束密度と同等の磁束密度を発生させるのに約4分の1の電力のみを必要とする。MST動作には高出力レベルが必要とされるため、この効率性における利得は得に重要である。
図1を再度参照して説明すると、1実施形態において、前記コイル8はコイル保定装置9で位置決めされている場合がある。前記コイル保定装置は、技師が患者の適切な部位に前記コイルを配置するのを補助するサブシステムであり、当該コイルの重さを支持し、MST手順の間前記コイルの位置を保持する。前記コイル保定装置は機械的、電気機械的、ロボティックであってもよく、かつ光学的配列法、磁気配列法、またはビデオ配列法を利用する場合もある。1実施形態において、「Method And Apparatus For Coil Positioning For TMS Studies」と題する、2004年1月6日に提出された米国特許出願第10/752,164号(代理人整理番号NNI−0011)の方法に従って、前記装置を適所に位置決めおよび保持してもよい(当該特許出願はこの参照によりその全体を複製したものとして本明細書に組み込まれる。)
1実施形態において、前記システム1は、さらに、支持機構を有する(図示せず)。
Claims (22)
- 磁気痙攣療法を必要とする患者に該磁気痙攣療法を行うためのシステムであって、
磁気コイルと、
前記磁気コイルの誘導電流密度が前記患者に痙攣を起させるのに十分であるように電流パルスを該磁気コイルに印加するための電源スイッチと、
前記患者をモニターするためのモニター装置と、
前記磁気コイルによって発生された磁界を予測的に調節するため及び痙攣が進行しているときは追加的な刺激を防ぐための制御装置であって、前記患者に痙攣を誘発するのに十分になるまで前記磁界を増大させる制御装置
を有することを特徴とするシステム。 - 請求項1記載のシステムにおいて、前記モニター装置は、EEGモニター、ECGモニター、血圧モニター、および心拍数モニターのうちの少なくとも1つを含むことを特徴とするシステム。
- 請求項1記載のシステムにおいて、前記制御装置は、前記磁気コイルへの電流の流れを中断することにより追加的な刺激を防ぐことを特徴とするシステム。
- 請求項1記載のシステムにおいて、前記制御装置は、前記患者を磁場から遮断することにより追加的な刺激を防ぐことを特徴とするシステム。
- 請求項1記載のシステムにおいて、前記制御装置は、前記磁気コイルを前記患者から十分な距離を置いて移動させて追加的な刺激を防ぐことにより、刺激を防ぐことを特徴とするシステム。
- 請求項1記載のシステムにおいて、前記電流パルスは2〜8秒の間印加されるバーストの一部であることを特徴とするシステム。
- 請求項6記載のシステムにおいて、前記バーストは40〜60ヘルツのパルス繰り返し数で印加されることを特徴とするシステム。
- 請求項6記載のシステムにおいて、前記バーストは100ヘルツを超えるパルス繰り返し数で印加されることを特徴とするシステム。
- 請求項6記載のシステムにおいて、さらに、
前記バーストの後1分未満の待機時間後に、第2のバーストを有することを特徴とするシステム。 - 請求項1記載のシステムにおいて、さらに、
前記磁気痙攣療法におけるパラメータを記録するための装置を有することを特徴とするシステム。 - 請求項1記載のシステムにおいて、前記制御装置は、痙攣の発生を示す信号を提供することを特徴とするシステム。
- 請求項1記載のシステムにおいて、前記磁気コイルは、半球状磁気コアであって、少なくとも0.5テスラの磁気飽和を有することを特徴とするシステム。
- 請求項1記載のシステムにおいて、このシステムは、さらに、
前記磁気コイルによって発生する磁場を調節するフィードバック回路を有することを特徴とするシステム。 - 請求項13記載のシステムにおいて、前記フィードバック回路はパルス繰り返し数を調節することを特徴とするシステム。
- 請求項13記載のシステムにおいて、前記フィードバック回路はバースト長を調節することを特徴とするシステム。
- 請求項13記載のシステムにおいて、前記フィードバック回路は磁束密度を調節することを特徴とするシステム。
- 請求項1記載のシステムにおいて、さらに、
前記モニター装置によって提供される信号を解析するためのコンピュータ処理装置を有することを特徴とするシステム。 - 請求項17記載のシステムにおいて、前記処理装置は、患者の測定された皮質興奮性と痙攣を反映した皮質興奮性とを比較することを特徴とするシステム。
- 請求項18記載のシステムにおいて、前記痙攣を反映した皮質興奮性は所定のEEG信号であることを特徴とするシステム。
- 請求項18記載のシステムにおいて、前記患者の測定された皮質興奮性はEEG信号の関数であることを特徴とするシステム。
- 請求項17記載のシステムにおいて、前記処理装置は、前記磁気コイルによって発生する磁場を調節するフィードバック回路に信号を提供することを特徴とするシステム。
- 請求項17記載のシステムにおいて、前記処理装置は表示装置に信号を提供し、前記磁気コイルによって発生する磁場を手動調節することを可能にすることを特徴とするシステム。
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PCT/US2005/013886 WO2005115530A2 (en) | 2004-05-24 | 2005-04-22 | Seizure therapy method and apparatus |
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