JP5052338B2 - 癌治療薬 - Google Patents
癌治療薬 Download PDFInfo
- Publication number
- JP5052338B2 JP5052338B2 JP2007522294A JP2007522294A JP5052338B2 JP 5052338 B2 JP5052338 B2 JP 5052338B2 JP 2007522294 A JP2007522294 A JP 2007522294A JP 2007522294 A JP2007522294 A JP 2007522294A JP 5052338 B2 JP5052338 B2 JP 5052338B2
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- crm197
- egf
- therapeutic agent
- diphtheria toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Description
1. HB-EGFに結合することによりHB-EGFとEGFレセプターとの結合を阻害する物質を有効成分とする癌治療薬であって、前記有効成分がジフテリア毒素の変異体であってHB-EGFとEGFレセプターとの結合を阻害する活性を有し、かつ、ジフテリア毒素の毒性を実質的に有さないポリペプチドであり、癌が大腸癌、膀胱癌および腹膜播種転移癌からなる群から選ばれる、癌治療薬。
2. 膀胱癌治療薬である、項1に記載の癌治療薬。
3. 大腸癌治療薬である、項1に記載の癌治療薬。
4. 腹膜播種性転移癌の治療薬である、項1に記載の癌治療薬。
5. 腹膜播種性転移癌が、胃癌または膵癌から転移した腹膜播種転移癌である項4に記載の癌治療薬。
6. 有効成分がCRM197である、項1〜5のいずれかに記載の癌治療薬。
(a) ジフテリア毒素の一部からなり、該ジフテリア毒素のレセプター結合ドメインを少なくとも含むポリペプチド。
(b) (a)のポリペプチドのレセプター結合ドメインの1若しくは複数(例えば数個もしくは数十個)のアミノ酸が欠失、置換若しくは付加されたアミノ酸配列からなるポリペプチド。
(c) (a)及び(b)のいずれかのタンパク質を含む複合ポリペプチド。
(実施例1)
腹膜播種モデル。1 x 107のヒト胃癌細胞株MKN28、MKN45、MKN74細胞をヌードマウス腹腔内に接種。CRM197を腹腔内に計5回(50mg / kg / week)投与し、接種後6週目に開腹。腹腔内の播種巣を全て切除し、総重量を計測した(図1)。
(実施例2)
ヌードマウスを用いた造腫瘍性実験を行った。
(実施例3)
ヌードマウスを用いた造腫瘍性実験を行った。
(実施例4)
腹膜播種モデル
1 x 107のヒト膵癌細胞株PANK1をヌードマウス腹腔内に接種。CRM197を腹腔内に計5回(50mg/kg/week)投与し、接種後6週目に開腹。腹腔内の播種巣を全て切除し、総重量を計測した(図4)。
Claims (2)
- HB-EGFに結合することによりHB-EGFとEGFレセプターとの結合を阻害する物質を有効成分とする腹膜播種性転移癌治療薬であって、前記有効成分がCRM197である、腹膜播種性転移癌治療薬。
- 腹膜播種性転移癌が、胃癌または膵癌から転移した腹膜播種性転移癌である請求項1に記載の癌治療薬。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007522294A JP5052338B2 (ja) | 2005-06-21 | 2006-06-20 | 癌治療薬 |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005181314 | 2005-06-21 | ||
JP2005181314 | 2005-06-21 | ||
JP2006027581 | 2006-02-03 | ||
JP2006027581 | 2006-02-03 | ||
JP2007522294A JP5052338B2 (ja) | 2005-06-21 | 2006-06-20 | 癌治療薬 |
PCT/JP2006/312321 WO2006137398A1 (ja) | 2005-06-21 | 2006-06-20 | 癌治療薬 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2006137398A1 JPWO2006137398A1 (ja) | 2009-01-22 |
JP5052338B2 true JP5052338B2 (ja) | 2012-10-17 |
Family
ID=37570427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007522294A Expired - Fee Related JP5052338B2 (ja) | 2005-06-21 | 2006-06-20 | 癌治療薬 |
Country Status (9)
Country | Link |
---|---|
US (1) | US7700546B2 (ja) |
EP (1) | EP1894575B1 (ja) |
JP (1) | JP5052338B2 (ja) |
KR (1) | KR101052090B1 (ja) |
CN (1) | CN101208106B (ja) |
AU (1) | AU2006260240B2 (ja) |
CA (1) | CA2610281C (ja) |
HK (1) | HK1110224A1 (ja) |
WO (1) | WO2006137398A1 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5110980B2 (ja) * | 2007-06-26 | 2012-12-26 | 一般財団法人阪大微生物病研究会 | 肺がん治療薬 |
FR2988393B1 (fr) | 2012-03-20 | 2014-05-09 | Commissariat Energie Atomique | Inhibiteur de l'hb-egf derive du domaine r de la toxine diphterique pour le traitement des maladies associees a l'activation de la voie hb-egf/egfr |
JP5987175B2 (ja) * | 2012-07-02 | 2016-09-07 | 学校法人福岡大学 | 乳癌,胃癌及び卵巣癌等に対する制癌剤 |
US11965009B2 (en) | 2016-03-10 | 2024-04-23 | The Johns Hopkins University | Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses |
CN109790545A (zh) * | 2016-03-10 | 2019-05-21 | 约翰·霍普金斯大学 | 产生不含聚集物的单体白喉毒素融合蛋白的方法和治疗用途 |
US20200331973A1 (en) * | 2017-09-01 | 2020-10-22 | Lorven Biologics Private Limited | Nucleic acid encoding crm197 and process for improved expression thereof |
CA3104833A1 (en) | 2018-07-16 | 2020-01-23 | Dcprime B.V. | A combination product for use in tumor vaccination. |
AU2020264083A1 (en) | 2019-04-25 | 2021-12-02 | Mendus B.V. | Methods of tumor vaccination |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4203742B2 (ja) | 2002-10-15 | 2009-01-07 | 財団法人阪大微生物病研究会 | 制癌剤 |
-
2006
- 2006-06-20 CA CA2610281A patent/CA2610281C/en not_active Expired - Fee Related
- 2006-06-20 CN CN2006800220039A patent/CN101208106B/zh not_active Expired - Fee Related
- 2006-06-20 US US11/917,706 patent/US7700546B2/en not_active Expired - Fee Related
- 2006-06-20 KR KR1020087000638A patent/KR101052090B1/ko active IP Right Grant
- 2006-06-20 WO PCT/JP2006/312321 patent/WO2006137398A1/ja active Application Filing
- 2006-06-20 JP JP2007522294A patent/JP5052338B2/ja not_active Expired - Fee Related
- 2006-06-20 AU AU2006260240A patent/AU2006260240B2/en not_active Ceased
- 2006-06-20 EP EP06766982A patent/EP1894575B1/en not_active Not-in-force
-
2008
- 2008-04-24 HK HK08104563.1A patent/HK1110224A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPWO2006137398A1 (ja) | 2009-01-22 |
WO2006137398A1 (ja) | 2006-12-28 |
AU2006260240B2 (en) | 2012-03-15 |
CN101208106B (zh) | 2011-07-27 |
US20090105135A1 (en) | 2009-04-23 |
EP1894575B1 (en) | 2013-02-20 |
AU2006260240A1 (en) | 2006-12-28 |
CN101208106A (zh) | 2008-06-25 |
CA2610281A1 (en) | 2006-12-28 |
KR101052090B1 (ko) | 2011-07-27 |
EP1894575A4 (en) | 2010-02-24 |
KR20080017093A (ko) | 2008-02-25 |
CA2610281C (en) | 2014-07-29 |
US7700546B2 (en) | 2010-04-20 |
EP1894575A1 (en) | 2008-03-05 |
HK1110224A1 (en) | 2008-07-11 |
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