JP5023902B2 - Emulsifying device - Google Patents

Description

  The present invention relates to an emulsifying device.

  In general, in an emulsion, an oil (also referred to as a dispersed phase) is dispersed in water (also referred to as a continuous phase) by applying a shearing force to two liquids that do not dissolve each other, such as water and oil. It is formed into a mold or W / O type in which water (also referred to as a dispersed phase) is dispersed in oil (also referred to as a continuous phase).

  As a conventional emulsion forming method, a batch method using a dispersion method is known. In this method, water and oil are put into a large container, and a large amount of emulsion is obtained at once with a rotary stirring device. However, in this method, since the shearing force is not uniformly applied to the liquid, there are problems that the particle diameter of the emulsion to be produced is non-uniform and that the production takes time.

On the other hand, as a method for solving the above-described problem, recently, an emulsion preparation using a micro liquid chip has been proposed.
For example, in Patent Document 1, oil and water are divided into a number of flows, and these are alternately arranged to increase the contact area between the liquids, and the liquid generated between the channel walls by narrowing the channels in stages. There is a method using a shear rate.

  Further, in Patent Document 2, there is a method in which two liquids to be emulsified are mixed in advance, the mixed liquid is introduced into the apparatus, and an emulsion is obtained by cavitation lowering action due to repeated branching and collision with the flow path wall surface and pressure drop.

  On the other hand, in Non-Patent Document 1, there is a method of obtaining an emulsion by forming a sheath flow with the dispersed phase on the inside and the continuous phase on the outside, and then dividing the dispersed phase flowing inside the sheath flow.

JP 2004-81924 A JP 1999-42431 A J. Micromech. Microeng. 16 (2006) 23362344

  Regarding the emulsification methods described in Patent Documents 1 and 2, although the particle size distribution of the emulsion is improved as compared with the batch method, a certain degree of spread appears. Moreover, the subject that it is difficult to produce an emulsion with a comparatively large particle diameter remains. Further, in the method described in Patent Document 2, a mechanism for previously mixing two liquids to be emulsified in an apparatus is necessary.

  On the other hand, in the apparatus described in Non-Patent Document 1, it is possible to make the particle diameters uniform, and it is possible to obtain emulsion particles having a relatively large particle diameter. In order to increase the throughput by as little as about 1 mL per minute, parallel flow paths are essential.

  By the way, in the apparatus described in Non-Patent Document 1, two kinds of liquid introduction flow paths and a merge flow path, a flow path forming a sheath flow, and a flow path where the sheath flow is divided and all the flow paths where particles are formed are stacked. The structure is formed on the lamination plane of the members. For this reason, since the direction in which the flow paths can be paralleled without changing the number of stacked plate members is limited to one direction, the processing amount cannot be increased efficiently.

  Further, when it is desired to parallelize the flow paths in two directions, a configuration in which the flow paths are paralleled in one direction is further stacked, so that the number of stacked layers increases as the number of flow paths to be parallelized is increased. For this reason, the number of steps required for processing increases, and it becomes a problem that processing becomes difficult due to a problem of positioning accuracy due to a device having a fine structure.

  In addition, since the flow path in the apparatus described in Non-Patent Document 1 is formed by stacking grooves formed by photolithography, the processing of the flow path formation itself requires a complicated process.

  Further, in the method for obtaining particles by forming a sheath flow as described in Non-Patent Document 1, as a method for controlling the particle diameter, the flow velocity is changed or the dispersed phase / continuous phase flow ratio is changed and the flow of the sheath flow channel is changed. When there is a change in the channel width, and the particle diameter is to be significantly changed, it is desirable to change the channel width of the sheath flow channel.

  However, in the configuration described in Non-Patent Document 1, since the flow path forming the sheath flow and the other flow path exist on the same member as described above, the flow width of the sheath flow flow path is changed. In order to adjust the particle diameter, it is necessary to recreate the entire flow path.

  An object of the present invention is to provide an emulsifying apparatus capable of increasing the throughput for preparing an emulsion having a uniform particle size.

The above object is connected to the introducing member, a first member coupling with said introducing member, a second member connected to the first member, a third member connected to the second member, a third member An emulsifying device provided to stack the lead-out member, the dispersed phase inflow channel passing through the introduction member and the first member in the stacking direction and allowing the first liquid to flow therethrough, and the first A continuous-phase inflow passage provided between the member and the second member, through which the second liquid flows, and a first through the second member in the stacking direction and inflow from the dispersed-phase inflow passage. A mixing flow path that forms a sheath flow in which the liquid mixture flows inward from the continuous phase inflow flow path, and the second liquid that does not dissolve with the first liquid flows outside, said lead-out member and the third member penetrating in the stacking direction, and a wide enlarged mixing flow path of the flow path width than the mixing channel Are provided so that the dispersed-phase inflow channel, the mixing channel, and the expansion mixing channel are coaxial, and the mixing channel and the expansion mixing channel are respectively provided on different members. The first liquid contained in the mixed liquid is divided while flowing through the mixing flow path and the enlarged mixing flow path, and is emulsified by becoming emulsion particles. The

  The above-mentioned object is achieved by forming at least two continuous phase inflow channels and being symmetrical about the axes of the dispersed phase inflow channel and the mixing channel.

  Moreover, the said objective is achieved by the said mixing flow path and the said expansion mixing flow path being formed on another member.

The above object, on the plane with the continuous phase inlet flow channel, a continuous phase dividing flow channel connecting the continuous phase inlet flow channel is achieved by being formed.

  The above object is achieved by arranging a plurality of the dispersed phase inflow channel, the continuous phase inflow channel, the mixing channel, and the enlarged mixing channel in a laminated member forming them.

  Further, the object is to distribute the dispersed phases to the plurality of dispersed phase inflow channels on at least one of the lamination planes of the member forming the dispersed phase inflow channel or another member laminated adjacent to the member. On the laminating plane of at least one of the dispersed phase branching channel and the member forming the mixing channel or the member forming the expanded mixing channel or another member stacked adjacent to any of the members, This is achieved by forming a mixed liquid merging flow path for merging liquids flowing through the plurality of mixed flow paths or the enlarged mixed flow paths.

  ADVANTAGE OF THE INVENTION According to this invention, the emulsification apparatus which shortened the preparation time of the emulsion can be provided.

  Hereinafter, an embodiment of the present invention will be described with reference to the drawings.

FIG. 1 is a configuration diagram of a system including an emulsification apparatus including an embodiment of the present invention.
In this embodiment, an example in which an O / W emulsion is prepared using water containing a surfactant as a continuous phase and oil as a dispersed phase will be described.

  In FIG. 1, water and oil are stored in the raw material tanks 101A and 101B, respectively. Liquid is fed from the raw material tanks 101A and 101B using the pumps 102A and 102B. These pumps 102A and 102B are preferably used properly, such as a syringe pump or a gear pump, depending on the purpose. The liquids sent by the pumps 102A and 102B flow into the emulsifying device 104 through the introduction tubes 103A and 103B, and an emulsion is created in the emulsifying device 104. The created emulsion is stored in the emulsion tank 106 through the outlet tube 105. In addition, when temperature adjustment is needed for emulsion preparation, it is possible to take the method of installing the emulsification apparatus 104 in the thermostat 107, for example, filling the thermostat 107 inside with a heat medium, and adjusting temperature. Alternatively, a Peltier element or the like may be installed outside the emulsifying device 104.

  Next, the configuration of the emulsifying device 104 and the flow of the liquid in the emulsifying device 104 will be described with reference to FIGS.

FIG. 2 is a perspective view showing the decomposition structure of the emulsifying device 104 from the introduction side of the continuous phase and the dispersed phase.
FIG. 3 is a perspective view shown from the emulsion outlet side.
FIG. 4 is a perspective view showing the merging channel portion 202 shown in FIGS. 2 and 3 from the emulsion outlet portion side.

  FIG. 5 is a cross-sectional view taken along the line AA shown in FIG. 2 by combining the members of the emulsifying device 104 shown in FIGS.

  FIG. 6 is an enlarged view in a circle indicated by B in FIG.

  The emulsifying device 104 shown in FIG. 1 includes a liquid introducing portion 201, a merging passage portion 202, a sheath passage portion 203, an enlarged passage portion 204, and a liquid outlet portion 205 as shown in FIGS. These are fastened using screws (not shown) that penetrate the screw holes 206. Each member to be fastened is provided with a sealing groove 207, and a sealing member (not shown) is sandwiched between the sealing grooves 207 to prevent liquid leakage. Alternatively, the members may be bonded or bonded as necessary. Moreover, about the material of each member which comprises the emulsification apparatus 104, a metal, resin, glass, etc. are used according to the kind of liquid to send. Further, the material of each member does not have to be the same, and the material can be changed for each member in accordance with processing characteristics, heat transfer properties, and the like.

  Water serving as a continuous phase and oil serving as a dispersed phase are introduced into the liquid introduction unit 201 from a continuous phase introduction port 208 and a dispersed phase introduction port 209, respectively. Inlet tubes 103A and 103B shown in FIG. 1 are connected to continuous phase inlet 208 and dispersed phase inlet 209 using a joint (not shown), and each liquid is fed into emulsifier 104 by pumps 102A and 102B. To do.

  The water introduced into the emulsifying device 104 passes through the continuous phase introduction flow path 210, and the continuous phase branch flow path 301 (shown in FIGS. 3, 4 and 5) formed on the lamination plane of the merge flow path section 202. ). The water distributed here is to a continuous phase inflow channel 302 (shown in FIGS. 3 and 4) formed on the same plane as the continuous phase branch channel 301 and symmetrical about the axis of the dispersed phase inflow channel 211. And introduced from the outside. On the other hand, the oil introduced from the dispersed phase introduction port 209 (shown in FIG. 5) passes through the dispersed phase introduction flow path 303 (shown in FIGS. 3 and 5), and is further laminated in the joining flow path section 202. Flows into the joining point of the continuous-phase inflow channel 302 through the dispersed-phase inflow channel 211 (shown in FIG. 4) formed so as to be in the vertical direction, where the two liquids merge.

  In other words, the dispersed phase (oil) from the dispersed phase introducing channel 303 extending in the direction in which the liquid introducing unit 201, the joining channel unit 202, the sheath channel unit 203, the enlarged channel unit 204, and the liquid outlet unit 205 are laminated. Flows into the dispersed phase inflow channel 211 provided in the merge channel unit 202. The confluence channel section 202 is provided with a continuous phase inflow channel 302 that intersects with the dispersed phase inflow channel 211 and through which a continuous phase (water) flows. Oil and water merge at this intersection.

  The water and oil merged in the continuous phase inflow channel 302 enter the sheath channel 212 formed in the sheath channel 203 so as to be coaxial with the disperse phase inflow channel 211 and perpendicular to the plane of lamination of the members. In this case, a sheath flow is formed with the oil as the dispersed phase inside and the water as the continuous phase outside. Further, this sheath flow is transferred to an enlarged flow channel 213 formed in the enlarged flow channel portion 204 located downstream of the sheath flow channel portion 203 so as to be coaxial with the sheath flow channel 212 and to be perpendicular to the plane of lamination of the members. Flow, where an O / W emulsion is formed. The formed O / W emulsion is taken out from the emulsion outlet 304 through the emulsion outlet passage 214.

  In the enlarged flow channel 213, in order to obtain an emulsion efficiently by using a change in flow velocity, the flow channel width of the sheath flow channel 212 is made the smallest, and the other flow channel widths are wider than the flow channel width of the sheath flow channel 212. It is desirable to take. In addition, for the continuous phase branch flow path 301 that distributes water to the continuous phase inflow flow path 302, the flow width of the continuous phase branch flow path 301 in order to distribute water evenly to the plurality of continuous phase inflow flow paths 302. It is desirable to design so that the pressure loss generated in the continuous phase inflow channel 302 becomes dominant by taking a sufficient width with respect to the channel width of the continuous phase inflow channel 302.

  Further, the cross-sectional shape of each flow path is not limited to the shape shown in the present embodiment. For example, the cross-sectional shapes of the continuous phase introduction flow path 210, the sheath flow path 212, and the expansion flow path 213 may be rectangular. However, in order to form a stable sheath flow and obtain uniform emulsion particles, it is desirable that the cross-sectional shapes of the sheath channel 212 and the enlarged channel 213 are axisymmetric with respect to the axis of the channel.

  3 and 4, the two continuous phase inflow channels 302 are symmetrical with respect to the axis of the disperse phase inflow channel 211 with respect to the disperse phase inflow channel 211 formed in the merging channel unit 202. As shown in FIG. 3 and FIG. 4, the arrangement number and the detailed shape of the continuous phase inflow channel 302 are shown in FIGS. 3 and 4 as long as the arrangement is symmetrical with respect to the axis of the dispersed phase inflow channel 211. It does not have to be as shown.

Next, an example in which the arrangement number or shape of the continuous phase inflow channel 302 is changed in FIG. 7 will be described.
FIGS. 7A and 7B are perspective views of continuous-phase inflow channels having different shapes.
In FIG. 7A, four continuous phase inflow channels 302 are arranged with respect to the dispersed phase inflow channel 211, and the continuous phase flows from four directions. In FIG. 7B, eight continuous phase inflow channels 302 are configured, and the eight channels are integrated in the middle. Thus, the continuous phase is joined from all directions in a planar direction toward the dispersed phase inflow channel 211 having the center. In any shape, the arrangement of the continuous phase inflow channel 302 is axially symmetric with respect to the axis of the dispersed phase inflow channel 211 so that the continuous phase is distributed by the continuous phase branch channel 301 formed on the same plane. It is configured.

Next, the state of the liquid in the flow path of the sheath flow path 212 will be described with reference to FIG.
FIG. 8 is an enlarged schematic cross-sectional view of the sheath channel.
In FIG. 8, the oil discharged from the dispersed phase inflow channel 211 merges with water flowing from the outside in the continuous phase inflow channel 302 to form a sheath flow 801 with the oil inside. The oil-inward sheath flow 801 is divided while flowing through the sheath flow channel 212 and the enlarged flow channel 213 downstream thereof, so that emulsion particles 802 are formed.

A method for controlling the particle diameter of the emulsion particles 802 will be described with reference to FIGS.
In the figure, the particle diameter of emulsion particles 802 increases as the width of the sheath flow 801 occupying the oil in the oil flow path increases. Therefore, as a method for controlling the particle diameter of the emulsion particles 802, the flow rate ratio of water and oil introduced from the continuous phase introduction port 208 and the dispersed phase introduction port 209 is changed, or the flow channel width of the sheath flow channel 212 is increased. It can be considered that the width of the oil in the sheath flow 801 occupied in the flow path is increased or shortened.

  Here, in the present invention, since the sheath channel portion 203 including the sheath channel 212 is configured by a member independent of other members, this sheath channel is used when it is desired to change the particle diameter of the emulsion particles 802. Several types of sheath channel portions 203 with different inner diameters 212 are prepared, and this sheath channel portion 203 can be handled only by exchanging them according to the desired particle diameter.

Next, with reference to FIGS. 9 to 12, the apparatus configuration, detailed shape, and flow of liquid in the emulsifying device 104 when a plurality of flow paths for forming a sheath flow in the emulsifying device 104 are obtained in parallel are used. explain.
FIG. 9 is an exploded perspective view of an emulsification apparatus provided with another embodiment.
FIG. 10 is a perspective view of the emulsifying device of FIG. 9 as viewed from the emulsion outlet portion side.
FIG. 11 is a perspective view of the merging channel section viewed from the emulsion outlet section side.
FIG. 12 is an enlarged perspective view of a portion C indicated by a broken line in FIG.
As shown in FIGS. 9 and 10, the emulsifying device 104 includes a liquid introduction part 201, a merging channel part 202, a sheath channel part 203, an enlarged channel part 204, and a liquid outlet part 205, which are screwed. Fastened using a screw (not shown) that passes through hole 206. Each member is provided with a seal groove 207 to prevent liquid leakage by sandwiching a seal member (not shown). Alternatively, the members may be bonded or bonded as necessary. Moreover, about the material of each member which comprises the emulsification apparatus 104, a metal, resin, glass, etc. are used according to the kind of liquid to send. Further, the material of each member does not have to be the same, and the material can be changed for each member in accordance with processing characteristics, heat transfer properties, and the like.

  Water serving as a continuous phase and oil serving as a dispersed phase are introduced into the liquid introduction unit 201 from a continuous phase introduction port 208 and a dispersed phase introduction port 209, respectively. The continuous tube inlet 208 and the dispersed phase inlet 209 are connected to the inlet tube 103 shown in FIG. 1 using a joint (not shown), and each liquid is fed into the emulsifier 104 by the pump 102.

  The introduced water is distributed via a continuous phase introduction flow path 210 in a continuous phase branch flow path 301 (shown in FIG. 10) formed on the lamination plane of the merge flow path section 202. A plurality of continuous-phase inflow channels 302 are arranged on the plane where the continuous-phase branch channel 301 is formed. Here, water as a continuous phase is branched and flows into the continuous-phase inflow channel 302.

  On the other hand, the oil introduced from the dispersed phase introduction port 209 passes through the dispersed phase introduction flow path 303. Thereafter, the liquid is distributed by the dispersed phase branch flow channel 1001 formed on the lamination plane of the liquid introduction unit 201 and passes through the dispersed phase inflow channel 211 formed in the merging channel unit 202 so as to be perpendicular to the lamination plane. To do. After that, it flows into the joining portion of the continuous phase inflow channel 302 arranged so as to be axially symmetric with respect to the axis of the dispersed phase inflow channel 211.

  Water and oil merged at the merging portion of each continuous phase inflow channel 302 and dispersed phase inflow channel 211 are coaxial with the disperse phase inflow channel 211 and perpendicular to the plane of lamination of the members in the sheath channel 203. It flows into the sheath flow channel 212 formed in plural. The flowing water and oil form a sheath flow with oil inside and water outside. Further, a plurality of expanded flow paths are formed in the expanded flow path portion 204 positioned downstream of the sheath flow path section 203 so that the sheath flow is coaxial with the sheath flow path 212 and perpendicular to the laminating plane of the members. It flows into 213 and an O / W emulsion is formed. The formed O / W emulsion is aggregated by the emulsion merging channel 901 formed on the laminating plane of the liquid outlet 205 located downstream thereof, and taken out from the emulsion outlet 304 via the emulsion outlet channel 214. .

  In the enlarged flow channel 213, in order to obtain an emulsion efficiently by using a change in flow rate, the flow channel width of the sheath flow channel 212 is made the smallest, and the widths of the other flow channels are larger than the flow channel width of the sheath flow channel 212. It is desirable to take it widely. In addition, the continuous phase branch flow path 301 for distributing water to the plurality of continuous phase inflow paths 302 and the dispersed phase branch flow path 1001 for distributing oil to the plurality of dispersed phase discharge ports are equally water or oil. Need to be distributed. Therefore, the continuous-phase inflow channel is formed by making the channel widths of the continuous-phase branch channel 301 and the dispersed-phase branch channel 1001 sufficiently wider than the channel widths of the continuous-phase inflow channel 302 and the dispersed-phase inflow channel 211. It is desirable to design so that the pressure loss generated in 302 and the dispersed phase inflow channel 211 is dominant.

  Further, the cross-sectional shape of each flow path is not limited to the shape shown in the present embodiment. For example, the cross-sectional shapes of the continuous phase introduction channel 210, the sheath channel 212, and the enlarged channel 213 may be rectangular. However, in order to form a stable sheath flow and obtain uniform emulsion particles, the cross-sectional shapes of the sheath channel 212 and the enlarged channel 213 are desirably axisymmetric with respect to the axis of the channel.

  In FIGS. 10, 11, and 12, two continuous-phase inflow channels 302 are connected to the axis of the disperse-phase inflow channel 211 with respect to one disperse-phase inflow channel 211 formed in the merging channel unit 202. The figure arranged so that it may become axially symmetrical is shown. However, the continuous phase inflow channel 302 does not have to have a shape as shown in each figure. For example, four continuous phase inflow channels 302 are arranged so as to be axially symmetric with respect to the axis of the dispersed phase inflow channel 211. It does not matter if the shape is As long as any shape is formed so as to satisfy an axially symmetric arrangement with respect to the axis of the dispersed phase inflow channel 211, the present patent is not limited to the detailed shape.

  In other words, in the case where the dispersed phase inflow channel and the continuous phase inflow channel as described in the non-patent document are on the same plane, the present invention is continuous with the dispersed phase inflow channel to increase the amount of emulsion treatment. There is a limit to increasing the number of phase inflow channels. That is, in particular, since the dispersed phase inflow channel extends in the paper surface direction, if a plurality of dispersed phase inflow channels and a plurality of continuous phase inflow channels are arranged in parallel, the emulsifier becomes large overall.

  Therefore, in the present invention, since the dispersed phase inflow channel has a structure extending in the depth direction of the paper surface as shown in FIG. 12, even if a plurality of dispersed phase inflow channels and continuous phase inflow channels are arranged, the length of the dispersed phase inflow channel is long. It can be arranged without worrying about.

  Therefore, in the present invention, a plurality of dispersed-phase inflow channels and continuous-phase inflow channels can be arranged only by considering the number of continuous-phase inflow channels, so that the amount of emulsion creation processing can be increased accordingly. It is.

  As in the present invention, a sheath flow formed of two kinds of liquids that do not dissolve in each other can be formed in the stacking direction of the members. Therefore, the sheath flow method has a uniform particle size and a somewhat large particle size. An emulsion can be created.

  In addition, it is possible to arrange a plurality of flow paths in two directions at a time without changing the number of constituent members, and thus it is easy to configure an emulsification apparatus that increases the throughput. Further, since it is not necessary to change the number of members constituting, the problem of positioning accuracy is solved.

  In addition, by forming a continuous phase branch channel that distributes and introduces the continuous phase to the substantially continuous phase inflow channel on a plane having the almost continuous phase inflow channel, each continuous phase inflow is made after the continuous phase is branched. Since there is no need to form a flow path for introducing a continuous phase into the flow path, flow path processing is facilitated, and thus it is easier to construct an emulsification apparatus that increases the throughput.

  Further, by having these features, the machining required for each member is only drilling or simple grooving, and a plurality of sheath channels can be formed by a simple process only by machining.

  Further, by having these characteristics, the flow path forming the sheath flow and other flow paths can be disassembled, and only the member having the mixed flow path is changed to the member having the mixed flow path having different flow widths. It is possible to control the particle size of the emulsion particles by changing the channel width of the sheath flow channel simply by replacement.

It is a block diagram of the system containing the emulsification apparatus provided with one Example of this invention. It is the perspective view which showed the decomposition | disassembly structure of the emulsification apparatus from the introduction part side of the continuous phase and the dispersed phase. It is the perspective view shown from the emulsion derivation part side. It is the perspective view which showed the confluence | merging flow path part 202 shown in FIG. 2, FIG. 3 from the emulsion derivation | leading-out part side. FIG. 4 is a cross-sectional view taken along the line AA shown in FIG. 2 by combining the members of the emulsifying device 104 shown in FIGS. 2 and 3. FIG. 6 is an enlarged view inside a circle indicated by B in FIG. 5. (A) (b) is a perspective view of the continuous phase inflow flow path from which a shape differs. It is an expansion schematic cross section of a sheath channel. It is a disassembled perspective view of the emulsification apparatus provided with the other Example. It is the perspective view which looked at the emulsification device of Drawing 9 from the emulsion derivation part side. It is the perspective view which looked at the confluence | merging flow path part from the emulsion derivation | leading-out part side. It is an expansion perspective view of C section shown with the broken line of FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 101 Raw material tank 102 Pump 103 Introducing tube 104 Emulsifier 105 Deriving tube 106 Emulsion tank 107 Constant temperature bath 201 Liquid introducing part 202 Confluence channel part 203 Sheath channel part 204 Enlarged channel part 205 Liquid outlet part 206 Screw hole 207 Sealing groove 208 Continuous phase inlet 209 Dispersed phase inlet 210 Continuous phase inlet channel 211 Dispersed phase inlet channel 212 Sheath channel 213 Expansion channel 214 Emulsion outlet channel 301 Continuous phase branch channel 302 Continuous phase inlet channel 303 Dispersed phase Introduction channel 304 Emulsion outlet 801 Sheath flow with oil inside 802 Emulsion particle 901 Emulsion merge channel 1001 Dispersed phase branch channel

Claims (5)

An introduction member;
A first member connected to the introduction member;
A second member coupled to the first member;
A third member coupled to the second member;
An emulsifying device provided to stack the lead member connected to the third member,
A dispersed phase inflow passage that penetrates the introduction member and the first member in the stacking direction, and through which the first liquid flows;
A continuous phase inflow channel that is provided between the first member and the second member and through which the second liquid that does not dissolve with the first liquid flows;
A sheath that flows through the second member in the laminating direction, and in which a mixed liquid flows with the first liquid flowing in from the dispersed-phase inflow channel on the inside and the second liquid flowing in from the continuous-phase inflow channel on the outside A mixing channel forming a flow;
An enlarged mixing channel that penetrates the third member and the outlet member in the stacking direction and has a wider channel width than the mixing channel;
Are provided so that the dispersed-phase inflow channel, the mixing channel, and the expansion mixing channel are coaxial, and the mixing channel and the expansion mixing channel are respectively provided on different members. Is formed,
The emulsification apparatus is characterized in that the first liquid contained in the mixed liquid is divided while flowing through the mixing flow path and the enlarged mixing flow path to become emulsion particles, whereby emulsification is performed. The emulsifying device according to claim 1,
At least two or more continuous phase inflow channels are formed, and the emulsification apparatus is arranged so as to be axisymmetric with respect to the axes of the dispersed phase inflow channel and the mixing channel. The emulsification apparatus according to claim 1 or 2,
An emulsifying apparatus, wherein a continuous phase branching channel connecting the continuous phase inflow channels is formed on a plane having the continuous phase inflow channel. In the emulsification device according to claims 1 to 3,
The emulsification apparatus, wherein a plurality of the dispersed phase inflow channel, the continuous phase inflow channel, the mixing channel, and the expansion mixing channel are arranged in a laminated member forming them. The emulsification device according to claim 4,
Dispersed phase branch flow for distributing dispersed phases to a plurality of dispersed phase inflow channels on at least one of the members forming the dispersed phase inflow channel or another member laminated adjacent to the members. A plurality of the mixed flows on a laminating plane of at least one of a member forming a channel and the mixing channel, a member forming the expanded mixing channel, or another member stacked adjacent to any one of the members. An emulsification apparatus characterized by forming a mixed liquid merging flow path for merging liquid flowing in a passage or the enlarged mixed flow path.

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