JP4982385B2 - イメージングフローサイトメータを使用した血液及び細胞の分析 - Google Patents

イメージングフローサイトメータを使用した血液及び細胞の分析 Download PDF

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JP4982385B2
JP4982385B2 JP2007554187A JP2007554187A JP4982385B2 JP 4982385 B2 JP4982385 B2 JP 4982385B2 JP 2007554187 A JP2007554187 A JP 2007554187A JP 2007554187 A JP2007554187 A JP 2007554187A JP 4982385 B2 JP4982385 B2 JP 4982385B2
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JP2008533440A (ja
JP2008533440A5 (cg-RX-API-DMAC7.html
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オーティン ウィリアム
バシジ デビッド
ジョージ タデオス
モリシー フィリップ
ホール ブライアン
ペリー デビッド
ジマーマン キャスリーン
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アムニス コーポレイション
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape

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  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Theoretical Computer Science (AREA)
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  • Biomedical Technology (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2007554187A 2005-02-01 2006-02-01 イメージングフローサイトメータを使用した血液及び細胞の分析 Active JP4982385B2 (ja)

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Application Number Priority Date Filing Date Title
US64937305P 2005-02-01 2005-02-01
US60/649,373 2005-02-01
PCT/US2006/003573 WO2006083969A2 (en) 2005-02-01 2006-02-01 Blood analysis using a flow imaging cytometer

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JP2008533440A JP2008533440A (ja) 2008-08-21
JP2008533440A5 JP2008533440A5 (cg-RX-API-DMAC7.html) 2009-03-26
JP4982385B2 true JP4982385B2 (ja) 2012-07-25

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EP (1) EP1844426A4 (cg-RX-API-DMAC7.html)
JP (1) JP4982385B2 (cg-RX-API-DMAC7.html)
WO (1) WO2006083969A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160047432A (ko) * 2013-05-28 2016-05-02 세모메테크 에이/에스 이미지 형성 세포 계수기

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US9164037B2 (en) 2007-01-26 2015-10-20 Palo Alto Research Center Incorporated Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances
JP5013410B2 (ja) * 2007-03-14 2012-08-29 独立行政法人産業技術総合研究所 微粒子測定方法及び装置
ATE528722T1 (de) * 2007-05-14 2011-10-15 Historx Inc Abteilungsauftrennung durch pixelcharakterisierung unter verwendung von bilddatenclusterung
CA2690633C (en) 2007-06-15 2015-08-04 Historx, Inc. Method and system for standardizing microscope instruments
CA2604317C (en) 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CA2596204C (en) 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
WO2009029810A1 (en) 2007-08-31 2009-03-05 Historx, Inc. Automatic exposure time selection for imaging tissue
US7782452B2 (en) * 2007-08-31 2010-08-24 Kla-Tencor Technologies Corp. Systems and method for simultaneously inspecting a specimen with two distinct channels
US7817254B2 (en) * 2008-01-30 2010-10-19 Palo Alto Research Center Incorporated Obtaining information from time variation of sensing results
US8629981B2 (en) 2008-02-01 2014-01-14 Palo Alto Research Center Incorporated Analyzers with time variation based on color-coded spatial modulation
FR2935802B1 (fr) * 2008-09-05 2012-12-28 Horiba Abx Sas Procede et dispositif de classification, de visualisation et d'exploration de donnees biologiques
CN102165489B (zh) 2008-09-16 2015-11-25 赫斯托克斯公司 生物标志物表达的可再现量化
JP5438962B2 (ja) * 2008-12-25 2014-03-12 シスメックス株式会社 細胞画像表示装置
US9025850B2 (en) 2010-06-25 2015-05-05 Cireca Theranostics, Llc Method for analyzing biological specimens by spectral imaging
WO2011163624A1 (en) * 2010-06-25 2011-12-29 Cellmark Theranostics, Llc Method for analyzing biological specimens by spectral imaging
US9129371B2 (en) 2010-06-25 2015-09-08 Cireca Theranostics, Llc Method for analyzing biological specimens by spectral imaging
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US9228898B2 (en) * 2011-03-31 2016-01-05 Gnubio, Inc. Scalable spectroscopic detection and measurement
WO2013002223A1 (ja) * 2011-06-27 2013-01-03 シスメックス株式会社 細胞分析装置
WO2013033271A2 (en) * 2011-08-29 2013-03-07 Derren Barken Method to augment immune system in response to disease or injury
ES2828660T3 (es) * 2012-07-05 2021-05-27 Beckman Coulter Inc Método y aparato para determinar recuentos de leucocitos
US9690976B2 (en) * 2013-03-11 2017-06-27 Roche Diagnostics Hematology, Inc. Imaging blood cells
CA2907504C (en) 2013-03-27 2023-01-17 Theranos, Inc. Methods, devices, and systems for sample analysis
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
CN106662521B (zh) * 2014-08-28 2018-06-12 希森美康株式会社 粒子拍摄装置及粒子拍摄方法
JP2018509615A (ja) * 2015-02-19 2018-04-05 プレミアム ジェネティクス （ユーケー） リミテッド 走査型赤外線測定システム
US10460439B1 (en) 2015-08-12 2019-10-29 Cireca Theranostics, Llc Methods and systems for identifying cellular subtypes in an image of a biological specimen
JP6654271B2 (ja) * 2016-06-10 2020-02-26 ルミネックス コーポレーション イメージングフローサイトメーター（ｉｆｃ）から取得された画像を使用した、細胞画像のセグメンテーションおよび形態分析のための明視野と蛍光チャンネルの統合方法
CN107356515B (zh) * 2017-07-20 2020-04-03 上海睿钰生物科技有限公司 一种荧光图像的荧光强度确定方法和系统
US11314994B2 (en) 2018-01-30 2022-04-26 Riken Mask structure optimization device, mask structure optimization method, and program
FR3078777B1 (fr) * 2018-03-07 2020-11-13 Alain Rousseau Procede d’analyse d’un echantillon biologique contenant des cellules biologiques, et appareil d’analyse pour la mise en œuvre du procede d’analyse
JP7109229B2 (ja) * 2018-03-30 2022-07-29 シスメックス株式会社 フローサイトメーター及び粒子検出方法
JP7678424B2 (ja) 2018-05-10 2025-05-16 学校法人順天堂 画像解析方法、装置、コンピュータプログラム、及び深層学習アルゴリズムの生成方法
BR112020023607A2 (pt) 2018-05-23 2021-02-17 Abs Global, Inc. sistemas e métodos para focalização de partículas em microcanais
WO2020215011A1 (en) 2019-04-18 2020-10-22 Abs Global, Inc. System and process for continuous addition of cryoprotectant
JP7381003B2 (ja) * 2019-04-26 2023-11-15 学校法人順天堂 疾患解析を支援する方法、装置、及びコンピュータプログラム、並びにコンピュータアルゴリズムを訓練する方法、装置、及びプログラム
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
US20230245478A1 (en) * 2020-07-30 2023-08-03 Hamamatsu Photonics K.K. Assessment device, assessment method, assessment program, and recording medium
WO2022087299A1 (en) 2020-10-21 2022-04-28 Abs Global, Inc. Methods and systems for processing genetic samples to determine identity or detect contamination
EP4248190A4 (en) 2020-11-23 2024-12-25 ABS Global, Inc. MODULAR FLOW CYTOMETRY SYSTEMS AND METHODS FOR PROCESSING SAMPLES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62134559A (ja) * 1985-12-07 1987-06-17 Japan Spectroscopic Co 血液細胞自動分析方法および装置
US6259807B1 (en) * 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US6975400B2 (en) * 1999-01-25 2005-12-13 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US20030228565A1 (en) * 2000-04-26 2003-12-11 Cytokinetics, Inc. Method and apparatus for predictive cellular bioinformatics
EP1334338A4 (en) * 2000-10-12 2008-03-19 Amnis Corp PICTURE AND ANALYSIS OF PARAMETERS OF SMALL MOBILE OBJECTS, SUCH AS CELLS, FOR EXAMPLE
US7369696B2 (en) * 2003-04-02 2008-05-06 Ge Healthcare Uk Limited Classification of cells into subpopulations using cell classifying data

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160047432A (ko) * 2013-05-28 2016-05-02 세모메테크 에이/에스 이미지 형성 세포 계수기
KR102162213B1 (ko) 2013-05-28 2020-10-07 세모메테크 에이/에스 이미지 형성 세포 계수기

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WO2006083969A2 (en) 2006-08-10
JP2008533440A (ja) 2008-08-21
EP1844426A4 (en) 2016-09-07
WO2006083969A3 (en) 2008-06-26
EP1844426A2 (en) 2007-10-17

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