JP4980048B2 - 腫瘍壊死因子結合タンパク質の液体製剤 - Google Patents

腫瘍壊死因子結合タンパク質の液体製剤 Download PDF

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Publication number
JP4980048B2
JP4980048B2 JP2006502021A JP2006502021A JP4980048B2 JP 4980048 B2 JP4980048 B2 JP 4980048B2 JP 2006502021 A JP2006502021 A JP 2006502021A JP 2006502021 A JP2006502021 A JP 2006502021A JP 4980048 B2 JP4980048 B2 JP 4980048B2
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tumor necrosis
necrosis factor
tnf
binding protein
receptor
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JP2006519210A (ja
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サマリターニ，ファブリツィオ
リオ，アレッサンドラ デル
アゴスティネット，リタ
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アレス トレーディング ソシエテ アノニム
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP2006502021A 2003-02-28 2004-02-11 腫瘍壊死因子結合タンパク質の液体製剤 Expired - Fee Related JP4980048B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03100505.1 2003-02-28
EP03100505 2003-02-28
PCT/EP2004/050118 WO2004075918A1 (en) 2003-02-28 2004-02-11 Liquid formulations of tumor necrosis factor-binding proteins

Publications (2)

Publication Number Publication Date
JP2006519210A JP2006519210A (ja) 2006-08-24
JP4980048B2 true JP4980048B2 (ja) 2012-07-18

Family

ID=32921619

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006502021A Expired - Fee Related JP4980048B2 (ja) 2003-02-28 2004-02-11 腫瘍壊死因子結合タンパク質の液体製剤

Country Status (22)

Country Link
US (3) US8937045B2 (pl)
EP (1) EP1603596B1 (pl)
JP (1) JP4980048B2 (pl)
KR (1) KR20050105486A (pl)
CN (1) CN100563712C (pl)
AR (1) AR043418A1 (pl)
AT (1) ATE394123T1 (pl)
BR (1) BRPI0407649A (pl)
CA (1) CA2515539A1 (pl)
DE (1) DE602004013557D1 (pl)
EA (1) EA009079B1 (pl)
ES (1) ES2304602T3 (pl)
HK (1) HK1085677A1 (pl)
HR (1) HRP20050706A2 (pl)
IL (1) IL170414A (pl)
MX (1) MXPA05009135A (pl)
NO (1) NO20054440L (pl)
PL (1) PL213501B1 (pl)
RS (1) RS51041B (pl)
UA (1) UA82503C2 (pl)
WO (1) WO2004075918A1 (pl)
ZA (1) ZA200506504B (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
NZ602498A (en) * 2007-11-30 2014-08-29 Abbvie Inc Protein formulations and methods of making same
CA2760185A1 (en) * 2009-05-04 2010-11-11 Abbott Biotechnology Ltd. Stable high protein concentration formulations of human anti-tnf-alpha antibodies
TWI603739B (zh) 2010-11-11 2017-11-01 艾伯維生物技術有限責任公司 具有增進高濃度之抗－ＴＮＦα抗體之液體調配物
CN103930124B (zh) 2011-07-01 2021-05-11 生物基因Ma公司 无精氨酸的tnfr：fc-融合多肽组合物及使用方法
US10493151B2 (en) 2011-10-18 2019-12-03 Coherus Biosciences, Inc. Etanercept formulations stabilized with sodium chloride
PT2768525T (pt) 2011-10-18 2019-07-17 Coherus Biosciences Inc Formulações etanercept estabilizadas com iões de magnésio
SI3091029T1 (sl) 2011-10-31 2023-03-31 F. Hoffmann - La Roche Ag Pripravki protiteles proti IL13
EP2869817A4 (en) 2012-07-09 2016-04-06 Coherus Biosciences Inc STABLE AQUEOUS FORMULATIONS OF ETANERCEPT
PL2895188T3 (pl) 2012-09-11 2018-06-29 Coherus Biosciences, Inc. Prawidłowo pofałdowany etanercept o wysokiej czystości i doskonałej wydajności
BR112015009462A2 (pt) 2012-10-26 2017-07-04 Lupin Atlantis Holdings Sa composição farmacêutica estável do tnfr:fc proteína de fusão
MX2016016148A (es) 2014-06-26 2017-04-25 Maruishi Pharma Preparacion de rocuronio con estabilidad mejorada.
RU2724900C1 (ru) * 2019-10-24 2020-06-26 Маруиси Фармасьютикал Ко., Лтд. Препарат рокурония с улучшенной стабильностью

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6552170B1 (en) * 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
CA2123593C (en) * 1992-09-15 2000-03-14 Craig A. Smith Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists
CA2139385C (en) * 1994-02-04 2001-12-25 Gottfried Alber Products containing g-csf and tnf binding protein
US6225300B1 (en) * 1995-07-14 2001-05-01 Applied Research Systems Ars Holding Nv TNF receptor and steroid hormone in a combined therapy
TR199802238T2 (xx) * 1996-05-08 1999-02-22 F. Hoffmann-La Roche Ag Astımın TNFR-Ig ile tedavisi.
PT942740E (pt) * 1996-12-06 2004-01-30 Amgen Inc Terapia de combinacao utilizando uma proteina de ligacao de tnf para tratamento de doencas mediadas por tnf
US7087224B2 (en) 2000-10-31 2006-08-08 Amgen Inc. Method of treating anemia by administering IL-1ra
US6818613B2 (en) * 2001-11-07 2004-11-16 Ortho-Mcneil Pharmaceutical, Inc. Aqueous sustained-release formulations of proteins
WO2003072060A2 (en) * 2002-02-27 2003-09-04 Immunex Corporation Polypeptide formulation

Also Published As

Publication number Publication date
IL170414A (en) 2009-11-18
EP1603596B1 (en) 2008-05-07
US9512215B2 (en) 2016-12-06
CN1774266A (zh) 2006-05-17
JP2006519210A (ja) 2006-08-24
HRP20050706A2 (en) 2005-12-31
NO20054440L (no) 2005-09-26
US20150098950A1 (en) 2015-04-09
US20070053906A1 (en) 2007-03-08
ES2304602T3 (es) 2008-10-16
DE602004013557D1 (de) 2008-06-19
BRPI0407649A (pt) 2006-02-21
RS20050662A (en) 2007-11-15
RS51041B (sr) 2010-10-31
CA2515539A1 (en) 2004-09-10
ZA200506504B (en) 2006-12-27
WO2004075918A1 (en) 2004-09-10
EA009079B1 (ru) 2007-10-26
ATE394123T1 (de) 2008-05-15
US8937045B2 (en) 2015-01-20
EA200501230A1 (ru) 2006-04-28
EP1603596A1 (en) 2005-12-14
PL213501B1 (pl) 2013-03-29
AU2004216483A1 (en) 2004-09-10
US20170020960A1 (en) 2017-01-26
MXPA05009135A (es) 2005-10-20
AR043418A1 (es) 2005-07-27
HK1085677A1 (en) 2006-09-01
UA82503C2 (uk) 2008-04-25
CN100563712C (zh) 2009-12-02
PL378290A1 (pl) 2006-03-20
KR20050105486A (ko) 2005-11-04

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