JP4969459B2 - 核酸鋳型合成において使用される遊離反応体 - Google Patents

核酸鋳型合成において使用される遊離反応体 Download PDF

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Publication number
JP4969459B2
JP4969459B2 JP2007552363A JP2007552363A JP4969459B2 JP 4969459 B2 JP4969459 B2 JP 4969459B2 JP 2007552363 A JP2007552363 A JP 2007552363A JP 2007552363 A JP2007552363 A JP 2007552363A JP 4969459 B2 JP4969459 B2 JP 4969459B2
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reactive
reaction
sequence
oligonucleotide
template
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JP2008528000A (ja
JP2008528000A5 (enExample
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デイビッド リュー，
香里 櫻井
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Harvard University
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Harvard University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2007552363A 2005-01-21 2006-01-20 核酸鋳型合成において使用される遊離反応体 Expired - Lifetime JP4969459B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64658405P 2005-01-21 2005-01-21
US60/646,584 2005-01-21
PCT/US2006/002420 WO2006079061A2 (en) 2005-01-21 2006-01-20 Free reactant use in nucleic acid-templated synthesis

Publications (3)

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JP2008528000A JP2008528000A (ja) 2008-07-31
JP2008528000A5 JP2008528000A5 (enExample) 2009-03-26
JP4969459B2 true JP4969459B2 (ja) 2012-07-04

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JP2007552363A Expired - Lifetime JP4969459B2 (ja) 2005-01-21 2006-01-20 核酸鋳型合成において使用される遊離反応体

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EP (1) EP1856256B1 (enExample)
JP (1) JP4969459B2 (enExample)
CN (1) CN101107357B (enExample)
AU (1) AU2006206219B2 (enExample)
CA (1) CA2595590C (enExample)
DE (1) DE602006007819D1 (enExample)
WO (1) WO2006079061A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
CN102838654B (zh) 2002-10-30 2016-05-18 纽韦卢森公司 合成双功能复合物的方法
DE60330406D1 (de) 2002-12-19 2010-01-14 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US8017323B2 (en) 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
LT3018206T (lt) 2005-12-01 2021-12-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
SG173627A1 (en) 2009-02-13 2011-09-29 Chem Inc X Methods of creating and screening dna-encoded libraries
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
DK2748357T3 (en) * 2011-09-07 2018-07-16 X Chem Inc Methods for labeling DNA-encoded libraries
KR102146721B1 (ko) 2012-07-13 2020-08-21 엑스-켐, 인크. 폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리
EP3472376A4 (en) 2016-06-16 2019-12-18 Richard Edward Watts OLIGONUCLEOTIDE CONTROLLED AND RECORDED COMBINATORY SYNTHESIS OF CODED PROBE MOLECULES
EP3619340A4 (en) * 2017-05-02 2021-01-20 Haystack Sciences Corporation OLIGONUCLEOTID-DRIVEN COMBINATORY SYNTHESIS VERIFICATION MOLECULES AND ASSOCIATED MANUFACTURING AND USE PROCESSES
EP4594480A2 (en) * 2022-09-26 2025-08-06 Ansa Biotechnologies, Inc. Cleavable linkers for the tethering of polymerases to nucleotides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US7479472B1 (en) * 1998-10-19 2009-01-20 The Board Of Trustees Of The Leland Stanford Junior University DNA-templated combinatorial library chemistry
CN1539014A (zh) * 2001-06-20 2004-10-20 ŦΤ¬ɭ��˾ 模控分子和使用这种分子的方法
AU2003247266A1 (en) * 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function

Also Published As

Publication number Publication date
CA2595590A1 (en) 2006-07-27
WO2006079061A3 (en) 2006-09-28
AU2006206219A1 (en) 2006-07-27
EP1856256B1 (en) 2009-07-15
WO2006079061A2 (en) 2006-07-27
DE602006007819D1 (de) 2009-08-27
AU2006206219B2 (en) 2012-07-26
JP2008528000A (ja) 2008-07-31
CN101107357A (zh) 2008-01-16
CN101107357B (zh) 2013-01-02
EP1856256A2 (en) 2007-11-21
CA2595590C (en) 2015-04-21

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KR101411361B1 (ko) 구조적 핵산에 의해 가이드되는 화학적 합성
JP2008528000A (ja) 核酸鋳型合成において使用される遊離反応体
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