CN101107357B - 用于以核酸为模板的合成中的游离反应物 - Google Patents

用于以核酸为模板的合成中的游离反应物 Download PDF

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Publication number
CN101107357B
CN101107357B CN200680002864.0A CN200680002864A CN101107357B CN 101107357 B CN101107357 B CN 101107357B CN 200680002864 A CN200680002864 A CN 200680002864A CN 101107357 B CN101107357 B CN 101107357B
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reaction
oligonucleotide
sequence
template
free reactant
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Chinese (zh)
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CN101107357A (zh
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戴维德·刘
樱井馨
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Harvard University
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Harvard University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200680002864.0A 2005-01-21 2006-01-20 用于以核酸为模板的合成中的游离反应物 Expired - Fee Related CN101107357B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64658405P 2005-01-21 2005-01-21
US60/646,584 2005-01-21
PCT/US2006/002420 WO2006079061A2 (en) 2005-01-21 2006-01-20 Free reactant use in nucleic acid-templated synthesis

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CN101107357A CN101107357A (zh) 2008-01-16
CN101107357B true CN101107357B (zh) 2013-01-02

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CN200680002864.0A Expired - Fee Related CN101107357B (zh) 2005-01-21 2006-01-20 用于以核酸为模板的合成中的游离反应物

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EP (1) EP1856256B1 (enExample)
JP (1) JP4969459B2 (enExample)
CN (1) CN101107357B (enExample)
AU (1) AU2006206219B2 (enExample)
CA (1) CA2595590C (enExample)
DE (1) DE602006007819D1 (enExample)
WO (1) WO2006079061A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (en) 2001-06-20 2004-03-31 Nuevolution A/S Nucleoside derivatives for library preparation
CN101006177B (zh) 2002-03-15 2011-10-12 纽韦卢森公司 改善的用于合成模制分子的方法
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
CN106337046B (zh) 2002-10-30 2021-03-23 纽韦卢森公司 合成双功能复合物的方法
ATE450609T1 (de) 2002-12-19 2009-12-15 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US8017323B2 (en) 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
LT3018206T (lt) 2005-12-01 2021-12-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
WO2010094036A1 (en) 2009-02-13 2010-08-19 X-Chem, Inc. Methods of creating and screening dna-encoded libraries
CA2832672A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
SG10201605812YA (en) * 2011-09-07 2016-09-29 Chem Inc X Methods for tagging dna-encoded libraries
KR102146721B1 (ko) 2012-07-13 2020-08-21 엑스-켐, 인크. 폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리
WO2017218293A1 (en) 2016-06-16 2017-12-21 Richard Edward Watts Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
WO2018204420A1 (en) 2017-05-02 2018-11-08 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
CA3268062A1 (en) * 2022-09-26 2024-04-04 Ansa Biotechnologies Inc Cleavable binders for attaching polymers to nucleotides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002103008A2 (en) * 2001-06-20 2002-12-27 Nuevolution A/S Templated molecules and methods for using such molecules
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
CA2346989A1 (en) * 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002103008A2 (en) * 2001-06-20 2002-12-27 Nuevolution A/S Templated molecules and methods for using such molecules
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Xiaoyu Li ,David R. Liu.DNA-Templated Organic Synthesis: Nature ├s Strategyfor Controlling Chemical Reactivity Applied to SyntheticMolecules.Angew. Chem. Int. Ed.43.2004,434849-4867.
Xiaoyu Li,David R. Liu.DNA-Templated Organic Synthesis: Nature ├s Strategyfor Controlling Chemical Reactivity Applied to SyntheticMolecules.Angew. Chem. Int. Ed.43.2004,434849-4867. *

Also Published As

Publication number Publication date
EP1856256A2 (en) 2007-11-21
CA2595590C (en) 2015-04-21
EP1856256B1 (en) 2009-07-15
CN101107357A (zh) 2008-01-16
WO2006079061A3 (en) 2006-09-28
AU2006206219B2 (en) 2012-07-26
DE602006007819D1 (de) 2009-08-27
JP2008528000A (ja) 2008-07-31
WO2006079061A2 (en) 2006-07-27
CA2595590A1 (en) 2006-07-27
JP4969459B2 (ja) 2012-07-04
AU2006206219A1 (en) 2006-07-27

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