CN101107357B - 用于以核酸为模板的合成中的游离反应物 - Google Patents

用于以核酸为模板的合成中的游离反应物 Download PDF

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Publication number
CN101107357B
CN101107357B CN200680002864.0A CN200680002864A CN101107357B CN 101107357 B CN101107357 B CN 101107357B CN 200680002864 A CN200680002864 A CN 200680002864A CN 101107357 B CN101107357 B CN 101107357B
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reaction
oligonucleotide
sequence
template
free reactant
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Expired - Fee Related
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Chinese (zh)
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CN101107357A (zh
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戴维德·刘
樱井馨
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Harvard University
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Harvard University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200680002864.0A 2005-01-21 2006-01-20 用于以核酸为模板的合成中的游离反应物 Expired - Fee Related CN101107357B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64658405P 2005-01-21 2005-01-21
US60/646,584 2005-01-21
PCT/US2006/002420 WO2006079061A2 (en) 2005-01-21 2006-01-20 Free reactant use in nucleic acid-templated synthesis

Publications (2)

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CN101107357A CN101107357A (zh) 2008-01-16
CN101107357B true CN101107357B (zh) 2013-01-02

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CN200680002864.0A Expired - Fee Related CN101107357B (zh) 2005-01-21 2006-01-20 用于以核酸为模板的合成中的游离反应物

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EP (1) EP1856256B1 (enExample)
JP (1) JP4969459B2 (enExample)
CN (1) CN101107357B (enExample)
AU (1) AU2006206219B2 (enExample)
CA (1) CA2595590C (enExample)
DE (1) DE602006007819D1 (enExample)
WO (1) WO2006079061A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
US10731151B2 (en) 2002-03-15 2020-08-04 Nuevolution A/S Method for synthesising templated molecules
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
CN102838654B (zh) 2002-10-30 2016-05-18 纽韦卢森公司 合成双功能复合物的方法
DE60330406D1 (de) 2002-12-19 2010-01-14 Nuevolution As Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US8017323B2 (en) 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
ATE447626T1 (de) 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
LT3018206T (lt) 2005-12-01 2021-12-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
SG173627A1 (en) 2009-02-13 2011-09-29 Chem Inc X Methods of creating and screening dna-encoded libraries
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
DK2748357T3 (en) * 2011-09-07 2018-07-16 X Chem Inc Methods for labeling DNA-encoded libraries
KR102146721B1 (ko) 2012-07-13 2020-08-21 엑스-켐, 인크. 폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리
EP3472376A4 (en) 2016-06-16 2019-12-18 Richard Edward Watts OLIGONUCLEOTIDE CONTROLLED AND RECORDED COMBINATORY SYNTHESIS OF CODED PROBE MOLECULES
EP3619340A4 (en) * 2017-05-02 2021-01-20 Haystack Sciences Corporation OLIGONUCLEOTID-DRIVEN COMBINATORY SYNTHESIS VERIFICATION MOLECULES AND ASSOCIATED MANUFACTURING AND USE PROCESSES
EP4594480A2 (en) * 2022-09-26 2025-08-06 Ansa Biotechnologies, Inc. Cleavable linkers for the tethering of polymerases to nucleotides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002103008A2 (en) * 2001-06-20 2002-12-27 Nuevolution A/S Templated molecules and methods for using such molecules
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US7479472B1 (en) * 1998-10-19 2009-01-20 The Board Of Trustees Of The Leland Stanford Junior University DNA-templated combinatorial library chemistry

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002103008A2 (en) * 2001-06-20 2002-12-27 Nuevolution A/S Templated molecules and methods for using such molecules
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) * 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Xiaoyu Li ,David R. Liu.DNA-Templated Organic Synthesis: Nature ├s Strategyfor Controlling Chemical Reactivity Applied to SyntheticMolecules.Angew. Chem. Int. Ed.43.2004,434849-4867.
Xiaoyu Li,David R. Liu.DNA-Templated Organic Synthesis: Nature ├s Strategyfor Controlling Chemical Reactivity Applied to SyntheticMolecules.Angew. Chem. Int. Ed.43.2004,434849-4867. *

Also Published As

Publication number Publication date
CA2595590A1 (en) 2006-07-27
WO2006079061A3 (en) 2006-09-28
AU2006206219A1 (en) 2006-07-27
EP1856256B1 (en) 2009-07-15
WO2006079061A2 (en) 2006-07-27
DE602006007819D1 (de) 2009-08-27
AU2006206219B2 (en) 2012-07-26
JP2008528000A (ja) 2008-07-31
CN101107357A (zh) 2008-01-16
EP1856256A2 (en) 2007-11-21
JP4969459B2 (ja) 2012-07-04
CA2595590C (en) 2015-04-21

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