AU2006206219B2 - Free reactant use in nucleic acid-templated synthesis - Google Patents
Free reactant use in nucleic acid-templated synthesis Download PDFInfo
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- AU2006206219B2 AU2006206219B2 AU2006206219A AU2006206219A AU2006206219B2 AU 2006206219 B2 AU2006206219 B2 AU 2006206219B2 AU 2006206219 A AU2006206219 A AU 2006206219A AU 2006206219 A AU2006206219 A AU 2006206219A AU 2006206219 B2 AU2006206219 B2 AU 2006206219B2
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- reactive
- reaction
- oligonucleotide
- sequence
- reaction intermediate
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- 238000003786 synthesis reaction Methods 0.000 title claims abstract description 65
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- 108091034117 Oligonucleotide Proteins 0.000 claims abstract description 141
- 239000007795 chemical reaction product Substances 0.000 claims abstract description 101
- 238000006243 chemical reaction Methods 0.000 claims abstract description 93
- 238000000034 method Methods 0.000 claims abstract description 92
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
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- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
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| US64658405P | 2005-01-21 | 2005-01-21 | |
| US60/646,584 | 2005-01-21 | ||
| PCT/US2006/002420 WO2006079061A2 (en) | 2005-01-21 | 2006-01-20 | Free reactant use in nucleic acid-templated synthesis |
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| AU2006206219A1 AU2006206219A1 (en) | 2006-07-27 |
| AU2006206219B2 true AU2006206219B2 (en) | 2012-07-26 |
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| EP (1) | EP1856256B1 (enExample) |
| JP (1) | JP4969459B2 (enExample) |
| CN (1) | CN101107357B (enExample) |
| AU (1) | AU2006206219B2 (enExample) |
| CA (1) | CA2595590C (enExample) |
| DE (1) | DE602006007819D1 (enExample) |
| WO (1) | WO2006079061A2 (enExample) |
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| EP1401850A1 (en) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nucleoside derivatives for library preparation |
| CN101006177B (zh) | 2002-03-15 | 2011-10-12 | 纽韦卢森公司 | 改善的用于合成模制分子的方法 |
| AU2003247266A1 (en) | 2002-08-01 | 2004-02-23 | Nuevolution A/S | Multi-step synthesis of templated molecules |
| CN106337046B (zh) | 2002-10-30 | 2021-03-23 | 纽韦卢森公司 | 合成双功能复合物的方法 |
| ATE450609T1 (de) | 2002-12-19 | 2009-12-15 | Nuevolution As | Durch quasizufallsstrukturen und funktionen geführte synthesemethode |
| US20070026397A1 (en) | 2003-02-21 | 2007-02-01 | Nuevolution A/S | Method for producing second-generation library |
| US8017323B2 (en) | 2003-03-26 | 2011-09-13 | President And Fellows Of Harvard College | Free reactant use in nucleic acid-templated synthesis |
| ATE447626T1 (de) | 2003-09-18 | 2009-11-15 | Nuevolution As | Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen |
| LT3018206T (lt) | 2005-12-01 | 2021-12-10 | Nuevolution A/S | Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei |
| WO2010094036A1 (en) | 2009-02-13 | 2010-08-19 | X-Chem, Inc. | Methods of creating and screening dna-encoded libraries |
| CA2832672A1 (en) | 2010-04-16 | 2011-10-20 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
| SG10201605812YA (en) * | 2011-09-07 | 2016-09-29 | Chem Inc X | Methods for tagging dna-encoded libraries |
| KR102146721B1 (ko) | 2012-07-13 | 2020-08-21 | 엑스-켐, 인크. | 폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리 |
| WO2017218293A1 (en) | 2016-06-16 | 2017-12-21 | Richard Edward Watts | Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules |
| WO2018204420A1 (en) | 2017-05-02 | 2018-11-08 | Haystack Sciences Corporation | Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same |
| CA3268062A1 (en) * | 2022-09-26 | 2024-04-04 | Ansa Biotechnologies Inc | Cleavable binders for attaching polymers to nucleotides |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002103008A2 (en) * | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Templated molecules and methods for using such molecules |
| WO2004013070A2 (en) * | 2002-08-01 | 2004-02-12 | Nuevolution A/S | Multi-step synthesis of templated molecules |
| WO2004016767A2 (en) * | 2002-08-19 | 2004-02-26 | The President And Fellows Of Harvard College | Evolving new molecular function |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5573905A (en) * | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| CA2346989A1 (en) * | 1998-10-19 | 2000-04-27 | The Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
-
2006
- 2006-01-20 EP EP06733839A patent/EP1856256B1/en not_active Not-in-force
- 2006-01-20 JP JP2007552363A patent/JP4969459B2/ja active Active
- 2006-01-20 CA CA2595590A patent/CA2595590C/en not_active Expired - Fee Related
- 2006-01-20 AU AU2006206219A patent/AU2006206219B2/en not_active Ceased
- 2006-01-20 WO PCT/US2006/002420 patent/WO2006079061A2/en not_active Ceased
- 2006-01-20 DE DE602006007819T patent/DE602006007819D1/de active Active
- 2006-01-20 CN CN200680002864.0A patent/CN101107357B/zh not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002103008A2 (en) * | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Templated molecules and methods for using such molecules |
| WO2004013070A2 (en) * | 2002-08-01 | 2004-02-12 | Nuevolution A/S | Multi-step synthesis of templated molecules |
| WO2004016767A2 (en) * | 2002-08-19 | 2004-02-26 | The President And Fellows Of Harvard College | Evolving new molecular function |
Non-Patent Citations (4)
| Title |
|---|
| CALDERONE, CHRISTOPHER T. et al. 'Directing Otherwise Incompatible Reactions in a Single Solution by Using DNA-Templated Organic Synthesis.' Angew. Chem. Int. Ed. 2002, Vol. 41, No. 21, pages 4104-4108 * |
| GARTNER, ZEV J. et al. 'Expanding the Reaction Scope of DNA-Templated Synthesis.' Angew. Chem. Int. Ed. 2002, Vol. 41, No. 10, pages 1796-1800 * |
| KNIGHT, JULIAN C. et al. 'Clinical Chemistry. 1999, Vol. 45, No. 10, pages 1860-1863 * |
| NPL LI XIAOYU ET AL: "DNA-templated organic synthesis: nature's strategy for controlling chemical reactivity applied to synthetic molecules." ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH) 20 SEP 2004, vol. 43, no. 37, 20 September 2004 (2004-09-20), pages 4848-4870 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1856256A2 (en) | 2007-11-21 |
| CA2595590C (en) | 2015-04-21 |
| EP1856256B1 (en) | 2009-07-15 |
| CN101107357B (zh) | 2013-01-02 |
| CN101107357A (zh) | 2008-01-16 |
| WO2006079061A3 (en) | 2006-09-28 |
| DE602006007819D1 (de) | 2009-08-27 |
| JP2008528000A (ja) | 2008-07-31 |
| WO2006079061A2 (en) | 2006-07-27 |
| CA2595590A1 (en) | 2006-07-27 |
| JP4969459B2 (ja) | 2012-07-04 |
| AU2006206219A1 (en) | 2006-07-27 |
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