JP4954374B2 - カプセル化された細胞ベースの送達のためのプラットホーム細胞株としてのarpe−19 - Google Patents
カプセル化された細胞ベースの送達のためのプラットホーム細胞株としてのarpe−19 Download PDFInfo
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- JP4954374B2 JP4954374B2 JP2000609543A JP2000609543A JP4954374B2 JP 4954374 B2 JP4954374 B2 JP 4954374B2 JP 2000609543 A JP2000609543 A JP 2000609543A JP 2000609543 A JP2000609543 A JP 2000609543A JP 4954374 B2 JP4954374 B2 JP 4954374B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts or implants
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P27/12—Ophthalmic agents for cataracts
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
- A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
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- A—HUMAN NECESSITIES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Psychology (AREA)
- Wood Science & Technology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12792699P | 1999-04-06 | 1999-04-06 | |
| US60/127,926 | 1999-04-06 | ||
| US09/543,119 | 2000-04-05 | ||
| US09/543,119 US6361771B1 (en) | 1999-04-06 | 2000-04-05 | ARPE-19 as a platform cell line for encapsulated cell-based delivery |
| PCT/US2000/009150 WO2000060051A2 (en) | 1999-04-06 | 2000-04-06 | Arpe-19 as a platform cell line for encapsulated cell-based delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010256357A Division JP2011074079A (ja) | 1999-04-06 | 2010-11-16 | カプセル化された細胞ベースの送達のためのプラットホーム細胞株としてのarpe−19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003524621A JP2003524621A (ja) | 2003-08-19 |
| JP2003524621A5 JP2003524621A5 (enExample) | 2011-01-13 |
| JP4954374B2 true JP4954374B2 (ja) | 2012-06-13 |
Family
ID=26826092
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000609543A Expired - Lifetime JP4954374B2 (ja) | 1999-04-06 | 2000-04-06 | カプセル化された細胞ベースの送達のためのプラットホーム細胞株としてのarpe−19 |
| JP2010256357A Withdrawn JP2011074079A (ja) | 1999-04-06 | 2010-11-16 | カプセル化された細胞ベースの送達のためのプラットホーム細胞株としてのarpe−19 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010256357A Withdrawn JP2011074079A (ja) | 1999-04-06 | 2010-11-16 | カプセル化された細胞ベースの送達のためのプラットホーム細胞株としてのarpe−19 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6361771B1 (enExample) |
| EP (1) | EP1171573B1 (enExample) |
| JP (2) | JP4954374B2 (enExample) |
| AT (1) | ATE269715T1 (enExample) |
| AU (1) | AU773387B2 (enExample) |
| BR (1) | BR0009562A (enExample) |
| CA (1) | CA2365532C (enExample) |
| DE (1) | DE60011761T2 (enExample) |
| DK (1) | DK1171573T3 (enExample) |
| ES (1) | ES2219335T3 (enExample) |
| NO (1) | NO20014856D0 (enExample) |
| WO (1) | WO2000060051A2 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6878544B2 (en) * | 1996-04-19 | 2005-04-12 | Neurotech Sa | Retinal cell lines with extended life-span and their applications |
| US6593133B1 (en) * | 1998-07-06 | 2003-07-15 | Nsgene A/S | Neurotrophic factors |
| US20070071734A1 (en) * | 1999-04-06 | 2007-03-29 | Weng Tao | ARPE-19 as platform cell line for encapsulated cell-based delivery |
| US6361771B1 (en) * | 1999-04-06 | 2002-03-26 | Neurotech S.A. | ARPE-19 as a platform cell line for encapsulated cell-based delivery |
| US7442370B2 (en) | 2001-02-01 | 2008-10-28 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
| US7276580B2 (en) * | 2001-03-12 | 2007-10-02 | Biogen Idec Ma Inc. | Neurotrophic factors |
| WO2003033016A1 (en) * | 2001-10-16 | 2003-04-24 | Jenny Phipps | Use of neurotrophic factors for treating neurodegenerative diseases and cancer |
| EP1501541A1 (en) * | 2002-04-30 | 2005-02-02 | Canadian Blood Services | Encapsulated cells to elicit immune responses |
| JP4571776B2 (ja) * | 2002-11-05 | 2010-10-27 | Jx日鉱日石エネルギー株式会社 | 潤滑油組成物 |
| EP1897552B1 (en) | 2003-04-18 | 2009-06-17 | Biogen Idec MA Inc. | Polymer-conjugated glycosylated neublastin |
| AU2004245175C1 (en) * | 2003-06-10 | 2010-03-18 | Biogen Ma Inc. | Improved secretion of neublastin |
| US7927599B2 (en) | 2003-09-08 | 2011-04-19 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| US7897384B2 (en) * | 2003-09-08 | 2011-03-01 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| US8257963B2 (en) | 2007-06-01 | 2012-09-04 | Depuy Mitek, Inc. | Chondrocyte container and method of use |
| US7598059B2 (en) * | 2003-10-02 | 2009-10-06 | Biogen Idec Ma Inc. | Neublastin expression constructs |
| CN1897977A (zh) * | 2003-10-20 | 2007-01-17 | Ns基因公司 | 帕金森氏病的体内基因治疗 |
| AU2004283053A1 (en) | 2003-10-20 | 2005-05-06 | Nsgene A/S | In vivo gene therapy of Parkinson's Disease |
| AU2005229434B2 (en) | 2004-03-30 | 2010-09-30 | Nsgene A/S | Therapeutic use of a growth factor, NsG33 |
| DK1786454T3 (da) * | 2004-08-19 | 2010-09-06 | Biogen Idec Inc | Neublastinvarianter |
| CN101043899B (zh) | 2004-08-19 | 2011-03-30 | 比奥根艾迪克Ma公司 | 重折叠转化型生长因子beta家族蛋白 |
| US8088567B2 (en) * | 2005-04-01 | 2012-01-03 | Nsgene A/S | Human immortalised neural precursor cell line |
| WO2006122551A2 (en) * | 2005-05-17 | 2006-11-23 | Nsgene A/S | An implantable therapy system for treating a living being with an active factor |
| WO2007042040A2 (en) * | 2005-10-11 | 2007-04-19 | Ns Gene A/S | TREATMENT OF RETINOPATHIES USING GFRα3 AGONISTS |
| AU2006308312A1 (en) * | 2005-10-28 | 2007-05-03 | Nsgene A/S | Implantable Biocompatible Immunoisolatory Vehicle for Delivery of GDNF |
| EP1971288B1 (en) * | 2005-12-30 | 2013-02-13 | Neurotech USA, Inc. | Micronized device for the delivery of biologically active molecules and methods of use thereof |
| TWI501774B (zh) | 2006-02-27 | 2015-10-01 | Biogen Idec Inc | 神經性病症之治療 |
| US20100056440A1 (en) * | 2006-03-01 | 2010-03-04 | Biogen Idec Ma Inc. | Compositions and methods for administering gdnf ligand family proteins |
| TWI445544B (zh) | 2007-05-01 | 2014-07-21 | Biogen Idec Inc | 增進血管形成之組合物及方法 |
| US20110135648A1 (en) * | 2007-08-08 | 2011-06-09 | Biogen Idec Ma Inc. | Anti-neublastin antibodies and uses thereof |
| US20090196854A1 (en) * | 2008-02-04 | 2009-08-06 | Kytos Biosystems S.A. | Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery |
| US8075537B2 (en) * | 2008-08-15 | 2011-12-13 | Oxyband Technologies, Inc. | Multiple cell therapeutic diffusion device |
| CA2750027C (en) | 2009-01-23 | 2020-11-10 | Nsgene A/S | Improved cell lines and their use in encapsulated cell biodelivery |
| WO2010083842A2 (en) | 2009-01-23 | 2010-07-29 | Nsgene A/S | Expression of neuropeptides in mammalian cells |
| US20150024024A1 (en) * | 2009-04-23 | 2015-01-22 | Neurotech Usa, Inc. | Cell Lines That Produce Prostaglandin F2 Alpha (PGF2A) And Uses Thereof |
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| US8877489B2 (en) | 2011-12-05 | 2014-11-04 | California Institute Of Technology | Ultrathin parylene-C semipermeable membranes for biomedical applications |
| WO2012149468A2 (en) | 2011-04-29 | 2012-11-01 | University Of Southern California | Instruments and methods for the implantation of cell-seeded substrates |
| CN110777124A (zh) | 2011-10-27 | 2020-02-11 | 威尔斯达眼科制剂公司 | 编码视杆细胞来源的视锥细胞活力因子的载体 |
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| EP3043836B1 (en) * | 2013-09-11 | 2023-05-10 | Neurotech USA, Inc. | Encapsulated cell therapy cartridge |
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| JP7523622B2 (ja) * | 2021-10-28 | 2024-07-26 | ヴィアサイト インコーポレイテッド | 埋め込み可能な封入デバイスと共に使用するツールおよび器具 |
| KR20240118796A (ko) | 2021-12-10 | 2024-08-05 | 호바 세라퓨틱스 에이피에스 | 침해수용성 통증의 치료 |
| CN121285568A (zh) | 2023-03-30 | 2026-01-06 | 制药五有限责任公司 | 编码视杆细胞源性视锥细胞活力因子和人IgK信号序列的载体 |
| WO2026072752A1 (en) | 2024-09-27 | 2026-04-02 | Pharma Cinq, Llc | Rod-derived cone viability factor fusion protein |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106627A (en) | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
| US5156844A (en) | 1987-11-17 | 1992-10-20 | Brown University Research Foundation | Neurological therapy system |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
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-
2000
- 2000-04-05 US US09/543,119 patent/US6361771B1/en not_active Expired - Lifetime
- 2000-04-06 AT AT00923144T patent/ATE269715T1/de active
- 2000-04-06 DK DK00923144T patent/DK1171573T3/da active
- 2000-04-06 CA CA2365532A patent/CA2365532C/en not_active Expired - Lifetime
- 2000-04-06 JP JP2000609543A patent/JP4954374B2/ja not_active Expired - Lifetime
- 2000-04-06 EP EP00923144A patent/EP1171573B1/en not_active Expired - Lifetime
- 2000-04-06 AU AU43319/00A patent/AU773387B2/en not_active Expired
- 2000-04-06 ES ES00923144T patent/ES2219335T3/es not_active Expired - Lifetime
- 2000-04-06 WO PCT/US2000/009150 patent/WO2000060051A2/en not_active Ceased
- 2000-04-06 US US09/958,040 patent/US7115257B1/en not_active Expired - Lifetime
- 2000-04-06 BR BRPI0009562-1A patent/BR0009562A/pt not_active IP Right Cessation
- 2000-04-06 DE DE60011761T patent/DE60011761T2/de not_active Expired - Lifetime
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2001
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Also Published As
| Publication number | Publication date |
|---|---|
| BR0009562A (pt) | 2007-05-29 |
| DK1171573T3 (da) | 2004-09-27 |
| ATE269715T1 (de) | 2004-07-15 |
| AU4331900A (en) | 2000-10-23 |
| AU773387B2 (en) | 2004-05-27 |
| WO2000060051A2 (en) | 2000-10-12 |
| DE60011761D1 (de) | 2004-07-29 |
| ES2219335T3 (es) | 2004-12-01 |
| WO2000060051A8 (en) | 2001-04-05 |
| US7115257B1 (en) | 2006-10-03 |
| NO20014856D0 (no) | 2001-10-05 |
| JP2003524621A (ja) | 2003-08-19 |
| WO2000060051A3 (en) | 2002-03-28 |
| JP2011074079A (ja) | 2011-04-14 |
| EP1171573B1 (en) | 2004-06-23 |
| EP1171573A1 (en) | 2002-01-16 |
| DE60011761T2 (de) | 2005-08-04 |
| CA2365532A1 (en) | 2000-10-12 |
| CA2365532C (en) | 2012-11-06 |
| US6361771B1 (en) | 2002-03-26 |
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