JP4950927B2 - 生乾き臭判定用指標物質 - Google Patents
生乾き臭判定用指標物質 Download PDFInfo
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- JP4950927B2 JP4950927B2 JP2008090845A JP2008090845A JP4950927B2 JP 4950927 B2 JP4950927 B2 JP 4950927B2 JP 2008090845 A JP2008090845 A JP 2008090845A JP 2008090845 A JP2008090845 A JP 2008090845A JP 4950927 B2 JP4950927 B2 JP 4950927B2
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- JP
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- Prior art keywords
- carboxylic acid
- dry odor
- odor
- acid
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000126 substance Substances 0.000 title claims description 41
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims abstract description 95
- 238000000034 method Methods 0.000 claims abstract description 29
- 239000000203 mixture Substances 0.000 claims abstract description 28
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 6
- 125000004429 atom Chemical group 0.000 claims abstract description 5
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims abstract description 3
- 150000001735 carboxylic acids Chemical class 0.000 claims description 7
- -1 aliphatic aldehyde Chemical class 0.000 claims description 5
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- 150000004665 fatty acids Chemical class 0.000 claims description 4
- 238000004088 simulation Methods 0.000 claims 1
- 230000000873 masking effect Effects 0.000 abstract description 4
- 235000019645 odor Nutrition 0.000 description 114
- 150000001875 compounds Chemical class 0.000 description 27
- 239000000047 product Substances 0.000 description 24
- 238000011156 evaluation Methods 0.000 description 21
- FTHUQCQZQRXJLF-HWKANZROSA-N (e)-5-methylhex-2-enoic acid Chemical compound CC(C)C\C=C\C(O)=O FTHUQCQZQRXJLF-HWKANZROSA-N 0.000 description 16
- YJJLHGCCADOOPZ-UHFFFAOYSA-N 5-methylhex-4-enoic acid Chemical class CC(C)=CCCC(O)=O YJJLHGCCADOOPZ-UHFFFAOYSA-N 0.000 description 16
- 239000003153 chemical reaction reagent Substances 0.000 description 14
- 239000004753 textile Substances 0.000 description 12
- 230000001953 sensory effect Effects 0.000 description 10
- 239000002253 acid Substances 0.000 description 8
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 239000000835 fiber Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000003786 synthesis reaction Methods 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000002781 deodorant agent Substances 0.000 description 5
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 150000001408 amides Chemical class 0.000 description 4
- 238000011088 calibration curve Methods 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- FKJSFKCZZIXQIP-UHFFFAOYSA-N 2-bromo-1-(4-bromophenyl)ethanone Chemical compound BrCC(=O)C1=CC=C(Br)C=C1 FKJSFKCZZIXQIP-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 238000004817 gas chromatography Methods 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 210000004243 sweat Anatomy 0.000 description 3
- NIONDZDPPYHYKY-SNAWJCMRSA-N (2E)-hexenoic acid Chemical compound CCC\C=C\C(O)=O NIONDZDPPYHYKY-SNAWJCMRSA-N 0.000 description 2
- QDYRHGGXBLRFHS-SNAWJCMRSA-N (e)-4-methylhex-2-enoic acid Chemical compound CCC(C)\C=C\C(O)=O QDYRHGGXBLRFHS-SNAWJCMRSA-N 0.000 description 2
- VKWJULLMBKNPEC-GQCTYLIASA-N (e)-4-methylhex-3-enoic acid Chemical compound CC\C(C)=C\CC(O)=O VKWJULLMBKNPEC-GQCTYLIASA-N 0.000 description 2
- CIBMDQOEVWDTDT-ONEGZZNKSA-N (e)-5-methylhex-3-enoic acid Chemical compound CC(C)\C=C\CC(O)=O CIBMDQOEVWDTDT-ONEGZZNKSA-N 0.000 description 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 2
- MBDOYVRWFFCFHM-UHFFFAOYSA-N 2-hexenal Chemical compound CCCC=CC=O MBDOYVRWFFCFHM-UHFFFAOYSA-N 0.000 description 2
- HNVRRHSXBLFLIG-UHFFFAOYSA-N 3-hydroxy-3-methylbut-1-ene Chemical compound CC(C)(O)C=C HNVRRHSXBLFLIG-UHFFFAOYSA-N 0.000 description 2
- YGHRJJRRZDOVPD-UHFFFAOYSA-N 3-methylbutanal Chemical compound CC(C)CC=O YGHRJJRRZDOVPD-UHFFFAOYSA-N 0.000 description 2
- QDYRHGGXBLRFHS-UHFFFAOYSA-N 4-Methyl-2-hexenoic acid Natural products CCC(C)C=CC(O)=O QDYRHGGXBLRFHS-UHFFFAOYSA-N 0.000 description 2
- HZAAQSZZIYJZKF-UHFFFAOYSA-N 4-methylhex-4-enoic acid Chemical compound CC=C(C)CCC(O)=O HZAAQSZZIYJZKF-UHFFFAOYSA-N 0.000 description 2
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- YWHLKYXPLRWGSE-UHFFFAOYSA-N Dimethyl trisulfide Chemical compound CSSSC YWHLKYXPLRWGSE-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- YKFRUJSEPGHZFJ-UHFFFAOYSA-N N-trimethylsilylimidazole Chemical compound C[Si](C)(C)N1C=CN=C1 YKFRUJSEPGHZFJ-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 235000002597 Solanum melongena Nutrition 0.000 description 2
- 230000010933 acylation Effects 0.000 description 2
- 238000005917 acylation reaction Methods 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 150000001805 chlorine compounds Chemical class 0.000 description 2
- 239000012459 cleaning agent Substances 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 2
- MMFCJPPRCYDLLZ-UHFFFAOYSA-N dec-2-enal Chemical compound CCCCCCCC=CC=O MMFCJPPRCYDLLZ-UHFFFAOYSA-N 0.000 description 2
- KSMVZQYAVGTKIV-UHFFFAOYSA-N decanal Chemical compound CCCCCCCCCC=O KSMVZQYAVGTKIV-UHFFFAOYSA-N 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000004332 deodorization Methods 0.000 description 2
- 230000001877 deodorizing effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
- WQOXQRCZOLPYPM-UHFFFAOYSA-N dimethyl disulfide Chemical compound CSSC WQOXQRCZOLPYPM-UHFFFAOYSA-N 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- SSNZFFBDIMUILS-UHFFFAOYSA-N dodec-2-enal Chemical compound CCCCCCCCCC=CC=O SSNZFFBDIMUILS-UHFFFAOYSA-N 0.000 description 2
- HFJRKMMYBMWEAD-UHFFFAOYSA-N dodecanal Chemical compound CCCCCCCCCCCC=O HFJRKMMYBMWEAD-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- UVECLJDRPFNRRQ-UHFFFAOYSA-N ethyl trifluoromethanesulfonate Chemical compound CCOS(=O)(=O)C(F)(F)F UVECLJDRPFNRRQ-UHFFFAOYSA-N 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- NDFKTBCGKNOHPJ-UHFFFAOYSA-N hept-2-enal Chemical compound CCCCC=CC=O NDFKTBCGKNOHPJ-UHFFFAOYSA-N 0.000 description 2
- FXHGMKSSBGDXIY-UHFFFAOYSA-N heptanal Chemical compound CCCCCCC=O FXHGMKSSBGDXIY-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- JARKCYVAAOWBJS-UHFFFAOYSA-N hexanal Chemical compound CCCCCC=O JARKCYVAAOWBJS-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 150000004667 medium chain fatty acids Chemical class 0.000 description 2
- CPHCIYGRSFZNRD-UHFFFAOYSA-N n-methyl-1-(4,5,6,7-tetrahydro-1h-indazol-3-yl)methanamine Chemical compound C1CCCC2=C1NN=C2CNC CPHCIYGRSFZNRD-UHFFFAOYSA-N 0.000 description 2
- GYHFUZHODSMOHU-UHFFFAOYSA-N nonanal Chemical compound CCCCCCCCC=O GYHFUZHODSMOHU-UHFFFAOYSA-N 0.000 description 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 2
- NUJGJRNETVAIRJ-UHFFFAOYSA-N octanal Chemical compound CCCCCCCC=O NUJGJRNETVAIRJ-UHFFFAOYSA-N 0.000 description 2
- 239000012044 organic layer Substances 0.000 description 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 2
- LIGACIXOYTUXAW-UHFFFAOYSA-N phenacyl bromide Chemical compound BrCC(=O)C1=CC=CC=C1 LIGACIXOYTUXAW-UHFFFAOYSA-N 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- UHUFTBALEZWWIH-UHFFFAOYSA-N tetradecanal Chemical compound CCCCCCCCCCCCCC=O UHUFTBALEZWWIH-UHFFFAOYSA-N 0.000 description 2
- NIDHFQDUBOVBKZ-NSCUHMNNSA-N trans-hex-4-enoic acid Chemical compound C\C=C\CCC(O)=O NIDHFQDUBOVBKZ-NSCUHMNNSA-N 0.000 description 2
- BGEHHAVMRVXCGR-UHFFFAOYSA-N tridecanal Chemical compound CCCCCCCCCCCCC=O BGEHHAVMRVXCGR-UHFFFAOYSA-N 0.000 description 2
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 2
- KMPQYAYAQWNLME-UHFFFAOYSA-N undecanal Chemical compound CCCCCCCCCCC=O KMPQYAYAQWNLME-UHFFFAOYSA-N 0.000 description 2
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- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
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- NDQXKKFRNOPRDW-UHFFFAOYSA-N 1,1,1-triethoxyethane Chemical compound CCOC(C)(OCC)OCC NDQXKKFRNOPRDW-UHFFFAOYSA-N 0.000 description 1
- ORHBGEQYIZTYHV-UHFFFAOYSA-N 1,1-di(propan-2-yl)urea Chemical compound CC(C)N(C(C)C)C(N)=O ORHBGEQYIZTYHV-UHFFFAOYSA-N 0.000 description 1
- GAYYMNBUXYCNSL-UHFFFAOYSA-N 1-(chloromethyl)indole-2,3-dione Chemical compound C1=CC=C2N(CCl)C(=O)C(=O)C2=C1 GAYYMNBUXYCNSL-UHFFFAOYSA-N 0.000 description 1
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- CTENSLORRMFPDH-UHFFFAOYSA-N 4-(bromomethyl)-7-methoxychromen-2-one Chemical compound BrCC1=CC(=O)OC2=CC(OC)=CC=C21 CTENSLORRMFPDH-UHFFFAOYSA-N 0.000 description 1
- KFXPOIKSDYRVKS-ONEGZZNKSA-N 4-Heptenoic acid Chemical compound CC\C=C\CCC(O)=O KFXPOIKSDYRVKS-ONEGZZNKSA-N 0.000 description 1
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- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Description
i)カルボン酸(1)のカルボキシ基に直接発色団を導入する方法
ii)カルボン酸(1)を誘導体に変換した後、誘導体に発色団を導入する方法
iii)カルボン酸(1)を分解した後、分解物に発色団を導入する方法
等が挙げられる。
強く生乾き臭(部屋干し臭)を発するジーンズ100gを裁断し、ジクロロメタンによりニオイ成分を抽出、濃縮した。続いてアルカリ水溶液を用いた酸―塩基抽出法により酸性成分のみ選択的に抽出、濃縮し、生乾き臭のキー成分の濃縮を行った。更に、ニオイ嗅ぎガスクロマトグラフィー(sniffing GC)を用いた専門評価者による評価によって生乾き臭のキーとなる成分のGC保持時間を特定した。今回sniffing GCにより評価した特徴的な生乾き臭を有するキー成分は非常に閾値が低い化合物であり、検出器においてはピークとして確認できない微量成分であった。
そのためその化合物の保持時間周辺をGestel社製 Preparative Fraction Collector(PFC)装置を用いて重点的に濃縮した後、得られたニオイ濃縮物をガスクロマトグラフィー−質量分析計(GC-MS)を用いて解析した。解析の結果、常法では検出できなかった化合物ピークが見られた。
これらの微量溶出成分のうちいくつかはニオイ嗅ぎガスクロマトグラフィーにおいて生乾き臭、部屋干し臭に極めて良く似た強いニオイを持っていた。これらの不明ピークはGC-MSの一般的なライブラリには無い化合物であり、マスフラグメント、GC保持時間から不明成分を類推し化学合成を重ねた結果、それらの不明ピークは5-メチル-2-ヘキセン酸、及び5-メチル-4-ヘキセン酸であることがわかった。
5-メチル-2-ヘキセン酸、5-メチル-4-ヘキセン酸は、衣類のニオイの構成成分としては今まで報告されたことがないが、今回検出したサンプル衣類からは各部位で検出された。
次に生乾き臭を持たない衣類に関しても同様な匂い抽出操作を行い、匂い成分を抽出しGC-MS分析を行ったところ、5-メチル-2-ヘキセン酸、5-メチル-4-ヘキセン酸は検出されなかった。
D. J. Schauer, Paul Helquist; Synthesis, 21, 3654-3660, (2006)に記載された方法に準じ、5-メチル-2-ヘキセン酸を合成した。
窒素雰囲気下、3口フラスコにトリフルオロメタンスルホン酸亜鉛(和光純薬工業)2.4g、(ジエトキシホスフィノイル)酢酸(和光純薬工業)0.48mL、N,N,N',N'―テトラメチルエチレンジアミン(和光純薬工業)0.5mL、1,8-ジアザビシクロ[5.4.0]ウンデカ-7-エン(DBU)(和光純薬工業)1.79mL及び無水THF(和光純薬)25mLを加えた。その後、イソバレルアルデヒド(東京化成工業)0.35mLを滴下しながら加え、20時間攪拌した。その後1N塩酸で反応を終了させ、ジクロロメタン50mL×2で抽出し、水50mL×2で洗浄し、硫酸マグネシウムで乾燥した後、溶剤を留去し、5-メチル-2-ヘキセン酸0.42g(収率99%)を得た。
得られた化合物は生臭く、アニマリックな臭いを有し、衣類の生乾きの匂いに酷似していた。
S. Menon et al, Tetrahedron, 63, 8788-8793, (2007)に記載された方法に準じ、5-メチル-4-ヘキセン酸を合成した。
ナスフラスコに冷却管を取り付け、そこに2-メチル-3-ブテン-2-オール(和光純薬工業)1.82mL、オルト酢酸トリエチル(Aldrich)29.8mL及び2-ニトロフェノール(東京化成工業)0.16gを加え、36時間加熱還流した。室温に戻した後、メタノール:水=1:1の混合液25mLを加え、5N塩酸で酸性にした。その後ジエチルエーテル100mLで抽出し、水100mLで洗浄後、有機層溶液を減圧濃縮した。
次に、濃縮した有機層を、冷却管を取り付けたナスフラスコに移し、水酸化ナトリウム1.25g、エタノール30mL及び水5.5mLを加え、24時間加熱還流した。得られた溶液を室温に戻し、5N塩酸で酸性にした後、ジエチルエーテル100mLで抽出、水100mLで洗浄の後に硫酸マグネシウムにて乾燥を行った。溶液を減圧留去し、5-メチル-4-ヘキセン酸を1.67g(収率67%)得た。
得られた化合物は汗様の酸臭と共に、シナモンのような甘さを有していた。更に低濃度においては生乾きの匂いを髣髴とさせるトーンが感じられた。
他の分岐不飽和脂肪酸について合成を行った。
5-メチル-3-ヘキセン酸をWO2006/083030A1中の記述を基に合成し、5-メチル-5-ヘキセン酸をBull. Chem. Doc. Jpn, 80(8), 1597-1604, (2007)の記載に従って合成した。また合成例1若しくは2、又は上記と同様な方法により、4-メチル-2-ヘキセン酸、4-メチル-3-ヘキセン酸、4-メチル-4-ヘキセン酸、4-メチル-5-ヘキセン酸を合成した。
それぞれの化合物のニオイについて、専門評価者による官能評価を行った。結果を表1に示す。
表2に示す擬似生乾き臭(部屋干し臭)組成物を調製し、下記の評価方法に基づいて官能評価を行った。表2中の各成分の含有量は質量%である。
(評価方法)
室温(25℃)、湿度65%の環境に保たれた室内にて、5×5cmの未使用のタオル(木綿製)に、各擬似生乾き臭組成物をイオン交換水にて1000倍に希釈したものを0.1mL塗布した。このタオルのニオイがどの程度生乾き臭に近いかについて、4人の専門評価者によって、10段階の官能評価(10:非常に生乾き的なニオイ〜1:生乾きのニオイではない)を行い、その平均値を表2に示した。
Claims (6)
- 請求項1記載のカルボン酸又はその誘導体を指標とする生乾き臭判定方法。
- (A)請求項1記載のカルボン酸を含有する擬似生乾き臭組成物。
- 更に、(B)炭素数2〜5の低級脂肪酸を含有する請求項3記載の擬似生乾き臭組成物。
- 更に、(C)炭素数6〜14の脂肪族アルデヒドを含有する請求項3又は4記載の擬似生乾き臭組成物。
- 更に、(D)炭素数6〜12の飽和脂肪酸を含有する請求項3〜5のいずれかに記載の擬似生乾き臭組成物。
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