JP4942307B2 - Animal mineral supplements - Google Patents

Description

  The present invention relates to an animal mineral supplement. More specifically, the present invention relates to an animal mineral supplement mainly composed of a magnesium hydroxide-based solid solution in which trace minerals-iron, zinc, copper and manganese- and ultratrace minerals-chromium, cobalt, nickel- are dissolved.

  Recent advances in inorganic biochemistry have revealed that trace metals are deeply involved in animal health and disease. The essential trace metals for animals are Fe, Zn, Cu and Mn with a daily intake requirement of about 1 to 10 mg, and the required intake is about 1 digit less than that (ultra-trace metal-Se (selenium)) , I (iodine), Mo (molybdenum), Cr (chromium), Co (cobalt)-etc. In order to ingest these essential trace minerals from their respective required foods, a large number of ingredients must be balanced. However, the current life of ordinary people has become busy, and many people are unable to satisfy the above conditions, so various mineral preparations are sold as dietary supplements. Zinc oxide, cupric oxide, sodium iron citrate, ferrous gluconate, manganese carbonate, zinc, manganese, selenium, copper, chromium and molybdenum yeast, etc. Various minerals as described above It is common to mix a portion with minerals such as calcium carbonate, magnesium carbonate, and dolomite that are needed in a relatively large amount, mix with excipients such as microcrystalline cellulose, mold into tablets, and take 2-4 g per day Has been done.

  Trace metals have a drawback that they are generally poor in absorptivity, while essential minerals -Ca and Mg-, which are required in relatively large amounts, have good absorptivity. There is an optimum amount of trace amount to ultra-trace amount mineral required individually for one day, and if it is less than that amount, various deficiencies are generated, and conversely, if it is too much, various excess diseases are generated. Therefore, it is necessary to accurately mix and homogenize about 10 kinds of minerals in about 400 mg to 3 g per tablet, and the production is complicated. In addition, there is a problem that precision is required and cost is increased.

  The present invention provides (a) the following formula (1)

（但し、式中、Ｍ ₁ はＣｒ^３＋，Ｃｏ^２＋ ，Ｎｉ^２＋の少なくとも１種以上を示し、ｘ_１〜ｘ₄，ｘ，ｙおよびｚはそれぞれ次の範囲にある、０＜ｘ_１＜０．１、好ましくは０．００６≦ｘ_１≦０．０４，０＜ｘ₂＜０．２、好ましくは０．００７≦ｘ₂≦０．０５，０＜ｘ₃＜０．０２、好ましくは０．００１≦ｘ₃≦０．００９，０＜ｘ₄＜０．０４、好ましくは０．００２≦ｘ₄≦０．０２，０＜ｘ＜０．１５、好ましくは０．０１≦ｘ≦０．１、特に好ましくは０．０２≦ｘ≦０．０８，ｘ_１＋ｘ₂＋ｘ₃＋ｘ₄＝ｘ，０≦ｙ≦０．００４、好ましくは０．０００２≦ｙ≦０．００４，０≦ｚ＜０．０５）で表される水酸化マグネシウム系固溶体、または該固溶体に（ｂ）セレン、ヨウ素、モリブデン含有化合の少なくとも１種以上を吸着または均一混合した物を有効成分として含有する動物用ミネラル補給剤を提供する。

(Wherein, M ₁ is ^{Cr 3+, Co} 2 +, indicates at least one or more kinds of ^{_{N i 2+, x 1 ~x 4}} , x, y and z are each in the following range, 0 _{<x 1} <0.1, preferably 0.006 ≦ x ₁ ≦ 0.04, 0 <x ₂ <0.2, preferably 0.007 ≦ x ₂ ≦ 0.05, 0 <x ₃ <0.02, preferably 0.001 ≦ x ₃ ≦ 0.009, 0 <x ₄ <0.04, preferably 0.002 ≦ x ₄ ≦ 0.02, 0 <x <0.15, preferably 0.01 ≦ x ≦ 0.1, particularly preferably 0.02 ≦ x ≦ 0.08, x ₁ + x ₂ + x ₃ + x ₄ = x , 0 ≦ y ≦ 0.004 , preferably 0.0002 ≦ y ≦ 0.004 , 0 ≦ z <0.05) or a magnesium hydroxide-based solid solution represented by z <0.05) or (b) a compound containing less selenium, iodine and molybdenum. It provides an animal for mineral supplement containing those also adsorbed or uniformly mixing one or more as an active ingredient.

  According to the present invention, it is possible to improve the absorbability of trace minerals and ultratrace minerals that are generally poorly absorbable, and greatly improve the bowel movement. Furthermore, most of the essential trace and ultra trace minerals can be dispersed in the magnesium hydroxide crystals at the respective required optimum amounts at the molecular level, omitting the formulation process including complicated weighing and difficult mixing or It can be simplified.

The mineral supplement represented by the formula (1) of the present invention is a so-called solid solution in which essential minerals are dispersed atomically in magnesium hydroxide crystals, and the X-ray diffraction pattern is a substance that shows only magnesium hydroxide. is there. The trace amount and the ultra-trace amount mineral each have a necessary amount per day, and it is preferable that each mineral is dissolved in an appropriate range. _Thus, x 1 ~x _4, a preferred range of x and y is _{0.006 ≦ x 1 ≦ 0.04,0.007 ≦ x} 2 ≦ 0.05,0.001 ≦ x 3 ≦ 0.009,0. 002 ≦ x ₄ ≦ 0.02, 0.01 ≦ x ≦ 0.1, 0.90 ≦ 1-xyz ≦ 0.99, 0.0002 ≦ y ≦ 0.004. Moreover, the preferable range of the total molar amount of selenium, iodine, and molybdenum adsorbed or uniformly mixed in the solid solution of the formula (1) is 0.0002 to 0.004 with respect to 1 mol of the solid solution of the formula (1). Is a mole.

  Examples of the selenium, iodine and molybdenum-containing compound used in the present invention include sodium selenite, sodium selenite, selenium yeast, potassium iodide, sodium iodide, sodium molybdate, ammonium molybdate and the like.

A preferable typical composition of the solid solution (component a) of the formula (1) of the mineral supplement of the present invention is as follows.
Mg _0.97 Fe _0.011 Zn _0.014 Cu _0.002 Mn _0.004 Cr _0.00007 (OH) ₂
Mg _0.94 Fe _0.02 Zn _0.026 Cu _0.0046 Mn _0.008 Cr _0.0001 (OH) ₂
As a preferred composition of the present invention, all of selenium, iodine and molybdenum in the above components are 0.01 mol or less, preferably 0.0002 mol to 0.004 mol, relative to 1 mol of the solid solution of the formula (1). In other words, about 1 mg or less of component (b) is added.

  The production of the magnesium hydroxide solid solution of the formula (1) used in the present invention comprises an aqueous solution of chlorides, nitrates, sulfates and the like of each mineral prepared at a target molar ratio, and sodium hydroxide equivalent to or more than this. It can implement by the method of coprecipitation using alkaline aqueous solution, such as. After the coprecipitation reaction, it can be produced by appropriately selecting steps such as filtration, washing with water, drying, and pulverization.

  A preferred method for adding the component (b) is to apply a drying method such as spray drying or freeze drying after addition and adsorption to the solid solution slurry of the formula (1) after washing with water. By this method, the component (b) can be uniformly adsorbed or mixed with the component (a). In particular, spray drying is preferable, and fluid powder can be obtained by this method and can be directly molded into a tablet.

  Since the mineral supplement of the present invention is mainly composed of magnesium hydroxide, it has the added value of improving bowel movement.

  In addition to the components (a) and (b), the mineral supplement of the present invention is calcium carbonate, calcium citrate, calcium malate, calcium citric acid and malic acid double salt, etc. in order to further supplement calcium. A mixture of compounds can also be used. The amount of these calcium compounds added is 10 to 300%, preferably 50 to 200%, based on the weight of component (a).

  Hereinafter, the present invention will be described in more detail based on examples.

Mixed aqueous solution of magnesium chloride, ferrous sulfate, zinc chloride, cupric nitrate, manganese (II) nitrate and chromium trichloride (Mg = 1.944 mol / liter, Fe ²⁺ = 0.019 mol / liter, Zn = 0.024 mol / liter, Cu ²⁺ = 0.0042 mol / liter, Mn ²⁺ = 0.0074 mol / liter, Cr ³⁺ = 0.0002 mol / liter) and 4 mol / liter sodium hydroxide aqueous solution respectively. Supply to a reaction tank with overflow of 2 liters by a metering pump at a flow rate of 100 ml / min (previously put about 500 cc of water), and adjust pH of sodium hydroxide to 10.0 to 10.4. (Temperature: 30 to 31 ° C.) was used for coprecipitation reaction. The obtained slurry was filtered, washed with water, redispersed in water, and dried using a spray dryer at an inlet temperature of about 200 ° C. and an outlet temperature of about 80 ° C. This powder had good fluidity and could be directly compressed. X-ray diffraction of this dry powder showed a diffraction pattern of magnesium hydroxide only. Therefore, each mineral is dissolved in the magnesium hydroxide crystal. After the dried product was dissolved in hydrochloric acid, elemental analysis was performed with 1CP, and the composition was examined. The results were as follows. Mg _0.9726 Fe _0.0095 Zn _0.012 Cu _0.0021 Mn _0.0037 Cr _0.0001 (OH) ₂ . When the content of each mineral per 1 g of this powder is expressed by weight, Mg = 392 mg (200 to 700 mg), Fe = 9 mg (8 to 12 mg), Zn = 13 mg (12 to 18 mg), Cu = 2.3 mg (2.2 ˜2.8 mg), Mn = 3.4 mg (3-5 mg), Cr = 0.05 mg (0.06-0.1 mg). The parentheses indicate the daily intake required for adults.

In Example 1, the following mineral mixed aqueous solution: Magnesium chloride, ferrous sulfate, zinc nitrate, cupric sulfate, manganese (II) chloride, chromium trichloride and cobaltous nitrate mixed aqueous solution (Mg ²⁺ = 1.84 mol / liter, Fe ²⁺ = 0.054 mol / liter, Zn = 0.068 mol / liter, Cu ²⁺ = 0.011 mol / liter, Mn ²⁺ = 0.02 mol / liter, Cr ³⁺ = 0.0003 mol / liter, Co ²⁺ = 0.0003 mol / liter). The X-ray diffraction pattern of the dried product was only magnesium hydroxide. The chemical composition was as follows: _{Mg 0.922 Fe 0.0267 Zn 0.0342 Cu 0.0058} Mn 0.0109 Cr 0.0001 Co 0.0001 (OH) 2. The content of each mineral per 1 g of this powder is Mg = 360 mg, Fe = 24 mg, Zn = 36 mg, Cu = 6 mg, Mn = 10 mg, Cr = 0.05 mg, Co = 0.05 mg. This amount corresponds to the amount of mineral required for approximately two days in an adult.

The cake before drying obtained in Example 1 was uniformly dispersed in water with a homomixer to prepare 10 liters of a slurry having a magnesium hydroxide solid solution concentration of about 200 g / liter. A solution prepared by dissolving 392 mg of sodium selenate (NaSeO ₄ ), 394 mg of potassium iodide, and 50 mg of molybdic acid (K ₂ MoO ₄ ) in 500 ml of water in advance was added to this slurry with stirring, and the mixture was stirred for about 20 minutes. This slurry was dried using a spray dryer at an inlet temperature of 200 ° C. and an outlet temperature of 80 ° C. As a result of the analysis of the dried product, the kind and amount of the mineral shown in Example 1 are not substantially changed, and in addition, Se = 0.07 mg, iodine (I) = 0.15 mg, and Mo = 0.01 mg are contained. It was.

In Example 3, the magnesium hydroxide solid solution slurry obtained in Example 2 was used in place of the magnesium hydroxide solid solution obtained in Example 1, and a BET specific surface area of 2.6 m ² / s together with selenium, iodine and molybdenum. After adding 1,400 g of g of particulate precipitated calcium carbonate, stirring sufficiently, and homogenizing, spray drying was performed in the same manner as in Example 3. The dried product has good fluidity and can be formed into a tablet as it is. The mineral content per gram of the dried product is Ca = 410 mg, Mg = 210 mg, Fe = 14 mg, Zn = 21 mg, Cu = 3 mg, Mn = 6 mg, Cr = 0.03 mg, Co = 0.03 mg, Se = 0.04 mg. , Iodine (I) = 0.09 mg, Mo = 0.006 mg.

And [Comparative Examples 1 to 4]
[Acid Solubility Test] The absorbability of each mineral by an animal is considered to depend on the solubility by gastric acid. Since the ideal gastric pH is 3-5, the solubility of minerals at pH 4 was evaluated using a pH stat. Using a pH stat (manufactured by Toa Denpa), 0.1 mol / liter (0.1 mol / l) consumed to maintain pH at 4 by adding 0.1 g of sample to 100 ml of water kept at 37 ° C., which is the same as human body temperature. The amount (ml) of hydrochloric acid (approximately equivalent to the concentration of gastric acid) was measured over time. Samples were magnesium hydroxide solid solutions obtained in Examples 1 and 2 [Examples 5 and 6], zinc oxide (first grade reagent) [Comparative Example 1], cupric oxide (first grade reagent) [Comparative Example 2], Manganese carbonate (first grade reagent) [Comparative Example 3] and diiron hydroxide [Comparative Example 4] were used, respectively. The evaluation results are shown in FIG. In FIG. 1, since the consumption of hydrochloric acid corresponds to the dissolution of the sample, it means that the more the consumption of hydrochloric acid is consumed in a short time, the higher the solubility of the sample.

  As is apparent from FIG. 1, the mineral supplement of the present invention dissolves well even at pH 4. However, zinc oxide, which is often used as a conventional mineral supplement, dissolves a little, but cupric oxide or manganese carbonate hardly dissolves.

  As a result of taking 1 g of the mineral supplement of the present invention obtained in Example 1 every day for 3 weeks by three constipation women, bowel movements were observed every day from the 2nd to 4th days.

  As a result of having an 80-90% gray hair male (50s) take the mineral supplement of the present invention obtained in Example 1 every day for 500 months for 2 months, black hair has increased since about one month. Was observed.

The pH stat test results are shown. Set pH = 4, Temperature 37 ° C. Vertical axis: 0.1 m / l of hydrochloric acid consumed to maintain pH at 4 (ml) Horizontal axis: Elapsed time (min)

Claims (6)

Following formula (1)

(Wherein, _{M 1} is Cr ^{3+, Co 2} +, it indicates at least one or more kinds of _{^{N i 2+, x 1, x}} 2, x 3, x 4, x, y and z satisfy the following conditions _{to, x 1 + x 2 + x} 3 + x 4 = x, 0 <x 1 <0.1,0 <x 2 <0.2,0 <x 3 <0.02,0 <x 4 <0.04,0 <X <0.15, 0 <= y <= 0.004 , 0 <= z <0.05) The mineral supplement for animals which contains the magnesium hydroxide type | system | group solid solution represented by an active ingredient as an active ingredient. Se (selenium), I (iodine) selected from the group consisting of sodium selenite, selenium yeast, potassium iodide, sodium iodide, sodium molybdate, ammonium molybdate and 1 mol of the solid solution of formula (1) Mo (molybdenum) in small without even the amount of one or more ultra-trace minerals M ₂ 0.01 mol of the compound, veterinary mineral supplement of claim 1 which has been adsorbed or uniformly mixed. In formula (1), x ₁ , x ₂ , x ₃ , x ₄ and x are in the following ranges, 0.006 ≦ x ≦ 0.04, 0.007 ≦ x ₂ ≦ 0.05, 0.001 ≦ x The animal mineral supplement according to claim 1, wherein ₃ ≤ 0.009, 0.002 ≤ x ₄ ≤ 0.02, 0.01 ≤ x ≤ 0.1. In the formula _(1), x 1 with respect to x, x _2, x _3, the ratio of x _{4, respectively, x 1 / x = 0.35 ±} 0.1, x 2 / x = 0.44 ± 0.1, _{x 3 / x = 0.077 ± 0.016} , veterinary mineral supplement according to claim 1, characterized in that the _{x 4 / x = 0.136 ± 0.027} . 10 to 300% of at least one selected from calcium carbonate, calcium citrate, calcium malate and complex calcium salt of citric acid and malic acid is mixed with the solid solution of formula (1) or the mixture of claim 2 The animal mineral supplement according to claim 1 or 2 . Following formula (1)

(In the formula, M ₁ represents at least _one of Cr ³⁺ , Co ²⁺ and Ni ²⁺ , and x ₁ , x ₂ , x ₃ , x ₄ , x, y and z satisfy the following conditions: _{x 1 + x 2 + x 3} + x 4 = x, 0 <x 1 <0.1,0 <x 2 <0.2,0 <x 3 <0.02,0 <x 4 <0.04,0 <x <0.15, 0 ≦ y ≦ 0.004, 0 ≦ z <0.05), magnesium hydroxide solid solution, sodium selenite, selenium yeast, potassium iodide, sodium iodide, molybdic acid Production of a mineral supplement for animals, wherein one or more of selenium, iodine and molybdenum-containing compounds selected from the group consisting of sodium and ammonium molybdate are mixed in an aqueous medium and then spray-dried or freeze-dried Method.

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