KR880002033B1 - Process for producing zn-fe-cu-methionine ligand complex - Google Patents

Abstract

A method for prepg. metal methionine ligand complex comprises (i) mixing each soln. of zinc (II), iron (II) and copper (II) or their resp. sulfate, chloride, acetate or oxide in the ratio of Zn 10-50%, Fe 1.0-20%, Cu 0.2-20% to form a soln., (ii) adding methionine soln. to the former soln. by the mole ratio of 1:1, (iii) heating for 0.5-3 hr at 60-90 deg.C and at pH 3.0-4.5 until to clear, (iv) adding EtOh to complete rxn. and cool in ambient temp. at pH 5.0-7.0 and (v) filtering and air-drying.

Description

Process for preparing zinc, iron, copper-methionine complex

1 shows the absorption relationship of trace substances in the gastrointestinal tract.

2 shows the interaction between trace minerals.

The present invention relates to a process for preparing zinc, iron, copper-methionine complexes useful as feed additives for livestock or poultry.

Among the 26 essential elements required for the maintenance and activity of living organisms, zinc, iron, copper, manganese, cobalt, and iodine are trace minerals involved in the process of energy and protein use and biochemical synthesis of essential nutrients.

Among them, zinc, iron, copper, etc. occupy an important position in terms of their role in vivo and their needs, and their in vivo activity has been found through many studies.

As shown in the deficiency of zinc, iron, and copper in Table 1, the lack of major minerals in livestock feed impedes significant inhibition in livestock growth, reproduction, and metabolic activity.

[Table 1. Zinc, Iron, Copper Deficiency]

The trace minerals contained in the feed are very stable covalent bonds, which form phyrites, which are insoluble salts (Ca-Mg salts) in cereals during absorption in the body, resulting in very low utilization, unbalanced quantity, and inadequate capacity. Artificial replenishment should prevent the deficiency.

Common sources of trace minerals include metal sulfates (eg ZnSO ₄ , FeSO ₄ , CuSO ₄ , or carbonates (eg ZnCO ₃ , FeCO ₃ , CuCO _3, etc.) and metal oxides (eg CuO, ZnO). It is added to feed or administered as a drug. The body absorption process of these microelements is in the form of primary hydrochloride in the stomach, dissociated in ionic state and absorbed by binding to organic compounds such as amino acids and proteins. It is formed and transferred to the plasma through the mesenteric membrane cells, which is shown in Figure 1.

However, the mutually quantitative imbalance of the supplied minerals causes the high interaction as shown in FIG. 2 and causes the inhibition of absorption.

That is, since most of the mineral supply agent is administered to the body in the form of an inorganic compound, an overdose of any one mineral is an element that occurs when the absorption tertiary complex with an organic compound such as amino acid or protein is in the gastrointestinal tract of at least one mineral. It is due to the competition between the competition. This is illustrated in FIG. 2.

Therefore, in order to perform the treatment quickly and effectively in the manifestation of trace element deficiency symptoms, it is necessary to consider fundamentally to avoid the absorption inhibition by hyperaction. Research on this has continued. However, no satisfactory results have been made. The present inventors have conducted a long study to quickly and effectively carry out the treatment upon the occurrence of trace element deficiency symptoms, and as shown in FIG. 1, if artificially formulated and administered the absorption tar ligand complex, which is a combination of a metal and an organic compound, FIG. The present invention was completed by discovering that the interaction between metals can be avoided as shown in FIG.

Accordingly, an object of the present invention is to provide a zinc, iron, copper-methionine complex in which the deficiency phenomenon of trace minerals is outstanding, and the amount of use of zinc, iron, and copper is generally combined with methionine, which is one of essential amino acids, in ligand form. .

The zinc, iron, and copper-methionine complexes have a form in which each of zinc, copper, and iron ions are bonded to one molecule of amino acid, and the bond is in the form of a ligand, so that other organometallic organic compounds, ie, hydrolyzed proteins or synthetic organics. It is a complex different from metal complexes bound to salts, and moreover, these metal complexes have a dynamical function of rapidly excreting excess metals (especially heavy metals) into the urine when taken, as well as many amino acids before they are absorbed and used in the intestines. Bound to and becomes insoluble.

The zinc, iron, and copper-methionine complexes do not decompose in the stomach and are absorbed directly by the intestine, which leads to the rapid and effective therapeutic effect of these trace elements. There is an advantage to administering at the same time.

The molecular formulas of zinc, iron and copper-methionine complexes are somewhat difficult to express uniformly, but are generally as shown below.

Next, the present invention will be described in detail by way of examples.

EXAMPLE

end. Preparation of zinc solution: Zinc sulfate, hydrochloride, acetate, nitrate and zinc oxide are dissolved in water. If necessary, dissolve completely by adding sulfuric acid, hydrochloric acid, acetic acid, etc. while heating.

I. Preparation of iron solution: Dissolve iron sulfate, acetate and iron oxide in water. If necessary, dissolve completely by adding sulfuric acid, hydrochloric acid, acetic acid, and hydrogen peroxide while heating.

All. Preparation of copper solution: Dissolve copper sulfate, chloride and copper oxide in water. If necessary, dissolve completely by adding sulfuric acid, hydrochloric acid, acetic acid, etc. while heating.

la. Mixing a certain ratio of each solution: calculate the concentration of only metal ions in each solution, and then add Zn ⁺⁺ into the stagnation solution; 10-50%, Fe ⁺⁺ ; 1.0-20%, Cu ⁺⁺ ; Mix to adjust to level of 0.2-20%.

hemp. Preparation of Aqueous Methionine Solution: The methionine powder is dissolved in water.

bar. Preparation of zinc, iron and copper-methionine complexes: The solutions prepared in (D) and (E) are mixed in a molar ratio of about 1: 1, and the (A) and (F) aqueous solutions are mixed with acids and alkalis. The mixture is heated to maintain a pH of about 3.04.5 and then reacted at 60-90 ° C. for 0.5-3 hours. When the reaction solution is a clear aqueous solution, ethanol is added to terminate the reaction. The reaction solution is maintained at pH 5.0-7.0 again with acid or alkaline solution and left to cool at room temperature. The resulting reaction is filtered and air dried.

Claims (1)

A method of preparing a zinc, iron, copper-methionine complex by mixing and reacting a solution of a mineral acid salt or oxide of zinc, an inorganic acid salt of iron or an oxide thereof, and an inorganic acid salt of copper or an oxide thereof and separately dissolving methionine.

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