JP4934036B2 - 抗癒着着バリア - Google Patents
抗癒着着バリア Download PDFInfo
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- JP4934036B2 JP4934036B2 JP2007527914A JP2007527914A JP4934036B2 JP 4934036 B2 JP4934036 B2 JP 4934036B2 JP 2007527914 A JP2007527914 A JP 2007527914A JP 2007527914 A JP2007527914 A JP 2007527914A JP 4934036 B2 JP4934036 B2 JP 4934036B2
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- film layer
- layer
- hydroxyethyl methacrylate
- gel layer
- adhesion
- Prior art date
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Description
本出願は、2004年8月17日に出願された米国仮出願第60/602,225号の利益およびそれへの優先権を主張しており、その全体の開示は、本明細書中に参考として援用される。
(技術分野)
本開示は、組織癒着を防ぎ、そして組織成長を促進するための複数層デバイスに関する。
内部手術のような内部医療ケアの分野では、手術後治癒期間中の癒着のような合併症を防ぎ得る組織再生デバイスに対する必要性がある。形成され得る癒着は、組織と組織の、または組織と骨との癒着を含む。隣接する内部身体表面を、手術後の組織再生の間にこれら表面間に接触が存在しないようにメッシュまたはフィルムを差しはさむことによって分離することが知られている。癒着を防ぐために採用されている1つの材料は、Gore−Tex(登録商標)として知られる発泡されたポリテトラフルオロエチレン材料である。この材料は、しかし、止血性ではなく、そしてヒト身体によって分解可能ではない。従って、このインプラントは身体中に残り、そして必要であれば、治癒プロセスの後、手術によって除去されなければならない。別の材料は、Interceed(登録商標)として知られるカルボキシメチルセルロースのメッシュバリアである。この材料は、しかし、血液が豊富な環境では利用されないかも知れない。なぜなら、このような環境下では、この材料は、そのバリア機能を急速に失うからである。ポリ(エチレンオキシド)およびポリエチレンテレフタレートから形成されるフィルムもまた、外科的癒着を防ぐためのバリア材料として提案されている。
図1に見られるように、本開示による抗癒着デバイス(数字10によってほぼ示される)は、第1の比較的円滑な薄いフィルム層11、および第2のゲル層12を有する。このフィルム側は手術後の癒着および瘢痕を阻害し、そしてゲル側は、組織の足場として作用し、そして創傷治癒、細胞浸潤を促進する。
Claims (17)
- 抗癒着デバイスであって:
第1のフィルム層および第2のゲル層のコンポジットを備え、ここで、該第1のフィルム層は第1の生分解可能なモノマーを含み、そして該第2のゲル層は第2の生分解可能なモノマーを含み、そしてここで、該第1のフィルム層の水分含量が約40%より少なく、そして該第2のゲル層の水分含量が約40と90%との間である、抗癒着デバイス。 - 前記第1の生分解可能なモノマーが、ポリ−(ヒドロキシエチルメタクリレート)、メタクリル酸、アクリル酸、n−ビニルピロリドン、スルホプロピルアクリル酸カリウム、スルホプロピルメタクリル酸カリウム、ヒドロキシエチルメタクリレート、アクリルアミド、ジメチルアクリルアミド、2−メタクリロイルオキシエチルホスホリルコリン、およびこれらの組み合わせからなる群から選択される、請求項1に記載の抗癒着デバイス。
- 前記第1の生分解可能なモノマーが、ポリ−(ヒドロキシエチルメタクリレート)である、請求項1に記載の抗癒着デバイス。
- 前記第2の生分解なモノマーが、ポリ−(ヒドロキシエチルメタクリレート)、メタクリル酸、アクリル酸、n−ビニルピロリドン、スルホプロピルアクリル酸カリウム、スルホプロピルメタクリル酸カリウム、ヒドロキシエチルメタクリレート、アクリルアミド、ジメチルアクリルアミド、2−メタクリロイルオキシエチルホスホリルコリン、およびこれらの組み合わせからなる群から選択される、請求項1に記載の抗癒着デバイス。
- 前記第2の生分解可能なモノマーが、ポリ−(ヒドロキシエチルメタクリレート)である、請求項1に記載の抗癒着デバイス。
- 前記第1のフィルム層の水分含量が、約5%と約35%との間である、請求項1に記載の抗癒着デバイス。
- 前記第2のゲル層の水分含量が、約45%と約85%との間である、請求項1に記載の抗癒着デバイス。
- 抗菌剤、抗生物質、抗有糸分裂剤、抗真菌剤、抗ウイルス剤、モノクローナル抗体、ポリクローナル抗体、抗微生物タンパク質、抗微生物ペプチド、抗微生物ペプチドのフラグメント、酵素、遺伝子治療剤、ウイルス粒子、化学療法剤、抗炎症剤、NSAIDS、ステロイド、テロメラーゼインヒビター、成長因子、ECM分子、細胞接着分子、多糖類、色素、およびこれらの組み合わせからなる群から選択される生物学的薬剤をさらに含む、請求項1に記載の抗癒着デバイス。
- 請求項1に記載の抗癒着デバイスを形成する方法であって:
第1のフィルム層を形成するために第1の生分解可能なモノマーを重合する工程、該第1のフィルム層を第2の生分解可能なモノマー中で膨潤する工程、および該第2の生分解可能なモノマー中で膨潤した第1のフィルム層を重合する工程、を包含する、方法。 - 重合の前に前記第2の生分解可能なモノマー中の膨潤する第1のフィルム層をインキュベートする工程をさらに包含する、請求項9に記載の方法。
- 組織と組織、または組織と骨の結合を防ぐシステムであって:
2つの組織の間、または組織と骨との間に配置されるデバイスを備え、該デバイスは、第1のフィルム層および第2のゲル層のコンポジットを備え、ここで、該第1のフィルム層が第1の生分解可能なモノマーを含み、そして該第2のゲル層が第2の生分解可能なモノマーを含み、そしてここで、該第1のフィルム層の水分含量が約40%より少なく、そして該第2のゲル層の水分含量が約40と90%との間である、システム。 - 前記デバイスが、第1のフィルム層および第2のゲル層のコンポジットを備え、該第1のフィルム層が、ポリ−(ヒドロキシエチルメタクリレート)、メタクリル酸、アクリル酸、n−ビニルピロリドン、スルホプロピルアクリル酸カリウム、スルホプロピルメタクリル酸カリウム、ヒドロキシエチルメタクリレート、アクリルアミド、ジメチルアクリルアミド、2−メタクリロイルオキシエチルホスホリルコリン、およびこれらの組み合わせからなる群から選択される第1の生分解可能なモノマーを含む、請求項11に記載のシステム。
- 前記デバイスが、第1のフィルム層および第2のゲル層のコンポジットを備え、該第2のゲル層が、ポリ−(ヒドロキシエチルメタクリレート)、メタクリル酸、アクリル酸、n−ビニルピロリドン、スルホプロピルアクリル酸カリウム、スルホプロピルメタクリル酸カリウム、ヒドロキシエチルメタクリレート、アクリルアミド、ジメチルアクリルアミド、2−メタクリロイルオキシエチルホスホリルコリン、およびこれらの組み合わせからなる群から選択される第2の生分解可能なモノマーを含む、請求項11に記載のシステム。
- 前記デバイスが、第1のフィルム層および第2のゲル層のコンポジットを備え、該第1のフィルム層が、ポリ−(ヒドロキシエチルメタクリレート)を含む、請求項11に記載のシステム。
- 前記デバイスが、第1のフィルム層および第2のゲル層のコンポジットを備え、該第2のゲル層が、ポリ−(ヒドロキシエチルメタクリレート)を含む、請求項11に記載のシステム。
- 前記デバイスが、第1のフィルム層および第2のゲル層のコンポジットを備え、該第1のフィルム層の水分含量が、約5%と約35%との間である、請求項11に記載のシステム。
- 前記デバイスが、第1のフィルム層および第2のゲル層のコンポジットを備え、該第2のゲル層の水分含量が、約45%と約85%との間である、請求項11に記載のシステム。
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CA2576422A1 (en) | 2006-03-02 |
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DE602005026015D1 (de) | 2011-03-03 |
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