JP2008509788A5 - - Google Patents
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- JP2008509788A5 JP2008509788A5 JP2007527914A JP2007527914A JP2008509788A5 JP 2008509788 A5 JP2008509788 A5 JP 2008509788A5 JP 2007527914 A JP2007527914 A JP 2007527914A JP 2007527914 A JP2007527914 A JP 2007527914A JP 2008509788 A5 JP2008509788 A5 JP 2008509788A5
- Authority
- JP
- Japan
- Prior art keywords
- layer
- hydroxyethyl methacrylate
- poly
- moisture content
- biodegradable monomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000006065 biodegradation reaction Methods 0.000 claims 13
- 239000000178 monomer Substances 0.000 claims 13
- 230000000181 anti-adherence Effects 0.000 claims 11
- 239000002131 composite material Substances 0.000 claims 9
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims 6
- WOBHKFSMXKNTIM-UHFFFAOYSA-N 2-hydroxyethyl 2-methylacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 6
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- ZSZRUEAFVQITHH-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CC(=C)C(=O)OCCOP([O-])(=O)OCC[N+](C)(C)C ZSZRUEAFVQITHH-UHFFFAOYSA-N 0.000 claims 4
- KFTHUBZIEMOORC-UHFFFAOYSA-N 2-methylbut-2-enamide Chemical compound CC=C(C)C(N)=O KFTHUBZIEMOORC-UHFFFAOYSA-N 0.000 claims 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinylpyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 4
- HRPVXLWXLXDGHG-UHFFFAOYSA-N acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 4
- CERQOIWHTDAKMF-UHFFFAOYSA-N methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 4
- WQQULELGMPVNIF-UHFFFAOYSA-N 3-(2-methylprop-2-enoyloxy)propane-1-sulfonic acid;potassium Chemical compound [K].CC(=C)C(=O)OCCCS(O)(=O)=O WQQULELGMPVNIF-UHFFFAOYSA-N 0.000 claims 2
- XORPFVDIGIRKGM-UHFFFAOYSA-N [K].CCCOC(=O)C(C)=C Chemical compound [K].CCCOC(=O)C(C)=C XORPFVDIGIRKGM-UHFFFAOYSA-N 0.000 claims 2
- 230000000379 polymerizing Effects 0.000 claims 2
- GBZVJCKJWKZSBW-UHFFFAOYSA-N potassium;3-prop-2-enoyloxypropane-1-sulfonic acid Chemical compound [K].OS(=O)(=O)CCCOC(=O)C=C GBZVJCKJWKZSBW-UHFFFAOYSA-N 0.000 claims 2
- 101710004799 sm-amp-x Proteins 0.000 claims 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 2
- -1 sulfopropyl potassium acrylate Chemical compound 0.000 claims 2
- 210000001519 tissues Anatomy 0.000 claims 2
- 229940116904 ANTIINFLAMMATORY THERAPEUTIC RADIOPHARMACEUTICALS Drugs 0.000 claims 1
- 229940064005 Antibiotic throat preparations Drugs 0.000 claims 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 claims 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 claims 1
- 210000000988 Bone and Bones Anatomy 0.000 claims 1
- 102000016289 Cell Adhesion Molecules Human genes 0.000 claims 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 claims 1
- 229940074726 OPHTHALMOLOGIC ANTIINFLAMMATORY AGENTS Drugs 0.000 claims 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000000845 anti-microbial Effects 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000003080 antimitotic agent Substances 0.000 claims 1
- 229960000070 antineoplastic Monoclonal antibodies Drugs 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 230000003115 biocidal Effects 0.000 claims 1
- 239000003124 biologic agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 150000004676 glycans Polymers 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229940079866 intestinal antibiotics Drugs 0.000 claims 1
- 108010045030 monoclonal antibodies Proteins 0.000 claims 1
- 229960000060 monoclonal antibodies Drugs 0.000 claims 1
- 102000005614 monoclonal antibodies Human genes 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drugs Drugs 0.000 claims 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 108091008117 polyclonal antibodies Proteins 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000002522 swelling Effects 0.000 claims 1
- 239000003277 telomerase inhibitor Substances 0.000 claims 1
- 230000003612 virological Effects 0.000 claims 1
Claims (19)
- 抗癒着デバイスであって：
第１の層および第２の層のコンポジットを備え、ここで、該第１の層は第１の生分解可能なモノマーを含み、そして該第２の層は第２の生分解可能なモノマーを含み、そしてここで、該第１の層の水分含量が約４０％より少なく、そして該第２の層の水分含量が約４０と９０％との間である、抗癒着デバイス。 - 前記第１の生分解可能なモノマーが、ポリ−（ヒドロキシエチルメタクリレート）、メタクリル酸、アクリル酸、ｎ−ビニルピロリドン、スルホプロピルアクリル酸カリウム、スルホプロピルメタクリル酸カリウム、ヒドロキシエチルメタクリレート、アクリルアミド、ジメチルアクリルアミド、２−メタクリロイルオキシエチルホスホリルコリン、およびこれらの組み合わせからなる群から選択される、請求項１に記載の抗癒着デバイス。
- 前記生分解可能なモノマーが、ポリ−（ヒドロキシエチルメタクリレート）である、請求項１に記載の抗癒着デバイス。
- 前記第２の生分解なモノマーが、ポリ−（ヒドロキシエチルメタクリレート）、メタクリル酸、アクリル酸、ｎ−ビニルピロリドン、スルホプロピルアクリル酸カリウム、スルホプロピルメタクリル酸カリウム、ヒドロキシエチルメタクリレート、アクリルアミド、ジメチルアクリルアミド、２−メタクリロイルオキシエチルホスホリルコリン、およびこれらの組み合わせからなる群から選択される、請求項１に記載の抗癒着デバイス。
- 前記第２の生分解可能なモノマーが、ポリ−（ヒドロキシエチルメタクリレート）である、請求項１に記載の抗癒着デバイス。
- 前記コンポジットの第１の層が、フィルム、メッシュまたはゲルからなる群から選択される、請求項１に記載の抗癒着デバイス。
- 前記第２の層が、フィルム、メッシュまたはゲルからなる群から選択される、請求項１に記載の抗癒着デバイス。
- 前記第１の層の水分含量が、約５％と約３５％との間である、請求項１に記載の抗癒着デバイス。
- 前記第２の層の水分含量が、約４５％と約８５％との間である、請求項１に記載の抗癒着デバイス。
- 抗菌剤、抗生物質、抗有糸分裂剤、抗真菌剤、抗ウイルス剤、モノクローナル抗体、ポリクローナル抗体、抗微生物タンパク質、抗微生物ペプチド、抗微生物ペプチドのフラグメント、酵素、遺伝子治療剤、ウイルス粒子、化学療法剤、抗炎症剤、ＮＳＡＩＤＳ、ステロイド、テロメラーゼインヒビター、成長因子、ＥＣＭ分子、細胞接着分子、多糖類、色素、およびこれらの組み合わせからなる群から選択される生物学的薬剤をさらに含む、請求項１に記載の抗癒着デバイス。
- 抗癒着デバイスを形成する方法であって：
第１の層を形成するために第１の生分解可能なモノマーを重合する工程、該第１の層を第２の生分解可能なモノマー中で膨潤する工程、および該第２の生分解可能なモノマー中で膨潤した第１の層を重合する工程、を包含する、方法。 - 重合の前に前記第２の生分解可能なモノマー中の膨潤する第１の層をインキュベートする工程をさらに包含する、請求項１１に記載の方法。
- 組織と組織、または組織と骨の結合を防ぐシステムであって：
２つの組織の間、または組織と骨との間に配置されるデバイスを備え、該デバイスは、第１および第２の層のコンポジットを備え、ここで、該第１の層が第１の生分解可能なモノマーを含み、そして該第２の層が第２の生分解可能なモノマーを含み、そしてここで、該第１の層の水分含量が約４０％より少なく、そして該第２の層の水分含量が約４０と９０％との間である、システム。 - 前記デバイスが、第１および第２の層のコンポジットを備え、該第１の層が、ポリ−（ヒドロキシエチルメタクリレート）、メタクリル酸、アクリル酸、ｎ−ビニルピロリドン、スルホプロピルアクリル酸カリウム、スルホプロピルメタクリル酸カリウム、ヒドロキシエチルメタクリレート、アクリルアミド、ジメチルアクリルアミド、２−メタクリロイルオキシエチルホスホリルコリン、およびこれらの組み合わせからなる群から選択される第１の生分解可能なモノマーを含む、請求項１３に記載のシステム。
- 前記デバイスが、第１および第２の層のコンポジットを備え、該第２の層が、ポリ−（ヒドロキシエチルメタクリレート）、メタクリル酸、アクリル酸、ｎ−ビニルピロリドン、スルホプロピルアクリル酸カリウム、スルホプロピルメタクリル酸カリウム、ヒドロキシエチルメタクリレート、アクリルアミド、ジメチルアクリルアミド、２−メタクリロイルオキシエチルホスホリルコリン、およびこれらの組み合わせからなる群から選択される第２の生分解可能なモノマーを含む、請求項１３に記載のシステム。
- 前記デバイスが、第１および第２の層のコンポジットを備え、該第１の層が、ポリ−（ヒドロキシエチルメタクリレート）を含む、請求項１３に記載のシステム。
- 前記デバイスが、第１および第２の層のコンポジットを備え、該第２の層が、ポリ−（ヒドロキシエチルメタクリレート）を含む、請求項１３に記載のシステム。
- 前記デバイスが、第１および第２の層のコンポジットを備え、該第１の層の水分含量が、約５％と約３５％との間である、請求項１３に記載のシステム。
- 前記デバイスが、第１および第２の層のコンポジットを備え、該第２の層の水分含量が、約４５％と約８５％との間である、請求項１３に記載のシステム。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60222504P | 2004-08-17 | 2004-08-17 | |
| US60/602,225 | 2004-08-17 | ||
| PCT/US2005/028985 WO2006023444A2 (en) | 2004-08-17 | 2005-08-16 | Anti-adhesion barrier |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008509788A JP2008509788A (ja) | 2008-04-03 |
| JP2008509788A5 true JP2008509788A5 (ja) | 2008-08-21 |
| JP4934036B2 JP4934036B2 (ja) | 2012-05-16 |
Family
ID=35968093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527914A Expired - Fee Related JP4934036B2 (ja) | 2004-08-17 | 2005-08-16 | 抗癒着着バリア |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9034357B2 (ja) |
| EP (1) | EP1778144B1 (ja) |
| JP (1) | JP4934036B2 (ja) |
| AU (1) | AU2005277591B2 (ja) |
| CA (1) | CA2576422C (ja) |
| DE (1) | DE602005026015D1 (ja) |
| ES (1) | ES2356748T3 (ja) |
| WO (1) | WO2006023444A2 (ja) |
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| US7833284B2 (en) | 2006-06-28 | 2010-11-16 | The Cleveland Clinic Foundation | Anti-adhesion membrane |
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| US8317808B2 (en) | 2008-02-18 | 2012-11-27 | Covidien Lp | Device and method for rolling and inserting a prosthetic patch into a body cavity |
| US8758373B2 (en) | 2008-02-18 | 2014-06-24 | Covidien Lp | Means and method for reversibly connecting a patch to a patch deployment device |
| US9393093B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
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| US8808314B2 (en) | 2008-02-18 | 2014-08-19 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
| US9301826B2 (en) | 2008-02-18 | 2016-04-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
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| US9398944B2 (en) | 2008-02-18 | 2016-07-26 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9833240B2 (en) | 2008-02-18 | 2017-12-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| CA2715740C (en) | 2008-02-18 | 2014-05-27 | Polytouch Medical Ltd. | A device and method for deploying and attaching a patch to a biological tissue |
| US8668863B2 (en) | 2008-02-26 | 2014-03-11 | Board Of Regents, The University Of Texas System | Dendritic macroporous hydrogels prepared by crystal templating |
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| AU2009305958B9 (en) | 2008-10-20 | 2013-07-11 | Covidien Lp | A device for attaching a patch to a biological tissue |
| CA2748337A1 (en) | 2008-12-29 | 2010-07-08 | Synthes (U.S.A.) | A method of forming and the resulting membrane composition for surgical site preservation |
| JP5504279B2 (ja) * | 2009-04-16 | 2014-05-28 | 学校法人慶應義塾 | 移植用器具 |
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| JP2896216B2 (ja) * | 1990-09-19 | 1999-05-31 | テルモ株式会社 | 創傷被覆材 |
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| ATE227963T1 (de) * | 1992-04-24 | 2002-12-15 | Osteotech Inc | Vorrichtung zum vermeiden von gewebeadhäsionen |
| US6403655B1 (en) * | 1995-03-06 | 2002-06-11 | Ethicon, Inc. | Method of preventing adhesions with absorbable polyoxaesters |
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| AUPP297898A0 (en) | 1998-04-16 | 1998-05-07 | Unisearch Limited | Production of furanones |
| US7029700B2 (en) * | 2000-01-14 | 2006-04-18 | Brown University Research Foundation | Micronized freeze-dried particles |
| US20040018228A1 (en) | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
| CA2438047A1 (en) * | 2001-02-14 | 2002-08-22 | Hildegard M. Kramer | Biocompatible fleece for hemostasis and tissue engineering |
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| EP1498420B1 (en) | 2002-03-29 | 2017-02-01 | Nof Corporation | Phospholipid derivative |
| US20050208093A1 (en) | 2004-03-22 | 2005-09-22 | Thierry Glauser | Phosphoryl choline coating compositions |
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| US20060129225A1 (en) * | 2004-12-15 | 2006-06-15 | Kopia Gregory A | Device for the delivery of a cardioprotective agent to ischemic reperfused myocardium |
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-
2005
- 2005-08-16 AU AU2005277591A patent/AU2005277591B2/en not_active Ceased
- 2005-08-16 WO PCT/US2005/028985 patent/WO2006023444A2/en active Application Filing
- 2005-08-16 US US11/660,577 patent/US9034357B2/en active Active
- 2005-08-16 CA CA2576422A patent/CA2576422C/en not_active Expired - Fee Related
- 2005-08-16 JP JP2007527914A patent/JP4934036B2/ja not_active Expired - Fee Related
- 2005-08-16 ES ES05786516T patent/ES2356748T3/es active Active
- 2005-08-16 DE DE602005026015T patent/DE602005026015D1/de active Active
- 2005-08-16 EP EP05786516A patent/EP1778144B1/en not_active Not-in-force
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