JP4897681B2 - イオン・チャネルを通過する時間的に変化する電流を検出するための方法及び装置 - Google Patents

イオン・チャネルを通過する時間的に変化する電流を検出するための方法及び装置 Download PDF

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JP4897681B2
JP4897681B2 JP2007522825A JP2007522825A JP4897681B2 JP 4897681 B2 JP4897681 B2 JP 4897681B2 JP 2007522825 A JP2007522825 A JP 2007522825A JP 2007522825 A JP2007522825 A JP 2007522825A JP 4897681 B2 JP4897681 B2 JP 4897681B2
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channel
electrode
membrane
voltage
detection
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JP2008507703A5 (enExample
JP2008507703A (ja
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ヒッブス，アンドリュー・ディー
デュガン，レジナ・イー
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エレクトロニック・バイオサイエンシーズ・エルエルシー
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R19/00—Arrangements for measuring currents or voltages or for indicating presence or sign thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R27/00—Arrangements for measuring resistance, reactance, impedance, or electric characteristics derived therefrom
    • G01R27/02—Measuring real or complex resistance, reactance, impedance, or other two-pole characteristics derived therefrom, e.g. time constant
    • G01R27/26—Measuring inductance or capacitance; Measuring quality factor, e.g. by using the resonance method; Measuring loss factor; Measuring dielectric constants ; Measuring impedance or related variables
    • G01R27/2605—Measuring capacitance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/22—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
JP2007522825A 2004-07-23 2005-07-22 イオン・チャネルを通過する時間的に変化する電流を検出するための方法及び装置 Expired - Fee Related JP4897681B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59035104P 2004-07-23 2004-07-23
US60/590,351 2004-07-23
PCT/US2005/026181 WO2006012571A1 (en) 2004-07-23 2005-07-22 Method and apparatus for sensing a time varying current passing through an ion channel

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JP2008507703A JP2008507703A (ja) 2008-03-13
JP2008507703A5 JP2008507703A5 (enExample) 2011-06-02
JP4897681B2 true JP4897681B2 (ja) 2012-03-14

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US (1) US7622934B2 (enExample)
JP (1) JP4897681B2 (enExample)
DE (1) DE112005001781B4 (enExample)
GB (1) GB2431013B (enExample)
WO (1) WO2006012571A1 (enExample)

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Also Published As

Publication number Publication date
GB0700995D0 (en) 2007-02-28
US7622934B2 (en) 2009-11-24
GB2431013B (en) 2008-05-21
DE112005001781T5 (de) 2007-05-31
DE112005001781B4 (de) 2017-12-14
GB2431013A (en) 2007-04-11
JP2008507703A (ja) 2008-03-13
WO2006012571A1 (en) 2006-02-02
US20080094076A1 (en) 2008-04-24

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