JP4891250B2 - 脱アミドされたインターフェロンβ - Google Patents
脱アミドされたインターフェロンβ Download PDFInfo
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- JP4891250B2 JP4891250B2 JP2007540208A JP2007540208A JP4891250B2 JP 4891250 B2 JP4891250 B2 JP 4891250B2 JP 2007540208 A JP2007540208 A JP 2007540208A JP 2007540208 A JP2007540208 A JP 2007540208A JP 4891250 B2 JP4891250 B2 JP 4891250B2
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- ifn
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- deamidated
- protein
- protein analog
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
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- Biomedical Technology (AREA)
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- Neurosurgery (AREA)
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- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US62683704P | 2004-11-10 | 2004-11-10 | |
| US60/626,837 | 2004-11-10 | ||
| PCT/US2005/040758 WO2006053134A2 (en) | 2004-11-10 | 2005-11-10 | Deamidated interferon-beta |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008519769A JP2008519769A (ja) | 2008-06-12 |
| JP2008519769A5 JP2008519769A5 (enExample) | 2008-11-13 |
| JP4891250B2 true JP4891250B2 (ja) | 2012-03-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2007540208A Expired - Fee Related JP4891250B2 (ja) | 2004-11-10 | 2005-11-10 | 脱アミドされたインターフェロンβ |
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| Country | Link |
|---|---|
| US (2) | US7595040B2 (enExample) |
| EP (1) | EP1809662B1 (enExample) |
| JP (1) | JP4891250B2 (enExample) |
| KR (1) | KR101330626B1 (enExample) |
| CN (1) | CN101056890B (enExample) |
| AT (1) | ATE415421T1 (enExample) |
| AU (1) | AU2005304486B2 (enExample) |
| BR (1) | BRPI0517697A (enExample) |
| CA (1) | CA2587061C (enExample) |
| DE (1) | DE602005011321D1 (enExample) |
| ES (1) | ES2318575T3 (enExample) |
| MX (1) | MX2007004990A (enExample) |
| PL (1) | PL1809662T3 (enExample) |
| PT (1) | PT1809662E (enExample) |
| RU (1) | RU2404190C2 (enExample) |
| WO (1) | WO2006053134A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030190307A1 (en) | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
| AU2007284964A1 (en) * | 2006-08-08 | 2008-02-21 | Novartis Ag | Recombinant interferon-beta with enhanced biological activity |
| CN101675071B (zh) | 2007-05-02 | 2014-06-18 | Ambrx公司 | 经修饰干扰素β多肽和其用途 |
| EP2207890A4 (en) * | 2007-10-05 | 2010-12-15 | Barofold Inc | HIGH PRESSURE PROCESSING OF AGGREGATED INTERFERONS |
| ES2736503T3 (es) * | 2014-04-04 | 2020-01-02 | Ares Trading Sa | Nuevos análogos de la proteína IFN beta |
| RU2739261C1 (ru) * | 2019-12-31 | 2020-12-22 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Способ количественного определения антипролиферативной активности интерферона-бета человека |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588585A (en) * | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
| US4737462A (en) * | 1982-10-19 | 1988-04-12 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β |
| US4959314A (en) * | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
| GB9111902D0 (en) * | 1991-06-03 | 1991-07-24 | Glaxo Group Ltd | Chemical compounds |
| US20030190307A1 (en) * | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
| DE69729880T3 (de) | 1996-12-24 | 2012-05-10 | Biogen Idec Ma Inc. | Stabile flüssige interferon-zubereitungen |
| US6696423B1 (en) * | 1997-08-29 | 2004-02-24 | Biogen, Inc. | Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta |
| DK1017413T4 (da) * | 1997-09-23 | 2008-03-25 | Rentschler Biotech Gmbh | Flydende formulering af interferon-beta |
| JP2003508028A (ja) * | 1999-07-28 | 2003-03-04 | ジェネンテック・インコーポレーテッド | 腫瘍治療のための組成物と方法 |
| ES2180416B1 (es) * | 2001-03-12 | 2004-06-01 | BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. | Procedimiento para la preparacion de mezclas de reaccion estabilizadas, total o parcialmente desecadas, que comprenden, al menos, una enzima, mezclas de reaccion y kits que las contienen. |
| UY27373A1 (es) * | 2001-07-09 | 2003-02-28 | Schering Ag | Formulaciones de interferón beta-humano |
| RU2216345C1 (ru) * | 2002-03-21 | 2003-11-20 | Закрытое Акционерное Общество "Биокад" | Средство, обладающее иммуномодулирующим, противовирусным, противобактериальным, регенерирующим, репаративным, мембрано- и гепатопротекторным действием |
| KR100541850B1 (ko) | 2003-03-31 | 2006-01-11 | 삼성정밀화학 주식회사 | 인간 인터페론-베타 변이체 및 그의 제조방법 |
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2005
- 2005-11-10 DE DE602005011321T patent/DE602005011321D1/de not_active Expired - Lifetime
- 2005-11-10 CA CA2587061A patent/CA2587061C/en not_active Expired - Fee Related
- 2005-11-10 PL PL05818235T patent/PL1809662T3/pl unknown
- 2005-11-10 MX MX2007004990A patent/MX2007004990A/es active IP Right Grant
- 2005-11-10 JP JP2007540208A patent/JP4891250B2/ja not_active Expired - Fee Related
- 2005-11-10 PT PT05818235T patent/PT1809662E/pt unknown
- 2005-11-10 ES ES05818235T patent/ES2318575T3/es not_active Expired - Lifetime
- 2005-11-10 KR KR1020077011869A patent/KR101330626B1/ko not_active Expired - Fee Related
- 2005-11-10 CN CN2005800381182A patent/CN101056890B/zh not_active Expired - Fee Related
- 2005-11-10 AU AU2005304486A patent/AU2005304486B2/en not_active Ceased
- 2005-11-10 EP EP05818235A patent/EP1809662B1/en not_active Expired - Lifetime
- 2005-11-10 US US11/271,516 patent/US7595040B2/en not_active Expired - Fee Related
- 2005-11-10 RU RU2007121515/04A patent/RU2404190C2/ru not_active IP Right Cessation
- 2005-11-10 BR BRPI0517697-2A patent/BRPI0517697A/pt not_active IP Right Cessation
- 2005-11-10 AT AT05818235T patent/ATE415421T1/de active
- 2005-11-10 WO PCT/US2005/040758 patent/WO2006053134A2/en not_active Ceased
-
2009
- 2009-03-25 US US12/410,540 patent/US20090263355A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005304486B2 (en) | 2011-08-11 |
| PT1809662E (pt) | 2009-02-26 |
| BRPI0517697A (pt) | 2008-10-14 |
| DE602005011321D1 (de) | 2009-01-08 |
| CA2587061C (en) | 2011-08-16 |
| RU2007121515A (ru) | 2008-12-20 |
| WO2006053134A2 (en) | 2006-05-18 |
| RU2404190C2 (ru) | 2010-11-20 |
| PL1809662T3 (pl) | 2009-07-31 |
| US20060120998A1 (en) | 2006-06-08 |
| US7595040B2 (en) | 2009-09-29 |
| ATE415421T1 (de) | 2008-12-15 |
| KR101330626B1 (ko) | 2013-11-18 |
| AU2005304486A1 (en) | 2006-05-18 |
| MX2007004990A (es) | 2007-06-14 |
| JP2008519769A (ja) | 2008-06-12 |
| CN101056890A (zh) | 2007-10-17 |
| CA2587061A1 (en) | 2006-05-18 |
| CN101056890B (zh) | 2012-05-09 |
| KR20070084559A (ko) | 2007-08-24 |
| ES2318575T3 (es) | 2009-05-01 |
| WO2006053134A3 (en) | 2006-08-31 |
| EP1809662A2 (en) | 2007-07-25 |
| EP1809662B1 (en) | 2008-11-26 |
| US20090263355A1 (en) | 2009-10-22 |
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