JP4869719B2 - 動物実験用の試験物質投与システム - Google Patents
動物実験用の試験物質投与システム Download PDFInfo
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- JP4869719B2 JP4869719B2 JP2006020537A JP2006020537A JP4869719B2 JP 4869719 B2 JP4869719 B2 JP 4869719B2 JP 2006020537 A JP2006020537 A JP 2006020537A JP 2006020537 A JP2006020537 A JP 2006020537A JP 4869719 B2 JP4869719 B2 JP 4869719B2
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- 238000010171 animal model Methods 0.000 claims description 47
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 39
- 230000000241 respiratory effect Effects 0.000 claims description 36
- 210000000214 mouth Anatomy 0.000 claims description 25
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- 239000003814 drug Substances 0.000 claims description 13
- 229940079593 drug Drugs 0.000 claims description 11
- 238000012806 monitoring device Methods 0.000 claims description 10
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Description
2 呼吸モニタリング装置
3 投与装置
4 投与器
5 エア供給機構
6 ノズル
7 エアポンプ
8 アクチュエータ
10 圧力センサ
11 風量センサ
21 空圧源
22 エア回路
23 自動バルブ
29 マウスピース
Claims (5)
- 動物実験に用いる薬物や化学物質等の試験物質を実験動物の鼻もしくは口から投与する動物実験用の試験物質投与システムであって、呼吸ピックアップで検出される実験動物の呼吸状態を監視して呼気相から吸気相へ切り替わるタイミングを測定し、そのタイミングでトリガー信号を出力する呼吸モニタリング装置と、前記トリガー信号が出力された時に実験動物の鼻腔内もしくは口腔内に一定量の試験物質を噴射する投与装置とで構成され、該投与装置が、粉末剤、液剤あるいは懸濁化剤等の分散可能な剤型を有する試験物質を加圧エアにより噴射する投与器と、前記トリガー信号が出力された時に前記投与器に前記加圧エアを供給するエア供給機構とで構成されて、前記投与器に、実験動物の鼻腔内もしくは口腔内に試験物質を噴射するためのノズル又はマウスピースが取り付けられると共に、該ノズル又は前記マウスピースに前記呼吸ピックアップが添設され、前記エア供給機構が、空圧源から前記加圧エアを供給するエア回路と、該エア回路を開閉する自動バルブとを具備し、該自動バルブが前記トリガー信号によって開放されるように構成されていることを特徴とする動物実験用の試験物質投与システム。
- 前記呼吸ピックアップが、実験動物の呼気と吸気の温度差によって呼吸状態を検出する温度センサである請求項1記載の試験物質投与システム。
- 前記呼吸ピックアップが、実験動物の呼吸により生ずる前記ノズル内又は前記マウスピース内の圧力変動によって呼吸状態を検出する圧力センサである請求項1記載の試験物質投与システム。
- 前記呼吸ピックアップが、前記圧力センサと、前記ノズル内又は前記マウスピース内に流入する実験動物の呼気の流量によって呼吸状態を検出する風量センサとを併用したものである請求項3記載の試験物質投与システム。
- 前記呼吸ピックアップが、実験動物の呼吸により周長が変化する実験動物の胸部もしくは腹部に巻き付けた導電性ゴムの伸縮による電気抵抗値の変化によって呼吸状態を検出する電気抵抗式センサである請求項1記載の試験物質投与システム。
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JP2006020537A JP4869719B2 (ja) | 2006-01-30 | 2006-01-30 | 動物実験用の試験物質投与システム |
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JP2006020537A JP4869719B2 (ja) | 2006-01-30 | 2006-01-30 | 動物実験用の試験物質投与システム |
Publications (2)
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JP2007195869A JP2007195869A (ja) | 2007-08-09 |
JP4869719B2 true JP4869719B2 (ja) | 2012-02-08 |
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JP2006020537A Active JP4869719B2 (ja) | 2006-01-30 | 2006-01-30 | 動物実験用の試験物質投与システム |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2713767C (en) * | 2008-01-31 | 2013-06-11 | Wyeth Llc | Swine vaccination system |
WO2015021064A1 (en) * | 2013-08-05 | 2015-02-12 | Mannkind Corporation | Insufflation apparatus and methods |
KR102202595B1 (ko) * | 2019-03-14 | 2021-01-13 | 고려대학교 산학협력단 | 흡입 실험을 위한 삽관 및 영상 장치 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS643603A (en) * | 1987-06-26 | 1989-01-09 | Hitachi Ltd | Condenser color filter |
SE9400992L (sv) * | 1994-03-24 | 1995-05-02 | Siemens Elema Ab | Andningsgassystem med en trycköverförande bäljanordning mellan andningskretsen och drivgasapparaten |
US5522385A (en) * | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
JP4093661B2 (ja) * | 1998-12-21 | 2008-06-04 | 株式会社三幸製作所 | 動物用麻酔装置 |
JP2000300673A (ja) * | 1999-04-26 | 2000-10-31 | Teijin Ltd | 呼吸同調型気体供給装置 |
JP2003070915A (ja) * | 2001-09-05 | 2003-03-11 | Kawasaki Safety Service Industries Ltd | 人工呼吸器用ガス混合装置およびガス混合方法 |
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