JP4869719B2 - 動物実験用の試験物質投与システム - Google Patents
動物実験用の試験物質投与システム Download PDFInfo
- Publication number
- JP4869719B2 JP4869719B2 JP2006020537A JP2006020537A JP4869719B2 JP 4869719 B2 JP4869719 B2 JP 4869719B2 JP 2006020537 A JP2006020537 A JP 2006020537A JP 2006020537 A JP2006020537 A JP 2006020537A JP 4869719 B2 JP4869719 B2 JP 4869719B2
- Authority
- JP
- Japan
- Prior art keywords
- test substance
- air
- pickup
- respiratory
- breathing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000126 substance Substances 0.000 title claims description 55
- 238000012360 testing method Methods 0.000 title claims description 50
- 241001465754 Metazoa Species 0.000 title claims description 20
- 238000002474 experimental method Methods 0.000 title claims description 14
- 238000010171 animal model Methods 0.000 claims description 47
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 39
- 230000000241 respiratory effect Effects 0.000 claims description 36
- 210000000214 mouth Anatomy 0.000 claims description 25
- 210000003928 nasal cavity Anatomy 0.000 claims description 24
- 239000003814 drug Substances 0.000 claims description 13
- 229940079593 drug Drugs 0.000 claims description 11
- 238000012806 monitoring device Methods 0.000 claims description 10
- 210000001331 nose Anatomy 0.000 claims description 10
- 230000003434 inspiratory effect Effects 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000000375 suspending agent Substances 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 4
- 210000001015 abdomen Anatomy 0.000 claims description 3
- 230000008602 contraction Effects 0.000 claims description 3
- 238000012544 monitoring process Methods 0.000 claims description 3
- 210000004072 lung Anatomy 0.000 description 11
- 230000000694 effects Effects 0.000 description 6
- 239000002775 capsule Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000010352 nasal breathing Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Images
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Description
2 呼吸モニタリング装置
3 投与装置
4 投与器
5 エア供給機構
6 ノズル
7 エアポンプ
8 アクチュエータ
10 圧力センサ
11 風量センサ
21 空圧源
22 エア回路
23 自動バルブ
29 マウスピース
Claims (5)
- 動物実験に用いる薬物や化学物質等の試験物質を実験動物の鼻もしくは口から投与する動物実験用の試験物質投与システムであって、呼吸ピックアップで検出される実験動物の呼吸状態を監視して呼気相から吸気相へ切り替わるタイミングを測定し、そのタイミングでトリガー信号を出力する呼吸モニタリング装置と、前記トリガー信号が出力された時に実験動物の鼻腔内もしくは口腔内に一定量の試験物質を噴射する投与装置とで構成され、該投与装置が、粉末剤、液剤あるいは懸濁化剤等の分散可能な剤型を有する試験物質を加圧エアにより噴射する投与器と、前記トリガー信号が出力された時に前記投与器に前記加圧エアを供給するエア供給機構とで構成されて、前記投与器に、実験動物の鼻腔内もしくは口腔内に試験物質を噴射するためのノズル又はマウスピースが取り付けられると共に、該ノズル又は前記マウスピースに前記呼吸ピックアップが添設され、前記エア供給機構が、空圧源から前記加圧エアを供給するエア回路と、該エア回路を開閉する自動バルブとを具備し、該自動バルブが前記トリガー信号によって開放されるように構成されていることを特徴とする動物実験用の試験物質投与システム。
- 前記呼吸ピックアップが、実験動物の呼気と吸気の温度差によって呼吸状態を検出する温度センサである請求項1記載の試験物質投与システム。
- 前記呼吸ピックアップが、実験動物の呼吸により生ずる前記ノズル内又は前記マウスピース内の圧力変動によって呼吸状態を検出する圧力センサである請求項1記載の試験物質投与システム。
- 前記呼吸ピックアップが、前記圧力センサと、前記ノズル内又は前記マウスピース内に流入する実験動物の呼気の流量によって呼吸状態を検出する風量センサとを併用したものである請求項3記載の試験物質投与システム。
- 前記呼吸ピックアップが、実験動物の呼吸により周長が変化する実験動物の胸部もしくは腹部に巻き付けた導電性ゴムの伸縮による電気抵抗値の変化によって呼吸状態を検出する電気抵抗式センサである請求項1記載の試験物質投与システム。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006020537A JP4869719B2 (ja) | 2006-01-30 | 2006-01-30 | 動物実験用の試験物質投与システム |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006020537A JP4869719B2 (ja) | 2006-01-30 | 2006-01-30 | 動物実験用の試験物質投与システム |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007195869A JP2007195869A (ja) | 2007-08-09 |
JP4869719B2 true JP4869719B2 (ja) | 2012-02-08 |
Family
ID=38451051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006020537A Active JP4869719B2 (ja) | 2006-01-30 | 2006-01-30 | 動物実験用の試験物質投与システム |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP4869719B2 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2010008461A (es) | 2008-01-31 | 2010-08-30 | Wyeth Llc | Sistema de vacunacion de ganado porcino. |
CA2920488C (en) * | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Insufflation apparatus and methods |
KR102202595B1 (ko) * | 2019-03-14 | 2021-01-13 | 고려대학교 산학협력단 | 흡입 실험을 위한 삽관 및 영상 장치 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS643603A (en) * | 1987-06-26 | 1989-01-09 | Hitachi Ltd | Condenser color filter |
SE9400992L (sv) * | 1994-03-24 | 1995-05-02 | Siemens Elema Ab | Andningsgassystem med en trycköverförande bäljanordning mellan andningskretsen och drivgasapparaten |
US5522385A (en) * | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
JP4093661B2 (ja) * | 1998-12-21 | 2008-06-04 | 株式会社三幸製作所 | 動物用麻酔装置 |
JP2000300673A (ja) * | 1999-04-26 | 2000-10-31 | Teijin Ltd | 呼吸同調型気体供給装置 |
JP2003070915A (ja) * | 2001-09-05 | 2003-03-11 | Kawasaki Safety Service Industries Ltd | 人工呼吸器用ガス混合装置およびガス混合方法 |
-
2006
- 2006-01-30 JP JP2006020537A patent/JP4869719B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
JP2007195869A (ja) | 2007-08-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5959022B2 (ja) | 実験動物経肺投与用装置 | |
ES2241330T3 (es) | Mejoras en y con relacion a aparatos de administracion de farmacos. | |
US7347201B2 (en) | Nasal delivery devices | |
JP6425668B2 (ja) | 吸入装置、制御方法およびコンピュータプログラム | |
EP0681491B1 (en) | Intrapulmonary delivery of hormones | |
AU2006227168B2 (en) | Methods and systems for operating an aerosol generator | |
JP6644705B2 (ja) | 治療ガスが必要で、少なくとも圧力及び/又は流量を変化させる人工呼吸器から呼吸ガスを受け取る患者へ、促進治療ガス(no)流量測定器を使用して、治療ガスを供給するシステム及び方法 | |
JP2009508645A5 (ja) | ||
JP2001525710A (ja) | 肺を介する医療用エーロゾル剤の投与装置 | |
EP0998320A1 (en) | Medical dosing device having dosing chamber with a pressure sensor | |
JP2001525717A (ja) | 呼吸装置のための気管通気供給システム | |
WO2000021601A1 (en) | Method and apparatus for delivering a measured amount of a gas | |
ES2880924T3 (es) | Administración controlada por la respiración de aerosol en polvo durante la respiración artificial o el soporte respiratorio de un paciente | |
WO2002009574A3 (en) | Generation, delivery, measurement and control of aerosol boli for diagnostics and treatment of the respiratory tract | |
US6474333B1 (en) | Method for purging a medical fluid administration system | |
JP4869719B2 (ja) | 動物実験用の試験物質投与システム | |
JP2024527178A (ja) | 人工呼吸器用薬物エアロゾル供給装置 | |
KR20190035682A (ko) | 에어로졸화된 약제의 전달을 위한 방법 및 시스템 | |
WO2015157524A1 (en) | Systems and methods for high concentration nitric oxide delivery | |
US10293123B2 (en) | Test substance administration system for animal experiment | |
WO2001087395A1 (en) | Method and apparatus for the administration of continuous positive airway pressure therapy | |
US20220176056A1 (en) | Medicine delivery devices and methods for the use thereof | |
ES2712701T3 (es) | Dispositivo de suministro de gas terapéutico con control de flujo continuo y pulsado |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090129 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20091029 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20110216 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110301 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110428 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20111025 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20111116 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 4869719 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20141125 Year of fee payment: 3 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |