WO2002009574A3 - Generation, delivery, measurement and control of aerosol boli for diagnostics and treatment of the respiratory tract - Google Patents

Generation, delivery, measurement and control of aerosol boli for diagnostics and treatment of the respiratory tract Download PDF

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Publication number
WO2002009574A3
WO2002009574A3 PCT/US2001/024183 US0124183W WO0209574A3 WO 2002009574 A3 WO2002009574 A3 WO 2002009574A3 US 0124183 W US0124183 W US 0124183W WO 0209574 A3 WO0209574 A3 WO 0209574A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
patient
boli
diagnostics
aerosol
Prior art date
Application number
PCT/US2001/024183
Other languages
French (fr)
Other versions
WO2002009574A2 (en
Inventor
Frederick M Shofner
F Michael Ii Shofner
Original Assignee
Shofner Engineering Associates
Frederick M Shofner
F Michael Ii Shofner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/005948 external-priority patent/WO2001063255A2/en
Application filed by Shofner Engineering Associates, Frederick M Shofner, F Michael Ii Shofner filed Critical Shofner Engineering Associates
Priority to US10/499,473 priority Critical patent/US20050066968A1/en
Priority to AU2001278131A priority patent/AU2001278131A1/en
Publication of WO2002009574A2 publication Critical patent/WO2002009574A2/en
Publication of WO2002009574A3 publication Critical patent/WO2002009574A3/en
Priority to GBGB0415458.9A priority patent/GB0415458D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008—Electronic counters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/0813—Measurement of pulmonary parameters by tracers, e.g. radioactive tracers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/087—Measuring breath flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method and apparatus for controlled delivery of medicament to the respiratory system of a patient, a measured quantity of a medicament or bolus (32) is introduced into the inspiratory flow stream of a patient, via a breathing tube (18) and inhaled by the action of the patient's breathing cycle. In the course of a breathing cycle, numerous properties or characteristics of the bolus, the inspiratory flow, the expiratory flow and other information are derived. The derived information is used to control subsequent delivery of boli to the patient, including the delivery of each bolus as a function of the commencement or progression of the breathing cycle, as input for calculations or determinations which are useful in analyzing the effectiveness of delivery of the medicament to the patient, patient compliance, and direction of flow through the breathing tube along with other uses.
PCT/US2001/024183 2000-08-01 2001-08-01 Generation, delivery, measurement and control of aerosol boli for diagnostics and treatment of the respiratory tract WO2002009574A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/499,473 US20050066968A1 (en) 2000-08-01 2001-08-01 Generation, delivery, measurement and control of aerosol boli for diagnostics and treatments of the respiratory/pulmonary tract of a patient
AU2001278131A AU2001278131A1 (en) 2000-08-01 2001-08-01 Generation, delivery, measurement and control of aerosol boli for diagnostics and treatments of the respiratory/pulmonary tract of a patient
GBGB0415458.9A GB0415458D0 (en) 2000-08-01 2004-07-09 Generation, delivery, measurement and control of aerosol boli for diagnostics and treatment of the respiratory tract

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US22257500P 2000-08-01 2000-08-01
US22227300P 2000-08-01 2000-08-01
US60/222,273 2000-08-01
US60/222,575 2000-08-01
US25111400P 2000-12-04 2000-12-04
US60/251,114 2000-12-04
USPCT/US01/05948 2001-02-22
PCT/US2001/005948 WO2001063255A2 (en) 2000-02-22 2001-02-22 Measurement of aerosol mass concentration and mass delivery rate

Publications (2)

Publication Number Publication Date
WO2002009574A2 WO2002009574A2 (en) 2002-02-07
WO2002009574A3 true WO2002009574A3 (en) 2002-04-18

Family

ID=27485939

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024183 WO2002009574A2 (en) 2000-08-01 2001-08-01 Generation, delivery, measurement and control of aerosol boli for diagnostics and treatment of the respiratory tract

Country Status (2)

Country Link
AU (1) AU2001278131A1 (en)
WO (1) WO2002009574A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9061352B2 (en) 2010-08-30 2015-06-23 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
US9433576B2 (en) 2010-09-29 2016-09-06 Pulmatrix, Inc. Cationic dry powders

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003092654A1 (en) 2002-05-02 2003-11-13 President And Fellows Of Harvard College Formulations limiting spread of pulmonary infections
GB2395437C (en) 2002-11-20 2010-10-20 Profile Respiratory Systems Ltd Improved inhalation method and apparatus
GB2396825B (en) * 2002-11-20 2004-12-08 Profile Respiratory Systems Lt Improved inhalation method and apparatus
US7380550B2 (en) 2004-01-30 2008-06-03 Hewlett-Packard Development Company, L.P. Systems and methods for particle detection
NZ549588A (en) 2004-02-24 2009-03-31 Microdose Technologies Inc Directional flow sensor inhaler
US20050207983A1 (en) 2004-03-05 2005-09-22 Pulmatrix, Inc. Formulations decreasing particle exhalation
US8627821B2 (en) 2005-01-10 2014-01-14 Pulmatrix, Inc. Method and device for decreasing contamination
CN103228273B (en) 2010-09-29 2017-04-05 普马特里克斯营业公司 Monovalent metal cation dry powder doses are used in suction
CA2865972C (en) 2012-02-29 2022-01-04 Pulmatrix, Inc. Inhalable dry powders
CN104797190B (en) * 2012-11-15 2018-07-17 杰普呼吸技术公司 Device and method for pulmonary function measurement
CA2907566C (en) 2013-04-01 2023-08-22 Pulmatrix, Inc. Tiotropium dry powders
EP3831432B1 (en) 2016-03-24 2023-06-07 Trudell Medical International Respiratory care system with electronic indicator
MX2018014121A (en) 2016-05-19 2019-04-29 Trudell Medical Int Smart valved holding chamber.
CA3028604C (en) 2016-07-08 2023-12-05 Trudell Medical International Smart oscillating positive expiratory pressure device
CN110049795B (en) 2016-12-09 2022-07-19 特鲁德尔医学国际公司 Intelligent atomizer
MX2020007026A (en) 2018-01-04 2020-12-03 Trudell Medical Int Smart oscillating positive expiratory pressure device.
WO2019234586A1 (en) 2018-06-04 2019-12-12 Trudell Medical International Smart valved holding chamber
DE102018212411A1 (en) * 2018-07-25 2020-01-30 Robert Bosch Gmbh Method for obtaining a breath sample from a test subject and device
CN109091731A (en) * 2018-09-12 2018-12-28 上海朔茂网络科技有限公司 A kind of novel intelligent inhalation device and application method
US11712175B2 (en) 2019-08-27 2023-08-01 Trudell Medical International Smart oscillating positive expiratory pressure device with feedback indicia

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5156776A (en) * 1991-10-19 1992-10-20 Solvay Deutschland Gmbh Aerosol generating system
US5666947A (en) * 1993-10-28 1997-09-16 Orbital Engine Company (Australia) Pty. Limited Formation and delivery of an atomized liquid
US5755218A (en) * 1991-03-05 1998-05-26 Aradigm Corporation Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US6000394A (en) * 1994-10-26 1999-12-14 Paul Rizau Pari-Werk Gmbh Generation of an aerosol of an exact dose

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5755218A (en) * 1991-03-05 1998-05-26 Aradigm Corporation Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval
US5156776A (en) * 1991-10-19 1992-10-20 Solvay Deutschland Gmbh Aerosol generating system
US5666947A (en) * 1993-10-28 1997-09-16 Orbital Engine Company (Australia) Pty. Limited Formation and delivery of an atomized liquid
US6000394A (en) * 1994-10-26 1999-12-14 Paul Rizau Pari-Werk Gmbh Generation of an aerosol of an exact dose

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9061352B2 (en) 2010-08-30 2015-06-23 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
US9233158B2 (en) 2010-08-30 2016-01-12 Pulmatrix, Inc. Dry powder formulations and methods for treating pulmonary diseases
US9433576B2 (en) 2010-09-29 2016-09-06 Pulmatrix, Inc. Cationic dry powders

Also Published As

Publication number Publication date
WO2002009574A2 (en) 2002-02-07
AU2001278131A1 (en) 2002-02-13

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