JP4866364B2 - マイクロメートルサイズ深さフローチャンバ内のセンサを自己参照するためのシステム及び方法 - Google Patents
マイクロメートルサイズ深さフローチャンバ内のセンサを自己参照するためのシステム及び方法 Download PDFInfo
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- G01N2201/12723—Self check capacity; automatic, periodic step of checking
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- Y10T436/00—Chemistry: analytical and immunological testing
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Description
・ 名称を「マイクロ流体システムにおける材料のその場濃縮及び/または希釈のための方法及び装置(Methods and Apparatus for In Situ Concentration and/or Dilution of Materials in Microfluidic Systems)」とする、米国特許第5869004号明細書;
・ エス・ケイ・ダブリュー・ダーティンジャー(S. K. W. Dertinger)等,「マイクロ流体網を用いる複雑な形状を有する勾配の生成(Generation of Gradients having Complex Shapes using Microfluidic Networks)」,Anal. Chem.,2001年,第73巻,p.1240〜1246;
・ 名称を「勾配生成のための方法及び装置(Method and Apparatus for Gradient Generation)」とする、米国特許出願公開第2002/011309A1号明細書;
マイクロ流体デバイス内に入れられた試料に濃度勾配を生成するためのこれらの方法のいずれも、本発明のこの実施形態において実施することができる。
・ 名称を「光検定:方法及び装置(Optical Assay: Method and Apparatus)」とする、欧州特許出願公開第0202021A2号明細書;
・ 名称を「気体、液体、固体及び多孔質の試料における物質の選択的検出のため及び/または屈折率変化の検出のための光センサ(Optical Sensor for selective Detection of Substances and/or for the Detection of Refractive Index Change in Gaseous, Liquid, Solid and Porous Samples)」とする、米国特許第4815843号明細書;
これらの文献の内容は本明細書に参照として含まれる。
101 マイクロ流体デバイス
102 センサ
104 試料溶液
106 参照溶液
107a,107b,107c,107d フローチャネル
108 マイクロメートルサイズ深さフローチャネル
109a,109b 流入口
110 呼掛けシステム
111a,111b 流出口
112 入力光ビーム
114 出力光ビーム
116 検知領域
116a 検出領域
116b 参照領域
118 コンピュータ/ハードウエア
Claims (10)
- 呼掛けシステムを用いて1本のマイクロメートルサイズ深さフローチャネルに付帯するセンサを自己参照するための方法であって、
前記1本のマイクロメートルサイズ深さフローチャネル内を互いに並行して流れる試料溶液及び参照溶液内に検知領域を有する前記センサに、前記呼掛けシステムによって指向された光ビームを向ける工程、
前記センサから出力光ビームを前記呼掛けシステムによって受け取る工程、
前記出力光ビームを分析して、前記センサの前記検知領域の検出領域内を流れている前記試料溶液に関係付けられる検出信号を決定し、かつ前記センサの前記検知領域の参照領域内を流れている前記参照溶液に関係付けられる参照信号を決定する工程、及び
前記検出信号から前記参照信号を差し引いて補正検出信号を生成する工程、
を含む方法。 - 前記補正検出信号が前記1本のマイクロメートルサイズ深さフローチャネル内を流れている前記試料溶液内で生体分子結合イベントがおこったか否かを示すことを特徴とする請求項1に記載の方法。
- 前記センサが回折格子結合導波路センサまたは表面プラズモン共鳴センサであることを特徴とする請求項1に記載の方法。
- 前記試料溶液内に複数の濃度勾配が前記1本のマイクロメートルサイズ深さフローチャネルにおいて生成され、コンピュータが前記出力光ビームを分析して前記試料溶液内の前記複数の濃度勾配に対応する複数の検出信号を決定できることを特徴とする請求項1に記載の方法。
- センサ、
試料溶液及び参照溶液が前記センサの検知領域内を互いに並行して流れる1本のマイクロメートルサイズ深さフローチャネル、
前記センサに入力光ビームを向け、前記センサから出力光ビームを受け取るための、出力像を表す電気信号に前記光ビームを変換するためのカメラを有する、呼掛けシステム、
前記センサの前記検知領域の検出領域内を流れている前記試料溶液に関係付けられる検出信号を決定するため及び前記センサの前記検知領域の参照領域内を流れている前記参照溶液に関係付けられる参照信号を決定するために前記出力像を分析するための、前記検出信号から前記参照信号を差し引いて補正検出信号を生成する、コンピュータ、
を含むシステム。 - 前記補正検出信号が前記1本のマイクロメートルサイズ深さフローチャネル内を流れている前記試料溶液内で生体分子結合イベントがおこったか否かを示すことを特徴とする請求項5に記載のシステム。
- 前記センサが回折格子結合導波路センサまたは表面プラズモン共鳴センサであることを特徴とする請求項5に記載のシステム。
- 前記試料溶液内に複数の濃度勾配が前記1本のマイクロメートルサイズ深さフローチャネルにおいて生成され、前記コンピュータが前記出力光ビームを分析して前記試料溶液内の前記複数の濃度勾配に対応する複数の検出信号を決定できることを特徴とする請求項5に記載のシステム。
- 呼掛けシステムにおいて、
1本のマイクロメートルサイズ深さフローチャネル内を互いに並行して流れる試料溶液及び参照溶液内に検知領域を有するセンサに光ビームを向ける工程、
前記センサから出力光ビームを受け取る工程、
を実施することができ、
前記出力光ビームが分析されて、前記センサの前記検知領域の検出領域内を流れている前記試料溶液に関係付けられる検出信号を決定し、かつ前記センサの前記検知領域の参照領域内を流れている前記参照溶液に関係付けられる参照信号を決定し、
前記参照信号が前記検出信号から差し引かれて補正検出信号が生成され、
前記補正検出信号が前記1本のマイクロメートルサイズ深さフローチャネル内を流れている前記試料溶液内で生体分子結合イベントがおこったか否かを示す、
ことを特徴とする呼掛けシステム。 - 試料溶液及び参照溶液がセンサの検知領域内を互いに並行して流れる1本のマイクロメートルサイズ深さフローチャネルを含み、呼掛けシステムが入力光ビームを前記センサに向け、出力光ビームを前記センサから受け取るマイクロ流体デバイスであって、
前記出力光ビームがコンピュータまたは検出器システムによって分析されて、前記センサの前記検知領域の検出領域内を流れている前記試料溶液に関係付けられる検出信号及び前記センサの前記検知領域の参照領域内を流れている前記参照溶液に関係付けられる参照信号が決定される、
ことを特徴とするマイクロ流体デバイス。
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US10/993,565 US7285420B2 (en) | 2004-11-18 | 2004-11-18 | System and method for self-referencing a sensor in a micron-sized deep flow chamber |
US10/993,565 | 2004-11-18 | ||
PCT/US2005/040845 WO2006055401A1 (en) | 2004-11-18 | 2005-11-09 | System and method for self-referencing a sensor in a micron-sized deep flow chamber |
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US20060106557A1 (en) | 2006-05-18 |
JP2008521005A (ja) | 2008-06-19 |
US20110305598A1 (en) | 2011-12-15 |
US8021613B2 (en) | 2011-09-20 |
EP1812786A1 (en) | 2007-08-01 |
WO2006055401A1 (en) | 2006-05-26 |
US20080063569A1 (en) | 2008-03-13 |
US7285420B2 (en) | 2007-10-23 |
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