JP4865129B2 - タンパク質キナーゼ阻害剤を設計するための新規の方法 - Google Patents

タンパク質キナーゼ阻害剤を設計するための新規の方法 Download PDF

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JP4865129B2
JP4865129B2 JP2000593770A JP2000593770A JP4865129B2 JP 4865129 B2 JP4865129 B2 JP 4865129B2 JP 2000593770 A JP2000593770 A JP 2000593770A JP 2000593770 A JP2000593770 A JP 2000593770A JP 4865129 B2 JP4865129 B2 JP 4865129B2
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src
inhibitors
inhibitor
peptide
protein kinase
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JP2002534132A (ja
JP2002534132A5 (fr
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デイビッド ジー． ジュニア ハンガー
トーマス エイチ． マーシルジェ
カレン エル． ミルキウイッツ
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Research Foundation of State University of New York
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2000593770A 1999-01-13 2000-01-13 タンパク質キナーゼ阻害剤を設計するための新規の方法 Expired - Lifetime JP4865129B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11564399P 1999-01-13 1999-01-13
US60/115,643 1999-01-13
PCT/US2000/000803 WO2000042213A1 (fr) 1999-01-13 2000-01-13 Nouveau procede d'identification d'inhibiteurs de proteines kinase

Related Child Applications (1)

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JP2010151851A Division JP2010279363A (ja) 1999-01-13 2010-07-02 タンパク質キナーゼ阻害剤を設計するための新規の方法

Publications (3)

Publication Number Publication Date
JP2002534132A JP2002534132A (ja) 2002-10-15
JP2002534132A5 JP2002534132A5 (fr) 2007-04-12
JP4865129B2 true JP4865129B2 (ja) 2012-02-01

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JP2000593770A Expired - Lifetime JP4865129B2 (ja) 1999-01-13 2000-01-13 タンパク質キナーゼ阻害剤を設計するための新規の方法
JP2010151851A Pending JP2010279363A (ja) 1999-01-13 2010-07-02 タンパク質キナーゼ阻害剤を設計するための新規の方法

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JP2010151851A Pending JP2010279363A (ja) 1999-01-13 2010-07-02 タンパク質キナーゼ阻害剤を設計するための新規の方法

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Country Link
US (1) US7901894B2 (fr)
EP (1) EP1147214B1 (fr)
JP (2) JP4865129B2 (fr)
AT (1) ATE494388T1 (fr)
AU (1) AU3208200A (fr)
BR (1) BR0007532A (fr)
CA (1) CA2360581A1 (fr)
DE (1) DE60045474D1 (fr)
MX (1) MXPA01007099A (fr)
WO (1) WO2000042213A1 (fr)

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WO1998007695A1 (fr) * 1996-08-23 1998-02-26 Sugen, Inc. Banques combinatoires d'indolinone, produits et procedes associes pour traiter des maladies

Also Published As

Publication number Publication date
CA2360581A1 (fr) 2000-07-20
BR0007532A (pt) 2001-11-20
MXPA01007099A (es) 2002-03-27
JP2002534132A (ja) 2002-10-15
JP2010279363A (ja) 2010-12-16
EP1147214B1 (fr) 2011-01-05
US7901894B2 (en) 2011-03-08
DE60045474D1 (de) 2011-02-17
WO2000042213A1 (fr) 2000-07-20
ATE494388T1 (de) 2011-01-15
EP1147214A1 (fr) 2001-10-24
EP1147214A4 (fr) 2008-08-27
US20060089401A1 (en) 2006-04-27
AU3208200A (en) 2000-08-01

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