JP4862120B2 - 腫瘍治療のためのプロドラッグとしてのベンズ−インドールおよびベンゾ−キノリン誘導体 - Google Patents
腫瘍治療のためのプロドラッグとしてのベンズ−インドールおよびベンゾ−キノリン誘導体 Download PDFInfo
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- JP4862120B2 JP4862120B2 JP2002567297A JP2002567297A JP4862120B2 JP 4862120 B2 JP4862120 B2 JP 4862120B2 JP 2002567297 A JP2002567297 A JP 2002567297A JP 2002567297 A JP2002567297 A JP 2002567297A JP 4862120 B2 JP4862120 B2 JP 4862120B2
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- alkyl
- phenyl
- heteroaryl
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01301634 | 2001-02-22 | ||
| EP01301634.0 | 2001-02-22 | ||
| PCT/GB2002/000801 WO2002067930A1 (en) | 2001-02-22 | 2002-02-22 | Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004522779A JP2004522779A (ja) | 2004-07-29 |
| JP2004522779A5 JP2004522779A5 (enExample) | 2006-01-05 |
| JP4862120B2 true JP4862120B2 (ja) | 2012-01-25 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002567297A Expired - Fee Related JP4862120B2 (ja) | 2001-02-22 | 2002-02-22 | 腫瘍治療のためのプロドラッグとしてのベンズ−インドールおよびベンゾ−キノリン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7192977B2 (enExample) |
| EP (1) | EP1408960B1 (enExample) |
| JP (1) | JP4862120B2 (enExample) |
| AT (1) | ATE327750T1 (enExample) |
| DE (1) | DE60211905T2 (enExample) |
| WO (1) | WO2002067930A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| NZ536107A (en) * | 2004-10-22 | 2007-06-29 | Auckland Uniservices Ltd | Nitrobenzindoles and their use in cancer therapy |
| GB0505644D0 (en) | 2005-03-18 | 2005-04-27 | Univ London Pharmacy | Analogues of the azinomycins as anti-tumour agents and as prodrugs |
| US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
| PT2344478T (pt) | 2008-11-03 | 2017-11-28 | Syntarga Bv | Análogos de cc-1065 e seus conjugados |
| DK3108886T3 (da) | 2010-04-21 | 2020-08-10 | Syntarga Bv | Konjugater af CC-1065-analoger og bifunktionelle linkere |
| PT2948184T (pt) | 2014-01-10 | 2016-07-08 | Synthon Biopharmaceuticals Bv | Conjugados de anticorpo-fármaco de duocarmicina apresentando uma melhor atividade antitumoral in vivo. |
| KR102323301B1 (ko) | 2014-01-10 | 2021-11-09 | 비온디스 비.브이. | Cys 연결된 항체-약물 접합체의 정제 방법 |
| SG11201605597VA (en) | 2014-01-10 | 2016-08-30 | Synthon Biopharmaceuticals Bv | Duocarmycin adcs for use in treatment of endometrial cancer |
| CN109020820B (zh) * | 2017-06-08 | 2021-06-25 | 杭州惠诺医药科技有限公司 | 一种6-溴-2-氨基萘的制备方法 |
| JPWO2019004413A1 (ja) * | 2017-06-30 | 2020-05-07 | 東レ株式会社 | インドリン誘導体及びそれを含む細胞毒性剤 |
| CN113292554A (zh) * | 2021-06-25 | 2021-08-24 | 守恒(厦门)医疗科技有限公司 | 二氢萘并[2,1-d]异噁唑酰胺类衍生物及其在抗肿瘤药物的应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997012862A1 (en) * | 1995-10-03 | 1997-04-10 | The Scripps Research Institute | Cbi analogs of cc-1065 and the duocarmycins |
| WO1997032850A1 (en) * | 1996-03-08 | 1997-09-12 | The Scripps Research Institute | Mcbi analogs of cc-1065 and the duocarmycins |
| WO1997044000A2 (en) * | 1996-05-23 | 1997-11-27 | Panorama Research, Inc. | Dna-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents |
| WO1998011101A2 (en) * | 1996-09-12 | 1998-03-19 | Cancer Research Campaign Technology Limited | Condensed n-aclyindoles as antitumor agents |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4413132A (en) * | 1980-11-18 | 1983-11-01 | The Upjohn Company | Antibiotic CC-1065 indoline intermediates |
| GB9519490D0 (en) | 1995-09-25 | 1995-11-29 | Melvin William T | Use of a cytochrome P450 enzyme in tumour cells as a marker and target |
| EP0934269A4 (en) | 1996-05-31 | 2000-01-12 | Scripps Research Inst | ANALOGS OF CC-1065 AND DUOCARMYCINE |
| EP1051383B1 (en) | 1998-02-06 | 2004-07-28 | De Montfort University | Hydroxylation activated prodrugs |
| DE60220057T2 (de) * | 2001-02-22 | 2008-01-10 | School Of Pharmacy, University Of London | Indoline und Tetrahydrochinoline als Prodrugs zur Tumorbehandlung |
| WO2002068412A1 (en) * | 2001-02-22 | 2002-09-06 | School Of Pharmacy, University Of London | Pyrrolo-indole and pyrrolo-quinoline derivatives as prodrugs for tumour treatment |
| US7087600B2 (en) * | 2001-05-31 | 2006-08-08 | Medarex, Inc. | Peptidyl prodrugs and linkers and stabilizers useful therefor |
| WO2004101767A2 (en) * | 2003-05-13 | 2004-11-25 | The Scripps Research Institute | Cbi analogues of the duocarmycins and cc-1065 |
| JP4806680B2 (ja) * | 2004-05-19 | 2011-11-02 | メダレックス インコーポレイテッド | 自己犠牲リンカー及び薬剤複合体 |
-
2002
- 2002-02-22 US US10/468,744 patent/US7192977B2/en not_active Expired - Lifetime
- 2002-02-22 DE DE60211905T patent/DE60211905T2/de not_active Expired - Lifetime
- 2002-02-22 WO PCT/GB2002/000801 patent/WO2002067930A1/en not_active Ceased
- 2002-02-22 JP JP2002567297A patent/JP4862120B2/ja not_active Expired - Fee Related
- 2002-02-22 AT AT02701418T patent/ATE327750T1/de not_active IP Right Cessation
- 2002-02-22 EP EP02701418A patent/EP1408960B1/en not_active Expired - Lifetime
-
2007
- 2007-02-27 US US11/710,899 patent/US8017640B2/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997012862A1 (en) * | 1995-10-03 | 1997-04-10 | The Scripps Research Institute | Cbi analogs of cc-1065 and the duocarmycins |
| WO1997032850A1 (en) * | 1996-03-08 | 1997-09-12 | The Scripps Research Institute | Mcbi analogs of cc-1065 and the duocarmycins |
| WO1997044000A2 (en) * | 1996-05-23 | 1997-11-27 | Panorama Research, Inc. | Dna-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents |
| WO1998011101A2 (en) * | 1996-09-12 | 1998-03-19 | Cancer Research Campaign Technology Limited | Condensed n-aclyindoles as antitumor agents |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60211905T2 (de) | 2007-01-18 |
| EP1408960B1 (en) | 2006-05-31 |
| US20040138246A1 (en) | 2004-07-15 |
| JP2004522779A (ja) | 2004-07-29 |
| US8017640B2 (en) | 2011-09-13 |
| US7192977B2 (en) | 2007-03-20 |
| WO2002067930A1 (en) | 2002-09-06 |
| ATE327750T1 (de) | 2006-06-15 |
| EP1408960A1 (en) | 2004-04-21 |
| US20070161669A1 (en) | 2007-07-12 |
| DE60211905D1 (de) | 2006-07-06 |
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