ATE327750T1 - Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung - Google Patents

Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung

Info

Publication number
ATE327750T1
ATE327750T1 AT02701418T AT02701418T ATE327750T1 AT E327750 T1 ATE327750 T1 AT E327750T1 AT 02701418 T AT02701418 T AT 02701418T AT 02701418 T AT02701418 T AT 02701418T AT E327750 T1 ATE327750 T1 AT E327750T1
Authority
AT
Austria
Prior art keywords
benz
prodrugs
indole
benzo
tumor treatment
Prior art date
Application number
AT02701418T
Other languages
German (de)
English (en)
Inventor
Mark Searcey
Laurence Patterson
Original Assignee
Univ London Pharmacy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ London Pharmacy filed Critical Univ London Pharmacy
Application granted granted Critical
Publication of ATE327750T1 publication Critical patent/ATE327750T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT02701418T 2001-02-22 2002-02-22 Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung ATE327750T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01301634 2001-02-22

Publications (1)

Publication Number Publication Date
ATE327750T1 true ATE327750T1 (de) 2006-06-15

Family

ID=8181736

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02701418T ATE327750T1 (de) 2001-02-22 2002-02-22 Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung

Country Status (6)

Country Link
US (2) US7192977B2 (enExample)
EP (1) EP1408960B1 (enExample)
JP (1) JP4862120B2 (enExample)
AT (1) ATE327750T1 (enExample)
DE (1) DE60211905T2 (enExample)
WO (1) WO2002067930A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
NZ536107A (en) * 2004-10-22 2007-06-29 Auckland Uniservices Ltd Nitrobenzindoles and their use in cancer therapy
GB0505644D0 (en) 2005-03-18 2005-04-27 Univ London Pharmacy Analogues of the azinomycins as anti-tumour agents and as prodrugs
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
NO2344478T3 (enExample) * 2008-11-03 2018-02-24
MX374267B (es) 2010-04-21 2025-03-06 Syntarga Bv Conjugados novedosos de analogos cc-1065 y ligaduras bifuncionales.
KR20160099725A (ko) 2014-01-10 2016-08-22 신톤 바이오파머슈티칼즈 비.브이. 자궁내막암의 치료에서 사용하기 위한 듀오카르마이신 adc
SG10201911860VA (en) 2014-01-10 2020-02-27 Synthon Biopharmaceuticals Bv Duocarmycin adcs showing improved in vivo antitumor activity
MX373458B (es) 2014-01-10 2020-05-11 Byondis Bv Metodo para purificar conjugados de anticuerpo-farmaco enlazados a cisteina.
CN109020820B (zh) * 2017-06-08 2021-06-25 杭州惠诺医药科技有限公司 一种6-溴-2-氨基萘的制备方法
JPWO2019004413A1 (ja) * 2017-06-30 2020-05-07 東レ株式会社 インドリン誘導体及びそれを含む細胞毒性剤
CN113292554A (zh) * 2021-06-25 2021-08-24 守恒(厦门)医疗科技有限公司 二氢萘并[2,1-d]异噁唑酰胺类衍生物及其在抗肿瘤药物的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
GB9519490D0 (en) 1995-09-25 1995-11-29 Melvin William T Use of a cytochrome P450 enzyme in tumour cells as a marker and target
US6548530B1 (en) * 1995-10-03 2003-04-15 The Scripps Research Institute CBI analogs of CC-1065 and the duocarmycins
ATE301639T1 (de) * 1996-03-08 2005-08-15 Scripps Research Inst Mcbi analoge von cc-1065 und die duocarmycine
US5843937A (en) * 1996-05-23 1998-12-01 Panorama Research, Inc. DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
CA2255703A1 (en) * 1996-05-31 1997-12-04 Dale L. Boger Analogs of cc-1065 and the duocarmycins
ATE310725T1 (de) * 1996-09-12 2005-12-15 Auckland Uniservices Ltd Kondensierte n-acylindole als antitumormittel
CA2319836C (en) 1998-02-06 2010-11-23 De Montfort University Hydroxylation activated prodrugs
EP1408970B1 (en) * 2001-02-22 2007-05-09 School Of Pharmacy, University Of London Indolines and tetrahydro-quinolines as prodrugs for tumour treatment
ES2299560T3 (es) * 2001-02-22 2008-06-01 University Of Bradford Derivados de pirrolindol y de pirroloquinolina como profarmacos para el tratamiento de tumores.
WO2002096910A1 (en) * 2001-05-31 2002-12-05 Medarex, Inc. Cytotoxins, prodrugs, linkers and stabilizers useful therefor
WO2004101767A2 (en) * 2003-05-13 2004-11-25 The Scripps Research Institute Cbi analogues of the duocarmycins and cc-1065
WO2005112919A2 (en) * 2004-05-19 2005-12-01 Medarex, Inc. Self-immolative linkers and drug conjugates

Also Published As

Publication number Publication date
JP2004522779A (ja) 2004-07-29
JP4862120B2 (ja) 2012-01-25
US8017640B2 (en) 2011-09-13
US20070161669A1 (en) 2007-07-12
DE60211905D1 (de) 2006-07-06
EP1408960A1 (en) 2004-04-21
US20040138246A1 (en) 2004-07-15
EP1408960B1 (en) 2006-05-31
US7192977B2 (en) 2007-03-20
WO2002067930A1 (en) 2002-09-06
DE60211905T2 (de) 2007-01-18

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