JP4824553B2 - ペンタン−1,5−ジオールを用いることによる抗生物質耐性細菌の増殖阻害方法 - Google Patents
ペンタン−1,5−ジオールを用いることによる抗生物質耐性細菌の増殖阻害方法 Download PDFInfo
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- JP4824553B2 JP4824553B2 JP2006517050A JP2006517050A JP4824553B2 JP 4824553 B2 JP4824553 B2 JP 4824553B2 JP 2006517050 A JP2006517050 A JP 2006517050A JP 2006517050 A JP2006517050 A JP 2006517050A JP 4824553 B2 JP4824553 B2 JP 4824553B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
- Y10T442/20—Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
- Y10T442/2525—Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]
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- Animal Behavior & Ethology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Communicable Diseases (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
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- Wood Science & Technology (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Description
本発明は、多剤耐性菌の増殖阻害方法及び対応する組成物の製造方法、かかる組成物及び当該組成物の使用に関する。
よく「多剤耐性」と称される、細菌の抗生物質耐性株によって起こる感染は、保険医療において主な問題である。「多剤耐性」は、対応する非耐性株に対して効果的であることが知られている少なくとも1つの抗生物質に対する耐性と理解される。この明細書の文脈では、抗生物質は、医薬の形態で人に局所投与される薬剤であり、及び組成物が、それが使用される細菌又は細菌類の代謝と特異的に相互作用する薬剤である。従って、用語「抗生物質」は、皮膚に対しても有害である非特異的抗菌作用を示す単なる殺菌剤、及び皮膚がせいぜい短時間暴露されるか又は全く暴露されないような単なる殺菌剤、例えばそれぞれクロルヘキシジン及び水溶性次亜鉛素酸塩、を排除する。
本発明の目的は、多剤耐性菌の増殖の阻害方法を提供することである。
本発明は、ペンタン-1,5-ジオールが多剤耐性菌に対して効果的である、という洞察に基づく。本発明者らは、15重量%以上のペンタン-1,5-ジオール、及び特定の微生物に関して、静菌作用を欠くか又はペンタン-1,5-ジオールの静菌作用の重量基準で5%未満である静菌作用を有する好適な担体を含む組成物が、多剤耐性菌に対して効果的な静菌作用を提供する、ことを見出した。これは、ペンタン-1,5-ジオール及び類似のジオールについて公知の中程度の抗菌作用の点からでさえ、全く予想外である。加えて、本発明の静菌作用が、その他の低分子脂肪族ジオール、例えばプロパン-1,2-ジオール、プロパン-1,3-ジオール、ブタン-1,2-ジオール、ブタン-1,3-ジオール、ブタン-1,4-ジオール、ブタン-2,3-ジオール、2-メチルプロパン-1,2-ジオール、2-メチルプロパン-1,3-ジオール、2-ヒドロキシメチル-1-プロパノール、ペンタン-1,2-ジオール、ペンタン-2,3-ジオール、2-ヒドロキシメチル-1-ブタノール、2-メチルブタン-1,2-ジオール、3-メチルブタン-1,2-ジオール、2-メチルブタン-1,3-ジオール、3-メチルブタン-1,3-ジオール、2-メチルブタン-1,4-ジオール、ヘキサン-1,2-ジオール、ヘキサン-1,6-ジオール、2-メチルペンタン-1,5-ジオール、3-メチルペンタン-1,5-ジオールと共有されると考えられる理由がある。
−15重量%以上のペンタン-1,5-ジオール及び好適な担体を含む殺菌組成物を提供すること;
−当該組成物を当該表面に適用すること;
−場合により、当該組成物を室温で5分〜24時間の期間、当該表面に接触し続けること;及び
−当該表面を水又は水溶性界面活性剤組成物で濯ぐこと
を含む、多剤耐性菌で汚染された表面の殺菌方法を更に開示する。
実施例1 菌に対するペンタン-1,5-ジオールの阻害活性の測定
多数の菌に対するペンタン-1,5-ジオールの最小阻害濃度(MIC)は、標準血液アガー希釈法によって得た(24時間、37℃)。重量で2.5%ずつ増加させたペンタン-1,5-ジオール濃度の試料を、凝固の前に、アガーの凝固温度より高い温度で成分を混合することによって調製した。以下の菌を試験した:メシチリン-耐性黄色ブドウ球菌(Staphylococcus aureus)(MSRA);フシジン酸-耐性黄色ブドウ球菌(S. aureus);非-耐性化膿性連鎖球菌(S. pyogenes);凝固-陰性ブドウ球菌(staphylococci)(耐性については、以下の表1を参照されたい);バンコマイシン-耐性腸球菌(enterococci)(Enterococcus CCUG van A及びvan B);非-耐性大腸菌(Escherichia coli);セファドロキシル、ニトロフラントイン、メシリナムに対するアシネトバクター属耐性;ほとんどの抗生物質の種類に対するセラシア属マルトフィリア(Serratia maltophilia)耐性;エンテロバクター属(Enterobacter)(耐性については、以下の表1を参照されたい;セファドロキシル及びニトロフラントインに対する追加の耐性);非-耐性α-連鎖球菌(streptococci);非-耐性連鎖球菌(Streptococcus)群G;緑膿菌(Pseudomonas aeruginosa)(耐性については以下の表2を参照されたい)。103及び105細菌の接種材料を用いた。接種材料に大きな差は見られなかった。これは、ペンタン-1,5-ジオールの阻害効果が、一般的な大多数の抗生物質の挙動に比較した接種材料の大きさの基本的に無関係である、ことを示すものである。結果を表1及び2に示す;耐性は選択した抗生物質のみに対して示した。
ペンタン-1,5-ジオールの急性毒性を経口投与及び局所投与及び吸入について試験した。
ペンタン-1,5-ジオール組成物を含む医療パッチで皮膚炎症を試験した。ミシン目のあるポリエチレンフィルムで裏打ちした5 x 5 x 1 cm (非圧縮)の大きさの殺菌医療綿パッチの前面に3 gのペンタン-1,5-ジオールを塗布し、24時間、男性のボランティアの皮膚(左腕上部)に貼布した。パッチを取り除いた時に、皮膚は炎症していないようだった。
Claims (2)
フシジン酸耐性黄色ブドウ球菌(Staphylococcus aureus);
フシジン酸耐性凝固-陰性ブドウ球菌(Staphylococci);
メシチリン及びフシジン酸耐性黄色ブドウ球菌;
フシジン酸耐性腸球菌(Enterococcus);
フシジン酸及びバンコマイシン耐性腸球菌;
フシジン酸、シプロフロキサシン及びトリメトプリム耐性腸球菌;
フシジン酸及びトリメトプリム耐性腸球菌;
バンコマイシン耐性腸球菌;
セファドロキシル、ニトロフラントイン及びメシリナム耐性アシネトバクター(Acinetobacter)属細菌;
トリメトプリム耐性大腸菌(Escherichia coli);
バンコマイシン耐性緑膿菌(Pseudomonas aeruginosa);
トリメトプリム耐性緑膿菌;並びに
シプロフロキサシン及びトリメトプリム耐性緑膿菌
からなる群より選ばれる、組成物。
フシジン酸耐性黄色ブドウ球菌(Staphylococcus aureus);
フシジン酸耐性凝固-陰性ブドウ球菌(Staphylococci);
メシチリン及びフシジン酸耐性黄色ブドウ球菌;
フシジン酸耐性腸球菌(Enterococcus);
フシジン酸及びバンコマイシン耐性腸球菌;
フシジン酸、シプロフロキサシン及びトリメトプリム耐性腸球菌;
フシジン酸及びトリメトプリム耐性腸球菌;
バンコマイシン耐性腸球菌;
セファドロキシル、ニトロフラントイン及びメシリナム耐性アシネトバクター(Acinetobacter)属細菌;
トリメトプリム耐性大腸菌(Escherichia coli);
バンコマイシン耐性緑膿菌(Pseudomonas aeruginosa);
トリメトプリム耐性緑膿菌;並びに
シプロフロキサシン及びトリメトプリム耐性緑膿菌
からなる群より選ばれる、パッチ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0301862A SE0301862D0 (sv) | 2003-06-26 | 2003-06-26 | Sätt att inhibera tillväxten av mot antibiotika resistenta bakterier |
SE0301862-9 | 2003-06-26 | ||
PCT/SE2004/001001 WO2004112765A1 (en) | 2003-06-26 | 2004-06-23 | Method for inhibiting the growth of antibiotic-resistant of bacteria by using pentane-1,5-diol |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007521265A JP2007521265A (ja) | 2007-08-02 |
JP4824553B2 true JP4824553B2 (ja) | 2011-11-30 |
Family
ID=27656597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2006517050A Expired - Fee Related JP4824553B2 (ja) | 2003-06-26 | 2004-06-23 | ペンタン−1,5−ジオールを用いることによる抗生物質耐性細菌の増殖阻害方法 |
Country Status (16)
Country | Link |
---|---|
US (1) | US7973080B2 (ja) |
EP (1) | EP1635802B1 (ja) |
JP (1) | JP4824553B2 (ja) |
KR (1) | KR20060103817A (ja) |
CN (1) | CN1812775B (ja) |
AT (1) | ATE403421T1 (ja) |
AU (1) | AU2004249102A1 (ja) |
BR (1) | BRPI0411749A (ja) |
CA (1) | CA2529287A1 (ja) |
DE (1) | DE602004015597D1 (ja) |
DK (1) | DK1635802T3 (ja) |
ES (1) | ES2313038T3 (ja) |
PL (1) | PL1635802T3 (ja) |
RU (1) | RU2355392C9 (ja) |
SE (1) | SE0301862D0 (ja) |
WO (1) | WO2004112765A1 (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0518676A2 (pt) | 2004-11-29 | 2008-12-02 | Ambria Dermatology Ab | composiÇço, uso da mesma, e, mÉtodos de fabricar uma composiÇço e de tratar uma infecÇço microbiana |
US20090232761A1 (en) * | 2005-11-29 | 2009-09-17 | Jan Faergemann | Use of a Composition Comprising Pentane-1, 5-Diol as Deodorant |
SE533425C2 (sv) * | 2008-07-07 | 2010-09-21 | Ambria Dermatology Ab | Antimikrobiell sammansättning |
FR2940281B1 (fr) | 2008-12-22 | 2011-04-01 | Fabre Pierre Dermo Cosmetique | Ester de diol et d'acide gras polyinsature comme agent anti-acne |
CN103816165B (zh) * | 2014-03-11 | 2019-03-01 | 北京德默高科医药技术有限公司 | 一种治疗痤疮的组合物 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015597A1 (en) * | 1989-06-13 | 1990-12-27 | Gunnar Swanbeck | Preparation for topical treatment of infections caused by virus, bacteria and fungi |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0381617T3 (da) * | 1989-01-31 | 1996-06-10 | Ciba Geigy Ag | Desinfektions- og rensemiddel til kontaktlinser |
US5369129A (en) * | 1989-06-13 | 1994-11-29 | Hydro Pharma Ab | Preparation of topical treatment of infections caused by virus, bacteria and fungi |
SE500777C2 (sv) * | 1992-04-14 | 1994-08-29 | Hydro Pharma Ab | Antimikrobiell komposition med potentierad effekt innehållande bl a vissa monoglycerider, förfarande för framställning därav samt användning därav |
US5370876A (en) * | 1993-01-08 | 1994-12-06 | Microbarriers | Antimicrobial protective skin composition and method for protecting skin from body fluids |
US5879690A (en) * | 1995-09-07 | 1999-03-09 | Perricone; Nicholas V. | Topical administration of catecholamines and related compounds to subcutaneous muscle tissue using percutaneous penetration enhancers |
GB9626513D0 (en) * | 1996-12-20 | 1997-02-05 | Bioglan Ireland R & D Ltd | A pharmaceutical composition |
US6548074B1 (en) | 1999-07-22 | 2003-04-15 | Elizabeth Arden Co., Division Of Conopco, Inc. | Silicone elastomer emulsions stabilized with pentylene glycol |
US6649176B1 (en) | 2000-06-29 | 2003-11-18 | Johnson & Johnson Consumer Companies, Inc. | Compositions containing mineral water |
US20020192273A1 (en) * | 2001-06-15 | 2002-12-19 | Teri Buseman | Therapeutic patch useful for the treatment of hemorrhoids |
-
2003
- 2003-06-26 SE SE0301862A patent/SE0301862D0/xx unknown
-
2004
- 2004-06-23 DK DK04749039T patent/DK1635802T3/da active
- 2004-06-23 KR KR1020057024973A patent/KR20060103817A/ko not_active Application Discontinuation
- 2004-06-23 AT AT04749039T patent/ATE403421T1/de not_active IP Right Cessation
- 2004-06-23 RU RU2005140049A patent/RU2355392C9/ru active
- 2004-06-23 ES ES04749039T patent/ES2313038T3/es not_active Expired - Lifetime
- 2004-06-23 EP EP04749039A patent/EP1635802B1/en not_active Expired - Lifetime
- 2004-06-23 WO PCT/SE2004/001001 patent/WO2004112765A1/en active Search and Examination
- 2004-06-23 JP JP2006517050A patent/JP4824553B2/ja not_active Expired - Fee Related
- 2004-06-23 CN CN2004800177928A patent/CN1812775B/zh not_active Expired - Fee Related
- 2004-06-23 BR BRPI0411749 patent/BRPI0411749A/pt not_active IP Right Cessation
- 2004-06-23 US US10/562,608 patent/US7973080B2/en not_active Expired - Fee Related
- 2004-06-23 PL PL04749039T patent/PL1635802T3/pl unknown
- 2004-06-23 CA CA 2529287 patent/CA2529287A1/en not_active Abandoned
- 2004-06-23 DE DE200460015597 patent/DE602004015597D1/de not_active Expired - Lifetime
- 2004-06-23 AU AU2004249102A patent/AU2004249102A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015597A1 (en) * | 1989-06-13 | 1990-12-27 | Gunnar Swanbeck | Preparation for topical treatment of infections caused by virus, bacteria and fungi |
Also Published As
Publication number | Publication date |
---|---|
WO2004112765A1 (en) | 2004-12-29 |
ATE403421T1 (de) | 2008-08-15 |
US7973080B2 (en) | 2011-07-05 |
DE602004015597D1 (de) | 2008-09-18 |
CN1812775B (zh) | 2011-07-27 |
RU2005140049A (ru) | 2006-07-27 |
PL1635802T3 (pl) | 2009-01-30 |
AU2004249102A1 (en) | 2004-12-29 |
CA2529287A1 (en) | 2004-12-29 |
KR20060103817A (ko) | 2006-10-04 |
EP1635802A1 (en) | 2006-03-22 |
EP1635802B1 (en) | 2008-08-06 |
US20070020322A1 (en) | 2007-01-25 |
RU2355392C9 (ru) | 2009-07-27 |
RU2355392C2 (ru) | 2009-05-20 |
SE0301862D0 (sv) | 2003-06-26 |
DK1635802T3 (da) | 2008-12-08 |
JP2007521265A (ja) | 2007-08-02 |
CN1812775A (zh) | 2006-08-02 |
BRPI0411749A (pt) | 2006-08-08 |
ES2313038T3 (es) | 2009-03-01 |
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