JP4813886B2 - Skin preparation for improving skin barrier function - Google Patents

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin suitable for cosmetics.

Skin upset with a marked increase in transdermal water dispersion loss (TEWL) is one of the phenomena that has been increasing rapidly in recent years. With a marked increase in TEWL, the skin barrier function is significantly reduced,
This is a phenomenon in which the skin itself becomes more sensitive. In recent years it increased to have sensitive skin, in the chemical hypersensitivity, to the beginning of the decline of the barrier function, which is said to be not a few things that symptoms became serious and repeat the vicious circle. It is also said that one of the causes of the decrease in the skin barrier function that is the origin of this is a marked increase in the sympathetic nerve on the living body side against an excessively stressed state. Since the increase in TEWL also leads to further increase in sympathetic nerve, it is important for skin improvement to end this vicious circle, and the development of such a technique has been desired. In response to such a request, various studies have been made, and it is attempted to improve micro blood flow by administration of ursolic acid and the like, thereby improving stress-induced skin barrier function and improving TEWL enhancement. that is (for example, see Patent Document 1). The effect of ursolic acid is certainly remarkable, but the biggest problem is that in the skin with enhanced TEWL, even the components of ordinary cosmetics may induce inflammation and have low water solubility. in ursolic acids, upon administration to effect suppression of TEWL, suitable vehicle to be carrying it is exist a problem that does not exist. In order to improve the skin barrier function, for example, it is useful to construct a protective layer on the skin using a hydrophilic polymer having excellent water retention ability such as polymethacryloyloxyethyl phosphorylcholine. is that known (e.g., see Patent Document 2). However, such a hydrophilic polymer hydrated protective film has a problem in maintaining the film for a long time. That is, in the skin where TEWL is enhanced, an external preparation for skin that suppresses TEWL by administration has been desired, but it has not been obtained.

Alginic acid, on the other hand, is a water-soluble polymer and is widely used in cosmetics as a moisturizer. Alginic acid polyhydric alcohol esters are hydrophilic polymers with emulsifying power and are already known to be usable in emulsified cosmetics. It is that not (e.g., see Patent Document 3). Furthermore, it branched fatty acids such as isostearic acid that has been known to use the emulsified cosmetic with an alkyl-modified carboxyvinyl polymers (for example, see Patent Document 4). However, there is no known skin external preparation containing 1) one or more selected from alginic acid, polyhydric alcohol esters of alginic acid and salts thereof, and 2) branched fatty acids and / or salts thereof. Also, it has not been known at all that it has the effect of improving the TEWL when administered to a person with increased transcutaneous water dispersion loss (TEWL) by adopting such a configuration.

JP 2002-97135 A JP 9-315949 A JP 2004-196728 A JP 2004-231620 A

  The present invention has been made under such circumstances, and an object of the present invention is to provide a means for improving the TEWL by administering to a person with increased transdermal water dispersion loss (TEWL).

In view of such a situation, the present inventors have made extensive research efforts to find a means for improving the TEWL by administering it to a person with increased transcutaneous water dispersion loss (TEWL). A skin external preparation containing one or more selected from alginic acid, polyhydric alcohol ester of alginic acid and salts thereof, and 2) a branched fatty acid and / or a salt thereof has such characteristics. I found out and came to complete the invention. That is, the present invention is as follows.
(1) An external preparation for skin comprising 1) alginic acid and / or a salt thereof, 2) propylene glycol ester of alginate, and 3) 1 to 5% by mass of isostearic acid and / or a salt thereof .
(2) The external preparation for skin according to (1), which is in the form of an oil-in-water emulsifier .
(3) The external preparation for skin according to (1) or (2), which is for improving transdermal water dispersion loss (TEWL) .
(4) Further, Bakumondo extract, camellia extract, clove extract, soy protein, tonin extract, butterfly extract, cucumber extract, tonin extract, chorei extract, hypericum extract, lauren extract, morning glory extract, carrot extract, bucurium extract, marjoram Extract, yarrow extract, rosemary extract, sage extract, mint extract, sulfated alginic acid and its salt, optionally sulfated trehalose and its salt, polymer or copolymer comprising methacryloyloxyethyl phosphorylcholine as a constituent monomer, par Polymers or copolymers containing fluoroalkyl-modified methacrylic acid as constituents, polymers or copolymers containing methacryloyl lysine as constituent monomers, glucosyl ethyl Polymers or copolymers containing methacrylate as a constituent monomer, resorcinol derivatives, ascorbic acid or derivatives thereof, horse chestnut extract, ganoderma extract, royal jelly or extract thereof, koki extract, fucoidan, macadamia nut extract, lavender extract, tranexamic acid And derivatives thereof, quince extract, hyaluronic acid and salts thereof, glycyrrhetinic acid and derivatives thereof, saponin, simanol derivatives and salts thereof, polysulfated polysaccharides, glutamyl lysine and esculetin and glycosides thereof. The skin external preparation according to any one of (1) to (3), which contains at least a seed.

  ADVANTAGE OF THE INVENTION According to this invention, the means for improving the TEWL can be provided by administering to a person with increased transcutaneous water dispersion loss (TEWL).

(1) Alginic acids which are essential components of the external preparation for skin of the present invention The external preparation for skin of the present invention contains one or more selected from alginic acid, polyhydric alcohol esters of alginic acid and salts thereof as essential components. contains. Alginic acid is a water-soluble polymer that is already widely used as a raw material for cosmetics, and such cosmetic grades can be used. As the polyhydric alcohol constituting the polyhydric alcohol ester of alginic acid, as long as it is used in such a skin external preparation can be used without particular limitation, those having 2 to 4 carbon atoms Are preferred, and those having no ether bond are preferred. Specifically, propylene glycol, glycerin, 1,3-butanediol, ethylene glycol and the like can be preferably exemplified, and propylene glycol can be particularly preferably exemplified from the balance between hydrophilicity and lipophilicity. Any esters of polyhydric alcohols of these alginic acid are also known compounds, their preparation methods are already known. As such a alginate preparation of polyhydric alcohols esters of phosphate, a salt of alginic acid such as sodium alginic acid, the corresponding polyhydric alcohol monohalide can be exemplified be the presence of alkali reactions. For example, if the alginic acid propylene glycol ester, may be reacted in the presence of a such as potassium carbonate alginic acid sodium and 1-chloro-2-propanol in aqueous alcohol, there in alginic acid glyceryl esters For example, it can be produced by treating 1-chloro- 2- propanol in the above reaction in the same manner instead of 1-chloro-2,3-propanediol. In addition, in such esters also present those that are already commercially available, can also be used to purchase such a commercially available product. Suitable commercially available products, for example, if the alginic acid propylene glycol ester, sold by Ltd. Chimica, "Kimiroido LLV", "Kimiroido LV", "Kimiroido MV", "Kimiroido HV", "Kimiroido BF "," Kimiloid NLSK "and the like. These differ in viscosity and degree of esterification. Particularly preferred for use as the emulsified composition of the present invention is “Chimiloid NLSK”. In the emulsified composition of the present invention, esters of polyhydric alcohols such alginic acid has an effect to stabilize an emulsion dispersion of oily components. It These esters of polyhydric alcohols alginic acid may also be contained only species, may also be contained in combination of two or more. In the skin external preparation of the present invention, a preferred content of the polyhydric alcohol esters of such alginic acid, relative to the total amount of the skin treatment composition, in a total amount, it is from 0.05 to 5 wt%, more preferably 0 .1 to 2% by weight. Moreover, when it contains the polyhydric alcohol ester of alginic acid, it is more preferable to contain alginic acid and / or its salt together. The preferable content of alginic acid and / or a salt thereof in such a case is 0.1 to 5% by mass, more preferably 0.2 to 1% by mass , based on the total amount of the external preparation for skin. . Such a component can be used by partially constructing a crosslinked structure by adding a salt such as calcium chloride or magnesium chloride if desired. By containing these, the micelles of the emulsion and the solubilized product can be stabilized and allowed to exist on the skin. In addition, these components form a moderately crosslinked structure with a branched fatty acid, which will be described later, and in order to carry moisture in the crosslinked structure, a moisture retention barrier layer is constructed on the skin. By constructing such a structure, it is possible to prevent an irritant from entering the skin. Furthermore, since an oily component is also included in such a protective barrier layer, there is very little probability of inducing inflammation in the skin where TEWL is enhanced by contact with an external preparation for skin.

(2) Branched fatty acid which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention contains a branched fatty acid and / or a salt thereof as an essential component. The branched fatty acid forms a crosslinked structure of a complex salt via alginic acid or a carboxyl group of a polyhydric alcohol ester of alginic acid and an alkali, and includes moisture and fats and oils in this structure. By constructing a film having such a structure on the skin, a skin with enhanced TEWL is exhibited with a very low probability of inducing inflammation while forming a moisturizing film. In order to express such an effect, the alkyl chain of the branched fatty acid preferably has a certain length, and preferably has 10 to 30 carbon chains. In addition, since it does not have flexibility when it is linear, it is difficult to form a crosslinked structure in the film, and the above-described effects cannot be obtained. Specific examples of preferred branched fatty acids include isooctanoic acid, isopalmitic acid, isostearic acid, octyldodecanoic acid and the like, and isostearic acid or isopalmitic acid is particularly preferred. In the external preparation for skin of the present invention, such a branched fatty acid can contain only one species, or can contain two or more species in combination. The preferable content of the branched fatty acid in the external preparation for skin of the present invention is a total amount of 0.1 to 10% by mass, and more preferably 1 to 5% by mass with respect to the total amount of external preparation for skin. If the amount is too small, the above effect may not be achieved, and if the amount is too large, the film does not stop in the membrane and may be stimulated.

(3) The skin external preparation of this invention The skin external preparation of this invention contains the said essential component, It is characterized by the above-mentioned. Furthermore, the external preparation for skin of the present invention is suitably administered to a person with increased transdermal water dispersion loss (TEWL). For this reason, the skin external preparation of this invention can contain the component which has the effect | action which suppresses the enhancement of TEWL like ursolic acid, for example, The form containing such a component is preferable.

  Examples of the ursolic acid include ursolic acid, a salt of ursolic acid, and an ester of ursolic acid, and the salt of ursolic acid can be used without any particular limitation as long as it is an alkali salt commonly known in cosmetics. For example, alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium and magnesium, organic amine salts such as ammonium salt, triethanolamine salt and triethylamine salt, bases such as lysine salt and arginine salt Preferred amino acid salts and the like. The ursolic acid ester is preferably an aliphatic or aromatic ester having 1 to 30 carbon atoms. For example, as an aliphatic ester, methyl ester, ethyl ester, hexyl ester, 2-ethylhexyl Preferred examples include esters, lauryl esters, stearyl esters, behenyl esters, isostearyl esters, oleyl esters and the like, and aromatic esters include benzyl esters, phenethyl esters, cinnamyl esters, and the like. Such an ester can be produced by reacting an alcohol forming an ester with a halogenating reagent such as thionyl chloride, converting it to a halide, and then condensing with ursolic acid in the presence of an alkali. A production example is shown below. Such components preferably contain 0.01 to 0.5% by mass of one or two or more.

<Production Example 1>
4.5 g of ursolic acid is dissolved in 100 ml of dimethylformamide, 1 g of potassium carbonate is added thereto, the temperature is raised to 80 ° C., 1 ml of methyl iodide is added dropwise thereto, and the mixture is allowed to react at 80 ° C. for 3 hours. After distillation, the residue was purified by silica gel column chromatography (elution solvent: chloroform) to obtain 2.7 g of ursolic acid methyl ester.

<Production Example 2>
4.5 g of ursolic acid and stearyl chloride obtained by reacting 3 g of stearyl alcohol and 2 ml of thionyl chloride were treated in the same manner as in Production Example 1 to obtain 3.9 g of ursolic acid stearyl ester.

<Production Example 3>
4.5 g of ursolic acid and oleyl chloride obtained by reacting 3 g of oleyl alcohol and 2 ml of thionyl chloride were treated by the same procedure as in Production Example 1 to obtain 3.2 g of oleic acid oleyl ester.

<Production Example 4>
4.5 g of ursolic acid and 1.5 ml of benzyl chloride were treated in the same manner as in Production Example 1 to obtain 2.4 g of ursolic acid benzyl ester.

  The external preparation for skin of the present invention can be applied without particular limitation as long as it is used externally on the skin, and examples thereof include cosmetics including quasi-drugs, external preparations for skin, and external items for skin. Among these, cosmetics are preferable, and quasi drugs that have promoted anti-inflammatory effects are particularly preferable because they suppress inflammation. Also, the dosage form can be applied without particular limitation as long as it is known for external preparations for skin, such as an emulsifier form, a solubilizer form, and a microemulsion form. A particularly preferred dosage form is an emulsifier form, and an oil-in-water emulsifier form is particularly preferred.

In the external preparation for skin of the present invention, in addition to the above-mentioned components, optional components that are usually used in cosmetics and external preparations for skin can be contained. Examples of such optional components, e.g., macadamia nut oil, Abou transient oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, cured Oils such as coconut oil, hydrogenated oil, molasses, hydrogenated castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, waxes; liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin Hydrocarbons such as petrolatum, microcrystalline wax; higher fatty acids such as oleic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl alcohol, behe Higher alcohols such as alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, diacid malate Isostearyl, ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glycerin tri-2-ethylhexanoate, tri-2-ethylhexanoate trimethylolpropane, triisostearin Synthetic ester oils such as acid trimethylolpropane and tetra-2-ethylhexanoic acid pentane erythritol; dimethylpolysiloxane, methylphenylpolysiloxane, diphenyl Chain polysiloxanes such as polypolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified Oil agents such as silicone oil such as modified polysiloxane such as polysiloxane; Anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, trisulfamine amine alkyl sulfate; stearyl trimethyl chloride Cationic surfactants such as ammonium, benzalkonium chloride and laurylamine oxide; imidazoline-based amphoteric surfactants (2-
Amphoteric surfactants such as cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt), betaine surfactants (alkylbetaine, amidebetaine, sulfobetaine, etc.), acylmethyltaurine; sorbitan Fatty acid esters (such as sorbitan monostearate, sorbitan sesquioleate), glycerin fatty acids (such as glyceryl monostearate), propylene glycol fatty acid esters (such as propylene glycol monostearate), hydrogenated castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), PO Glycerin fatty acid esters (such as POE-glycerin monoisostearate), POE fatty acid esters (such as polyethylene glycol monooleate and POE distearate), POE alkyl ethers (such as POE2-octyldodecyl ether), POE alkylphenyl ethers (POE) Nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.) ), Nonionic surfactants such as sucrose fatty acid esters and alkyl glucosides; polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, mal Polyhydric alcohols such as tall, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol; pyrrolidone Moisturizing ingredients such as sodium carboxylate, lactic acid, sodium lactate; surface may be treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate Powders such as, etc . ; surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments; surface may be treated Pearl agents such as titanium mica, fish phosphorus foil, bismuth oxychloride; may be raked Red 202, red 228, red 226, yellow 4, blue 404, yellow 5, red 505, red 230, red 223, orange 201, red 213, yellow 204, yellow Organic dyes such as No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204; Organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer; Paraaminobenzoic acid type UV absorbers; anthranilic acid UV absorbers; salicylic acid UV absorbers ; cinnamic acid UV absorbers ; benzophenone UV absorbers; sugar UV absorbers; 2- (2′-hydroxy-5′-t-octyl) UV absorbers such as phenyl) benzotriazole and 4-methoxy-4′-t-butyldibenzoylmethane; ethanol, isopropanol Vitamin B such as vitamin A or its derivative, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or its derivative, vitamin B12, vitamin B15 or its derivative; α- Vitamin E such as tocopherol, β-tocopherol, γ-tocopherol and vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, vitamins such as pyrroloquinoline quinone and the like; antibacterial agents such as phenoxyethanol are preferably exemplified . In particular, the following can be exemplified as preferable components added in a small amount. (However, numerical values in parentheses indicate preferred contents.)

(Preferred trace component)
Bacmond extract (0.001 to 0.1% by mass), Clover extract (0.001 to 0.1% by mass), clove extract (0.001 to 0.1% by mass), soy protein (0.001) To 0.1% by mass), Tonin extract (0.001 to 0.1% by mass), Butterflyfish extract (0.001 to 0.1% by mass), Kudin extract (0.001 to 0.1% by mass), Tonin extract (0.001-0.1% by mass), cholay extract (0.001-0.1% by mass), hypericum extract (0.001-0.1% by mass), oren extract (0.001-0. 1% by weight), morning glory extract (0.001 to 0.1% by weight), carrot extract (0.001 to 0.1% by weight), horse chestnut extract (0.001 to 0.1% by weight), marjoram extract (0.001-0.1 %), Yarrow extract (0.001-0.1% by mass), rosemary extract (0.001-0.1% by mass), sage extract (0.001-0.1% by mass), mint extract (0.001 to 0.1% by mass), sulfated alginic acid and its salt (0.001 to 0.1% by mass), trehalose which may be sulfated and its salt (0.001 to 0.1% by mass) %), A polymer or copolymer (0.001 to 0.1% by mass) containing methacryloyloxyethyl phosphorylcholine as a constituent monomer, or a polymer or copolymer (0.001 to 0.001%) containing perfluoroalkyl-modified methacrylic acid as a constituent element. 1% by mass), a polymer or copolymer (0.001 to 0.1% by mass) containing methacryloyl lysine as a constituent monomer, glucosyl ethyl meta A polymer or copolymer (0.001 to 0.1% by mass), a resorcinol derivative (0.001 to 0.5% by mass), an ascorbic acid or a derivative thereof (0.001 to 0.1%) containing relate as a constituent monomer (Mass%), horse chestnut extract (0.001 to 0.1 mass%), ginger extract (0.001 to 0.1 mass%), royal jelly or its extract (0.001 to 0.1 mass%) , Koki extract (0.001-0.1% by mass), Fucoidan (0.001-0.1% by mass), Macadamia nut extract (0.001-0.1% by mass), Lavender extract (0.001) -0.1 mass%), tranexamic acid and its derivatives (0.001-0.1 mass%), quince extract (0.001-0.1 mass%), hyaluronic acid and its salts (0.0 01-0.1% by mass), glycyrrhetinic acid and its derivatives (0.001-0.1% by mass), saponin, simnol derivatives and their salts (0.001-0.1% by mass), polysulfated polysaccharides (0.001 to 0.1% by mass), glutamyllysine and esculetin and glycosides thereof (0.001 to 0.1% by mass)

  The external preparation for skin of the present invention can be produced by treating these components according to a conventional method.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to these examples.

  According to the formulation shown below, a cosmetic 1 in the form of an oil-in-water emulsifier, which is an external preparation for skin of the present invention, was produced. That is, ingredients (a), (b), and (c) were heated to 80 ° C., and (b) was gradually added to a with stirring.

<Test Example 1>
Four parts of 2cm x 4cm were made on the inner side of the forearm of a volunteer paneler (n = 5), and these parts were stripped 10 times with adhesive tape, and then a 2 mass% sodium lauryl sulfate aqueous solution was applied for 24 hours. And a rough skin vicious circle model was created. That is, this model is a model in which rough skin with poor recoverability is created by exposing the skin to irritant stress for a long time by removing the barrier layer of the skin and applying inflammatory stress to the skin. This can be confirmed by the TEWL value after rough skin creation. As described above, TEWL was measured with a tevameter (manufactured by Integral Co., Ltd.), and it was confirmed that there was no difference between the parts. The cosmetic of Comparative Example 1 in which the acid was replaced with stearic acid was applied, and the cosmetic of Comparative Example 2 in which sodium alginate and propylene glycol alginate of cosmetic 1 were replaced with an alkyl-modified carboxyvinyl polymer was applied to one site. did. The remaining 1 site was not treated. After this treatment was continued once a day, TEWL of each part was again measured with a tevameter. The results are shown in Table 1. From this, the cosmetic 1 alginate, a polyalcohol ester and salt of alginic acid, a synergistic effect of isostearic acid and salts thereof, it can be seen that expressing a re-establishment function excellent skin barrier function.

  In the same manner as in cosmetic 1 of Example 1, cosmetic 2 as an external preparation for skin of the present invention was produced according to the formulation shown in Table 3 below. In the evaluation of the method of Test Example 1, the TEWL, which was 34.8 at the beginning, changed to 19.8 after the test was completed, and the effect of the present invention was confirmed.

  In the same manner as in cosmetic 1 of Example 1, cosmetic 3 as an external preparation for skin of the present invention was produced according to the formulation shown in Table 4 below. In the evaluation of the method of Test Example 1, the TEWL, which was 35.1 at the beginning, changed to 19.7 after the test was completed, and the effect of the present invention was confirmed.

  In the same manner as cosmetic 1 in Example 1, cosmetic 4 as an external preparation for skin of the present invention was produced according to the formulation shown in Table 5 below. In the evaluation of the method of Test Example 1, the TEWL, which was 35.1 at the beginning, changed to 21.1 after the test was completed, and the effect of the present invention was confirmed.

  The present invention can be applied to external preparations for skin such as cosmetics.

Claims (4)

A skin external preparation characterized by containing 1) alginic acid and / or a salt thereof, 2) alginate propylene glycol ester, and 3) 1 to 5% by mass of isostearic acid and / or a salt thereof . The skin external preparation of Claim 1 which is an oil-in-water emulsifier form. The external preparation for skin according to claim 1 or 2, which is used for improving transdermal water dispersion loss (TEWL). In addition, Bakumondo extract, camellia extract, clove extract, soy protein, tonin extract, butterfly extract, cucumber extract, tonin extract, chorei extract, hypericum extract, scallop extract, morning glory extract, carrot extract, budweed extract, marjoram extract, seiyou Yarrow extract, rosemary extract, sage extract, mint extract, sulfated alginic acid and its salt, optionally sulfated trehalose and its salt, polymer or copolymer containing methacryloyloxyethyl phosphorylcholine as a constituent monomer, perfluoroalkyl modified Polymer or copolymer containing methacrylic acid as a constituent, polymer or copolymer containing methacryloyl lysine as a constituent monomer, glucosylethyl methacrylate Polymers or copolymers comprising relate as constituent monomers, resorcinol derivatives, ascorbic acid or derivatives thereof, horse chestnut extract, ganoderma extract, royal jelly or extract thereof, koki extract, fucoidan, macadamia nut extract, lavender extract, tranexamic acid And derivatives thereof, quince extract, hyaluronic acid and salts thereof, glycyrrhetinic acid and derivatives thereof, saponin, simanol derivatives and salts thereof, polysulfated polysaccharides, glutamyl lysine and esculetin and glycosides thereof. The skin external preparation according to any one of claims 1 to 3, comprising at least a seed.