JP4809930B2 - 関節リウマチ治療剤 - Google Patents

関節リウマチ治療剤 Download PDF

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Publication number
JP4809930B2
JP4809930B2 JP2010511837A JP2010511837A JP4809930B2 JP 4809930 B2 JP4809930 B2 JP 4809930B2 JP 2010511837 A JP2010511837 A JP 2010511837A JP 2010511837 A JP2010511837 A JP 2010511837A JP 4809930 B2 JP4809930 B2 JP 4809930B2
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JP
Japan
Prior art keywords
antibody
amino acid
seq
acid sequence
set forth
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Active
Application number
JP2010511837A
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English (en)
Japanese (ja)
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JPWO2010107108A1 (ja
Inventor
智之 井川
慎也 石井
敦彦 前田
実香 櫻井
哲郎 小嶋
達彦 橘
宙丈 白岩
浩行 角田
義信 樋口
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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Priority to JP2010511837A priority Critical patent/JP4809930B2/ja
Application granted granted Critical
Publication of JP4809930B2 publication Critical patent/JP4809930B2/ja
Publication of JPWO2010107108A1 publication Critical patent/JPWO2010107108A1/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2010511837A 2009-03-19 2010-03-19 関節リウマチ治療剤 Active JP4809930B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2010511837A JP4809930B2 (ja) 2009-03-19 2010-03-19 関節リウマチ治療剤

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2009067358 2009-03-19
JP2009067358 2009-03-19
JP2010511837A JP4809930B2 (ja) 2009-03-19 2010-03-19 関節リウマチ治療剤
PCT/JP2010/054763 WO2010107108A1 (ja) 2009-03-19 2010-03-19 関節リウマチ治療剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011104172A Division JP2011219478A (ja) 2009-03-19 2011-05-09 関節リウマチ治療剤

Publications (2)

Publication Number Publication Date
JP4809930B2 true JP4809930B2 (ja) 2011-11-09
JPWO2010107108A1 JPWO2010107108A1 (ja) 2012-09-20

Family

ID=42739764

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010511837A Active JP4809930B2 (ja) 2009-03-19 2010-03-19 関節リウマチ治療剤
JP2011104172A Pending JP2011219478A (ja) 2009-03-19 2011-05-09 関節リウマチ治療剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011104172A Pending JP2011219478A (ja) 2009-03-19 2011-05-09 関節リウマチ治療剤

Country Status (5)

Country Link
JP (2) JP4809930B2 (ko)
KR (1) KR101314880B1 (ko)
RU (1) RU2524152C2 (ko)
TW (1) TWI457134B (ko)
WO (1) WO2010107108A1 (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2564392T3 (es) 2007-01-23 2016-03-22 Shinshu University Inhibidores de IL-6 para el tratamiento de rechazo crónico
CN102256623A (zh) 2008-06-05 2011-11-23 独立行政法人国立癌症研究中心 神经浸润抑制剂
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
RS63800B1 (sr) 2010-05-28 2022-12-30 Chugai Pharmaceutical Co Ltd Poboljšanje antitumorskog odgovora t ćelije
EP3009518B1 (en) 2013-06-11 2020-08-12 National Center of Neurology and Psychiatry Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy
KR101892883B1 (ko) 2015-02-27 2018-10-05 추가이 세이야쿠 가부시키가이샤 Il-6 관련 질환 치료용 조성물
PL3299810T3 (pl) 2015-05-19 2021-12-13 National Center Of Neurology And Psychiatry Sposób określania zastosowania nowej terapii u pacjentów ze stwardnieniem rozsianym (sm)
JP7185884B2 (ja) 2017-05-02 2022-12-08 国立研究開発法人国立精神・神経医療研究センター Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法
WO2019078344A1 (ja) 2017-10-20 2019-04-25 学校法人兵庫医科大学 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物
TWI822728B (zh) 2018-01-31 2023-11-21 加藤元一 含有il-6抑制劑的哮喘治療劑
CN113660951A (zh) 2019-03-29 2021-11-16 中外制药株式会社 含有抗il-6受体抗体的抑制bbb功能低下的抑制剂
MX2021012163A (es) 2019-04-17 2022-01-31 Univ Hiroshima Agente terapeutico para cancer urologico que se caracteriza por ser administrado con un inhibidor de il-6 y un inhibidor de ccr2 en combinacion.
KR20230156368A (ko) 2021-03-12 2023-11-14 추가이 세이야쿠 가부시키가이샤 중증 근무력증의 치료 또는 예방용의 의약 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL182089B1 (en) * 1994-10-21 2001-11-30 Chugai Pharmaceutical Co Ltd Pharmaceutic compositions for treating diseases caused by production of il-6
KR101564713B1 (ko) * 2004-12-28 2015-11-06 이나뜨 파르마 Ｎｋｇ2ａ에 대한 단클론 항체
WO2008020079A1 (en) * 2006-08-18 2008-02-21 Ablynx N.V. Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
WO2009010539A2 (en) * 2007-07-19 2009-01-22 Ablynx. N.V. Receptor for interleukin-6 (il-6) from macaca fascicularis
AU2008304756B8 (en) * 2007-09-26 2015-02-12 Chugai Seiyaku Kabushiki Kaisha Anti-IL-6 receptor antibody
AR068563A1 (es) * 2007-09-26 2009-11-18 Chugai Pharmaceutical Co Ltd Region constante de anticuerpo mutante
MY195714A (en) * 2008-04-11 2023-02-07 Chugai Pharmaceutical Co Ltd Antigen-Binding Molecule Capable of Binding to Two or More Antigen Molecules Repeatedly
TWI440469B (zh) * 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules

Also Published As

Publication number Publication date
KR101314880B1 (ko) 2013-10-04
KR20110139734A (ko) 2011-12-29
TWI457134B (zh) 2014-10-21
JP2011219478A (ja) 2011-11-04
RU2524152C2 (ru) 2014-07-27
WO2010107108A1 (ja) 2010-09-23
RU2011142183A (ru) 2013-04-27
JPWO2010107108A1 (ja) 2012-09-20
TW201034685A (en) 2010-10-01

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