JP4791359B2 - バクテリオシンおよびシソ科植物からの抽出物を含有する組成物 - Google Patents
バクテリオシンおよびシソ科植物からの抽出物を含有する組成物 Download PDFInfo
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- JP4791359B2 JP4791359B2 JP2006523669A JP2006523669A JP4791359B2 JP 4791359 B2 JP4791359 B2 JP 4791359B2 JP 2006523669 A JP2006523669 A JP 2006523669A JP 2006523669 A JP2006523669 A JP 2006523669A JP 4791359 B2 JP4791359 B2 JP 4791359B2
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- 235000007586 terpenes Nutrition 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical class [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- 229950010342 uridine triphosphate Drugs 0.000 description 1
- PGAVKCOVUIYSFO-UHFFFAOYSA-N uridine-triphosphate Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- UBORTCNDUKBEOP-UUOKFMHZSA-N xanthosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(NC(=O)NC2=O)=C2N=C1 UBORTCNDUKBEOP-UUOKFMHZSA-N 0.000 description 1
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Description
バクテリオシンはある細菌により産生することができる抗菌性タンパク質またはペプチドであり、密接に関連した細菌を死滅させるか、または成長を抑制することができる。乳酸菌によって産生されるバクテリオシンは、食品の保存能、および食物病原体の抑制能が大きく見込まれるので特に重要である(非特許文献1)。
(抗菌材料)
1つの好ましい態様において、抗菌材料はバクテリオシンである。
本明細書に述べるように抗菌材料がナイシンから成る場合、組成物は該組成物に対して0.075重量%未満の量のカルバクロール、および該組成物に対して15重量%未満の量の中のカルボンを含む。
本明細書で述べるように、本発明は材料中の微生物の成長を防止および/または阻害するか、および/または微生物を殺菌することができる。これは、細菌などの微生物を本発明の組成物と接触させて存在させることにより微生物を緩慢にさせ、または停止させるか、あるいは微生物を死滅させることによるものである。
本発明の組成物、プロセス、および使用により、材料中の微生物の成長を防止および/または阻害されるか、および/または微生物を殺菌することができる。しかしながら、食料の腐敗および汚染に関連した問題、および食料中の本発明の特定の有効性を考慮すると、組成物が食料であるか、あるいは組成物が食料に添加されることが好ましい。当業者には当然のことであるが、本発明の組成物が食料である場合、必須である(a)抗菌材料および(b)シソ科の植物から得られるか、あるいは得ることのできる抽出物の成分が、既に食料中に存在している。それらは1つ以上の手段によって提供されてもよい。例えば、それらはバクテリオシンおよび抽出物を含む組成物の形態で添加されてもよい。2つの成分(バクテリオシンおよび前述の抽出物)を食料に連続して加えてもよい。1つのさらなる態様では、1つ以上の成分が食料中のイン・サイチユで形成されてもよい。例えば、バクテリオシンは、乳製品スタータカルチャー細菌Lactococcus lactis亜種lactisの発酵による食料中のイン・サイチユで形成される。
本発明の組成物、あるいは本発明で使用される組成物は1つ以上の追加成分を含んでもよい。しかしながら、いくつかの態様において、(食料への添加に適する)本発明の保護剤組成物は、追加成分を含まず、あるいは実質的に組成物の特性に影響を及ぼす追加成分を含まない。これらの態様において、本発明は、以下のものを提供する。
上記の金属イオン封鎖剤の多くは、その塩形態で食品加工に有用であり、一般にナトリウム、カリウム、あるいはカルシウムなどのアルカリ金属またはアルカリ土類塩、または第四級アンモニウム塩である。例えば食品系のコーティングにおいて、pH値を調整するか、あるいは選択的に金属イオンを導入または吸収するために多価の金属イオン封鎖化合物が好ましく用いられる。キレート剤に関するほかの情報は、T.E.Furia(Ed.),CRC Handbook of Food Additives,2nd Ed.,pp.271−294(1972,Chemical Rubber Co.),and M.S.Peterson and A.M.Johnson(Eds.),Encyclopaedia of Food Science,pp.694−699(1978,AVI Publishing Company,Inc.)で開示され、これらの文献はともに参照によって本明細書に引用されている。
本明細書の1つの態様で述べたように、本発明は材料中の微生物の成長を防止および/または阻害するか、および/または微生物を殺菌するためのプロセスを提供する。このプロセスは、(a)抗菌材料および(b)シソ科の植物から得られるあるいは得ることのできる抽出物と材料とを接触させるステップを含み、(a)および(b)は異なり、組成物は該組成物に対して1.0重量%よりも多い量のフェノールジテルペンを含み、抗菌材料がナイシンから成る場合、組成物は該組成物に対して0.075重量%未満の量のカルバクロール、および該組成物に対して15重量%未満の量のカルボンを含む。
本明細書の1つの態様で述べたように、本発明は材料中の微生物の成長を防止および/または阻害するか、および/または微生物を殺菌するためのプロセスを提供する。このプロセスは、(a)抗菌材料および(b)シソ科の植物から得られるあるいは得ることのできる抽出物と材料とを接触させるステップを含み、(a)および(b)は異なり、組成物は該組成物に対して1.0重量%よりも多い量のフェノールジテルペンを含み、抗菌材料がナイシンから成る場合、組成物は該組成物に対して0.075重量%未満の量のカルバクロール、および組成物に対して15重量%未満の量のカルボンを含む。
本明細書に記載されたインビトロの試験は、ナイシンと>3.5%のフェノールジテルペンを含むRosmarinus officinalis抽出物との相乗作用を示し、これはナイシンの効果を有意に増加させるものである。この増強された活性は、食品モデル中でも観察され、ナイシンによるグラム陽性菌の殺菌および成長の抑制が増えていた。実験的研究は、フェノールジテルペンカルノジン酸およびカルノソールがこの相乗作用に関与することをさらに実証した。さらに、結果から、この相乗効果はフェノールジテルペンで観察されたそれほど強くないが、ローズマリー酸もナイシン活性をさらに増強することがわかった。
材料:GUARDIAN(商標)ローズマリー抽出物09(ダニスコ)(GRE09)。これは4%のフェノールジテルペンおよび<1%の精油を含み、ローズマリー葉より抽出され、担体ポリオキシエチレンソルビタンモノオレイン酸塩(ツイーン80)およびプロピレングリコールと組み合わされた水分散性の脱臭されたローズマリー抽出物である。1×106IU/gの力価のナイシンの市販抽出物:Nisaplin(登録商標)天然抗菌薬(ダニスコ)。
(A)Listeria monocytogenesに対する相乗作用)
試験化合物:0.1%、0.5%のGRE09、Nisaplin(登録商標)(ダニスコ)。
試験株:反応混液をL.monocytogenes菌株NCTC12426、NCTC5105、NCC FSM60、およびCRA3930により調製した。ブレインハートインフュージョン寒天培地上で一晩Listeria株を成長させ、続いて30℃、一晩ブロスへ接種した。ある量の各ブロスを互いに混合し、約109CFU/mlの細胞濃度を有する菌株の反応混液を得た。
試験株:Bacillus胞子の反応混液は、Bacillus cereus strain 204,Bacillus cereus strain 199,B.cereus strain Campden,and B.cereus strain ABC 4/9を使用する種菌として調製した。
試験株:Clostridium胞子の反応混液を、Clostridium sporogene系統Campden、Clostridium sporogenes 1.221、およびClostridium sporogenes NCIMB1793を使用する種菌として調製した。
上述のようにバイオスクリーンCアナライザーを使用して、試験培地中のListeria monocytogenesおよびB.cereus系統の成長曲線を分析した。30℃、24時間後に単独または併用で使用した試験化合物について、最小発育阻止濃度(MIC)を測定した。結果を表5に示す。試験化合物は、ナイシン(ダニスコのNisaplin(登録商標))、精製ローズマリー酸(RA、Sigma)、および一連の脱臭されたローズマリー抽出物を含む。これらを有機溶剤またはCO2のいずれかを用いる選択された抽出により調製し、28%のフェノールジテルペン(28RE、ダニスコ)を含む抽出物、および6%のローズマリー酸(6RA、ダニスコ)を含むローズマリー抽出物を得た。精製ローズマリー酸と結合したナイシンの組み合わせ(RA;これは、低pHレベルが一つの原因であると思われる)、6%ローズマリー酸(6RA)を含むローズマリー抽出物とナイシンとの組み合わせ、ならびに28%フェノールジテルペンおよび<1%の精油(28RE)を含む脱臭されたローズマリー抽出物とナイシンとの組み合わせにおいてナイシン活性の増強が明瞭であった。ツイーン80による既知のナイシン相乗作用も観察された。別の担体プロピレングリコールはナイシン活性を増強しなかった。前述のように、ナイシン単独、他の試験化合物、および2つを併用した場合のMICレベルを比較することにより相乗作用を観察することができる(表5を参照)。
試験株:Listeria monocytogenes株272、CRA3930、およびNCTC12426
前述のように、チキンスープモデルを使用した。以下の試料を試験した:GRE09、28%あるいは70%のフェノールジテルペン(RE28およびRE70、ダニスコ)を含む脱臭されたローズマリー抽出物、6%ローズマリー酸(6RA、ダニスコ)を含むる水溶性ローズマリー抽出物、および精製ローズマリー酸(RA、Sigma)。適切にスープへの添加を行った。スープを低温殺菌し(70℃/2分)、pH値を記録し、続いてスープに前述のように調製されたListeria細胞の反応混液を接種した。この試験液を20℃でインキュベートし、20℃で0、2、4、および24時間後に生菌数算定を行った。最初のListeriaレベルは1.3×105CFU/mlであった。2つのナイシンレベル、および異なる時間で試験を繰り返し行った。添加なしのスープのpHはpH6.20〜6.06であった。0.1%のローズマリー酸を添加すると、pH5.75までわずかにpHが低下した。6%のRAを添加はすると、スープpHはpH5.75〜5.78となった。0.5%RE28を添加すると、スープpHはpH5.98となった。0.5%RE70を添加すると、pH6.10となった。0.5%GRE09を添加すると、スープpHはpH6.02〜6.09となった。
(A)低温殺菌されたチキンスープ試験)
方法:ナイシン(ダニスコのNisaplin(登録商標))、28%フェノールジテルペン(RE28)を含むローズマリー抽出物、およびローズマリー抽出物を含むナイシンブレンドの種々の添加物を50IU/mgのレベルで、さらに4.2%フェノールジテルペンを、他の防腐剤を含まない市販のチキンスープに添加した。化合物の添加後、スープ(pH5.8)を70℃、2分間のコア温度で低温殺菌した。スープを室温まで冷却し、Listeria monocytogenes菌株またはBacillus cereus胞子のいずれかの固定相細胞の反応混液を接種した。菌株反応混液は、L.monocytogenes菌株NCIMB12426、菌株358、菌株272、菌株CRA3930を含む。B.cereus反応混液は菌株204、199、ABC4/9、および3.046を含む。最初の接種レベルは約102〜103CFU/gであった。Bacillus試験は15℃でインキュベートし、Listeria試験は8℃でインキュベートした。微生物学的分析は定期的な間隔で行った(ミルク・プレート・カウント寒天、オクスフォードListeria選択寒天)。
方法:ソースは、脂肪のない牛ひき肉(50%)、トマトおよびジュース(48.9%)、デンプン(0.5%)、塩(0.4%)およびショ糖(0.2%)より調製された。褐色になるまで牛肉を5分間油で炒め、続いて乾燥した成分を加え、次にジュースを含むトマトを混合した。ソースを10分間煮込み、冷やしてから滑らかになるまでブレンドする。最終pHは5.13であった。添加物はナイシン、ローズマリー抽出物、およびブレンドで作られた。2分間80℃のコア温度でソースを低温殺菌した。低温殺菌後、Listeria monocytogenes菌株(上述のように)の混液を接種し、試験液を8℃でインキュベートした。
方法:クリーム、スモーク・ベーコン、チーズ、マスカルポーネ、バター、デンプン、タマネギ、ニンニクピューレを含む市販のチルド低温殺菌されたソースを使用した。タンパク質7g、炭水化物6g、脂肪17g。試験化合物の添加物は低温殺菌(70℃のコア温度で10分)前に調製した。ソースを一旦冷却後接種を行った。試料は定期的に微生物数の分析を行った。
結果:これらを図8および9に示す。前述のように、フェノールジテルペン含有抽出物(8.4ppm)は、Listeria細胞およびBacillus胞子に対するナイシン成長抑制性活性を相乗的に増強した。ローズマリー抽出物単独では活性を示さなかった。
方法:希釈したチキンスープ(pH6.2)を上記のように調製し、2つのバッチに分割し、1つのバッチを塩酸でpH4.5に調整した。ナイシン、ローズマリー抽出物、およびブレンドの適切な添加物を作製し、続いてこのスープを低温殺菌した。105CFU/gの初期種菌を与えるまでListeria菌株の混液を接種した。0および2時間後に微生物学的分析により生細胞をカウントした。
結果:結果は、フェノールジテルペンを含むローズマリー抽出物の存在により、特に酸性条件が高いと(図10)ナイシンの殺菌活性を相乗的に増強する(図10および11)ことが分かった。ローズマリー抽出物単独では有意な殺菌効果は認められなかった。
(バクテリオシン+ローズマリーの組合せ)
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上記明細書で言及されたすべての刊行物は、本明細書中に参考として援用される。本発明の記載された方法およびシステムの種々の改変およびバリエーションは、本発明の範囲および趣旨から逸脱することなく、当業者に明らかである。本発明は、特定の好ましい実施形態と組合せて説明されてきたが、請求項に係る本発明は、このような特定の実施形態に過度に制限されるべきではないことが理解されるべきである。実際、化学、生物、食品科学または関連分野の当業者に自明でない、本発明を実施するために記載された様式の種々の改変は、添付の特許請求の範囲の範囲内であることが意図される。
Claims (47)
- (a)ナイシンと、
(b)ローズマリーから得られるかあるいは得ることのできる抽出物と
を含む組成物であって、(a)と(b)とは異なり、
該組成物は、該組成物に対して1.0重量%よりも多い量のフェノールジテルペンを含み、
該組成物は、該組成物に対して0.075重量%未満の量のカルバクロール、該組成物に対して0.075重量%未満の量のカルボン、および該組成物に対して0.1重量%未満の量のチモールを含む、組成物。 - 前記組成物が、該組成物に対して0.04重量%未満の量のカルバクロールを含むことを特徴とする請求項1に記載の組成物。
- 前記組成物が、該組成物に対して0.02重量%未満の量のカルバクロールを含むことを特徴とする請求項1または2に記載の組成物。
- 前記組成物が、該組成物に対して0.04重量%未満の量のカルボンを含むことを特徴とする請求項1〜3のいずれか1項に記載の組成物。
- 前記組成物が、該組成物に対して0.02重量%未満の量のカルボンを含むことを特徴とする請求項1〜4のいずれか1項に記載の組成物。
- 前記組成物が、該組成物に対して0.075重量%未満の量のチモールを含むことを特徴とする請求項1〜5のいずれか1項に記載の組成物。
- 前記組成物が、該組成物に対して0.05重量%未満の量のチモールを含むことを特徴とする請求項1〜6のいずれか1項に記載の組成物。
- 前記組成物が、該組成物に対して2.0重量%より多い量のフェノールジテルペンを含むことを特徴とする請求項1〜7のいずれか1項に記載の組成物。
- 前記組成物が、該組成物に対して3.0重量%より多い量のフェノールジテルペンを含むことを特徴とする請求項1〜8のいずれか1項に記載の組成物。
- 前記組成物が、該組成物に対して3.5重量%より多い量のフェノールジテルペンを含むことを特徴とする請求項1〜9のいずれか1項に記載の組成物。
- 前記フェノールジテルペンが、カルノジン酸、カルノソール、メチルカルノジン酸、およびこれらの混合物から選択されることを特徴とする請求項1〜10のいずれか1項に記載の組成物。
- 前記抽出物が、フェノールジテルペンおよびローズマリー酸を含むか、またはこれらから選択されることを特徴とする請求項1〜11のいずれか1項に記載の組成物。
- 前記抽出物がローズマリー酸を含むことを特徴とする請求項1〜12のいずれか1項に記載の組成物。
- 前記組成物に対するローズマリー酸の量が3.5重量%よりも多いことを特徴とする請求項13に記載の組成物。
- フェノールジテルペンおよびローズマリー酸の組み合わせた量が前記組成物に対して3.5重量%よりも多いことを特徴とする請求項1〜14のいずれか1項に記載の組成物。
- 前記抽出物が前記組成物に対して1重量%未満の量の風味誘発化合物および/または精油を含むことを特徴とする請求項1〜15のいずれか1項に記載の組成物であって、該精油は、植物から得られる揮発性エーテル分画に含まれるものである、組成物。
- 前記抽出物が前記組成物に対して1重量%未満の量の精油を含むことを特徴とする請求項1〜16のいずれか1項に記載の組成物であって、該精油は、植物から得られる揮発性エーテル分画に含まれるものである、組成物。
- 前記ナイシンおよび/または前記抽出物が殺微生物効果または微生物に対する静菌効果を提供する量で存在することを特徴とする請求項1〜17のいずれか1項に記載の組成物。
- 前記ナイシンおよび前記抽出物が殺微生物効果または微生物に対する静菌効果を提供する量で存在することを特徴とする請求項1〜18のいずれか1項に記載の組成物。
- 前記ナイシンおよび前記抽出物が殺微生物相乗効果または微生物に対する静菌相乗効果を提供する量で存在することを特徴とする請求項1〜19のいずれか1項に記載の組成物。
- 前記ナイシンおよび前記抽出物が微生物に対する静菌相乗効果を提供する量で存在することを特徴とする請求項1〜20のいずれか1項に記載の組成物。
- 前記殺微生物効果または微生物に対する静菌効果が、殺菌効果または細菌に対する静菌効果であることを特徴とする請求項18〜21のいずれか1項に記載の組成物。
- 前記殺菌効果または前記細菌に対する静菌効果が、グラム陽性菌に関することを特徴とする請求項22に記載の組成物。
- 前記殺菌効果または前記細菌に対する静菌効果が、Bacillus種、Clostridium種、Listeria monocytogenes、乳酸菌、およびLactobacillus種から選択される生物に関することを特徴とする請求項23に記載の組成物。
- 前記殺菌効果または前記細菌に対する静菌効果が、Listeria monocytogenesに関することを特徴とする請求項22〜24のいずれか1項に記載の組成物。
- 前記組成物が食料であることを特徴とする請求項1〜25のいずれか1項に記載の組成物。
- 前記組成物が、食料への添加に適する保護剤組成物であることを特徴とする請求項1〜26のいずれか1項に記載の組成物。
- 前記食料が生肉、調理済みの肉、生の鶏肉製品、調理された鶏肉製品、生鮮シーフード製品、調理されたシーフード製品、インスタント食品、パスタソース、低温殺菌されたスープ、マヨネーズ、サラダドレッシング、水中油型乳剤、マーガリン、低脂肪スプレッド、油中水型乳剤、乳製品、チーズスプレッド、プロセスチーズ、乳製品デザート、フレーバーミルク、クリーム、発酵乳製品、チーズ、バター、練乳製品、アイスクリームミックス、大豆製品、低温殺菌された液状卵、ベーカリー製品、菓子製品、果実製品、および脂肪ベースの食品、または水含有フィリングから選択される請求項26または27に記載の組成物。
- 前記組成物が乳化剤をさらに含むことを特徴とする請求項1〜28のいずれか1項に記載の組成物。
- 前記乳化剤がポリソルベート、モノグリセリド、ジグリセリド、モノジグリセリドの酢酸エステル、モノジグリセリドの酒石酸エステル、およびモノジグリセリドのクエン酸エステルから選択されることを特徴とする請求項29に記載の組成物。
- 前記組成物がキレート剤をさらに含むことを特徴とする請求項1〜30のいずれか1項に記載の組成物。
- 前記キレート剤がEDTA、クエン酸、モノフォスフェート、ジフォスフェート、トリフォスフェート、およびポリフォスフェートから選択されることを特徴とする請求項31に記載の組成物。
- 前記キレート剤が前記抗菌材料の前記抗菌活性および/または抗菌スペクトルを増強することを特徴とする請求項31または32に記載の組成物。
- 前記キレート剤がグラム陰性菌に対する前記抗菌材料の前記抗菌活性および/または抗菌スペクトルを増強することを特徴とする請求項31、32、あるいは33に記載の組成物。
- 前記組成物が溶菌酵素をさらに含むことを特徴とする請求項1〜34のいずれか1項に記載の組成物。
- 前記溶菌酵素がリゾチームであることを特徴とする請求項35に記載の組成物。
- 請求項1に記載する組成物であって、
(a)ナイシンと、
(b)ローズマリーから得られた抽出物とを含み、該抽出物がローズマリー酸であり、
該ナイシンおよび該抽出物が殺菌または細菌に対する静菌の相乗効果を提供する量で存在することを特徴とする組成物。 - 材料中の微生物の成長を防止および/または阻害するか、および/または微生物を殺菌するためのプロセスであって、該プロセスが、該材料と、
(a)ナイシン、および
(b)ローズマリーから得られるかあるいは得ることのできる抽出物
を含む組成物とを接触させるステップを含み、
(a)と(b)とは異なり、
該組成物が、該組成物に対して1.0重量%よりも多い量のフェノールジテルペンを含み、
該組成物が、該組成物に対して0.075重量%未満の量のカルバクロール、該組成物に対して0.075重量%未満の量のカルボン、および該組成物に対して0.1重量%未満の量のチモールを含むことを特徴とするプロセス。 - 前記ナイシンと前記抽出物とが前記材料に一緒に添加されることを特徴とする請求項38に記載のプロセス。
- 前記ナイシンと前記抽出物とが前記材料に連続して添加されることを特徴とする請求項38に記載のプロセス。
- 前記ナイシンが前記材料に加えられることを特徴とする請求項38〜40のいずれか1項に記載のプロセス。
- 前記ナイシンが前記材料中のイン・サイチユで形成されることを特徴とする請求項38に記載のプロセス。
- 前記材料が食料であることを特徴とする請求項38〜42のいずれか1項に記載のプロセス。
- 材料中の微生物の成長を防止および/または阻害するか、および/または微生物を殺菌するための、(a)ナイシンおよび(b)ローズマリーから得られるかあるいは得ることのできる抽出物を含む組成物の使用であって、(a)と(b)とは異なり、該組成物が、該組成物に対して1.0重量%よりも多い量のフェノールジテルペンを含み、該組成物が、該組成物に対して0.075重量%未満の量のカルバクロール、該組成物に対して0.075重量%未満の量のカルボン、および該組成物に対して0.1重量%未満の量のチモールを含むことを特徴とする使用。
- 前記材料が食料であることを特徴とする請求項44に記載の使用。
- 相乗的に、材料中の微生物の成長を防止および/または阻害するか、および/または微生物を殺菌するための請求項44または45に記載の使用。
- 請求項1〜37のいずれか1項に記載の組成物を調製するためのキットであって、前記キットが個別のパッケージあるいは容器中に、
(a)ナイシンと、
(b)ローズマリーから得られるかあるいは得ることのできる抽出物と
を含み、(a)と(b)とは異なり、混合および/または接触および/または使用のための指示書を任意に含むことを特徴とするキット。
Applications Claiming Priority (13)
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US49740903P | 2003-08-22 | 2003-08-22 | |
US60/497,409 | 2003-08-22 | ||
GB0319817.3 | 2003-08-22 | ||
GB0319817A GB2388581A (en) | 2003-08-22 | 2003-08-22 | Coated aqueous beads |
GB0323335A GB0323335D0 (en) | 2003-10-06 | 2003-10-06 | Composition |
GB0323335.0 | 2003-10-06 | ||
US53305303P | 2003-12-30 | 2003-12-30 | |
US60/533,053 | 2003-12-30 | ||
US56027004P | 2004-04-08 | 2004-04-08 | |
US10/820,147 US20050042341A1 (en) | 2003-08-22 | 2004-04-08 | Natamycin dosage form, method for preparing same and use thereof |
US10/820,147 | 2004-04-08 | ||
US60/560,270 | 2004-04-08 | ||
PCT/GB2004/003423 WO2005018333A1 (en) | 2003-08-22 | 2004-08-06 | Composition comprising a bacteriocin and an extract from a plant of the labiatae family |
Publications (2)
Publication Number | Publication Date |
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JP2007503383A JP2007503383A (ja) | 2007-02-22 |
JP4791359B2 true JP4791359B2 (ja) | 2011-10-12 |
Family
ID=44882000
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JP2006523669A Expired - Fee Related JP4791359B2 (ja) | 2003-08-22 | 2004-08-06 | バクテリオシンおよびシソ科植物からの抽出物を含有する組成物 |
JP2006523668A Pending JP2007503293A (ja) | 2003-08-22 | 2004-08-06 | マイクロカプセル |
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JP2006523668A Pending JP2007503293A (ja) | 2003-08-22 | 2004-08-06 | マイクロカプセル |
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EP (3) | EP1662870A1 (ja) |
JP (2) | JP4791359B2 (ja) |
WO (3) | WO2005018322A1 (ja) |
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- 2004-08-06 WO PCT/GB2004/003397 patent/WO2005018322A1/en active Application Filing
- 2004-08-06 EP EP04767989A patent/EP1662870A1/en not_active Withdrawn
- 2004-08-06 EP EP04743676A patent/EP1663471A1/en not_active Withdrawn
- 2004-08-06 JP JP2006523669A patent/JP4791359B2/ja not_active Expired - Fee Related
- 2004-08-06 EP EP04768009.5A patent/EP1656026B1/en not_active Not-in-force
- 2004-08-06 WO PCT/GB2004/003423 patent/WO2005018333A1/en active Application Filing
- 2004-08-06 JP JP2006523668A patent/JP2007503293A/ja active Pending
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EP1662870A1 (en) | 2006-06-07 |
JP2007503293A (ja) | 2007-02-22 |
JP2007503383A (ja) | 2007-02-22 |
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WO2005018794A8 (en) | 2006-04-06 |
WO2005018794A1 (en) | 2005-03-03 |
EP1656026A1 (en) | 2006-05-17 |
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