JP4782671B2 - 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体 - Google Patents

低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体 Download PDF

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JP4782671B2
JP4782671B2 JP2006508164A JP2006508164A JP4782671B2 JP 4782671 B2 JP4782671 B2 JP 4782671B2 JP 2006508164 A JP2006508164 A JP 2006508164A JP 2006508164 A JP2006508164 A JP 2006508164A JP 4782671 B2 JP4782671 B2 JP 4782671B2
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phl
allergen
variant
seq
allergies
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Japanese (ja)
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JP2007536893A (ja
JP2007536893A5 (enExample
Inventor
ヴァルト，マルティン
クロムウェル，オリヴァー
ナンディー，アンドレーアス
カーレルト，ヘルガ
ヴェーバー，ベルンハルト
フィービク，ヘルムート
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Merck Patent GmbH
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Merck Patent GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2006508164A 2003-06-04 2004-05-06 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体 Expired - Fee Related JP4782671B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10325508 2003-06-04
DE10325508.7 2003-06-04
PCT/EP2004/004848 WO2004108758A1 (de) 2003-06-04 2004-05-06 Phl p 5a-derivate mit reduzierter allergenität und erhaltener t-zellreaktivität

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010207438A Division JP5363441B2 (ja) 2003-06-04 2010-09-16 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体

Publications (3)

Publication Number Publication Date
JP2007536893A JP2007536893A (ja) 2007-12-20
JP2007536893A5 JP2007536893A5 (enExample) 2010-11-11
JP4782671B2 true JP4782671B2 (ja) 2011-09-28

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JP2006508164A Expired - Fee Related JP4782671B2 (ja) 2003-06-04 2004-05-06 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体
JP2010207438A Expired - Fee Related JP5363441B2 (ja) 2003-06-04 2010-09-16 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体

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JP2010207438A Expired - Fee Related JP5363441B2 (ja) 2003-06-04 2010-09-16 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体

Country Status (13)

Country Link
US (3) US8628946B2 (enExample)
EP (3) EP2272863B1 (enExample)
JP (2) JP4782671B2 (enExample)
CN (1) CN1798763B (enExample)
AT (1) ATE513848T1 (enExample)
AU (1) AU2004245184B2 (enExample)
BR (1) BRPI0410908A (enExample)
CA (1) CA2528053C (enExample)
ES (3) ES2397778T3 (enExample)
PL (2) PL2287180T3 (enExample)
PT (3) PT2272863E (enExample)
RU (1) RU2368620C2 (enExample)
WO (1) WO2004108758A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR779201A0 (en) 2001-09-20 2001-10-11 University Of Melbourne, The Immunotherapeutic and immunoprophylactic reagents
US8628946B2 (en) * 2003-06-04 2014-01-14 Merck Patent Gmbh Phl p 5a derivatives having reduced allergeneity and retained T-cell reactivity
AT503690A1 (de) * 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
EP3170510A1 (de) * 2010-01-14 2017-05-24 Merck Patent GmbH Varianten der gruppe 5-allergene der süssgräser mit reduzierter allergenität durch mutagenese von prolinresten
US20230242922A1 (en) 2021-09-13 2023-08-03 Life Technologies Corporation Gene editing tools

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002511842A (ja) * 1997-03-27 2002-04-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 特異的免疫療法のためのイネ科花粉アレルゲン変異体及びそれらの製造及び使用
WO2002040676A2 (en) * 2000-11-16 2002-05-23 Alk-Abelló A/S Mutant allergens
WO2003025009A1 (en) * 2001-09-20 2003-03-27 The University Of Melbourne RECOMBINANT ALLERGEN WITH REDUCED IgE BINDING BUT UNDIMINISHED T-CELL ANTIGENICITY

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736362A (en) * 1990-10-26 1998-04-07 The University Of Melbourne Ryegrass pollen allergen
DE19918682A1 (de) 1999-04-23 2000-10-26 Merck Patent Gmbh DNA-Sequenz und rekombinante Herstellung eines Graminaen-Allergens
IT1318692B1 (it) 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti di proteine allergeniche di phleum pratense.
US8628946B2 (en) * 2003-06-04 2014-01-14 Merck Patent Gmbh Phl p 5a derivatives having reduced allergeneity and retained T-cell reactivity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002511842A (ja) * 1997-03-27 2002-04-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 特異的免疫療法のためのイネ科花粉アレルゲン変異体及びそれらの製造及び使用
WO2002040676A2 (en) * 2000-11-16 2002-05-23 Alk-Abelló A/S Mutant allergens
WO2003025009A1 (en) * 2001-09-20 2003-03-27 The University Of Melbourne RECOMBINANT ALLERGEN WITH REDUCED IgE BINDING BUT UNDIMINISHED T-CELL ANTIGENICITY

Also Published As

Publication number Publication date
PT2287180E (pt) 2013-10-31
PT1629006E (pt) 2011-09-28
US20160207967A1 (en) 2016-07-21
AU2004245184A1 (en) 2004-12-16
EP1629006A1 (de) 2006-03-01
PL2287180T3 (pl) 2013-12-31
US9522938B2 (en) 2016-12-20
ES2397778T3 (es) 2013-03-11
EP2287180B9 (de) 2013-11-06
JP2007536893A (ja) 2007-12-20
JP2011041566A (ja) 2011-03-03
CN1798763A (zh) 2006-07-05
CA2528053C (en) 2014-08-12
PT2272863E (pt) 2013-01-30
BRPI0410908A (pt) 2006-06-27
ES2367633T3 (es) 2011-11-07
ATE513848T1 (de) 2011-07-15
JP5363441B2 (ja) 2013-12-11
PL2272863T3 (pl) 2013-03-29
EP2272863A1 (de) 2011-01-12
US20100158955A1 (en) 2010-06-24
US20140255434A1 (en) 2014-09-11
CA2528053A1 (en) 2004-12-16
US8628946B2 (en) 2014-01-14
AU2004245184B2 (en) 2011-03-24
WO2004108758A1 (de) 2004-12-16
RU2368620C2 (ru) 2009-09-27
ES2434720T3 (es) 2013-12-17
EP2287180B1 (de) 2013-08-07
RU2005141524A (ru) 2006-09-10
EP2287180A1 (de) 2011-02-23
CN1798763B (zh) 2010-05-26
EP2272863B1 (de) 2012-10-31
EP1629006B1 (de) 2011-06-22

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