AU2004245184B2 - Phl p 5a derivatives with reduced allergenicity and retained T-cell reactivity - Google Patents

Phl p 5a derivatives with reduced allergenicity and retained T-cell reactivity Download PDF

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Publication number
AU2004245184B2
AU2004245184B2 AU2004245184A AU2004245184A AU2004245184B2 AU 2004245184 B2 AU2004245184 B2 AU 2004245184B2 AU 2004245184 A AU2004245184 A AU 2004245184A AU 2004245184 A AU2004245184 A AU 2004245184A AU 2004245184 B2 AU2004245184 B2 AU 2004245184B2
Authority
AU
Australia
Prior art keywords
allergen
variant
phi
group
allergy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004245184A
Other languages
English (en)
Other versions
AU2004245184A1 (en
Inventor
Oliver Cromwell
Helmut Fiebig
Helga Kahlert
Andreas Nandy
Martin Wald
Bernhard Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2004245184A1 publication Critical patent/AU2004245184A1/en
Application granted granted Critical
Publication of AU2004245184B2 publication Critical patent/AU2004245184B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2004245184A 2003-06-04 2004-05-06 Phl p 5a derivatives with reduced allergenicity and retained T-cell reactivity Ceased AU2004245184B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10325508.7 2003-06-04
DE10325508 2003-06-04
PCT/EP2004/004848 WO2004108758A1 (de) 2003-06-04 2004-05-06 Phl p 5a-derivate mit reduzierter allergenität und erhaltener t-zellreaktivität

Publications (2)

Publication Number Publication Date
AU2004245184A1 AU2004245184A1 (en) 2004-12-16
AU2004245184B2 true AU2004245184B2 (en) 2011-03-24

Family

ID=33494849

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004245184A Ceased AU2004245184B2 (en) 2003-06-04 2004-05-06 Phl p 5a derivatives with reduced allergenicity and retained T-cell reactivity

Country Status (13)

Country Link
US (3) US8628946B2 (enExample)
EP (3) EP1629006B1 (enExample)
JP (2) JP4782671B2 (enExample)
CN (1) CN1798763B (enExample)
AT (1) ATE513848T1 (enExample)
AU (1) AU2004245184B2 (enExample)
BR (1) BRPI0410908A (enExample)
CA (1) CA2528053C (enExample)
ES (3) ES2434720T3 (enExample)
PL (2) PL2272863T3 (enExample)
PT (3) PT2272863E (enExample)
RU (1) RU2368620C2 (enExample)
WO (1) WO2004108758A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR779201A0 (en) 2001-09-20 2001-10-11 University Of Melbourne, The Immunotherapeutic and immunoprophylactic reagents
JP4782671B2 (ja) * 2003-06-04 2011-09-28 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体
AT503690A1 (de) * 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
CA2786936A1 (en) 2010-01-14 2011-07-21 Merck Patent Gmbh Variants of group 5 allergens of the true grasses having reduced allergeneity due to mutagenesis of proline residues
KR20240055084A (ko) 2021-09-13 2024-04-26 라이프 테크놀로지스 코포레이션 유전자 편집 도구

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19713001A1 (de) * 1997-03-27 1998-10-01 Merck Patent Gmbh Graminaenpollenallergenmutanten zur spezifischen Immuntherapie, deren Herstellung und Verwendung
WO2003025009A1 (en) * 2001-09-20 2003-03-27 The University Of Melbourne RECOMBINANT ALLERGEN WITH REDUCED IgE BINDING BUT UNDIMINISHED T-CELL ANTIGENICITY

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736362A (en) * 1990-10-26 1998-04-07 The University Of Melbourne Ryegrass pollen allergen
DE19918682A1 (de) * 1999-04-23 2000-10-26 Merck Patent Gmbh DNA-Sequenz und rekombinante Herstellung eines Graminaen-Allergens
IT1318692B1 (it) * 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti di proteine allergeniche di phleum pratense.
PL214225B1 (pl) * 2000-11-16 2013-07-31 Alk Abello As Zrekombinowany alergen, zastosowanie zrekombinowanego alergenu, kompozycja farmaceutyczna, sposób przygotowania kompozycji farmaceutycznej, sposób przygotowania zrekombinowanego alergenu, sekwencja DNA kodujaca zrekombinowany alergen, wektor ekspresyjny, komórka gospodarza oraz sposób produkcji zrekombinowanego zmutowanego alergenu
JP4782671B2 (ja) * 2003-06-04 2011-09-28 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19713001A1 (de) * 1997-03-27 1998-10-01 Merck Patent Gmbh Graminaenpollenallergenmutanten zur spezifischen Immuntherapie, deren Herstellung und Verwendung
WO2003025009A1 (en) * 2001-09-20 2003-03-27 The University Of Melbourne RECOMBINANT ALLERGEN WITH REDUCED IgE BINDING BUT UNDIMINISHED T-CELL ANTIGENICITY

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHRAMM, GABRIELE et al. '"Allergen Engineering": Variants of the Timothy Grass Pollen Allergen Ph1 p 5b with Reduced IgE-Binding Capacity but Conserved T cell reactivity.' The Journal of Immunology. 1999, Vol. 162, pages 2406-2414 *

Also Published As

Publication number Publication date
WO2004108758A1 (de) 2004-12-16
ES2434720T3 (es) 2013-12-17
US20140255434A1 (en) 2014-09-11
PT1629006E (pt) 2011-09-28
EP2272863A1 (de) 2011-01-12
PT2272863E (pt) 2013-01-30
PL2287180T3 (pl) 2013-12-31
PT2287180E (pt) 2013-10-31
PL2272863T3 (pl) 2013-03-29
ES2367633T3 (es) 2011-11-07
US20160207967A1 (en) 2016-07-21
EP2287180B9 (de) 2013-11-06
JP4782671B2 (ja) 2011-09-28
ATE513848T1 (de) 2011-07-15
CA2528053C (en) 2014-08-12
ES2397778T3 (es) 2013-03-11
EP1629006B1 (de) 2011-06-22
JP2007536893A (ja) 2007-12-20
RU2005141524A (ru) 2006-09-10
US9522938B2 (en) 2016-12-20
US8628946B2 (en) 2014-01-14
CN1798763A (zh) 2006-07-05
US20100158955A1 (en) 2010-06-24
JP2011041566A (ja) 2011-03-03
RU2368620C2 (ru) 2009-09-27
CA2528053A1 (en) 2004-12-16
AU2004245184A1 (en) 2004-12-16
EP2287180A1 (de) 2011-02-23
EP2287180B1 (de) 2013-08-07
EP2272863B1 (de) 2012-10-31
JP5363441B2 (ja) 2013-12-11
BRPI0410908A (pt) 2006-06-27
CN1798763B (zh) 2010-05-26
EP1629006A1 (de) 2006-03-01

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired