JP4755113B2 - 線維性状態およびその他の疾患の治療のための、オリゴリボヌクレオチドおよびその使用方法 - Google Patents

線維性状態およびその他の疾患の治療のための、オリゴリボヌクレオチドおよびその使用方法 Download PDF

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JP4755113B2
JP4755113B2 JP2006550491A JP2006550491A JP4755113B2 JP 4755113 B2 JP4755113 B2 JP 4755113B2 JP 2006550491 A JP2006550491 A JP 2006550491A JP 2006550491 A JP2006550491 A JP 2006550491A JP 4755113 B2 JP4755113 B2 JP 4755113B2
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tgaseii
compound
fibrosis
sirna
polypeptide
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JP2007528216A (ja
JP2007528216A5 (enExample
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モル、オルナ
フェインステイン、エレナ
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Quark Pharmaceuticals Inc
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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JP2006550491A 2004-01-30 2005-01-27 線維性状態およびその他の疾患の治療のための、オリゴリボヌクレオチドおよびその使用方法 Expired - Fee Related JP4755113B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US54068704P 2004-01-30 2004-01-30
US60/540,687 2004-01-30
US64152205P 2005-01-04 2005-01-04
US60/641,522 2005-01-04
PCT/IL2005/000102 WO2005072057A2 (en) 2004-01-30 2005-01-27 Oligoribonucleotides and methods of use thereof for treatment of fibrotic conditions and other diseases

Related Child Applications (1)

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JP2011083817A Division JP2011172579A (ja) 2004-01-30 2011-04-05 線維性状態およびその他の疾患の治療のための、オリゴリボヌクレオチドおよびその使用方法

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JP2007528216A JP2007528216A (ja) 2007-10-11
JP2007528216A5 JP2007528216A5 (enExample) 2008-03-13
JP4755113B2 true JP4755113B2 (ja) 2011-08-24

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JP2006550491A Expired - Fee Related JP4755113B2 (ja) 2004-01-30 2005-01-27 線維性状態およびその他の疾患の治療のための、オリゴリボヌクレオチドおよびその使用方法
JP2011083817A Pending JP2011172579A (ja) 2004-01-30 2011-04-05 線維性状態およびその他の疾患の治療のための、オリゴリボヌクレオチドおよびその使用方法

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US (3) US20050197310A1 (enExample)
EP (2) EP2330111A3 (enExample)
JP (2) JP4755113B2 (enExample)
AT (1) ATE491715T1 (enExample)
DE (1) DE602005025347D1 (enExample)
WO (1) WO2005072057A2 (enExample)

Cited By (1)

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JP2013102767A (ja) * 2006-10-25 2013-05-30 Quark Pharmaceuticals Inc 新規のｓｉＲＮＡおよびその使用方法

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US9234048B2 (en) 2012-01-18 2016-01-12 Wisconsin Alumni Research Foundation Boronate-mediated delivery of molecules into cells
US9732101B2 (en) 2012-01-18 2017-08-15 Wisconsin Alumni Research Foundation Bioreversible boronates for delivery of molecules into cells
US9340784B2 (en) 2012-03-19 2016-05-17 Ionis Pharmaceuticals, Inc. Methods and compositions for modulating alpha-1-antitrypsin expression
WO2014043544A1 (en) 2012-09-14 2014-03-20 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
KR101881662B1 (ko) * 2016-05-12 2018-07-26 강원대학교산학협력단 당뇨성 합병증 예방 및 치료용 약제학적 조성물 및 당뇨성 합병증 예방 또는 치료제 스크리닝 방법
US10155948B2 (en) 2016-05-12 2018-12-18 Kangwon National University University-Industry Cooperation Foundation and Pharmaceutical composition for preventing or treating diabetic complications and screening method for preventive or therapeutic agent for diabetic complications
EP3548005A4 (en) 2016-11-29 2020-06-17 Puretech Health LLC Exosomes for delivery of therapeutic agents
IT201800009133A1 (it) * 2018-10-03 2020-04-03 Università Cattolica del Sacro Cuore Identificazione di biomarcatori molecolari predittivi di risposta al trattamento radiochemoterapico nel carcinoma della cervice
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US20080287386A1 (en) 2008-11-20
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