JP4739233B2 - 免疫グロブリンの精製 - Google Patents

免疫グロブリンの精製 Download PDF

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Publication number
JP4739233B2
JP4739233B2 JP2006546922A JP2006546922A JP4739233B2 JP 4739233 B2 JP4739233 B2 JP 4739233B2 JP 2006546922 A JP2006546922 A JP 2006546922A JP 2006546922 A JP2006546922 A JP 2006546922A JP 4739233 B2 JP4739233 B2 JP 4739233B2
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Japan
Prior art keywords
ligand
matrix
buffer
gel
sulfonamide
Prior art date
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Expired - Lifetime
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JP2006546922A
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English (en)
Japanese (ja)
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JP2007535658A5 (OSRAM
JP2007535658A (ja
Inventor
グラッド,ガンナー
ヨハンソン,ボー−レナート
マロワゼル,ジャン・ルック
ノーマン,ニルズ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
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Amersham Bioscience AB
GE Healthcare Bio Sciences Corp
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Publication of JP2007535658A5 publication Critical patent/JP2007535658A5/ja
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J20/26—Synthetic macromolecular compounds
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T428/249963—And a force disintegratable component [e.g., stencil sheet, etc.]

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2006546922A 2003-12-23 2004-12-21 免疫グロブリンの精製 Expired - Lifetime JP4739233B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0303532A SE0303532D0 (sv) 2003-12-23 2003-12-23 Purification of immunoglobulins
SE0303532-6 2003-12-23
PCT/SE2004/002007 WO2005061543A1 (en) 2003-12-23 2004-12-21 Purification of immunoglobulins

Publications (3)

Publication Number Publication Date
JP2007535658A JP2007535658A (ja) 2007-12-06
JP2007535658A5 JP2007535658A5 (OSRAM) 2008-02-14
JP4739233B2 true JP4739233B2 (ja) 2011-08-03

Family

ID=30768847

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006546922A Expired - Lifetime JP4739233B2 (ja) 2003-12-23 2004-12-21 免疫グロブリンの精製

Country Status (11)

Country Link
US (2) US20070151928A1 (OSRAM)
EP (1) EP1697416B1 (OSRAM)
JP (1) JP4739233B2 (OSRAM)
CN (1) CN100516086C (OSRAM)
AT (1) ATE391729T1 (OSRAM)
AU (1) AU2004303746B2 (OSRAM)
CA (1) CA2549923A1 (OSRAM)
DE (1) DE602004013040T2 (OSRAM)
ES (1) ES2304638T3 (OSRAM)
SE (1) SE0303532D0 (OSRAM)
WO (1) WO2005061543A1 (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0401665D0 (sv) 2004-06-24 2004-06-24 Amersham Biosciences Ab Purification of immunoglobulins
JP4677623B2 (ja) * 2005-05-16 2011-04-27 独立行政法人産業技術総合研究所 液体クロマトグラフィー用担体、該担体を充填したクロマトグラフィー用カラム、及び該カラムを用いた有機物の分離方法
SE529259C2 (sv) * 2005-08-31 2007-06-12 Ge Healthcare Bio Sciences Ab Tillverkning av kromarografimatriser, en kromarografimatris, en vätskekromatografikolonn, prcess för att isolera målföreningar och användning av en kromarografimatris för vätskekromatografi
WO2007064281A1 (en) * 2005-12-02 2007-06-07 Ge Healthcare Bio-Sciences Ab Hydrophobic interaction chromatography
US9044740B2 (en) 2007-03-30 2015-06-02 Ge Healthcare Bio-Sciences Ab Purification of immunoglobulins
WO2012099576A1 (en) * 2011-01-18 2012-07-26 Baxter International Inc. Measurement of anti-amyloid antibodies in human blood
CN102276840B (zh) * 2011-05-06 2012-08-01 中国药科大学 一种樟脑磺酰胺掺杂乙烷桥键球形介孔硅胶
EP2570183A1 (en) * 2011-09-15 2013-03-20 InstrAction GmbH Sorbent comprising on its surface an aliphatic unit for the purification of organic molecules
WO2014078729A1 (en) * 2012-11-15 2014-05-22 Genentech, Inc. IONIC STRENGTH-MEDIATED pH GRADIENT ION EXCHANGE CHROMATOGRAPHY
CN105579463B (zh) * 2014-03-14 2020-01-31 生物辐射实验室股份有限公司 混合模式配体
CN106102903A (zh) * 2014-03-14 2016-11-09 通用电气医疗集团生物工艺研发股份公司 用于生物颗粒纯化的分离基质
EP3137209B1 (en) 2014-05-02 2022-10-05 W.R. Grace & CO. - CONN. Functionalized support material and methods of making and using functionalized support material
CA3121103C (en) * 2018-11-28 2023-10-10 Cube Biotech Gmbh Solid-phase chelator material, method for producing thereof and use thereof for the purification of proteins

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4212905A (en) * 1976-06-30 1980-07-15 Board of Reagents, for and on behalf of the University of Florida Method of coating supports using addition copolymers of aminimides
JPS6145773A (ja) * 1984-08-07 1986-03-05 テルモ株式会社 体液浄化材
DE3664729D1 (en) * 1985-04-09 1989-09-07 Terumo Corp Immunoglobulin adsorbent and adsorption apparatus
US4752398A (en) * 1985-08-05 1988-06-21 Holbein Bruce E Method for removing mercury and other related metals from a liquid medium
JPS6253669A (ja) * 1985-08-31 1987-03-09 テルモ株式会社 免疫グロブリン物質の吸着材および吸着装置
JPS639450A (ja) * 1986-06-28 1988-01-16 テルモ株式会社 体液成分分離材およびこれを備えた体液成分分離装置
US5240602A (en) * 1987-06-08 1993-08-31 Chromatochem, Inc. Chromatographic material
DE3811042A1 (de) * 1988-03-31 1989-10-19 Merck Patent Gmbh Ionenaustauscher
US5043062A (en) * 1989-02-21 1991-08-27 Eastman Kodak Company High performance affinity chromatography column comprising non-porous, nondisperse polymeric packing material
JP2558007B2 (ja) * 1990-10-31 1996-11-27 株式会社資生堂 液体クロマトグラフィー用充填剤およびその製造方法
US5410648A (en) * 1991-08-30 1995-04-25 International Business Machines Corporation Debugging system wherein multiple code views are simultaneously managed
US6117996A (en) * 1995-09-20 2000-09-12 Novo Nordisk A/S Triazine based ligands and use thereof
SE9600590D0 (sv) * 1996-02-19 1996-02-19 Pharmacia Biotech Ab Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris
EP2095873A1 (en) * 1996-08-30 2009-09-02 Upfront Chromatography A/S Isolation of immunoglobulins
US5953526A (en) * 1997-11-10 1999-09-14 Internatinal Business Machines Corp. Object oriented programming system with displayable natural language documentation through dual translation of program source code
JP2005510609A (ja) * 2001-11-26 2005-04-21 アメルシャム・バイオサイエンシーズ・アクチボラグ 多孔性支持体の後修飾
WO2007064281A1 (en) * 2005-12-02 2007-06-07 Ge Healthcare Bio-Sciences Ab Hydrophobic interaction chromatography

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WO2005061543A1 (en) 2005-07-07
EP1697416B1 (en) 2008-04-09
AU2004303746B2 (en) 2011-03-24
AU2004303746A1 (en) 2005-07-07
JP2007535658A (ja) 2007-12-06
CN1898265A (zh) 2007-01-17
EP1697416A1 (en) 2006-09-06
US20100151581A1 (en) 2010-06-17
SE0303532D0 (sv) 2003-12-23
ATE391729T1 (de) 2008-04-15
US20070151928A1 (en) 2007-07-05
ES2304638T3 (es) 2008-10-16
CA2549923A1 (en) 2005-07-07
US8685248B2 (en) 2014-04-01
CN100516086C (zh) 2009-07-22
DE602004013040T2 (de) 2009-07-02
DE602004013040D1 (de) 2008-05-21

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