JP4709545B2 - 修飾された低分子干渉rna分子および使用方法 - Google Patents
修飾された低分子干渉rna分子および使用方法 Download PDFInfo
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- JP4709545B2 JP4709545B2 JP2004524748A JP2004524748A JP4709545B2 JP 4709545 B2 JP4709545 B2 JP 4709545B2 JP 2004524748 A JP2004524748 A JP 2004524748A JP 2004524748 A JP2004524748 A JP 2004524748A JP 4709545 B2 JP4709545 B2 JP 4709545B2
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| PCT/US2003/023104 WO2004011647A1 (en) | 2002-07-26 | 2003-07-25 | Modified small interfering rna molecules and methods of use |
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| US8202979B2 (en) * | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
| ATE556714T1 (de) | 2002-02-01 | 2012-05-15 | Life Technologies Corp | Doppelsträngige oligonukleotide |
| EP1572902B1 (en) * | 2002-02-01 | 2014-06-11 | Life Technologies Corporation | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
| AU2003219817B2 (en) * | 2002-02-20 | 2006-08-31 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis C virus |
| US20090192105A1 (en) * | 2002-02-20 | 2009-07-30 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF INTERCELLULAR ADHESION MOLECULE (ICAM) GENE EXPRESSION USING SHORT INTERFERING NUCELIC ACID (siNA) |
| US20040248094A1 (en) * | 2002-06-12 | 2004-12-09 | Ford Lance P. | Methods and compositions relating to labeled RNA molecules that reduce gene expression |
| GB2406169B (en) * | 2002-06-12 | 2006-11-01 | Ambion Inc | Methods and compositions relating to labeled rna molecules that reduce gene expression |
| US20100075423A1 (en) * | 2002-06-12 | 2010-03-25 | Life Technologies Corporation | Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference |
| AU2003261231A1 (en) | 2002-07-26 | 2004-02-16 | Chiron Corporation | Modified small interfering rna molecules and methods of use |
| US20040029275A1 (en) * | 2002-08-10 | 2004-02-12 | David Brown | Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs |
| US20060160759A1 (en) * | 2002-09-28 | 2006-07-20 | Jianzhu Chen | Influenza therapeutic |
| DE10302421A1 (de) * | 2003-01-21 | 2004-07-29 | Ribopharma Ag | Doppelsträngige Ribonukleinsäure mit verbesserter Wirksamkeit |
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| AU2003261231A8 (en) | 2004-02-16 |
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| ES2322145T3 (es) | 2009-06-17 |
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| US9139833B2 (en) | 2015-09-22 |
| US20120122962A1 (en) | 2012-05-17 |
| CA2884658A1 (en) | 2004-02-05 |
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