JP4689941B2 - 固相合成担体および方法 - Google Patents

固相合成担体および方法 Download PDF

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Publication number
JP4689941B2
JP4689941B2 JP2002579111A JP2002579111A JP4689941B2 JP 4689941 B2 JP4689941 B2 JP 4689941B2 JP 2002579111 A JP2002579111 A JP 2002579111A JP 2002579111 A JP2002579111 A JP 2002579111A JP 4689941 B2 JP4689941 B2 JP 4689941B2
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JP
Japan
Prior art keywords
linker
group
organic
functionalized
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2002579111A
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English (en)
Japanese (ja)
Other versions
JP2005500993A5 (https=
JP2005500993A (ja
Inventor
ケー． ラズムッセン，ジェラルド
アール． クレプスキ，ラリー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
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3M Innovative Properties Co
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Publication date
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Publication of JP2005500993A publication Critical patent/JP2005500993A/ja
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Application granted granted Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Structural Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2002579111A 2001-04-05 2002-02-28 固相合成担体および方法 Expired - Fee Related JP4689941B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/827,107 US6787635B2 (en) 2001-04-05 2001-04-05 Solid phase synthesis supports and methods
US09/827,107 2001-04-05
PCT/US2002/006367 WO2002081078A2 (en) 2001-04-05 2002-02-28 Solid phase synthesis supports and methods

Publications (3)

Publication Number Publication Date
JP2005500993A JP2005500993A (ja) 2005-01-13
JP2005500993A5 JP2005500993A5 (https=) 2005-12-22
JP4689941B2 true JP4689941B2 (ja) 2011-06-01

Family

ID=25248329

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002579111A Expired - Fee Related JP4689941B2 (ja) 2001-04-05 2002-02-28 固相合成担体および方法

Country Status (6)

Country Link
US (3) US6787635B2 (https=)
EP (1) EP1373167B1 (https=)
JP (1) JP4689941B2 (https=)
AU (1) AU2002247242A1 (https=)
CA (1) CA2441922C (https=)
WO (1) WO2002081078A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005295757A1 (en) * 2004-10-15 2006-04-27 3M Innovative Properties Company Pleated multi-layer filter media and cartridge
US20060258875A1 (en) * 2005-05-10 2006-11-16 Clementine Reyes Methods for manufacturing supported nanocatalysts and methods for using supported nanocatalysts
US20060260677A1 (en) * 2005-05-23 2006-11-23 Cornell Research Foundation, Inc. Polypropylene silicate nanocomposites
US8097229B2 (en) * 2006-01-17 2012-01-17 Headwaters Technology Innovation, Llc Methods for manufacturing functionalized inorganic oxides and polymers incorporating same
WO2009158071A2 (en) 2008-06-26 2009-12-30 3M Innovative Properties Company Solid support with a grafted chain

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3730922A (en) * 1971-08-09 1973-05-01 Shell Oil Co Cyclic ether polymerization process
US4350628A (en) * 1979-10-01 1982-09-21 Research Corporation Preparation of dehydropeptides
US4996243A (en) * 1981-10-29 1991-02-26 Minnesota Mining And Manufacturing Company Curable acrylamido oligomer compositions with initiator, and cured products
US4485236A (en) * 1982-09-27 1984-11-27 Minnesota Mining And Manufacturing Company Azlactone-functional compounds
US4918231A (en) 1984-07-30 1990-04-17 Minnesota Mining And Manufacturing Company Process for the production of 1,2-amino alcohols
US4871824A (en) 1987-03-13 1989-10-03 Minnesota Mining And Manufacturing Company Variably crosslinked polymeric supports
US5336742A (en) 1987-03-13 1994-08-09 Minnesota Mining And Manufacturing Company Polymeric supports
US5262484A (en) 1989-04-10 1993-11-16 Minnesota Mining And Manufacturing Company Azlactone graft copolymers
US5200471A (en) * 1990-11-05 1993-04-06 Minnesota Mining And Manufacturing Company Biomolecules covalently immobilized with a high bound specific biological activity and method of preparing same
US5198531A (en) 1991-06-14 1993-03-30 Research Diagnostic Antibodies Polymeric resin for peptide synthesis
US5993935A (en) 1991-10-11 1999-11-30 3M Innovative Properties Company Covalently reactive particles incorporated in a continous porous matrix
US5344701A (en) 1992-06-09 1994-09-06 Minnesota Mining And Manufacturing Company Porous supports having azlactone-functional surfaces
US5292514A (en) 1992-06-24 1994-03-08 Minnesota Mining And Manufacturing Company Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof
US5750245A (en) 1993-01-29 1998-05-12 Minnesota Mining And Manufacturing Company Thermally induced phase separated azlactone membrane
CA2158056A1 (en) 1993-03-29 1994-10-13 William H. Velander Method of coupling ligands within porous supports (p.e. azlactone) and uses thereof
US5576419A (en) 1993-06-30 1996-11-19 Regents Of The University Of Minnesota Mild solid-phase synthesis of aligned branched triple-helical peptides
US5408002A (en) 1993-09-09 1995-04-18 Minnesota Mining And Manufacturing Company Azlactone-functional polymer blends, articles produced therefrom and methods for preparing both
US5561097A (en) 1994-04-28 1996-10-01 Minnesota Mining And Manufacturing Company Method of controlling density of ligand coupled onto supports and products produced therefrom
US5510421A (en) 1994-05-26 1996-04-23 Minnesota Mining And Manufacturing Company Azlactone-functional membranes and methods of preparing and using same
US5695760A (en) * 1995-04-24 1997-12-09 Boehringer Inglehiem Pharmaceuticals, Inc. Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
US5656707A (en) 1995-06-16 1997-08-12 Regents Of The University Of Minnesota Highly cross-linked polymeric supports
EP0801083A3 (en) 1996-04-08 1999-12-29 Pfizer Inc. Improved functionalized resin for chemical synthesis
US5917015A (en) 1996-06-18 1999-06-29 Regents Of The University Of Minnesota Support material for solid phase organic synthesis
GB9716456D0 (en) 1997-08-05 1997-10-08 Univ St Andrews Modified ethylene polymer
WO2000012515A1 (en) * 1998-08-31 2000-03-09 Smithkline Beecham Corporation Vinyl substituted cyclic products of the ene-yne reaction
GB9821669D0 (en) * 1998-10-05 1998-12-02 Glaxo Group Ltd Chemical constructs and their uses
WO2000026262A2 (en) 1998-11-05 2000-05-11 Mitokor Functionalized polymeric substrates for binding molecular moieties
GB9923577D0 (en) * 1999-10-05 1999-12-08 Glaxo Group Ltd Chemical constructs

Also Published As

Publication number Publication date
AU2002247242A1 (en) 2002-10-21
US7166696B2 (en) 2007-01-23
US6787635B2 (en) 2004-09-07
US20020173051A1 (en) 2002-11-21
CA2441922A1 (en) 2002-10-17
US20040265899A1 (en) 2004-12-30
EP1373167A2 (en) 2004-01-02
US20070049728A1 (en) 2007-03-01
JP2005500993A (ja) 2005-01-13
WO2002081078A3 (en) 2003-03-27
US7820785B2 (en) 2010-10-26
CA2441922C (en) 2011-04-19
WO2002081078A2 (en) 2002-10-17
EP1373167B1 (en) 2015-12-09

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