JP4686126B2 - ペルオキシダーゼによって化学ルミネセンスを発生する優良化合物 - Google Patents

ペルオキシダーゼによって化学ルミネセンスを発生する優良化合物 Download PDF

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JP4686126B2
JP4686126B2 JP2003554650A JP2003554650A JP4686126B2 JP 4686126 B2 JP4686126 B2 JP 4686126B2 JP 2003554650 A JP2003554650 A JP 2003554650A JP 2003554650 A JP2003554650 A JP 2003554650A JP 4686126 B2 JP4686126 B2 JP 4686126B2
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JP2005514396A (ja
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アクハヴァン−タフティ ハシェム
デ シルヴァ レヌカ
シェ ウェンファ
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ルミゲン インク
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/64—Acridine or hydrogenated acridine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/908—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2003554650A 2001-12-20 2002-12-18 ペルオキシダーゼによって化学ルミネセンスを発生する優良化合物 Expired - Lifetime JP4686126B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/029,222 US6872828B2 (en) 2001-12-20 2001-12-20 Compounds for generating chemiluminescence with a peroxidase
US10/205,050 US6858733B2 (en) 2001-12-20 2002-07-25 Compounds for generating chemiluminescence with a peroxidase
PCT/US2002/037611 WO2003053934A1 (en) 2001-12-20 2002-12-18 Improved compounds for generating chemiluminescence with a peroxidase

Publications (3)

Publication Number Publication Date
JP2005514396A JP2005514396A (ja) 2005-05-19
JP2005514396A5 JP2005514396A5 (https=) 2006-02-16
JP4686126B2 true JP4686126B2 (ja) 2011-05-18

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JP2003554650A Expired - Lifetime JP4686126B2 (ja) 2001-12-20 2002-12-18 ペルオキシダーゼによって化学ルミネセンスを発生する優良化合物

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US (2) US6872828B2 (https=)
EP (1) EP2096110B1 (https=)
JP (1) JP4686126B2 (https=)
AT (2) ATE425969T1 (https=)
DE (1) DE60231645D1 (https=)
DK (1) DK2096110T3 (https=)
ES (2) ES2368509T3 (https=)
PT (1) PT2096110E (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7247726B2 (en) * 2001-02-26 2007-07-24 Lumigen, Inc. Compounds for generating chemiluminescence with a peroxidase
US7560556B2 (en) * 2001-12-20 2009-07-14 Lumigen, Inc. Assay methods using chemiluminescent detection of peroxidase
US20060205094A1 (en) * 2005-03-14 2006-09-14 Lumigen, Inc. Methods using novel chemiluminescent labels
US7682839B2 (en) * 2005-03-14 2010-03-23 Lumigen, Inc. Methods using novel chemiluminescent labels
US7972789B2 (en) * 2005-11-28 2011-07-05 Dako Denmark A/S Dye compounds
KR101243918B1 (ko) * 2006-01-03 2013-03-14 삼성디스플레이 주식회사 청색 발광 고분자, 그 제조방법 및 이를 채용한 유기 전계발광 소자
WO2009062027A1 (en) * 2007-11-07 2009-05-14 Beckman Coulter, Inc. Nonseparation assay methods using peroxide generating enzymes
WO2013142758A1 (en) * 2012-03-23 2013-09-26 Surmodics, Inc. Compositions and methods for in vitro diagnostic tests including sulfonic acid
EP3933384A1 (en) 2013-03-15 2022-01-05 Hycor Biomedical, LLC Device and associated method for performing luminescence and fluorescence measurements of a sample
CN114184584B (zh) * 2021-12-06 2024-06-04 山东航空学院 酶测定试胶束液及海洋天然产物抗氧化活性评价方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999066005A1 (en) * 1998-06-17 1999-12-23 Lumigen, Inc. Novel chemiluminescent labeling compounds
JP2001516760A (ja) * 1997-09-12 2001-10-02 ルミゲン インコーポレイテッド ペルオキシダーゼにより化学ルミネセンスを発生する新規化合物
JP2001516589A (ja) * 1997-09-12 2001-10-02 ルミゲン・インコーポレーテッド 化学ルミネセンス化合物及び方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0361470B1 (en) 1988-09-30 1993-12-22 Fujirebio Inc. Method for the chemiluminescence assay of the activity of peroxidase
EP0422252B1 (en) 1989-04-28 1995-07-26 Toray Industries, Inc. Method for detecting a substance using chemiluminescence
US5324835A (en) 1990-03-30 1994-06-28 Biosensor Laboratories Co., Ltd. Pyridazinoquinoxalinones for use as chemiluminescent agents
US5629168A (en) 1992-02-10 1997-05-13 British Technology Group Limited Chemiluminescent enhancers
JPH07509245A (ja) 1992-07-20 1995-10-12 デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 新規化学発光化合物およびその使用方法
US5552298A (en) 1992-10-23 1996-09-03 Lumigen, Inc. Enzyme-catalyzed chemiluminescence from hydroxyaryl cyclic diacylhydrazide compounds
JP3315775B2 (ja) 1992-12-24 2002-08-19 日立化成工業株式会社 標識物としてパーオキシダーゼを用いる化学発光分析方法
US5512451A (en) 1993-04-01 1996-04-30 British Technology Group Limited Enhancement of chemiluminescent reactions
US5593845A (en) 1993-05-17 1997-01-14 Lumigen, Inc. Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection
US5491072A (en) 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
US5523212A (en) 1993-05-17 1996-06-04 Lumigen, Inc. Aryl N-alkylacridanthiocarboxylate derivatives useful for chemiluminescent detection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001516760A (ja) * 1997-09-12 2001-10-02 ルミゲン インコーポレイテッド ペルオキシダーゼにより化学ルミネセンスを発生する新規化合物
JP2001516589A (ja) * 1997-09-12 2001-10-02 ルミゲン・インコーポレーテッド 化学ルミネセンス化合物及び方法
WO1999066005A1 (en) * 1998-06-17 1999-12-23 Lumigen, Inc. Novel chemiluminescent labeling compounds

Also Published As

Publication number Publication date
ES2368509T3 (es) 2011-11-17
US6872828B2 (en) 2005-03-29
ES2323303T3 (es) 2009-07-13
EP2096110A1 (en) 2009-09-02
US20030170771A1 (en) 2003-09-11
US20030170762A1 (en) 2003-09-11
ATE425969T1 (de) 2009-04-15
DK2096110T3 (da) 2011-10-10
HK1134088A1 (en) 2010-04-16
DE60231645D1 (de) 2009-04-30
ATE513814T1 (de) 2011-07-15
PT2096110E (pt) 2011-09-27
JP2005514396A (ja) 2005-05-19
US6858733B2 (en) 2005-02-22
EP2096110B1 (en) 2011-06-22

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